EuRBPDB

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TCGA tumor abbreviations
  • ACCAdrenocortical carcinoma
  • BLCABladder Urothelial Carcinoma
  • BRCABreast invasive carcinoma
  • CESCCervical squamous cell carcinoma and endocervical adenocarcinoma
  • CHOLCholangio carcinoma
  • COADColon adenocarcinoma
  • DLBCLymphoid Neoplasm Diffuse Large B-cell Lymphoma
  • ESCAEsophageal carcinoma
  • GBMGlioblastoma multiforme
  • HNSCHead and Neck squamous cell carcinoma
  • KICHKidney Chromophobe
  • KIRCKidney renal clear cell carcinoma
  • KIRPKidney renal papillary cell carcinoma
  • LAMLAcute Myeloid Leukemia
  • LGGBrain Lower Grade Glioma
  • LIHCLiver hepatocellular carcinoma
  • LUADLung adenocarcinoma
  • LUSCLung squamous cell carcinoma
  • MESOMesothelioma
  • OVOvarian serous cystadenocarcinoma
  • PAADPancreatic adenocarcinoma
  • PCPGPheochromocytoma and Paraganglioma
  • PRADProstate adenocarcinoma
  • READRectum adenocarcinoma
  • SARCSarcoma
  • SKCMSkin Cutaneous Melanoma
  • STADStomach adenocarcinoma
  • TGCTThyroid carcinoma
  • THCAThyroid carcinoma
  • THYMThymoma
  • UCECUterine Corpus Endometrial Carcinoma
  • UCSUterine Carcinosarcoma
  • UVMUveal Melanoma

Note: Click here to get the extension of tumor abbreviations.


  • Cancer Related Information
  • Basic Information

Cancer associated literatures
PIDTitleArticle TimeAuthorDoi
28981102Regulation of RIP3 by the transcription factor Sp1 and the epigenetic regulator UHRF1 modulates cancer cell necroptosis.Cell Death Dis2017 Oct 5Yang Cdoi: 10.1038/cddis.2017.483.
26147747UHRF1 promotes proliferation of gastric cancer via mediating tumor suppressor gene hypermethylation.Cancer Biol Ther2015Zhou Ldoi: 10.1080/15384047.2015.1056411
22552622Exogenous expression of UHRF1 promotes proliferation and metastasis of breast cancer cells.Oncol Rep2012 JulLi XLdoi: 10.3892/or.2012.1792
21611839UHRF1 is associated with tumor recurrence in non-muscle-invasive bladder cancer.Med Oncol2012 JunYang GLdoi: 10.1007/s12032-011-9983-z
25940709Regulation of UHRF1 by microRNA-9 modulates colorectal cancer cell proliferation and apoptosis.Cancer Sci2015 JulZhu Mdoi: 10.1111/cas.12689
25338120Chromatin remodelers HELLS and UHRF1 mediate the epigenetic deregulation of genes that drive retinoblastoma tumor progression.Oncotarget2014 Oct 30Benavente CA-
16195352Critical role of the ubiquitin ligase activity of UHRF1, a nuclear RING finger protein, in tumor cell growth.Mol Biol Cell2005 DecJenkins Y-
27839516Signalling pathways in UHRF1-dependent regulation of tumor suppressor genes in cancer.J Exp Clin Cancer Res2016 Nov 14Alhosin M-
28467809Functional dissection of the role of UHRF1 in the regulation of retinoblastoma methylome.Oncotarget2017 Jun 13Kan Gdoi: 10.18632/oncotarget.17078.
29507645Overexpression of UHRF1 promotes silencing of tumor suppressor genes and predicts outcome in hepatoblastoma.Clin Epigenetics2018 Mar 2Beck Adoi: 10.1186/s13148-018-0462-7
26070868Analysis of UHRF1 expression in human ovarian cancer tissues and its regulation in cancer cell growth.Tumour Biol2015 NovYan Fdoi: 10.1007/s13277-015-3638-1
12838312ICBP90 belongs to a new family of proteins with an expression that is deregulated in cancer cells.Br J Cancer2003 Jul 7Mousli M-
19491893UHRF1 is a novel molecular marker for diagnosis and the prognosis of bladder cancer.Br J Cancer2009 Jul 7Unoki Mdoi: 10.1038/sj.bjc.6605123
25416862Up-regulation of UHRF1 by oncogenic Ras promoted the growth, migration, and metastasis of pancreatic cancer cells.Mol Cell Biochem2015 FebCui Ldoi: 10.1007/s11010-014-2279-9
25207720Luteolin induces apoptosis in BE colorectal cancer cells by downregulating calpain, UHRF1, and DNMT1 expressions.Nutr Cancer2014Krifa Mdoi: 10.1080/01635581.2014.951729
25272010Upregulated UHRF1 promotes bladder cancer cell invasion by epigenetic silencing of KiSS1.PLoS One2014 Oct 1Zhang Ydoi: 10.1371/journal.pone.0104252
22286757UHRF1 coordinates peroxisome proliferator activated receptor gamma (PPARG) epigenetic silencing and mediates colorectal cancer progression.Oncogene2012 Dec 6Sabatino Ldoi: 10.1038/onc.2012.3
21351083UHRF1-mediated tumor suppressor gene inactivation in nonsmall cell lung cancer.Cancer2011 Mar 1Daskalos Adoi: 10.1002/cncr.25531
21539450Inhibition effect of siRNA-downregulated UHRF1 on breast cancer growth.Cancer Biother Radiopharm2011 AprYan Fdoi: 10.1089/cbr.2010.0886.
26464697Elevated expression of UHRF1 predicts unfavorable prognosis for patients with hepatocellular carcinoma.Int J Clin Exp Pathol2015 Aug 1Liang D-
19270723Adenovirus-mediated expression of UHRF1 reduces the radiosensitivity of cervical cancer HeLa cells to gamma-irradiation.Acta Pharmacol Sin2009 AprLi XLdoi: 10.1038/aps.2009.18
25572953Downregulation of UHRF1 promotes EMT via inducing CXCR4 in human cancer cells.Int J Oncol2015 MarJung YDdoi: 10.3892/ijo.2014.2813
26896831The correlation between miR-146a C/G polymorphism and UHRF1 gene expression level in gastric tumor.J Dig Dis2016 MarSoleimani Adoi: 10.1111/1751-2980.12329.
23537643Identification of UHRF1/2 as new N-methylpurine DNA glycosylase-interacting proteins.Biochem Biophys Res Commun2013 Apr 19Liang Cdoi: 10.1016/j.bbrc.2013.02.126
25743796Knockdown of UHRF1 by lentivirus-mediated shRNA inhibits ovarian cancer cell growth.Asian Pac J Cancer Prev2015Yan F-
25430639Negative modulation of the epigenetic regulator, UHRF1, by thyroid hormone receptors suppresses liver cancer cell growth.Int J Cancer2015 Jul 1Wu SMdoi: 10.1002/ijc.29368
26768845Long noncoding RNA UPAT promotes colon tumorigenesis by inhibiting degradation of UHRF1.Proc Natl Acad Sci U S A2016 Feb 2Taniue Kdoi: 10.1073/pnas.1500992113
26884069UHRF1 overexpression is involved in cell proliferation and biochemical recurrence in prostate cancer after radical prostatectomy.J Exp Clin Cancer Res2016 Feb 17Wan Xdoi: 10.1186/s13046-016-0308-0.
25323766Epigenetic repression of regulator of G-protein signaling 2 by ubiquitin-like with PHD and ring-finger domain1 promotes bladder cancer progression.FEBS J2015 JanYing Ldoi: 10.1111/febs.13116
23023523UHRF1 expression is upregulated and associated with cellular proliferation in colorectal cancer.Oncol Rep2012 DecKofunato Ydoi: 10.3892/or.2012.2064
26161699Analysis of the UHRF1 expression in serum and tissue for gastric cancer detection.Biomarkers2015Ge Mdoi: 10.3109/1354750X.2015.1061599
22219067UHRF1 promotes cell growth and metastasis through repression of p16(inka) in colorectal cancer.Ann Surg Oncol2012 AugWang Fdoi: 10.1245/s10434-011-2194-1
21067293UHRF1 confers radioresistance to human breast cancer cells.Int J Radiat Biol2011 MarLi Xdoi: 10.3109/09553002.2011.530335
28128913Overexpression of UHRF1 gene correlates with the major clinicopathological parameters in urinary bladder cancer.Int Braz J Urol2017 Mar-AprSaidi Sdoi: 10.1590/S1677-5538.IBJU.2016.0126.
27072587Regulation of UHRF1 by dual-strand tumor-suppressor microRNA-145 (miR-145-5p and miR-145-3p): Inhibition of bladder cancer cell aggressiveness.Oncotarget2016 May 10Matsushita Rdoi: 10.18632/oncotarget.8668.
27507047UHRF1 regulates global DNA hypomethylation and is associated with poor prognosis in esophageal squamous cell carcinoma.Oncotarget2016 Sep 6Nakamura Kdoi: 10.18632/oncotarget.11067.
28584306Downregulation of UHRF1 increases tumor malignancy by activating the CXCR4/AKT-JNK/IL-6/Snail signaling axis in hepatocellular carcinoma cells.Sci Rep2017 Jun 5Kim JHdoi: 10.1038/s41598-017-02935-2.

Differential Expression

Expression in 33 cancers

Mutations
CancerChrPosition Mutation TypedbSNPProtein-change Allele FreqRBD
ACCchr194930828Missense_MutationnovelS174F0.47
ACCchr194950692Silentrs781278514V533V0.19
BLCAchr194944417SilentnovelI424I0.32
BLCAchr194929317Silentrs373501649T83T0.2
BLCAchr194950897Missense_MutationnovelF573L0.26
BLCAchr194954689Missense_MutationnovelS666F0.17
BLCAchr194944236Nonsense_MutationnovelS393*0.09
BRCAchr194956751Missense_MutationnovelI725V0.31
BRCAchr194941604Missense_MutationnovelP288S0.21
BRCAchr194947181Missense_MutationnovelS496C0.2
BRCAchr194956720Missense_MutationnovelF714L0.33
BRCAchr194941532Missense_MutationnovelD264Y0.38
CESCchr194950928Missense_MutationnovelD584N0.11
CESCchr194941927Missense_MutationnovelE357K0.33
CESCchr194930851Missense_Mutationrs779117913V182I0.47
CESCchr194950952Missense_MutationnovelK592E0.39
CESCchr194954437Missense_Mutationrs747402498G636S0.46
CESCchr194929281SilentnovelL71L0.21
CESCchr194930806In_Frame_Delnovel0.07
CESCchr194950972Missense_Mutationrs773988215I598M0.22
CESCchr194941538SilentnovelL266L0.51
CESCchr194945938SilentnovelV461V0.53
COADchr194941902SilentnovelP348P0.08
COADchr194960762Missense_MutationnovelV781I0.19
COADchr194944154Missense_MutationnovelD366Y0.42
COADchr194932791Missense_MutationnovelR207P0.31
COADchr194954762Silentrs748982378N690N0.37
COADchr194930721SilentnovelN138N0.18
COADchr194932791Missense_Mutationrs756642363R207H0.14
COADchr194929457Missense_Mutationrs371706472T130M0.25
COADchr194950968Missense_MutationnovelR597Q0.42
COADchr194950614Silentrs775286606A507A0.19
COADchr194956741Silentrs769444008T721T0.31
COADchr194960699Missense_MutationnovelP760T0.27
COADchr194929407SilentnovelA113A0.31
DLBCchr194929336Missense_MutationnovelL90V0.38
ESCAchr194954389Nonsense_MutationnovelR620*0.39
ESCAchr1949619593'UTRnovel0.27
ESCAchr1949619593'UTRnovel0.1
ESCAchr194956789SilentnovelT737T0.16
ESCAchr1949108795'UTRrs7785268450.41
ESCAchr194944148SilentnovelR364R0.32
GBMchr194929245Silentrs555886001F59F0.12
GBMchr194932826Missense_MutationnovelV219M0.14
HNSCchr194960661Missense_MutationnovelC747Y0.24
HNSCchr194929366Missense_MutationnovelG100R0.21
HNSCchr194950623SilentnovelL510L0.39
HNSCchr194930822Missense_MutationnovelS172C0.16
HNSCchr194932894Silentrs769707191A241A0.25
HNSCchr194932895Missense_MutationnovelE242Q0.26
KIRCchr194950887Missense_MutationnovelK570R0.26
KIRCchr194954464Missense_MutationnovelG645C0.24
LIHCchr194910887Translation_Start_SitenovelM1?0.44
LUADchr194930789Missense_MutationnovelR161L0.66
LUADchr194910990SilentnovelL35L0.26
LUADchr194954438Missense_MutationnovelG636V0.23
LUADchr194944398Missense_MutationnovelY418C0.44
LUADchr194954731Missense_MutationnovelQ680R0.3
LUADchr194954419Missense_MutationnovelE630K0.13
LUSCchr194941620Missense_MutationnovelP293L0.58
LUSCchr194950893Missense_MutationnovelG572E0.28
LUSCchr194950937Missense_MutationnovelP587S0.06
LUSCchr194932875Missense_MutationnovelR235Q0.18
LUSCchr194947211Missense_MutationnovelR506K0.81
LUSCchr194929408Missense_MutationnovelA114S0.51
LUSCchr194950713Missense_MutationnovelK540N0.33
OVchr194954397SilentnovelK622K0.11
OVchr194932896Missense_MutationnovelE242V0.15
OVchr194954773Nonsense_MutationnovelW694*0.1
OVchr194944452Splice_SitenovelX435_splice0.3
OVchr194930810Missense_MutationnovelE168V0.21
OVchr194930801Missense_MutationnovelS165F0.08
OVchr194932872Missense_MutationnovelE234G0.3
PAADchr194950676Missense_Mutationrs377699288R528Q0.2
PAADchr1949608093'UTRnovel0.14
PRADchr194930822Missense_MutationnovelS172C0.25
PRADchr194929347Silentrs760355998T93T0.27
PRADchr194950676Missense_Mutationrs377699288R528Q0.43
READchr194929342Missense_MutationnovelD92N0.33
READchr194941828Missense_MutationnovelR324W0.14
SARCchr194941821Silentrs778664373C321C0.1
SARCchr194930808Silentrs377701384D167D0.51
SARCchr194960762Missense_MutationnovelV781I0.19
SARCchr1949615173'UTRnovel0.71
SKCMchr194930845Missense_MutationnovelE180K0.39
SKCMchr194950738Missense_MutationnovelP549S0.28
SKCMchr194929412Missense_MutationnovelA115V0.56
SKCMchr194930745Silentrs376248382T146T0.39
SKCMchr194911000Missense_MutationnovelE39K0.24
SKCMchr194954821Missense_Mutationrs758518832P710L0.26
SKCMchr194929239Silentrs764676069T57T0.34
SKCMchr194930845Missense_MutationnovelE180K0.37
SKCMchr194941573SilentnovelV277V0.29
SKCMchr194941605Missense_MutationnovelP288L0.71
SKCMchr194929257SilentnovelV63V0.13
STADchr194929279Missense_MutationnovelL71I0.09
STADchr194932930SilentnovelR253R0.13
STADchr194950908Missense_MutationnovelR577H0.19
STADchr194944437Missense_MutationnovelR431Q0.16
STADchr194954789SilentnovelA699A0.26
STADchr194930845Missense_MutationnovelE180Q0.79
STADchr194954806Missense_MutationnovelP705L0.33
STADchr194945872Silentrs369224803S439S0.32
STADchr194932923Missense_MutationnovelT251K0.25
STADchr194941585SilentnovelE281E0.2
STADchr194947108Missense_MutationnovelH472D0.15
STADchr194929411Missense_MutationnovelA115T0.3
STADchr194932868Frame_Shift_DelnovelK233Afs*300.25
STADchr194929347Silentrs760355998T93T0.13
STADchr194947145Missense_MutationnovelR484Q0.37
STADchr194954678Silentrs376205188P662P0.25
STADchr194932892Missense_MutationnovelA241T0.22
STADchr194954668Missense_MutationnovelA659V0.58
STADchr194930719Missense_MutationnovelN138D0.16
UCECchr194945926Silentrs374120623A457A0.25
UCECchr194932913Missense_MutationnovelE248K0.49
UCECchr194941626Missense_MutationnovelR295I0.38
UCECchr194950609Splice_SitenovelX506_splice0.23
UCECchr1949615403'UTRnovel0.36
UCECchr194910989Missense_MutationnovelL35P0.3
UCECchr194945867Missense_MutationnovelE438K0.35
UCECchr194932773Missense_MutationnovelS201Y0.15
UCECchr194954446Frame_Shift_InsnovelR641Qfs*560.3
UCECchr194944210Silentrs369756524A384A0.11
UCECchr194954425Missense_Mutationrs565758187Q632E0.13
UCECchr1949609213'UTRnovel0.5
UCECchr194929259Missense_MutationnovelR64H0.52
UCECchr194930756Missense_MutationnovelA150V0.53
UCECchr194941552Silentrs757137506R270R0.33
UCECchr1949608273'UTRrs7487307800.08
UCECchr194929330Missense_MutationnovelS88P0.38
UCECchr194954445Silentrs773435063A638A0.41
UCECchr194947188SilentnovelD498D0.16
UCECchr194929414Missense_MutationnovelE116K0.53
UCECchr194941629Splice_SitenovelX296_splice0.53
UCECchr1949616043'UTRnovel0.77
UCECchr194930811SilentnovelE168E0.28
UCECchr194950873Nonsense_MutationnovelW565*0.36
UCECchr194960686Missense_MutationnovelQ755H0.31
UCECchr194950870SilentnovelY564Y0.23
UCECchr194956741Silentrs769444008T721T0.22
UCECchr1949615473'UTRnovel0.29
UCECchr194960741Missense_MutationnovelV774M0.27
UCECchr194929435Missense_MutationnovelD123N0.2
UCECchr194960687Missense_MutationnovelV756M0.29
UCECchr194954434Missense_MutationnovelG635W0.37
UCECchr194910771Intronnovel0.07
UCECchr194954454Missense_MutationnovelR641S0.34
UCECchr194954802Missense_Mutationrs760435882R704W0.24
UCECchr194944387Silentrs762198120P414P0.29
UCECchr1949608263'UTRnovel0.46
UCECchr194929462Missense_MutationnovelL132V0.2
UCECchr194945933Missense_MutationnovelL460I0.39
UCECchr194941807Missense_MutationnovelA317T0.21
UCECchr194944420Silentrs201863626P425P0.42
UCECchr194947170Silentrs747016007T492T0.43
UCECchr194950901Missense_MutationnovelV575M0.28
UCECchr194932791Missense_MutationnovelR207P0.43
UCECchr194929322Missense_MutationnovelE85A0.26
UCECchr194941873Missense_MutationnovelA339T0.28

Copy Number Variations (CNVs)
CancerTypeFreq Q-value
LIHCDEL0.17844.7028e-08
PAADDEL0.13590.0060878
READDEL0.12120.23023
THCADEL0.0160.10598

Survival Analysis
CancerP-value Q-value
THYM0.0039

Kaplan-Meier Survival Analysis

KIRC0.0001

Kaplan-Meier Survival Analysis

STAD0.0033

Kaplan-Meier Survival Analysis

SARC0.0019

Kaplan-Meier Survival Analysis

SKCM0.0031

Kaplan-Meier Survival Analysis

PRAD0.036

Kaplan-Meier Survival Analysis

KIRP0.00011

Kaplan-Meier Survival Analysis

PAAD0.0002

Kaplan-Meier Survival Analysis

PCPG0.029

Kaplan-Meier Survival Analysis

CESC0.028

Kaplan-Meier Survival Analysis

LAML0.013

Kaplan-Meier Survival Analysis

KICH0.014

Kaplan-Meier Survival Analysis

LIHC0.00011

Kaplan-Meier Survival Analysis

LGG0.0047

Kaplan-Meier Survival Analysis

LUAD0.00011

Kaplan-Meier Survival Analysis

UVM0.0059

Kaplan-Meier Survival Analysis

  • Description
  • RBPome
  • Transcripts
  • Gene Model
  • Phenotypes
  • GWAS
  • PPI
  • Orthologs
  • Gene Ontology
Description
Ensembl ID
ENSG00000276043 (Gene tree)
Gene ID
29128
Gene Symbol
UHRF1
Alias
ICBP90|Np95|FLJ21925|RNF106|TDRD22
Full Name
ubiquitin like with PHD and ring finger domains 1
Gene Type
protein_coding
Species
Homo_sapiens
Status
putative
Strand
Plus strand
Length
59,075 bases
Position
chr19:4,903,080-4,962,154
Accession
12556
RBP type
non-canonical RBP
Summary
This gene encodes a member of a subfamily of RING-finger type E3 ubiquitin ligases. The protein binds to specific DNA sequences, and recruits a histone deacetylase to regulate gene expression. Its expression peaks at late G1 phase and continues during G2 and M phases of the cell cycle. It plays a major role in the G1/S transition by regulating topoisomerase IIalpha and retinoblastoma gene expression, and functions in the p53-dependent DNA damage checkpoint. It is regarded as a hub protein for the integration of epigenetic information. This gene is up-regulated in various cancers, and it is therefore considered to be a therapeutic target. Multiple transcript variants encoding different isoforms have been found for this gene. A related pseudogene exists on chromosome 12. [provided by RefSeq, Feb 2014]
RNA binding proteome (RBPome)
PIDTitleMethod TimeAuthorDoi
30607034Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)OOPS & HEK2932019 Jan 3Queiroz RMLDOI: 10.1038/s41587-018-0001-2
30607034Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)OOPS & U2OS2019 Jan 3Queiroz RMLDOI: 10.1038/s41587-018-0001-2
Transcripts
Transcript IDNameLengthRefSeq ID Protein IDLengthRefSeq IDUniportKB ID
ENST00000612630UHRF1-2014309-ENSP00000484739793 (aa)-Q96T88
ENST00000613817UHRF1-2021859-ENSP00000480214496 (aa)-A0A087WWG9
ENST00000616255UHRF1-2042661-ENSP00000478348793 (aa)-Q96T88
ENST00000624301UHRF1-2073898XM_011527942ENSP00000485604793 (aa)XP_011526244Q96T88
ENST00000622802UHRF1-2063230-ENSP00000479617806 (aa)-A0A087WVR3
ENST00000620565UHRF1-2053965-ENSP00000478171857 (aa)-A0A087WTW0
ENST00000615884UHRF1-2032651-ENSP00000478601793 (aa)-Q96T88
Gene Model
Click here to download ENSG00000276043's gene model file
Phenotypes
ensgIDTraitpValuePubmed ID
ENSG00000276043Iron1.1670000E-00419880490
ENSG00000276043Platelet Function Tests1.3942531E-006-
ENSG00000276043Platelet Function Tests1.4658826E-006-
ENSG00000276043Platelet Function Tests1.1014835E-006-
ENSG00000276043Child Development Disorders, Pervasive7.4000000E-005-
GWAS
ensgIDSNPChromosomePositionSNP-risk TraitPubmedID95% CIOr or BEAT EFO ID
ENSG00000276043rs17883331194954443AEducational attainment (MTAG)30038396[0.0075-0.0141] unit decrease0.0108EFO_0004784
ENSG00000276043rs17883331194954443AEducational attainment (years of education)30038396[0.0073-0.0143] unit decrease0.0108EFO_0004784
ENSG00000276043rs1840221194932267TSystolic blood pressure30578418[0.16-0.28] mmHg increase0.216EFO_0006335
ENSG00000276043rs12972366194920402?Cardiovascular disease30595370EFO_0000319
Protein-Protein Interaction (PPI)

Clik here to download ENSG00000276043's network

* RBP PPI network refers to all genes directly bind to RBP
Orthologs identified by RBPome
Ensembl IDGene SymbolCoverageIdentiy OrthologGene SymbolCoverageIdentiy Species
ENSG00000276043UHRF110074.559ENSMUSG00000001228Uhrf110078.667Mus_musculus
Gene Ontology
Go IDGo_termPubmedIDEvidenceCategory
GO:0000122negative regulation of transcription by RNA polymerase II21777816.IDAProcess
GO:0000790nuclear chromatin17673620.IDAComponent
GO:0000790nuclear chromatin-ISSComponent
GO:0000791euchromatin21777816.IDAComponent
GO:0000792heterochromatin17967883.21489993.21777816.IDAComponent
GO:0000987proximal promoter sequence-specific DNA binding10646863.IDAFunction
GO:0004842ubiquitin-protein transferase activity17967883.21745816.22945642.IDAFunction
GO:0005515protein binding15361834.17673620.17934516.19798101.21745816.22945642.IPIFunction
GO:0005634nucleus10646863.IDAComponent
GO:0005657replication fork17673620.IDAComponent
GO:0005720nuclear heterochromatin21873635.IBAComponent
GO:0006281DNA repair-IEAProcess
GO:0006511ubiquitin-dependent protein catabolic process22945642.IDAProcess
GO:0007049cell cycle-IEAProcess
GO:0008270zinc ion binding21777816.IDAFunction
GO:0008327methyl-CpG binding15361834.21029866.IDAFunction
GO:0010216maintenance of DNA methylation21873635.IBAProcess
GO:0010216maintenance of DNA methylation17673620.IMPProcess
GO:0010390histone monoubiquitination21873635.IBAProcess
GO:0010390histone monoubiquitination-ISSProcess
GO:0016363nuclear matrix-ISSComponent
GO:0016567protein ubiquitination21873635.IBAProcess
GO:0016574histone ubiquitination17967883.IDAProcess
GO:0031493nucleosomal histone binding-ISSFunction
GO:0032270positive regulation of cellular protein metabolic process10646863.IDAProcess
GO:0035064methylated histone binding17967883.21029866.21489993.IDAFunction
GO:0042393histone binding21777816.IDAFunction
GO:0042802identical protein binding-ISSFunction
GO:0044729hemi-methylated DNA-binding17673620.IDAFunction
GO:0045944positive regulation of transcription by RNA polymerase II10646863.ICProcess
GO:0050678regulation of epithelial cell proliferation15361834.IMPProcess
GO:0051865protein autoubiquitination17967883.21745816.IDAProcess
GO:0061630ubiquitin protein ligase activity21873635.IBAFunction
GO:0061630ubiquitin protein ligase activity-ISSFunction
GO:2000373positive regulation of DNA topoisomerase (ATP-hydrolyzing) activity10646863.ICProcess
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