EuRBPDB

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Cancer Related Information
Basic Information

Differential Expression

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq	RBD
BLCA	chr17	35930128	Missense_Mutation	novel	R75T	0.39	RRM_1
BLCA	chr17	35924638	Silent	novel	G178G	0.91
BLCA	chr17	35924713	Silent	rs373207074	P153P	0.28
BRCA	chr17	35922586	Missense_Mutation	novel	V220F	0.13
CESC	chr17	35930643	Missense_Mutation	novel	E29K	0.2
CESC	chr17	35924733	Missense_Mutation	novel	D147H	0.28
CESC	chr17	35925518	Silent	rs765443073	I132I	0.3
CHOL	chr17	35918398	Missense_Mutation	novel	Y267H	0.7
COAD	chr17	35922629	Silent	novel	A205A	0.26
COAD	chr17	35930223	Silent	rs755785027	G43G	0.15
COAD	chr17	35925633	Missense_Mutation	rs760143593	R94H	0.1
COAD	chr17	35920199	Silent	rs778251776	H247H	0.28
COAD	chr17	35930744	5'UTR	novel		0.34
COAD	chr17	35930076	Missense_Mutation	novel	K92N	0.06
COAD	chr17	35930707	Frame_Shift_Del	novel	*F7Lfs12**	0.28
COAD	chr17	35924643	Missense_Mutation	novel	I177V	0.16
GBM	chr17	35918315	3'UTR	novel		0.46
GBM	chr17	35930640	Missense_Mutation	novel	A30P	0.08
HNSC	chr17	35922571	Splice_Region	novel		0.19
KIRC	chr17	35930691	Missense_Mutation	novel	S13C	0.16
KIRC	chr17	35922620	Silent	rs112692396	K208K	0.27
KIRP	chr17	35930134	Missense_Mutation	novel	A73V	0.06	RRM_1
LGG	chr17	35922489	Intron	novel		0.07
LIHC	chr17	35930106	Silent	novel	R82R	0.19
LIHC	chr17	35918274	3'UTR	novel		0.26
LUAD	chr17	35924745	Missense_Mutation	rs148466061	R143G	0.06
LUAD	chr17	35924766	Nonsense_Mutation	novel	E136*	0.44
LUAD	chr17	35924664	Missense_Mutation	novel	C170G	0.56
LUSC	chr17	35922610	Missense_Mutation	novel	D212N	0.28
LUSC	chr17	35924640	Missense_Mutation	novel	G178C	0.22
LUSC	chr17	35915757	3'Flank	novel		0.34
LUSC	chr17	35920218	Missense_Mutation	rs192386068	R241T	0.26
OV	chr17	35930278	Intron	novel		0.16
OV	chr17	35924744	Missense_Mutation	novel	R143M	0.65
OV	chr17	35930138	Missense_Mutation	novel	A72T	0.08	RRM_1
PRAD	chr17	35920212	Missense_Mutation	novel	E243G	0.05
PRAD	chr17	35922533	Intron	novel		0.13
SKCM	chr17	35918293	3'UTR	novel		0.63
SKCM	chr17	35930699	Missense_Mutation	novel	P10L	0.23
SKCM	chr17	35918295	3'UTR	novel		0.14
SKCM	chr17	35918441	Splice_Region	novel	V252V	0.38
SKCM	chr17	35920229	Silent	rs761480550	I237I	0.49
SKCM	chr17	35918210	3'UTR	novel		0.42
SKCM	chr17	35922675	Missense_Mutation	novel	G190E	0.23
SKCM	chr17	35930757	5'UTR	novel		0.34
SKCM	chr17	35924713	Silent	rs373207074	P153P	0.18
SKCM	chr17	35918304	3'UTR	novel		0.31
STAD	chr17	35930076	Missense_Mutation	novel	K92N	0.2
STAD	chr17	35924623	Silent	novel	P183P	0.29
STAD	chr17	35922631	Missense_Mutation	novel	A205T	0.39
STAD	chr17	35930293	Intron	novel		0.13
STAD	chr17	35924604	Nonsense_Mutation	novel	G190*	0.28
UCEC	chr17	35915758	3'Flank	novel		0.29
UCEC	chr17	35930749	5'UTR	rs182528442		0.18
UCEC	chr17	35925627	Missense_Mutation	novel	G96D	0.24
UCEC	chr17	35922595	Missense_Mutation	novel	L217M	0.18
UCEC	chr17	35920229	Silent	rs761480550	I237I	0.47
UCEC	chr17	35922634	Missense_Mutation	novel	L204F	0.26
UCEC	chr17	35930653	Silent	novel	G25G	0.25
UCEC	chr17	35924687	Missense_Mutation	novel	A162D	0.43
UCEC	chr17	35915784	3'Flank	novel		0.51
UCEC	chr17	35924762	Missense_Mutation	novel	L137R	0.31
UCEC	chr17	35925557	Missense_Mutation	novel	N119K	0.33
UCEC	chr17	35930112	Silent	rs774535357	C80C	0.57
UCEC	chr17	35930086	Missense_Mutation	novel	S89F	0.3
UCEC	chr17	35930285	Intron	novel		0.38
UCEC	chr17	35925561	Missense_Mutation	rs150971295	A118V	0.11

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
DLBC	DEL	0.0208	0.18166
THCA	DEL	0.002	0.221
UCS	DEL	0.3929	0.19877
UVM	DEL	0.0125	0.22482

Survival Analysis

Cancer	P-value	Q-value
THYM	0.027	Kaplan-Meier Survival Analysis
KIRC	0.00016	Kaplan-Meier Survival Analysis
MESO	0.0001	Kaplan-Meier Survival Analysis
ACC	0.0026	Kaplan-Meier Survival Analysis
KIRP	0.00023	Kaplan-Meier Survival Analysis
PAAD	0.023	Kaplan-Meier Survival Analysis
BLCA	0.049	Kaplan-Meier Survival Analysis
CESC	0.041	Kaplan-Meier Survival Analysis
READ	0.021	Kaplan-Meier Survival Analysis
LAML	0.0088	Kaplan-Meier Survival Analysis
UCEC	0.003	Kaplan-Meier Survival Analysis
GBM	0.028	Kaplan-Meier Survival Analysis
LIHC	0.00011	Kaplan-Meier Survival Analysis
LUAD	0.018	Kaplan-Meier Survival Analysis
UVM	0.042	Kaplan-Meier Survival Analysis
OV	0.039	Kaplan-Meier Survival Analysis

Description

RBDs

Literatures

Transcripts

Gene Model

GWAS

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000278023 (Gene tree)
Gene ID: 201299
Gene Symbol: RDM1
Alias: MGC33977|RAD52B
Full Name: RAD52 motif containing 1
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Minus strand
Length: 12,746 bases
Position: chr17:35,918,066-35,930,811
Accession: 19950
RBP type: canonical RBP
Summary: This gene encodes a protein involved in the cellular response to cisplatin, a drug commonly used in chemotherapy. The protein encoded by this gene contains two motifs: a motif found in RAD52, a protein that functions in DNA double-strand breaks and homologous recombination, and an RNA recognition motif (RRM) that is not found in RAD52. The RAD52 motif region in RAD52 is important for protein function and may be involved in DNA binding or oligomerization. Alternatively spliced transcript variants encoding different isoforms have been reported. [provided by RefSeq, Jul 2008]

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000480131	RRM_1	PF00076.22	1.9e-05	1	1
ENSP00000491541	RRM_1	PF00076.22	2.7e-05	1	1
ENSP00000479622	RRM_1	PF00076.22	3.1e-05	1	1
ENSP00000483387	RRM_1	PF00076.22	3.9e-05	1	1
ENSP00000483890	RRM_1	PF00076.22	5.7e-05	1	1
ENSP00000482288	RRM_1	PF00076.22	6.4e-05	1	1
ENSP00000483933	RRM_1	PF00076.22	6.6e-05	1	1
ENSP00000478915	RRM_1	PF00076.22	7.3e-05	1	1
ENSP00000479310	RRM_1	PF00076.22	7.8e-05	1	1
ENSP00000483549	RRM_1	PF00076.22	8.4e-05	1	1

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
16630539	Nucleic acid-binding properties of the RRM-containing protein RDM1.	Biochem Biophys Res Commun	2006 May 26	Hamimes S	-
15611051	RDM1, a novel RNA recognition motif (RRM)-containing protein involved in the cell response to cisplatin in vertebrates.	J Biol Chem	2005 Mar 11	Hamimes S	-

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000619876	RDM1-227	1491	-	ENSP00000483890	213 (aa)	-	B4DZ74
ENST00000619193	RDM1-223	686	-	ENSP00000482981	139 (aa)	-	Q8NG50
ENST00000612980	RDM1-215	501	-	ENSP00000483387	166 (aa)	-	Q8NG50
ENST00000613308	RDM1-216	779	XM_011524509	ENSP00000482288	236 (aa)	XP_011522811	Q8NG50
ENST00000639942	RDM1-229	420	-	ENSP00000491541	139 (aa)	-	Q8NG50
ENST00000615378	RDM1-219	542	-	ENSP00000480131	116 (aa)	-	Q8NG50
ENST00000615024	RDM1-217	617	-	ENSP00000481648	116 (aa)	-	Q8NG50
ENST00000617591	RDM1-221	432	-	ENSP00000479622	143 (aa)	-	Q8NG50
ENST00000615288	RDM1-218	587	-	ENSP00000477869	137 (aa)	-	Q8NG50
ENST00000619262	RDM1-224	1535	-	ENSP00000479310	261 (aa)	-	Q8NG50
ENST00000616596	RDM1-220	1032	-	ENSP00000478915	251 (aa)	-	Q8NG50
ENST00000619828	RDM1-226	687	-	ENSP00000483933	228 (aa)	-	Q8NG50
ENST00000618511	RDM1-222	518	-	ENSP00000477995	114 (aa)	-	Q8NG50
ENST00000619368	RDM1-225	506	-	ENSP00000478131	79 (aa)	-	Q8NG50
ENST00000620284	RDM1-228	1177	-	ENSP00000483549	284 (aa)	-	Q8NG50

Gene Model

Click here to download ENSG00000278023's gene model file

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000278023	rs9907295	17	35930309	C	Fibroblast growth factor basic levels	27989323	[0.079-0.185] SD units increase	0.1319	EFO_0008130
ENSG00000278023	rs28695841	17	35926187	G	RANTES levels	27989323	[0.1-0.23] SD units increase	0.1658	EFO_0005117

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000278023's network

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000278023	RDM1	95	44.697	ENSAPOG00000021886	zgc:103564	84	34.348	Acanthochromis_polyacanthus
ENSG00000278023	RDM1	55	85.714	ENSAMEG00000019542	-	93	85.714	Ailuropoda_melanoleuca
ENSG00000278023	RDM1	95	44.697	ENSAPEG00000008929	zgc:103564	92	33.333	Amphiprion_percula
ENSG00000278023	RDM1	91	67.925	ENSAPLG00000004384	RDM1	96	53.571	Anas_platyrhynchos
ENSG00000278023	RDM1	96	56.061	ENSACAG00000012989	-	100	49.117	Anolis_carolinensis
ENSG00000278023	RDM1	100	92.806	ENSANAG00000032752	RDM1	100	92.806	Aotus_nancymaae
ENSG00000278023	RDM1	100	88.806	ENSBTAG00000000030	RDM1	100	78.596	Bos_taurus
ENSG00000278023	RDM1	100	94.245	ENSCJAG00000015031	RDM1	100	94.245	Callithrix_jacchus
ENSG00000278023	RDM1	90	83.495	ENSCAFG00000015160	-	100	73.828	Canis_familiaris
ENSG00000278023	RDM1	97	88.722	ENSCHIG00000020607	RDM1	100	78.723	Capra_hircus
ENSG00000278023	RDM1	97	78.947	ENSCPOG00000001495	-	99	68.662	Cavia_porcellus
ENSG00000278023	RDM1	100	92.086	ENSCCAG00000035763	RDM1	100	92.086	Cebus_capucinus
ENSG00000278023	RDM1	100	97.015	ENSCATG00000044451	RDM1	100	96.403	Cercocebus_atys
ENSG00000278023	RDM1	100	92.776	ENSCSAG00000006209	RDM1	100	92.776	Chlorocebus_sabaeus
ENSG00000278023	RDM1	90	70.874	ENSCPBG00000009105	RDM1	95	54.032	Chrysemys_picta_bellii
ENSG00000278023	RDM1	100	95.783	ENSCANG00000041322	RDM1	100	95.783	Colobus_angolensis_palliatus
ENSG00000278023	RDM1	97	79.699	ENSCGRG00001015927	Rdm1	99	72.438	Cricetulus_griseus_chok1gshd
ENSG00000278023	RDM1	95	39.394	ENSCVAG00000001956	zgc:103564	86	35.443	Cyprinodon_variegatus
ENSG00000278023	RDM1	95	85.577	ENSDNOG00000045224	-	94	81.890	Dasypus_novemcinctus
ENSG00000278023	RDM1	96	87.156	ENSEASG00005010554	RDM1	77	80.465	Equus_asinus_asinus
ENSG00000278023	RDM1	97	90.977	ENSECAG00000022182	RDM1	91	81.961	Equus_caballus
ENSG00000278023	RDM1	94	81.188	ENSEEUG00000006127	RDM1	100	72.619	Erinaceus_europaeus
ENSG00000278023	RDM1	99	90.323	ENSFCAG00000043429	RDM1	100	86.331	Felis_catus
ENSG00000278023	RDM1	96	63.636	ENSGALG00000000243	RDM1	97	53.791	Gallus_gallus
ENSG00000278023	RDM1	89	72.277	ENSGAGG00000000293	-	78	53.815	Gopherus_agassizii
ENSG00000278023	RDM1	100	98.193	ENSGGOG00000010584	RDM1	100	98.193	Gorilla_gorilla
ENSG00000278023	RDM1	95	41.985	ENSHCOG00000002518	-	89	35.857	Hippocampus_comes
ENSG00000278023	RDM1	100	87.313	ENSSTOG00000022491	RDM1	100	83.451	Ictidomys_tridecemlineatus
ENSG00000278023	RDM1	97	87.218	ENSLAFG00000029300	RDM1	100	77.622	Loxodonta_africana
ENSG00000278023	RDM1	100	97.015	ENSMFAG00000032968	RDM1	100	96.403	Macaca_fascicularis
ENSG00000278023	RDM1	100	97.015	ENSMMUG00000006847	RDM1	100	96.386	Macaca_mulatta
ENSG00000278023	RDM1	100	97.015	ENSMNEG00000039977	RDM1	100	96.403	Macaca_nemestrina
ENSG00000278023	RDM1	100	97.015	ENSMLEG00000041158	RDM1	100	96.386	Mandrillus_leucophaeus
ENSG00000278023	RDM1	89	66.337	ENSMGAG00000008774	RDM1	96	54.694	Meleagris_gallopavo
ENSG00000278023	RDM1	99	79.104	ENSMAUG00000018559	Rdm1	99	72.183	Mesocricetus_auratus
ENSG00000278023	RDM1	100	92.537	ENSMICG00000038651	RDM1	100	90.580	Microcebus_murinus
ENSG00000278023	RDM1	97	77.444	ENSMOCG00000015095	Rdm1	99	68.478	Microtus_ochrogaster
ENSG00000278023	RDM1	96	72.727	ENSMODG00000011101	RDM1	100	63.406	Monodelphis_domestica
ENSG00000278023	RDM1	97	82.707	MGP_CAROLIEiJ_G0017226	Rdm1	99	72.085	Mus_caroli
ENSG00000278023	RDM1	97	81.955	ENSMUSG00000010362	Rdm1	99	72.143	Mus_musculus
ENSG00000278023	RDM1	99	82.836	MGP_PahariEiJ_G0018356	Rdm1	99	72.535	Mus_pahari
ENSG00000278023	RDM1	97	81.203	MGP_SPRETEiJ_G0018069	Rdm1	99	71.731	Mus_spretus
ENSG00000278023	RDM1	97	89.474	ENSMPUG00000008363	RDM1	100	80.769	Mustela_putorius_furo
ENSG00000278023	RDM1	100	96.831	ENSNLEG00000014173	RDM1	100	96.831	Nomascus_leucogenys
ENSG00000278023	RDM1	96	72.727	ENSMEUG00000015826	RDM1	100	66.135	Notamacropus_eugenii
ENSG00000278023	RDM1	97	84.211	ENSOCUG00000022704	RDM1	97	77.470	Oryctolagus_cuniculus
ENSG00000278023	RDM1	100	85.821	ENSOGAG00000011332	RDM1	100	82.394	Otolemur_garnettii
ENSG00000278023	RDM1	100	98.507	ENSPPAG00000029969	RDM1	100	98.239	Pan_paniscus
ENSG00000278023	RDM1	100	98.795	ENSPTRG00000009031	RDM1	100	98.795	Pan_troglodytes
ENSG00000278023	RDM1	100	96.269	ENSPANG00000022933	RDM1	100	95.783	Papio_anubis
ENSG00000278023	RDM1	97	78.947	ENSPEMG00000018985	Rdm1	99	71.479	Peromyscus_maniculatus_bairdii
ENSG00000278023	RDM1	100	96.479	ENSPPYG00000008198	RDM1	100	96.479	Pongo_abelii
ENSG00000278023	RDM1	100	87.770	ENSPCOG00000017995	RDM1	100	87.770	Propithecus_coquereli
ENSG00000278023	RDM1	97	90.226	ENSPVAG00000001116	RDM1	100	83.267	Pteropus_vampyrus
ENSG00000278023	RDM1	97	81.955	ENSRNOG00000020751	Rdm1	99	71.786	Rattus_norvegicus
ENSG00000278023	RDM1	100	96.403	ENSRBIG00000030000	RDM1	100	96.403	Rhinopithecus_bieti
ENSG00000278023	RDM1	100	96.386	ENSRROG00000035242	RDM1	100	96.386	Rhinopithecus_roxellana
ENSG00000278023	RDM1	96	75.758	ENSSHAG00000013584	RDM1	100	67.029	Sarcophilus_harrisii
ENSG00000278023	RDM1	88	69.000	ENSSPUG00000010941	RDM1	94	53.585	Sphenodon_punctatus
ENSG00000278023	RDM1	95	45.455	ENSSPAG00000011690	-	95	36.226	Stegastes_partitus
ENSG00000278023	RDM1	82	83.036	ENSSSCG00000017574	-	93	72.768	Sus_scrofa
ENSG00000278023	RDM1	94	83.333	ENSTBEG00000010030	RDM1	99	62.698	Tupaia_belangeri
ENSG00000278023	RDM1	97	89.474	ENSUAMG00000027279	RDM1	100	82.042	Ursus_americanus
ENSG00000278023	RDM1	97	89.474	ENSUMAG00000015423	RDM1	98	82.042	Ursus_maritimus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0003677	DNA binding	-	IEA	Function
GO:0003723	RNA binding	-	IEA	Function
GO:0005515	protein binding	25416956.	IPI	Function
GO:0005730	nucleolus	-	IDA	Component
GO:0005829	cytosol	-	IDA	Component
GO:0015030	Cajal body	-	IEA	Component
GO:0016605	PML body	-	IEA	Component

Note: Click here to get the extension of tumor abbreviations.

Note: to get the extension of tumor abbreviations.