EuRBPDB

Note: to get the extension of tumor abbreviations.

Cancer Related Information
Basic Information

Cancer associated literatures

PID	Title	Article	Time	Author	Doi
24662837	Functional characterization of the tumor-suppressor MARCKS in colorectal cancer and its association with survival.	Oncogene	2015 Feb 26	Bickebller M	doi: 10.1038/onc.2014.40
28075441	miR34c3p acts as a tumor suppressor gene in osteosarcoma by targeting MARCKS.	Mol Med Rep	2017 Mar	Liu H	doi: 10.3892/mmr.2017.6108
27081703	MARCKS contributes to stromal cancer-associated fibroblast activation and facilitates ovarian cancer metastasis.	Oncotarget	2016 Jun 21	Yang Z	doi: 10.18632/oncotarget.8726.
29588366	The long noncoding RNA lncZic2 drives the self-renewal of liver tumor-initiating cells via the protein kinase C substrates MARCKS and MARCKSL1.	J Biol Chem	2018 May 25	Chen Z	doi: 10.1074/jbc.RA117.001321
25318062	Targeting myristoylated alanine-rich C kinase substrate phosphorylation site domain in lung cancer. Mechanisms and therapeutic implications.	Am J Respir Crit Care Med	2014 Nov 15	Chen CH	doi: 10.1164/rccm.201408-1505OC.
29295532	Stromal Expression of MARCKS Protein in Ovarian Carcinomas Has Unfavorable Prognostic Value.	Int J Mol Sci	2017 Dec 23	Doghri R	doi: 10.3390/ijms19010041.
23376641	Myristoylated Alanine-Rich protein Kinase C Substrate (MARCKS) expression modulates the metastatic phenotype in human and murine colon carcinoma in vitro and in vivo.	Cancer Lett	2013 Jun 10	Rombouts K	doi: 10.1016/j.canlet.2013.01.040
24735036	A novel predictor of cancer malignancy: up-regulation of myristoylated alanine-rich C kinase substrate phosphorylation in lung cancer.	Am J Respir Crit Care Med	2014 Apr 15	Chen CH	doi: 10.1164/rccm.201401-0053LE.
23876235	Global characterization of signalling networks associated with tamoxifen resistance in breast cancer.	FEBS J	2013 Nov	Browne BC	doi: 10.1111/febs.12441
19302977	MicroRNA-21 directly targets MARCKS and promotes apoptosis resistance and invasion in prostate cancer cells.	Biochem Biophys Res Commun	2009 Jun 5	Li T	doi: 10.1016/j.bbrc.2009.03.077
25524703	Targeting the effector domain of the myristoylated alanine rich C-kinase substrate enhances lung cancer radiation sensitivity.	Int J Oncol	2015 Mar	Rohrbach TD	doi: 10.3892/ijo.2014.2799
20047593	Myristoylated alanine-rich C kinase substrate phosphorylation promotes cholangiocarcinoma cell migration and metastasis via the protein kinase C-dependent pathway.	Cancer Sci	2010 Mar	Techasen A	doi: 10.1111/j.1349-7006.2009.01427.x
26015406	Elevated MARCKS phosphorylation contributes to unresponsiveness of breast cancer to paclitaxel treatment.	Oncotarget	2015 Jun 20	Chen CH	-
28166200	Upregulation of MARCKS in kidney cancer and its potential as a therapeutic target.	Oncogene	2017 Jun 22	Chen CH	doi: 10.1038/onc.2016.510
28009981	MARCKS protein overexpression in inflammatory breast cancer.	Oncotarget	2017 Jan 24	Manai M	doi: 10.18632/oncotarget.14057.

Differential Expression

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq
BLCA	chr6	113860574	Missense_Mutation	novel	E332K	0.24
BLCA	chr6	113857782	Missense_Mutation	novel	E13Q	0.37
BLCA	chr6	113860574	Missense_Mutation	NA	E332Q	0.59
CESC	chr6	113861404	3'UTR	novel		0.17
CESC	chr6	113857828	Missense_Mutation	NA	P28L	0.3
CESC	chr6	113861816	3'UTR	novel		0.2
CESC	chr6	113861816	3'UTR	novel		0.2
CHOL	chr6	113861400	3'UTR	novel		0.24
COAD	chr6	113860729	3'UTR	novel		0.5
COAD	chr6	113860554	Frame_Shift_Del	NA	*P327Qfs42**	0.26
COAD	chr6	113860515	Frame_Shift_Del	NA	*S314Hfs55**	0.1
COAD	chr6	113860713	3'UTR	novel		0.39
COAD	chr6	113860698	3'UTR	novel		0.46
COAD	chr6	113860699	3'UTR	novel		0.57
COAD	chr6	113860554	Frame_Shift_Del	NA	*P327Qfs42**	0.52
HNSC	chr6	113860538	Nonsense_Mutation	novel	E320*	0.17
HNSC	chr6	113859943	Silent	novel	A121A	0.53
KIRC	chr6	113857799	Missense_Mutation	NA	R18S	0.25
LAML	chr6	113860573	Silent	novel	A331A	0.09
LGG	chr6	113857727	5'UTR	novel		0.5
LIHC	chr6	113860815	3'UTR	novel		0.2
LUAD	chr6	113860493	Missense_Mutation	NA	A305T	0.13
LUAD	chr6	113860496	Missense_Mutation	novel	A306S	0.21
LUAD	chr6	113860585	3'UTR	novel		0.07
LUSC	chr6	113860079	Missense_Mutation	NA	S167C	0.39
LUSC	chr6	113860503	Missense_Mutation	NA	S308L	0.29
SARC	chr6	113857449	5'UTR	novel		0.48
SARC	chr6	113860981	3'UTR	novel		0.23
SKCM	chr6	113857831	Missense_Mutation	NA	S29F	0.31
STAD	chr6	113860162	Silent	NA	D194D	0.53
STAD	chr6	113860713	3'UTR	novel		0.36
STAD	chr6	113860452	Missense_Mutation	NA	P291L	0.53
STAD	chr6	113860538	Missense_Mutation	novel	E320K	0.39
STAD	chr6	113857719	5'UTR	novel		0.5
UCEC	chr6	113857697	5'UTR	novel		0.3
UCEC	chr6	113860788	3'UTR	novel		0.1
UCEC	chr6	113861895	3'UTR	novel		0.5
UCEC	chr6	113860712	3'UTR	novel		0.45
UCEC	chr6	113861246	3'UTR	novel		0.29
UCEC	chr6	113857449	5'UTR	novel		0.75
UCEC	chr6	113861816	3'UTR	novel		0.63
UCEC	chr6	113860554	Frame_Shift_Del	NA	*P327Qfs42**	0.22
UCEC	chr6	113861826	3'UTR	novel		0.41
UCEC	chr6	113860713	3'UTR	novel		0.27
UCEC	chr6	113861055	3'UTR	novel		0.16
UCEC	chr6	113860684	3'UTR	novel		0.47
UCEC	chr6	113860605	3'UTR	novel		0.36
UCEC	chr6	113861208	3'UTR	novel		0.4
UCEC	chr6	113861361	3'UTR	novel		0.16
UCEC	chr6	113860986	3'UTR	novel		0.24
UCEC	chr6	113861121	3'UTR	novel		0.19
UCEC	chr6	113861605	3'UTR	novel		0.19
UCEC	chr6	113860713	3'UTR	novel		0.49
UCEC	chr6	113860713	3'UTR	novel		0.44
UCEC	chr6	113860563	Missense_Mutation	novel	A328V	0.33
UCEC	chr6	113860656	3'UTR	novel		0.55
UCEC	chr6	113860790	3'UTR	novel		0.07
UCEC	chr6	113861734	3'UTR	novel		0.32
UCEC	chr6	113860849	3'UTR	novel		0.36
UCEC	chr6	113861815	3'UTR	novel		0.49
UCEC	chr6	113860604	3'UTR	novel		0.33
UCEC	chr6	113860713	3'UTR	novel		0.38
UCEC	chr6	113860554	Frame_Shift_Del	NA	*P327Qfs42**	0.54
UCEC	chr6	113860867	3'UTR	novel		0.34
UCEC	chr6	113861403	3'UTR	novel		0.38
UCEC	chr6	113860713	3'UTR	novel		0.41
UCEC	chr6	113860853	3'UTR	novel		0.37
UCS	chr6	113860553	Frame_Shift_Ins	rs770972906	*A328Sfs14**	0.66

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
BLCA	DEL	0.3725	3.4915e-05
DLBC	DEL	0.2708	0.00052595
ESCA	DEL	0.212	0.036953
GBM	DEL	0.2097	1.056e-05
KIRC	DEL	0.233	7.439e-11
LGG	DEL	0.1365	0.0054594
LUAD	DEL	0.4109	0.0021365
MESO	DEL	0.4253	0.05642
PAAD	DEL	0.3641	0.11274
SKCM	DEL	0.5368	1.5442e-06
STAD	DEL	0.1338	0.0044196
THYM	DEL	0.1301	0.10691

Survival Analysis

Cancer	P-value	Q-value
STAD	0.00013	Kaplan-Meier Survival Analysis
MESO	0.00034	Kaplan-Meier Survival Analysis
HNSC	0.026	Kaplan-Meier Survival Analysis
PRAD	0.037	Kaplan-Meier Survival Analysis
TGCT	0.05	Kaplan-Meier Survival Analysis
BLCA	0.038	Kaplan-Meier Survival Analysis
CESC	0.01	Kaplan-Meier Survival Analysis
LAML	0.0032	Kaplan-Meier Survival Analysis
UCEC	0.05	Kaplan-Meier Survival Analysis
GBM	0.035	Kaplan-Meier Survival Analysis
LIHC	0.00024	Kaplan-Meier Survival Analysis
LGG	0.00011	Kaplan-Meier Survival Analysis
LUAD	0.048	Kaplan-Meier Survival Analysis
UVM	0.00013	Kaplan-Meier Survival Analysis

Drugs

Cell lines and drugs in GSE70138 or GSE92742

Description

RBPome

Literatures

Transcripts

Gene Model

Pathways

PPI

Gene Ontology

Description

Ensembl ID: ENSG00000277443 (Gene tree)
Gene ID: 4082
Gene Symbol: MARCKS
Alias: PKCSL|80K-L|MACS
Full Name: myristoylated alanine rich protein kinase C substrate
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Plus strand
Length: 6,141 bases
Position: chr6:113,857,335-113,863,475
Accession: 6759
RBP type: non-canonical RBP
Summary: The protein encoded by this gene is a substrate for protein kinase C. It is localized to the plasma membrane and is an actin filament crosslinking protein. Phosphorylation by protein kinase C or binding to calcium-calmodulin inhibits its association with actin and with the plasma membrane, leading to its presence in the cytoplasm. The protein is thought to be involved in cell motility, phagocytosis, membrane trafficking and mitogenesis. [provided by RefSeq, Jul 2008]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & HEK293	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & Hela	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
12605686	The 3'-UTR of the mRNA coding for the major protein kinase C substrate MARCKS contains a novel CU-rich element interacting with the mRNA stabilizing factors HuD and HuR.	Eur J Biochem	2003 Jan	Wein G	-

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000612661	MARCKS-201	4275	-	ENSP00000478061	332 (aa)	-	P29966

Gene Model

Click here to download ENSG00000277443's gene model file

Pathways

Pathway ID	Pathway Name	Source
hsa04666	Fc gamma R-mediated phagocytosis	KEGG
hsa05206	MicroRNAs in cancer	KEGG

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000277443's network

* RBP PPI network refers to all genes directly bind to RBP

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0005080	protein kinase C binding	-	IEA	Function
GO:0005516	calmodulin binding	-	IEA	Function
GO:0005813	centrosome	-	IEA	Component
GO:0005886	plasma membrane	-	TAS	Component
GO:0005925	focal adhesion	21423176.	HDA	Component
GO:0005938	cell cortex	-	IEA	Component
GO:0015629	actin cytoskeleton	1560845.	TAS	Component
GO:0032432	actin filament bundle	-	IEA	Component
GO:0042585	germinal vesicle	-	IEA	Component
GO:0042802	identical protein binding	-	IEA	Function
GO:0051015	actin filament binding	-	IEA	Function
GO:0051017	actin filament bundle assembly	-	IEA	Process
GO:0051260	protein homooligomerization	-	IEA	Process
GO:0051764	actin crosslink formation	-	IEA	Process
GO:0070062	extracellular exosome	19056867.20458337.	HDA	Component

EuRBPDB

Note: to get the extension of tumor abbreviations.

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Description

RBPome

Literatures

Transcripts

Gene Model

Pathways

PPI

Gene Ontology

Note: Click here to get the extension of tumor abbreviations.

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Note: to get the extension of tumor abbreviations.