EuRBPDB

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TCGA tumor abbreviations
  • ACCAdrenocortical carcinoma
  • BLCABladder Urothelial Carcinoma
  • BRCABreast invasive carcinoma
  • CESCCervical squamous cell carcinoma and endocervical adenocarcinoma
  • CHOLCholangio carcinoma
  • COADColon adenocarcinoma
  • DLBCLymphoid Neoplasm Diffuse Large B-cell Lymphoma
  • ESCAEsophageal carcinoma
  • GBMGlioblastoma multiforme
  • HNSCHead and Neck squamous cell carcinoma
  • KICHKidney Chromophobe
  • KIRCKidney renal clear cell carcinoma
  • KIRPKidney renal papillary cell carcinoma
  • LAMLAcute Myeloid Leukemia
  • LGGBrain Lower Grade Glioma
  • LIHCLiver hepatocellular carcinoma
  • LUADLung adenocarcinoma
  • LUSCLung squamous cell carcinoma
  • MESOMesothelioma
  • OVOvarian serous cystadenocarcinoma
  • PAADPancreatic adenocarcinoma
  • PCPGPheochromocytoma and Paraganglioma
  • PRADProstate adenocarcinoma
  • READRectum adenocarcinoma
  • SARCSarcoma
  • SKCMSkin Cutaneous Melanoma
  • STADStomach adenocarcinoma
  • TGCTThyroid carcinoma
  • THCAThyroid carcinoma
  • THYMThymoma
  • UCECUterine Corpus Endometrial Carcinoma
  • UCSUterine Carcinosarcoma
  • UVMUveal Melanoma

Note: Click here to get the extension of tumor abbreviations.


  • Cancer Related Information
  • Basic Information

Cancer associated literatures
PIDTitleArticle TimeAuthorDoi
25231211Oncogenic nature of a novel mutant AATF and its interactome existing within human cancer cells.Cell Biol Int2015 MarSharma Sdoi: 10.1002/cbin.10379
27599843Human AATF/Che-1 forms a nucleolar protein complex with NGDN and NOL10 required for 40S ribosomal subunit synthesis.Nucleic Acids Res2016 Nov 16Bammert L-
29321668AATF suppresses apoptosis, promotes proliferation and is critical for Kras-driven lung cancer.Oncogene2018 MarWelcker Ddoi: 10.1038/s41388-017-0054-6
28214471Che-1 sustains hypoxic response of colorectal cancer cells by affecting Hif-1α stabilization.J Exp Clin Cancer Res2017 Feb 18Bruno Tdoi: 10.1186/s13046-017-0497-1.
20708154Che-1 promotes tumor cell survival by sustaining mutant p53 transcription and inhibiting DNA damage response activation.Cancer Cell2010 Aug 9Bruno Tdoi: 10.1016/j.ccr.2010.05.027.
20025740Mutation analysis of the AATF gene in breast cancer families.BMC Cancer2009 Dec 21Haanp Mdoi: 10.1186/1471-2407-9-457.
25996291Che-1 modulates the decision between cell cycle arrest and apoptosis by its binding to p53.Cell Death Dis2015 May 21Desantis Adoi: 10.1038/cddis.2015.117.

Expression in 33 cancers

Mutations
CancerChrPosition Mutation TypedbSNPProtein-change Allele FreqRBD
ACCchr1736953121Missense_MutationnovelE173D0.38
BLCAchr17370566683'UTRnovel0.25
BLCAchr1736986661Nonsense_MutationnovelQ293*0.22
BLCAchr1736952957Missense_MutationnovelE119K0.2
BLCAchr1737019011Nonsense_MutationnovelR469*0.17
BLCAchr1736990809SilentnovelL450L0.4
BLCAchr1736953257Missense_MutationnovelE219K0.1
BRCAchr17369490005'UTRnovel0.25
BRCAchr17369490365'UTRnovel0.5
BRCAchr1736988530Missense_MutationnovelS320Y0.36
CESCchr17369490975'UTRnovel0.18
CESCchr1736989286Missense_Mutationrs370934170D397N0.26
CESCchr1737033770Intronnovel0.47
CESCchr1736986692Missense_MutationnovelT303I0.12
CESCchr1736988591Missense_MutationnovelK340N0.43
COADchr1737021013Missense_Mutationrs199725061R516W0.55
COADchr1736953796SilentnovelR241R0.07
COADchr1737031619Missense_MutationnovelH518R0.4
COADchr1736986725Missense_Mutationrs200375945A314V0.28
COADchr1736950278SilentnovelV52V0.36
COADchr1736986637SilentnovelL285L0.19
COADchr1736986617Missense_MutationnovelS278N0.25
DLBCchr1736950229Missense_MutationnovelV36A0.39
GBMchr1736953076Missense_MutationnovelE158D0.17
GBMchr1737019011Nonsense_MutationnovelR469*0.39
GBMchr1737031669Missense_MutationnovelM535V0.5
HNSCchr1737031645Missense_Mutationrs779232104M527V0.25
HNSCchr17370567013'UTRnovel0.34
HNSCchr1736988701Missense_MutationnovelA377V0.13
HNSCchr1736949212Silentrs778372354E29E0.33
HNSCchr1736986686Missense_MutationnovelP301L0.18
KIRPchr17370567833'UTRnovel0.39
KIRPchr1736988627Missense_MutationnovelM352I0.54
LGGchr1736953041Missense_MutationnovelP147S0.49
LIHCchr1736952901Missense_MutationnovelD100G0.34
LIHCchr1736989312Missense_MutationnovelR405S0.33
LUADchr1736986714SilentnovelT310T0.22
LUADchr1736952939Missense_MutationnovelG113C0.18
LUADchr1737020973Frame_Shift_InsnovelV505Sfs*30.48
LUSCchr1736953218Missense_MutationnovelD206Y0.39
LUSCchr1736986622Missense_MutationnovelK280E0.48
LUSCchr1737056606Missense_MutationnovelE542V0.24
LUSCchr1736990795Missense_Mutationrs761448475A446T0.18
LUSCchr1737020973Frame_Shift_InsnovelV505Sfs*30.48
LUSCchr1736953801SilentnovelI242I0.06
OVchr1736953142Missense_MutationnovelM180I0.76
OVchr1737056629Missense_MutationnovelQ550E0.21
PRADchr1736988571Nonsense_Mutationrs200484699R334*0.08
READchr17370567873'UTRnovel0.5
READchr1736952893Missense_MutationnovelE97D0.42
SARCchr1736953158Missense_MutationnovelA186S0.08
SKCMchr1737020931Splice_Regionnovel0.36
SKCMchr1736989388Missense_MutationnovelP431S0.44
SKCMchr1736988654SilentnovelV361V0.85
SKCMchr1736989300Missense_MutationnovelM401I0.15
SKCMchr1736989301Missense_MutationnovelD402N0.16
SKCMchr1736953856Missense_MutationnovelP261S0.55
SKCMchr1737056662Nonstop_Mutationnovel*561Rext*290.59
SKCMchr1736990840Missense_MutationnovelD461N0.36
SKCMchr1737019039Missense_Mutationrs765796809S478F0.44
SKCMchr1737019040SilentnovelS478S0.43
SKCMchr1736953060Missense_MutationnovelS153N0.24
STADchr1736953112SilentnovelS170S0.32
STADchr1737056644Missense_Mutationrs114527666D555N0.35
STADchr1736990838Missense_MutationnovelD460V0.28
STADchr1737020960Missense_Mutationrs368531596R498Q0.2
STADchr1736989285SilentnovelI396I0.34
STADchr1736949143SilentnovelP6P0.38
STADchr1736988705SilentnovelS378S0.2
STADchr1736950403Missense_MutationnovelS94F0.27
STADchr1736950339Missense_MutationnovelG73S0.23
THYMchr17370566693'UTRrs3752472050.24
UCECchr1737021013Missense_Mutationrs199725061R516W0.31
UCECchr1736988683Missense_MutationnovelH371R0.2
UCECchr1736989349Nonsense_MutationnovelR418*0.17
UCECchr1736989285SilentnovelI396I0.41
UCECchr1737021013Missense_Mutationrs199725061R516W0.09
UCECchr1736952949Missense_MutationnovelE116G0.14
UCECchr17370566783'UTRrs7581013690.48
UCECchr1736989285SilentnovelI396I0.44
UCECchr1736990825Nonsense_MutationnovelE456*0.13
UCECchr1736950238Missense_MutationnovelR39M0.06
UCECchr1736953180Missense_MutationnovelS193N0.36
UCECchr1737033785Intronnovel0.36
UCECchr17370568243'UTRnovel0.29
UCECchr1736949177Missense_MutationnovelR18G0.33
UCECchr1736986654SilentnovelV290V0.34
UCECchr1737021013Missense_Mutationrs199725061R516W0.42
UCECchr1736990830SilentnovelI457I0.34
UCECchr1736953048Missense_MutationnovelF149S0.39
UCECchr1736989350Missense_Mutationrs139574552R418Q0.32
UCECchr1736953883Nonsense_MutationnovelE270*0.15
UCECchr1737019026Missense_Mutationrs760234359R474W0.21
UCECchr1736988665Missense_Mutationrs754559104R365H0.5
UCECchr1737020959Nonsense_Mutationrs754019125R498*0.34
UCECchr1736989320Missense_Mutationrs115334426R408Q0.32
UCECchr1736989338Missense_Mutationrs770259796R414H0.17
UCECchr17370568523'UTRnovel0.25
UCECchr1736953115Missense_MutationnovelE171D0.52
UCECchr1736953781Missense_MutationnovelQ236K0.25
UCECchr1736988571Nonsense_Mutationrs200484699R334*0.18
UCECchr1737033810Intronnovel0.23
UCECchr1736989412Splice_SitenovelX438_splice0.41
UCECchr17370566683'UTRnovel0.49
UCECchr1737019022Missense_Mutationrs748206822I472M0.44
UCECchr1736953867Missense_MutationnovelK264N0.23
UCECchr1736986685Missense_MutationnovelP301S0.41
UCECchr1736953190Silentrs372898811D196D0.42
UCECchr1736953805SilentnovelL244L0.37

Copy Number Variations (CNVs)
CancerTypeFreq Q-value
DLBCDEL00.18166
THCADEL0.0020.221
UCSDEL0.35710.19877
UVMDEL0.03750.22482

Survival Analysis
CancerP-value Q-value
THYM0.035

Kaplan-Meier Survival Analysis

STAD0.037

Kaplan-Meier Survival Analysis

ACC0.0002

Kaplan-Meier Survival Analysis

HNSC0.021

Kaplan-Meier Survival Analysis

KIRP0.00012

Kaplan-Meier Survival Analysis

PAAD0.014

Kaplan-Meier Survival Analysis

BLCA0.016

Kaplan-Meier Survival Analysis

CESC0.015

Kaplan-Meier Survival Analysis

READ0.00053

Kaplan-Meier Survival Analysis

KICH0.0015

Kaplan-Meier Survival Analysis

UCEC0.0058

Kaplan-Meier Survival Analysis

LIHC0.00015

Kaplan-Meier Survival Analysis

CHOL0.019

Kaplan-Meier Survival Analysis

LUAD0.011

Kaplan-Meier Survival Analysis

Drugs

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Eesembl ID



Cell lines and drugs in GSE70138 or GSE92742

  • Description
  • RBPome
  • PRI
  • Literatures
  • Transcripts
  • Gene Model
  • GWAS
  • PPI
  • Orthologs
  • Gene Ontology
Description
Ensembl ID
ENSG00000275700 (Gene tree)
Gene ID
26574
Gene Symbol
AATF
Alias
DED|CHE-1|CHE1|BFR2
Full Name
apoptosis antagonizing transcription factor
Gene Type
protein_coding
Species
Homo_sapiens
Status
confidence
Strand
Plus strand
Length
107,997 bases
Position
chr17:36,948,875-37,056,871
Accession
19235
RBP type
non-canonical RBP
Summary
The protein encoded by this gene was identified on the basis of its interaction with MAP3K12/DLK, a protein kinase known to be involved in the induction of cell apoptosis. This gene product contains a leucine zipper, which is a characteristic motif of transcription factors, and was shown to exhibit strong transactivation activity when fused to Gal4 DNA binding domain. Overexpression of this gene interfered with MAP3K12 induced apoptosis. [provided by RefSeq, Jul 2008]
RNA binding proteome (RBPome)
PIDTitleMethod TimeAuthorDoi
22681889The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts4SURIC & HEK2932012 MayBaltz AGDOI: 10.1016/j.molcel.2012.05.021
30607034Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)OOPS & HEK2932019 Jan 3Queiroz RMLDOI: 10.1038/s41587-018-0001-2
30528433The Human RNA-Binding Proteome and Its Dynamics during Translational ArrestXRNAX & HEK2932018 Dec 6Trendel JDOI: 10.1016/j.cell.2018.11.004
29431736Capturing the interactome of newly transcribed RNAPolyT-RICK & Hela2018 Feb 12Bao XDOI: 10.1038/nmeth.4595
22658674Insights into RNA biology from an atlas of mammalian mRNA-binding proteinsRIC & Hela2012 May 31Castello ADOI: 10.1016/j.cell.2012.04.031
30528433The Human RNA-Binding Proteome and Its Dynamics during Translational ArrestXRNAX & Hela2018 Dec 6Trendel JDOI: 10.1016/j.cell.2018.11.004
30528433The Human RNA-Binding Proteome and Its Dynamics during Translational ArrestXRNAX & MCF72018 Dec 6Trendel JDOI: 10.1016/j.cell.2018.11.004
27453046Comprehensive Identification of RNA-Binding Domains in Human CellsRIC & Hela2016 Aug 18Castello ADOI: 10.1016/j.molcel.2016.06.029
30352994Discovery of RNA-binding proteins and characterization of their dynamic responses by enhanced RNA interactome captureRIC & Jurkat2018 Oct 23Perez-Perri JIDOI:10.1038/s41467-018-06557-8
Protein-RNA interaction(RNA-Binding Site)
Click here to download all RNA binding sites

Literatures on RNA binding capacity
PIDTitleArticle TimeAuthorDoi
12847090Che-1 arrests human colon carcinoma cell proliferation by displacing HDAC1 from the p21WAF1/CIP1 promoter.J Biol Chem2003 Sep 19Di Padova M-
17634135The anti-apoptotic factor Che-1/AATF links transcriptional regulation, cell cycle control, and DNA damage response.Cell Div2007 Jul 16Passananti C-
17468107The prolyl isomerase Pin1 affects Che-1 stability in response to apoptotic DNA damage.J Biol Chem2007 Jul 6De Nicola F-
20708154Che-1 promotes tumor cell survival by sustaining mutant p53 transcription and inhibiting DNA damage response activation.Cancer Cell2010 Aug 9Bruno Tdoi: 10.1016/j.ccr.2010.05.027.
25210797HIPK2 sustains apoptotic response by phosphorylating Che-1/AATF and promoting its degradation.Cell Death Dis2014 Sep 11De Nicola Fdoi: 10.1038/cddis.2014.381.
23798705Centrosomal Che-1 protein is involved in the regulation of mitosis and DNA damage response by mediating pericentrin (PCNT)-dependent Chk1 protein localization.J Biol Chem2013 Aug 9Sorino Cdoi: 10.1074/jbc.M113.465302
25996291Che-1 modulates the decision between cell cycle arrest and apoptosis by its binding to p53.Cell Death Dis2015 May 21Desantis Adoi: 10.1038/cddis.2015.117.
25770584Che-1-induced inhibition of mTOR pathway enables stress-induced autophagy.EMBO J2015 May 5Desantis Adoi: 10.15252/embj.201489920
29232376Che1/AATF interacts with subunits of the histone acetyltransferase core module of SAGA complexes.PLoS One2017 Dec 12Caliskan Gdoi: 10.1371/journal.pone.0189193
29367285Che-1 is targeted by c-Myc to sustain proliferation in pre-B-cell acute lymphoblastic leukemia.EMBO Rep2018 MarFolgiero Vdoi: 10.15252/embr.201744871
22960635Che-ating death: CHE1/AATF protects from p53-mediated apoptosis.EMBO J2012 Oct 17Jackson JGdoi: 10.1038/emboj.2012.258
Transcripts
Transcript IDNameLengthRefSeq ID Protein IDLengthRefSeq IDUniportKB ID
ENST00000622432AATF-209376--- (aa)--
ENST00000616434AATF-206502-ENSP0000047788198 (aa)-A0A087WTH8
ENST00000616392AATF-205474--- (aa)--
ENST00000613840AATF-202648-ENSP0000047992655 (aa)-A0A087WW41
ENST00000610798AATF-201601-ENSP00000480472154 (aa)-A0A087WWS8
ENST00000616062AATF-204507--- (aa)--
ENST00000617141AATF-207586--- (aa)--
ENST00000615319AATF-2032044--- (aa)--
ENST00000619387AATF-2082141XM_011524611ENSP00000477848560 (aa)XP_011522913Q9NY61
Gene Model
Click here to download ENSG00000275700's gene model file
GWAS
ensgIDSNPChromosomePositionSNP-risk TraitPubmedID95% CIOr or BEAT EFO ID
ENSG00000275700rs23066581736949012GObesity-related traits23251661[NR] % increase0.03EFO_0005106
ENSG00000275700rs23066581736949012GObesity-related traits23251661[NR] cm increase0.02EFO_0005093
ENSG00000275700rs1862182301737027128GMacrophage inflammatory protein 1b levels27989323[0.19-0.38] SD units increase0.2824EFO_0008219
Protein-Protein Interaction (PPI)

Clik here to download ENSG00000275700's network

* RBP PPI network refers to all genes directly bind to RBP
Orthologs identified by RBPome
Ensembl IDGene SymbolCoverageIdentiy OrthologGene SymbolCoverageIdentiy Species
ENSG00000275700AATF10092.208ENSMUSG00000018697Aatf9977.818Mus_musculus
Gene Ontology
Go IDGo_termPubmedIDEvidenceCategory
GO:0003723RNA binding22658674.22681889.HDAFunction
GO:0005515protein binding10783144.12847090.17157788.22909821.25416956.29232376.30021884.IPIFunction
GO:0005634nucleus10580117.12429849.14627703.15207272.IDAComponent
GO:0005730nucleolus21873635.IBAComponent
GO:0005737cytoplasm14627703.15207272.IDAComponent
GO:0005794Golgi apparatus-IEAComponent
GO:0006974cellular response to DNA damage stimulus18049476.IEPProcess
GO:0007155cell adhesion-IEAProcess
GO:0007346regulation of mitotic cell cycle-IEAProcess
GO:0019901protein kinase binding-IEAFunction
GO:0032929negative regulation of superoxide anion generation15207272.IDAProcess
GO:0040016embryonic cleavage-IEAProcess
GO:0042254ribosome biogenesis-IEAProcess
GO:0042985negative regulation of amyloid precursor protein biosynthetic process-IEAProcess
GO:0043066negative regulation of apoptotic process15207272.IMPProcess
GO:0043522leucine zipper domain binding10580117.14627703.IPIFunction
GO:0045944positive regulation of transcription by RNA polymerase II18049476.IDAProcess
GO:0048156tau protein binding-IEAFunction
GO:2000378negative regulation of reactive oxygen species metabolic process15207272.IDAProcess
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