EuRBPDB

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TCGA tumor abbreviations
  • ACCAdrenocortical carcinoma
  • BLCABladder Urothelial Carcinoma
  • BRCABreast invasive carcinoma
  • CESCCervical squamous cell carcinoma and endocervical adenocarcinoma
  • CHOLCholangio carcinoma
  • COADColon adenocarcinoma
  • DLBCLymphoid Neoplasm Diffuse Large B-cell Lymphoma
  • ESCAEsophageal carcinoma
  • GBMGlioblastoma multiforme
  • HNSCHead and Neck squamous cell carcinoma
  • KICHKidney Chromophobe
  • KIRCKidney renal clear cell carcinoma
  • KIRPKidney renal papillary cell carcinoma
  • LAMLAcute Myeloid Leukemia
  • LGGBrain Lower Grade Glioma
  • LIHCLiver hepatocellular carcinoma
  • LUADLung adenocarcinoma
  • LUSCLung squamous cell carcinoma
  • MESOMesothelioma
  • OVOvarian serous cystadenocarcinoma
  • PAADPancreatic adenocarcinoma
  • PCPGPheochromocytoma and Paraganglioma
  • PRADProstate adenocarcinoma
  • READRectum adenocarcinoma
  • SARCSarcoma
  • SKCMSkin Cutaneous Melanoma
  • STADStomach adenocarcinoma
  • TGCTThyroid carcinoma
  • THCAThyroid carcinoma
  • THYMThymoma
  • UCECUterine Corpus Endometrial Carcinoma
  • UCSUterine Carcinosarcoma
  • UVMUveal Melanoma

Note: Click here to get the extension of tumor abbreviations.


  • Cancer Related Information
  • Basic Information

Cancer associated literatures
PIDTitleArticle TimeAuthorDoi
29056512Acetyl-CoA Carboxylase 1-Dependent Protein Acetylation Controls Breast Cancer Metastasis and Recurrence.Cell Metab2017 Dec 5Rios Garcia Mdoi: 10.1016/j.cmet.2017.09.018
24924473Increased expression of phospho-acetyl-CoA carboxylase protein is an independent prognostic factor for human gastric cancer without lymph node metastasis.Med Oncol2014 JulFang Wdoi: 10.1007/s12032-014-0015-7
16326698BRCA1 affects lipid synthesis through its interaction with acetyl-CoA carboxylase.J Biol Chem2006 Feb 10Moreau K-
21726077The lipogenesis pathway as a cancer target.J Med Chem2011 Aug 25Abramson HNdoi: 10.1021/jm2005805
25246709Chemical inhibition of acetyl-CoA carboxylase suppresses self-renewal growth of cancer stem cells.Oncotarget2014 Sep 30Corominas-Faja B-
18056116Aldo-keto reductase family 1 B10 affects fatty acid synthesis by regulating the stability of acetyl-CoA carboxylase-alpha in breast cancer cells.J Biol Chem2008 Feb 8Ma J-
17372234Haplotype-based analysis of common variation in the acetyl-coA carboxylase alpha gene and breast cancer risk: a case-control study nested within the European Prospective Investigation into Cancer and Nutrition.Cancer Epidemiol Biomarkers Prev2007 MarSinilnikova OM-
19710915Inhibition of stearoylCoA desaturase-1 inactivates acetyl-CoA carboxylase and impairs proliferation in cancer cells: role of AMPK.PLoS One2009 Aug 27Scaglia Ndoi: 10.1371/journal.pone.0006812.
17631500Up-regulation of acetyl-CoA carboxylase alpha and fatty acid synthase by human epidermal growth factor receptor 2 at the translational level in breast cancer cells.J Biol Chem2007 Sep 7Yoon S-
15333468Acetyl-CoA carboxylase alpha gene and breast cancer susceptibility.Carcinogenesis2004 DecSinilnikova OM-
27693630Acetyl-CoA carboxylase rewires cancer metabolism to allow cancer cells to survive inhibition of the Warburg effect by cetuximab.Cancer Lett2017 Jan 1Luo Jdoi: 10.1016/j.canlet.2016.09.020
29899443Structural basis for regulation of human acetyl-CoA carboxylase.Nature2018 JunHunkeler Mdoi: 10.1038/s41586-018-0201-4

Expression in 33 cancers

Mutations
CancerChrPosition Mutation TypedbSNPProtein-change Allele FreqRBD
ACCchr1737111591Missense_MutationnovelD2169Y0.12
BLCAchr1737188403SilentnovelL1550L0.29
BLCAchr1737284867Missense_MutationnovelR148C0.1
BLCAchr1737191156SilentnovelL1512L0.21
BLCAchr1737149959Missense_MutationnovelI1862V0.26
BLCAchr1737111550Missense_MutationnovelI2182M0.36
BLCAchr1737252942Nonsense_MutationnovelQ641*0.19
BLCAchr1737155727Silentrs757250697L1801L0.12
BLCAchr1737088979Missense_MutationnovelI2329M0.04
BLCAchr1737129436Missense_MutationnovelR1958T0.11
BLCAchr1737223596Silentrs753127166L1160L0.09
BLCAchr1737246967SilentnovelI773I0.24
BLCAchr1737192292Missense_MutationnovelR1405L0.38
BLCAchr1737277922Missense_MutationnovelD232N0.15
BLCAchr1737235064Missense_MutationnovelE1053Q0.24
BLCAchr1737263831Missense_MutationnovelL395V0.52
BLCAchr1737258349SilentnovelR509R0.18
BLCAchr1737275969Missense_MutationnovelL295F0.46
BLCAchr1737161918Missense_MutationnovelR1738G0.13
BLCAchr17370871843'UTRnovel0.83
BLCAchr1737263720Missense_MutationnovelI432V0.08
BLCAchr1737258262Missense_Mutationrs774611562P538S0.12
BLCAchr1737270787SilentnovelV361V0.09
BLCAchr1737097119SilentnovelL2256L0.67
BLCAchr1737097898Nonsense_MutationnovelQ2218*0.38
BLCAchr1737284966Missense_MutationnovelS115G0.41
BLCAchr17374063665'UTRnovel0.14
BLCAchr1737097952Missense_MutationnovelE2200Q0.24
BLCAchr1737188397SilentnovelI1552I0.43
BLCAchr1737257718Missense_MutationnovelR604K0.27
BLCAchr1737257754Missense_MutationnovelS592C0.14
BLCAchr1737188294Missense_MutationnovelD1587N0.51
BLCAchr1737259522SilentnovelV446V0.28
BLCAchr1737339825Missense_MutationnovelQ22E0.17
BLCAchr1737221735SilentnovelS1224S0.2
BLCAchr1737155727Silentrs757250697L1801L0.33
BRCAchr1737097065SilentnovelP2274P0.31
BRCAchr1737113186Silentrs779109355Y2118Y0.1
BRCAchr1737121384Missense_MutationnovelN2082S0.23
BRCAchr1737240480Missense_MutationnovelQ1039H0.18
BRCAchr17370869393'UTRnovel0.07
BRCAchr1737205773Missense_MutationnovelQ1350K0.13
BRCAchr1737206794Missense_MutationnovelD1313H0.05
BRCAchr1737221734Missense_MutationnovelH1225Y0.1
BRCAchr1737252978Missense_MutationnovelE629K0.17
BRCAchr1737149910Missense_MutationnovelV1878A0.24
BRCAchr1737284933Nonsense_MutationnovelR126*0.23
BRCAchr1737258311SilentnovelP521P0.21
BRCAchr17370871433'UTRnovel0.18
BRCAchr17370870543'UTRnovel0.21
BRCAchr1737257700Splice_Regionnovel0.33
BRCAchr1737097119SilentnovelL2256L0.38
BRCAchr1737161910SilentnovelS1740S0.32
BRCAchr1737259510Missense_MutationnovelK450N0.16
BRCAchr1737284860Missense_MutationnovelG150E0.18
BRCAchr1737111599Missense_MutationnovelR2166H0.19
BRCAchr1737206872Missense_MutationnovelD1287H0.43
BRCAchr1737248595Nonsense_MutationnovelK721*0.53
CESCchr1737330233Missense_MutationnovelS93L0.22
CESCchr1737299314Intronnovel0.43
CESCchr1737130161Missense_MutationnovelH1913Y0.25
CESCchr1737257847Frame_Shift_InsnovelG561Efs*120.12
CESCchr1737097055Missense_MutationnovelD2278H0.42
CESCchr1737149965Missense_Mutationrs758980216R1860W0.43
CESCchr1737192124Missense_MutationnovelR1461H0.34
CESCchr1737258319Missense_MutationnovelV519I0.42
CESCchr1737248110Missense_MutationnovelS737L0.26
CESCchr17374063035'UTRnovel0.3
CESCchr1737129472Nonsense_MutationnovelS1946*0.26
CESCchr1737221791Missense_MutationnovelR1206C0.36
CESCchr17374064335'UTRnovel0.18
CESCchr1737122594Frame_Shift_DelnovelE2026Kfs*50.24
CESCchr17370870433'UTRnovel0.35
COADchr1737257850Missense_MutationnovelS560L0.44
COADchr1737191145Missense_MutationnovelP1516H0.33
COADchr1737192125Missense_Mutationrs769240769R1461C0.31
COADchr1737235076Missense_Mutationrs758519292A1049T0.44
COADchr1737263748Missense_MutationnovelQ422H0.28
COADchr1737244601Missense_MutationnovelF910S0.09
COADchr1737113122Missense_MutationnovelR2140W0.4
COADchr1737188389Missense_Mutationrs764599804R1555H0.3
COADchr1737283329Missense_MutationnovelR183Q0.31
COADchr1737274231Nonsense_MutationnovelE324*0.39
COADchr1737284890Missense_MutationnovelA140V0.35
COADchr1737252903Missense_MutationnovelI654L0.1
COADchr1737130200Missense_MutationnovelY1900H0.16
COADchr1737235038SilentnovelV1061V0.31
COADchr1737248058SilentnovelS754S0.43
COADchr1737130073Splice_SitenovelX1941_splice0.14
COADchr1737221632Intronnovel0.16
COADchr1737248076Silentrs369806793D748D0.85
COADchr1737113122SilentnovelR2140R0.27
COADchr1737111570Missense_Mutationrs778168950R2176W0.45
COADchr1737246878Missense_MutationnovelI803T0.33
COADchr1737235091Missense_MutationnovelD1044N0.07
COADchr1737248076Silentrs369806793D748D0.36
COADchr1737240559Missense_MutationnovelR1013Q0.46
COADchr1737129483Splice_Regionrs201284070S1942S0.19
COADchr1737221632Intronnovel0.4
COADchr1737240526Missense_MutationnovelV1024A0.15
COADchr1737122717Intronnovel0.11
COADchr1737161995Missense_MutationnovelR1712Q0.07
COADchr1737246900Missense_MutationnovelA796S0.15
COADchr1737207744Missense_Mutationrs758156281S1255N0.08
COADchr1737252057Missense_MutationnovelA677P0.37
COADchr1737097829Splice_SitenovelX2240_splice0.09
COADchr1737130080Missense_MutationnovelP1940T0.11
COADchr1737221708Intronnovel0.08
COADchr1737283329Missense_MutationnovelR183Q0.09
COADchr1737330244SilentnovelA89A0.04
COADchr1737129395Nonsense_MutationnovelR1972*0.33
COADchr1737258302Missense_MutationnovelD524E0.18
COADchr1737206875Missense_MutationnovelF1286V0.14
COADchr1737226350Nonsense_MutationnovelR1117*0.21
COADchr1737188450Missense_MutationnovelR1535W0.28
COADchr1737277925Missense_MutationnovelL231I0.25
COADchr1737235017Silentrs112050484H1068H0.49
COADchr1737129401Missense_Mutationrs765097577D1970N0.49
COADchr1737299327Intronrs7777060960.06
COADchr1737161903Missense_Mutationrs199723320A1743T0.2
COADchr1737129460Missense_MutationnovelL1950Q0.27
COADchr1737192158Missense_MutationnovelG1450S0.36
COADchr1737149887In_Frame_InsnovelL1885_T1886insY0.11
COADchr1737097953Frame_Shift_InsnovelE2200Gfs*260.48
COADchr1737193385Missense_MutationnovelA1397T0.11
DLBCchr1737252978Missense_MutationnovelE629K0.19
ESCAchr1737210476Missense_MutationnovelT1233M0.49
ESCAchr1737330369Missense_MutationnovelL48V0.08
ESCAchr1737277040SilentnovelA265A0.49
ESCAchr1737161999Missense_MutationnovelG1711S0.38
ESCAchr1737089062Missense_MutationnovelD2302N0.35
ESCAchr1737242005Missense_MutationnovelE994Q0.25
ESCAchr1737161983Missense_MutationnovelV1716A0.33
ESCAchr1737207782Missense_MutationnovelN1242K0.2
ESCAchr1737221593Intronnovel0.25
GBMchr1737188407Missense_MutationnovelE1549V0.1
GBMchr1737241980Missense_MutationnovelT1002I0.15
GBMchr1737277104Frame_Shift_DelnovelA244Vfs*170.39
GBMchr1737274261Missense_MutationnovelR314C0.73
GBMchr1737248038Missense_MutationnovelT761S0.07
GBMchr1737122720Intronnovel0.4
GBMchr1737207703Missense_MutationnovelR1269W0.43
GBMchr1737284915Missense_MutationnovelD132Y0.18
GBMchr1737277057SilentnovelL260L0.17
GBMchr1737257823Missense_Mutationrs781293486R569H0.49
GBMchr1737244600Missense_MutationnovelF910L0.03
GBMchr1737240549SilentnovelI1016I0.32
GBMchr1737257703Missense_MutationnovelS609L0.11
GBMchr1737087320Missense_Mutationrs762756380T2383M0.86
GBMchr1737206818Missense_MutationnovelE1305Q0.1
GBMchr1737248024Nonsense_MutationnovelE766*0.52
GBMchr1737258340Missense_MutationnovelD512H0.17
HNSCchr1737257865Missense_MutationnovelG555D0.23
HNSCchr1737200165Missense_MutationnovelN1378D0.07
HNSCchr1737248075Missense_MutationnovelG749S0.12
HNSCchr1737225079SilentnovelS1129S0.07
HNSCchr1737299332Intronnovel0.2
HNSCchr1737207771Missense_Mutationrs749437417Y1246C0.18
HNSCchr1737274293Missense_Mutationrs73982299R303H0.34
HNSCchr1737277114Missense_MutationnovelA241S0.19
HNSCchr1737223547Missense_MutationnovelH1177D0.23
HNSCchr1737235069Missense_MutationnovelR1051Q0.16
HNSCchr1737243456Missense_Mutationrs371689992P949H0.13
HNSCchr1737257825SilentnovelF568F0.2
HNSCchr1737111613SilentnovelV2161V0.27
HNSCchr1737263777Missense_MutationnovelR413C0.09
HNSCchr1737245085Missense_MutationnovelQ864E0.06
HNSCchr1737243378Missense_MutationnovelS975N0.1
HNSCchr1737274206Missense_MutationnovelD332V0.18
HNSCchr1737243411Missense_MutationnovelS964N0.31
HNSCchr1737192178Missense_MutationnovelG1443E0.18
HNSCchr1737113258Silentrs372559158Y2094Y0.09
HNSCchr1737257817Frame_Shift_DelnovelN571Ifs*450.16
HNSCchr1737192292Missense_Mutationrs779594669R1405H0.35
HNSCchr1737284959Missense_MutationnovelS117C0.14
KIRCchr1737243435Missense_Mutationrs760725326K956R0.33
KIRCchr1737188460Missense_MutationnovelS1531R0.13
KIRPchr1737181234SilentnovelT1633T0.61
KIRPchr1737263813Missense_MutationnovelA401P0.08
KIRPchr1737258359SilentnovelI505I0.57
KIRPchr1737192297Missense_MutationnovelE1403D0.34
KIRPchr1737253027SilentnovelV612V0.64
LAMLchr1737122577Missense_MutationnovelE2031G0.18
LAMLchr1737283271Missense_MutationnovelN202K0.26
LAMLchr1737248033Missense_MutationnovelY763H0.1
LGGchr1737192125Missense_Mutationrs769240769R1461C0.52
LGGchr1737243540Missense_Mutationrs770987352R921Q0.25
LGGchr1737188420Missense_MutationnovelV1545I0.22
LGGchr1737223523Missense_MutationnovelA1185T0.13
LGGchr1737284972Splice_SitenovelX113_splice0.14
LGGchr1737283272Missense_MutationnovelN202S0.26
LGGchr1737243394Missense_MutationnovelL970F0.39
LGGchr1737244680Missense_MutationnovelE884K0.35
LGGchr1737097940Nonsense_MutationnovelK2204*0.14
LIHCchr1737263759Missense_Mutationrs747343847R419C0.44
LIHCchr1737274220SilentnovelY327Y0.32
LIHCchr17374063405'UTRnovel0.35
LIHCchr17374063415'UTRnovel0.33
LIHCchr1737257812Missense_MutationnovelN573D0.11
LIHCchr1737097899Frame_Shift_DelnovelY2216Rfs*20.23
LIHCchr1737129412Frame_Shift_DelnovelK1966Rfs*100.37
LIHCchr1737299502Intronnovel0.39
LIHCchr1737299359Intronnovel0.44
LIHCchr1737258324Missense_MutationnovelY517F0.17
LIHCchr1737188286SilentnovelR1589R0.41
LIHCchr1737181305Missense_MutationnovelI1610V0.5
LUADchr1737330389Missense_MutationnovelP41L0.16
LUADchr1737221744SilentnovelL1221L0.2
LUADchr1737207723Missense_MutationnovelS1262L0.11
LUADchr17370872393'UTRnovel0.18
LUADchr1737129478Missense_MutationnovelH1944L0.16
LUADchr1737258368Frame_Shift_DelnovelM503Wfs*130.25
LUADchr1737149959Missense_MutationnovelI1862F0.24
LUADchr1737206869Missense_MutationnovelE1288K0.06
LUADchr1737206870Nonsense_MutationnovelD1287Efs*30.07
LUADchr17374063055'UTRnovel0.3
LUADchr1737257745Missense_MutationnovelG595V0.06
LUADchr1737284926Missense_MutationnovelR128K0.2
LUADchr1737235013Missense_MutationnovelQ1070E0.11
LUADchr1737406270Missense_MutationnovelL10F0.12
LUADchr1737161897Frame_Shift_DelnovelA1745Qfs*320.56
LUADchr1737257839Nonsense_MutationnovelQ564*0.04
LUADchr1737097023Missense_MutationnovelW2288C0.56
LUADchr1737155722Missense_MutationnovelS1803C0.21
LUADchr1737252942Nonsense_MutationnovelQ641*0.05
LUADchr1737149908Missense_MutationnovelE1879K0.16
LUADchr1737089040Frame_Shift_InsnovelE2309Gfs*1640.07
LUADchr1737270823SilentnovelA349A0.19
LUADchr1737130177SilentnovelG1907G0.07
LUADchr1737221687Intronnovel0.07
LUADchr1737283363SilentnovelR172R0.25
LUADchr1737089041Nonsense_Mutationrs750543369E2309*0.14
LUADchr1737149911Missense_MutationnovelV1878F0.11
LUADchr1737330349SilentnovelS54S0.14
LUADchr1737245199Missense_MutationnovelM826V0.06
LUSCchr17370871843'UTRnovel0.33
LUSCchr1737234987Silentrs768329159V1078V0.22
LUSCchr1737192180Silentrs61746137L1442L0.3
LUSCchr1737225033Missense_MutationnovelI1145V0.5
LUSCchr1737122545Missense_MutationnovelD2042Y0.24
LUSCchr1737257730Missense_MutationnovelW600L0.33
LUSCchr1737089074Missense_MutationnovelA2298S0.12
LUSCchr1737243411Missense_MutationnovelS964I0.22
LUSCchr1737205869Missense_Mutationrs768387542P1318A0.36
LUSCchr1737122596Missense_MutationnovelV2025L0.21
LUSCchr1737257847Missense_MutationnovelG561E0.61
LUSCchr1737270774Missense_MutationnovelD366Y0.17
LUSCchr1737242012SilentnovelR991R0.43
LUSCchr1737274261Missense_MutationnovelR314C0.4
LUSCchr1737130144SilentnovelT1918T0.4
LUSCchr1737248157Splice_SitenovelX722_splice0.3
LUSCchr1737278006Splice_SitenovelX204_splice0.31
LUSCchr1737225024Missense_MutationnovelY1148H0.19
LUSCchr1737130108Missense_MutationnovelF1930L0.21
LUSCchr1737270821Missense_MutationnovelS350L0.12
LUSCchr1737283357Missense_MutationnovelI174L0.62
LUSCchr1737210491Splice_SitenovelX1228_splice0.07
OVchr1737089015Missense_MutationnovelE2317D0.06
OVchr1737206802Missense_MutationnovelS1310F0.09
OVchr1737097914SilentnovelL2212L0.72
OVchr1737339815Frame_Shift_Delrs752401577V24Efs*30.09
OVchr1737221842Missense_MutationnovelV1189L0.06
OVchr1737252957Missense_MutationnovelE636Q0.06
OVchr1737248016SilentnovelV768V0.03
OVchr1737252018Missense_MutationnovelH690Y0.05
PAADchr1737089073Missense_MutationnovelA2298D0.19
PAADchr1737097163Missense_MutationnovelI2242V0.14
PAADchr1737129479Missense_MutationnovelH1944Y0.12
PAADchr1737192206Missense_MutationnovelA1434T0.14
PCPGchr1737270833Missense_MutationnovelM346T0.1
PRADchr1737122584Missense_MutationnovelT2029A0.23
PRADchr1737248657Missense_MutationnovelA700V0.33
PRADchr1737113151Missense_MutationnovelW2130L0.36
PRADchr1737179374SilentnovelT1655T0.24
PRADchr1737181275Missense_MutationnovelL1620V0.37
PRADchr1737206782Splice_SitenovelX1316_splice0.44
PRADchr1737235070Nonsense_Mutationrs753014287R1051*0.37
PRADchr1737276039SilentnovelS271S0.39
READchr1737188356Missense_MutationnovelR1566H0.25
READchr1737253005Missense_MutationnovelI620F0.13
READchr1737263862Missense_MutationnovelF384L0.34
READchr1737097890Silentrs548821816A2220A0.24
READchr1737179401SilentnovelL1646L0.34
READchr1737257707Missense_MutationnovelI608V0.35
READchr1737161828Missense_MutationnovelR1768C0.39
READchr1737225068Missense_MutationnovelR1133H0.33
READchr1737192165SilentnovelV1447V0.28
READchr1737242012SilentnovelR991R0.38
SARCchr1737258264Missense_MutationnovelC537F0.85
SKCMchr1737111569Missense_MutationnovelR2176Q0.24
SKCMchr1737243499Missense_MutationnovelE935K0.33
SKCMchr1737122714Intronnovel0.27
SKCMchr1737122715Intronnovel0.25
SKCMchr1737245128SilentnovelG849G0.46
SKCMchr1737130206Missense_MutationnovelE1898K0.38
SKCMchr1737179352Missense_MutationnovelP1663S0.44
SKCMchr1737221693Intronnovel0.42
SKCMchr1737155685Splice_RegionnovelS1815S0.35
SKCMchr1737088947Missense_MutationnovelQ2340L0.33
SKCMchr1737088949SilentnovelK2339K0.29
SKCMchr1737246905Missense_MutationnovelP794L0.42
SKCMchr1737263839Frame_Shift_InsnovelS392Ffs*230.15
SKCMchr1737244605Missense_MutationnovelP909S0.04
SKCMchr1737274245Missense_MutationnovelP319L0.35
SKCMchr1737263715SilentnovelA433A0.08
SKCMchr1737257811Missense_MutationnovelN573I0.25
SKCMchr1737263848Missense_MutationnovelA389G0.47
SKCMchr1737270769SilentnovelF367F0.34
SKCMchr1737283307Silentrs752507997F190F0.45
SKCMchr1737179352Missense_MutationnovelP1663S0.47
SKCMchr1737205871Missense_MutationnovelV1317A0.2
SKCMchr1737277905SilentnovelI237I0.38
SKCMchr1737089007Missense_MutationnovelG2320D0.33
SKCMchr1737111565SilentnovelV2177V0.38
SKCMchr1737221792SilentnovelH1205H0.21
SKCMchr1737181354Splice_RegionnovelI1593I0.22
SKCMchr1737179361Missense_MutationnovelP1660S0.22
SKCMchr1737221750SilentnovelF1219F0.4
SKCMchr1737299324Intronnovel0.4
SKCMchr1737258312Missense_MutationnovelP521L0.24
SKCMchr1737200183Missense_MutationnovelD1372N0.33
SKCMchr1737283307Silentrs752507997F190F0.27
SKCMchr1737161828Missense_MutationnovelR1768C0.35
SKCMchr1737339806Missense_MutationnovelR28K0.23
SKCMchr1737149935Missense_MutationnovelR1870W0.44
SKCMchr1737121479SilentnovelQ2050Q0.48
SKCMchr1737244660SilentnovelF890F0.07
SKCMchr1737188456Missense_MutationnovelV1533I0.18
SKCMchr1737188457Missense_MutationnovelM1532I0.18
SKCMchr17370873053'UTRnovel0.13
SKCMchr1737263813Missense_MutationnovelA401T0.4
SKCMchr1737283307Silentrs752507997F190F0.09
SKCMchr1737252960SilentnovelL635L0.36
SKCMchr1737191144SilentnovelP1516P0.22
SKCMchr1737111601SilentnovelF2165F0.27
SKCMchr1737277066Missense_MutationnovelE257K0.32
SKCMchr1737193406Missense_MutationnovelP1390S0.08
SKCMchr1737179355Missense_MutationnovelP1662S0.29
SKCMchr1737258335SilentnovelI513I0.73
SKCMchr1737113177SilentnovelP2121P0.19
SKCMchr1737097855Missense_MutationnovelR2232Q0.35
SKCMchr1737181354Splice_RegionnovelI1593I0.81
SKCMchr1737192182Missense_MutationnovelL1442F0.8
SKCMchr1737284949SilentnovelH120H0.79
SKCMchr1737257703Missense_MutationnovelS609L0.46
SKCMchr1737161885Missense_MutationnovelP1749S0.25
STADchr1737188394SilentnovelN1553N0.11
STADchr1737111639Missense_MutationnovelS2153T0.18
STADchr1737263751SilentnovelH421H0.07
STADchr1737244694Missense_Mutationrs764378176T879M0.16
STADchr1737258287SilentnovelF529F0.42
STADchr1737223570Missense_MutationnovelD1169V0.28
STADchr1737113098Nonsense_MutationnovelR2148*0.3
STADchr1737121475Missense_MutationnovelG2052S0.21
STADchr1737257787Missense_MutationnovelA581V0.13
STADchr1737129402SilentnovelY1969Y0.24
STADchr1737161882Missense_MutationnovelR1750C0.34
STADchr1737330348Nonsense_MutationnovelR55*0.26
STADchr1737193398Missense_MutationnovelF1392L0.35
STADchr1737226343Missense_MutationnovelR1119H0.4
STADchr1737234977Missense_MutationnovelI1082V0.04
STADchr1737226397Missense_MutationnovelT1101I0.35
STADchr1737244681SilentnovelG883G0.15
STADchr1737406293Missense_MutationnovelW3R0.11
STADchr1737221632Intronnovel0.31
STADchr1737179351Frame_Shift_DelnovelP1663Lfs*70.14
STADchr1737339823Frame_Shift_InsnovelT23Dfs*180.18
STADchr1737179302Missense_MutationnovelQ1679H0.32
STADchr1737097835Missense_MutationnovelI2239V0.05
STADchr1737221632Intronnovel0.5
STADchr1737284857Missense_MutationnovelG151E0.45
STADchr1737122659Intronnovel0.57
STADchr1737192133Missense_MutationnovelF1458C0.22
STADchr1737181256Missense_MutationnovelQ1626R0.08
STADchr1737130212Missense_MutationnovelG1896R0.2
STADchr1737097969Missense_MutationnovelS2194T0.24
STADchr1737258281Missense_MutationnovelD531E0.22
STADchr1737221632Intronnovel0.25
STADchr1737210474SilentnovelL1234L0.2
STADchr1737121415Missense_MutationnovelR2072W0.08
STADchr1737246971Missense_MutationnovelR772H0.07
STADchr1737257787Missense_MutationnovelA581V0.07
TGCTchr1737088981Missense_MutationnovelI2329L0.28
UCECchr1737181215Nonsense_MutationnovelE1640*0.32
UCECchr1737191272Missense_MutationnovelA1474T0.34
UCECchr1737235093Missense_Mutationrs756018152Y1043C0.26
UCECchr1737240559Missense_MutationnovelR1013Q0.32
UCECchr1737097115Missense_Mutationrs761713389R2258C0.32
UCECchr1737149906Missense_MutationnovelE1879D0.32
UCECchr1737221833Nonsense_MutationnovelR1192*0.32
UCECchr1737235062Missense_MutationnovelE1053D0.31
UCECchr17370869853'UTRnovel0.11
UCECchr1737097028Missense_MutationnovelR2287C0.36
UCECchr1737206831SilentnovelS1300S0.45
UCECchr1737244735Splice_SitenovelX866_splice0.52
UCECchr1737248149Missense_MutationnovelR724Q0.14
UCECchr1737257779Frame_Shift_InsnovelG584Rfs*50.09
UCECchr1737097025Missense_MutationnovelW2288G0.31
UCECchr1737161906Missense_MutationnovelL1742I0.39
UCECchr1737240547Missense_MutationnovelR1017Q0.37
UCECchr1737257824Missense_Mutationrs145246486R569C0.3
UCECchr1737299453Intronnovel0.4
UCECchr17370870883'UTRnovel0.29
UCECchr1737111600Missense_MutationnovelR2166C0.37
UCECchr1737207673Missense_MutationnovelF1279V0.19
UCECchr1737270799SilentnovelG357G0.2
UCECchr1737283322SilentnovelE185E0.35
UCECchr1737191142Missense_MutationnovelT1517M0.22
UCECchr1737087350Missense_Mutationrs773877053R2373Q0.31
UCECchr1737206869Nonsense_MutationnovelE1288*0.03
UCECchr1737221673Intronnovel0.45
UCECchr1737097951Missense_MutationnovelE2200V0.43
UCECchr1737243411Missense_MutationnovelS964N0.54
UCECchr1737151317Missense_MutationnovelI1851T0.42
UCECchr1737087319Silentrs775240328T2383T0.32
UCECchr17370859793'UTRnovel0.2
UCECchr1737225001Missense_MutationnovelE1155D0.27
UCECchr1737244686SilentnovelR882R0.27
UCECchr1737161959Missense_MutationnovelR1724Q0.3
UCECchr1737263758Missense_MutationnovelR419H0.05
UCECchr1737111537Nonsense_MutationnovelR2187*0.22
UCECchr17374063875'UTRnovel0.18
UCECchr1737226437Missense_MutationnovelR1088W0.11
UCECchr1737122541Missense_MutationnovelS2043F0.05
UCECchr1737151376Frame_Shift_DelnovelE1832Rfs*80.31
UCECchr1737284916Missense_MutationnovelI131M0.36
UCECchr1737161793Missense_MutationnovelE1779D0.21
UCECchr17374064615'UTRnovel0.23
UCECchr1737284867Missense_MutationnovelR148C0.33
UCECchr17374064545'UTRnovel0.45
UCECchr1737221832Missense_MutationnovelR1192Q0.04
UCECchr1737188463SilentnovelR1530R0.37
UCECchr17370860143'UTRnovel0.67
UCECchr1737192233Missense_MutationnovelN1425H0.44
UCECchr1737257818Missense_MutationnovelN571D0.28
UCECchr1737330259SilentnovelG84G0.1
UCECchr1737162016Missense_MutationnovelS1705I0.32
UCECchr1737206819SilentnovelP1304P0.41
UCECchr1737226434Missense_MutationnovelD1089Y0.37
UCECchr17370868623'UTRnovel0.3
UCECchr1737181203Nonsense_MutationnovelQ1644*0.25
UCECchr1737192187Missense_MutationnovelL1440P0.27
UCECchr17374063305'UTRnovel0.3
UCECchr17370856393'UTRnovel0.28
UCECchr1737097115Missense_Mutationrs761713389R2258C0.46
UCECchr1737161993Missense_MutationnovelD1713Y0.34
UCECchr1737242033SilentnovelS984S0.37
UCECchr1737245077Splice_Regionnovel0.3
UCECchr1737149969Silentrs777992403T1858T0.44
UCECchr1737284870Missense_MutationnovelT147A0.23
UCECchr17370873103'UTRnovel0.33
UCECchr1737188437Missense_MutationnovelR1539H0.48
UCECchr1737263836Missense_Mutationrs187880919R393H0.42
UCECchr1737330392Missense_MutationnovelE40G0.05
UCECchr17370871433'UTRnovel0.46
UCECchr1737243446Missense_MutationnovelE952D0.61
UCECchr1737252009Nonsense_MutationnovelE693*0.43
UCECchr1737161959Missense_MutationnovelR1724Q0.28
UCECchr1737259475Missense_MutationnovelY462C0.41
UCECchr1737283368Missense_MutationnovelC170Y0.36
UCECchr1737111534Missense_MutationnovelL2188V0.31
UCECchr1737161947Missense_MutationnovelF1728S0.08
UCECchr1737179328Missense_MutationnovelY1671H0.29
UCECchr1737235076Missense_Mutationrs758519292A1049T0.31
UCECchr1737277074Missense_MutationnovelK254T0.35
UCECchr17370869693'UTRnovel0.32
UCECchr1737221798SilentnovelV1203V0.09
UCECchr1737226389Missense_MutationnovelT1104A0.26
UCECchr1737270800Missense_MutationnovelG357E0.31
UCECchr1737111569Missense_MutationnovelR2176Q0.33
UCECchr1737226384Missense_MutationnovelQ1105H0.35
UCECchr17370873103'UTRnovel0.49
UCECchr1737149961Missense_MutationnovelA1861V0.43
UCECchr1737245097Missense_MutationnovelP860S0.42
UCECchr1737259526Missense_Mutationrs570639605A445V0.39
UCECchr17374065195'UTRnovel0.52
UCECchr1737245119SilentnovelL852L0.18
UCECchr17370868413'UTRnovel0.23
UCECchr1737097855Missense_MutationnovelR2232Q0.41
UCECchr1737155750Missense_MutationnovelD1794Y0.45
UCECchr17374063575'UTRnovel0.22
UCECchr1737129401Missense_Mutationrs765097577D1970N0.38
UCECchr1737191201SilentnovelA1497A0.38
UCECchr1737191202Missense_MutationnovelA1497V0.4
UCECchr1737246862SilentnovelG808G0.11
UCECchr1737088945Missense_MutationnovelI2341F0.35
UCECchr1737161909Missense_MutationnovelE1741K0.46
UCECchr1737206843SilentnovelS1296S0.45
UCECchr1737221564Intronnovel0.24
UCECchr1737243545SilentnovelV919V0.33
UCECchr1737205803Missense_MutationnovelR1340G0.47
UCECchr1737248112SilentnovelG736G0.23
UCECchr1737111575In_Frame_InsnovelT2173_M2174insSKKKKKREKKKDLVKT0
UCECchr1737277904Missense_MutationnovelP238T0.34
UCECchr1737235073Missense_Mutationrs547263573L1050F0.22
UCECchr17370868153'UTRnovel0.2
UCECchr17370868213'UTRnovel0.37
UCECchr1737221632Intronnovel0.21
UCECchr1737161909Missense_MutationnovelE1741K0.46
UCECchr1737207801Splice_SitenovelX1236_splice0.33
UCECchr1737235062Missense_MutationnovelE1053D0.43
UCECchr1737257703Missense_MutationnovelS609L0.43
UCECchr1737330419Missense_MutationnovelR31I0.43
UCECchr1737244709Missense_MutationnovelP874L0.36
UCECchr1737111612Nonsense_MutationnovelE2162*0.19
UCECchr1737161828Missense_MutationnovelR1768C0.38
UCECchr1737192292Missense_Mutationrs779594669R1405H0.2
UCECchr1737097944Missense_MutationnovelE2202D0.3
UCECchr1737221833Nonsense_MutationnovelR1192*0.3
UCECchr1737149964Missense_MutationnovelR1860Q0.44
UCECchr1737225008Missense_MutationnovelC1153Y0.23
UCECchr1737243423Missense_MutationnovelA960D0.4
UCECchr1737248150Nonsense_MutationnovelR724*0.2
UCECchr1737259530Missense_MutationnovelC444R0.19
UCECchr1737284920Missense_MutationnovelK130T0.05
UCECchr1737097922Missense_MutationnovelE2210K0.36
UCECchr1737248126Missense_MutationnovelV732M0.29
UCECchr1737257749Missense_MutationnovelF594L0.34
UCECchr1737161910SilentnovelS1740S0.29
UCECchr1737246949SilentnovelT779T0.29
UCECchr1737274260Missense_Mutationrs756880093R314H0.3
UCECchr1737161801Missense_MutationnovelD1777N0.33
UCECchr1737181206Missense_MutationnovelR1643W0.39
UCECchr1737221833Nonsense_MutationnovelR1192*0.31
UCECchr1737129368Missense_MutationnovelP1981S0.32
UCSchr1737283359Missense_MutationnovelS173C0.1

Copy Number Variations (CNVs)
CancerTypeFreq Q-value
DLBCDEL00.18166
THCADEL0.0020.221
UCSDEL0.39290.19877
UVMDEL0.03750.22482

Survival Analysis
CancerP-value Q-value
THYM0.0034

Kaplan-Meier Survival Analysis

KIRC0.0048

Kaplan-Meier Survival Analysis

SARC0.0025

Kaplan-Meier Survival Analysis

MESO0.0024

Kaplan-Meier Survival Analysis

ACC0.003

Kaplan-Meier Survival Analysis

SKCM0.01

Kaplan-Meier Survival Analysis

LUSC0.04

Kaplan-Meier Survival Analysis

ESCA0.033

Kaplan-Meier Survival Analysis

KIRP0.044

Kaplan-Meier Survival Analysis

BLCA0.032

Kaplan-Meier Survival Analysis

CESC0.0062

Kaplan-Meier Survival Analysis

READ0.0062

Kaplan-Meier Survival Analysis

KICH0.0032

Kaplan-Meier Survival Analysis

LIHC0.00042

Kaplan-Meier Survival Analysis

LGG0.0004

Kaplan-Meier Survival Analysis

UVM0.0002

Kaplan-Meier Survival Analysis

OV0.0031

Kaplan-Meier Survival Analysis

Drugs

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Eesembl ID



Cell lines and drugs in GSE70138 or GSE92742

  • Description
  • RBPome
  • Literatures
  • Transcripts
  • Gene Model
  • Pathways
  • Phenotypes
  • GWAS
  • PPI
  • Gene Ontology
Description
Ensembl ID
ENSG00000278540 (Gene tree)
Gene ID
31
Gene Symbol
ACACA
Alias
ACC1|ACAC|ACC
Full Name
acetyl-CoA carboxylase alpha
Gene Type
protein_coding
Species
Homo_sapiens
Status
confidence
Strand
Minus strand
Length
321,835 bases
Position
chr17:37,084,988-37,406,822
Accession
84
RBP type
non-canonical RBP
Summary
Acetyl-CoA carboxylase (ACC) is a complex multifunctional enzyme system. ACC is a biotin-containing enzyme which catalyzes the carboxylation of acetyl-CoA to malonyl-CoA, the rate-limiting step in fatty acid synthesis. There are two ACC forms, alpha and beta, encoded by two different genes. ACC-alpha is highly enriched in lipogenic tissues. The enzyme is under long term control at the transcriptional and translational levels and under short term regulation by the phosphorylation/dephosphorylation of targeted serine residues and by allosteric transformation by citrate or palmitoyl-CoA. Multiple alternatively spliced transcript variants divergent in the 5' sequence and encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
RNA binding proteome (RBPome)
PIDTitleMethod TimeAuthorDoi
30607034Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)OOPS & HEK2932019 Jan 3Queiroz RMLDOI: 10.1038/s41587-018-0001-2
30607034Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)OOPS & MCF10A2019 Jan 3Queiroz RMLDOI: 10.1038/s41587-018-0001-2
30607034Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)OOPS & U2OS2019 Jan 3Queiroz RMLDOI: 10.1038/s41587-018-0001-2

Literatures on RNA binding capacity
PIDTitleArticle TimeAuthorDoi
30209975Thyroid hormone (T3) stimulates brown adipose tissue activation via mitochondrial biogenesis and MTOR-mediated mitophagy.Autophagy2019 JanYau WWdoi: 10.1080/15548627.2018.1511263
25048402Supplementation dietary zinc levels on growth performance, carcass traits, and intramuscular fat deposition in weaned piglets.Biol Trace Elem Res2014 OctZhang HBdoi: 10.1007/s12011-014-0078-5
30891825Arctigenin improves lipid metabolism by regulating AMP-activated protein kinase and downstream signaling pathways.J Cell Biochem2019 AugSong Ydoi: 10.1002/jcb.28602
19026012Phosphatase and tensin homolog (PTEN) regulates hepatic lipogenesis, microsomal triglyceride transfer protein, and the secretion of apolipoprotein B-containing lipoproteins.Hepatology2008 DecQiu Wdoi: 10.1002/hep.22565.
31137884Cyanidin-3-O-galactoside-enriched Aronia melanocarpa extract attenuates weight gain and adipogenic pathways in high-fat diet-induced obese C57BL/6 mice.Nutrients2019 May 27Lim SMdoi: 10.3390/nu11051190.
31297058Emodin Induced SREBP1-Dependent and SREBP1-Independent Apoptosis in Hepatocellular Carcinoma Cells.Front Pharmacol2019 Jun 25Yang Ndoi: 10.3389/fphar.2019.00709
12600843Addition of inulin to a moderately high-carbohydrate diet reduces hepatic lipogenesis and plasma triacylglycerol concentrations in humans.Am J Clin Nutr2003 MarLetexier D-
29230863Characterization of a Nilaparvata lugens (Stl) brummer gene and analysis of its role in lipid metabolism.Arch Insect Biochem Physiol2018 MarZhou Jdoi: 10.1002/arch.21442
Transcripts
Transcript IDNameLengthRefSeq ID Protein IDLengthRefSeq IDUniportKB ID
ENST00000614333ACACA-230655--- (aa)--
ENST00000619245ACACA-244635--- (aa)--
ENST00000617649ACACA-2407912XM_005257267ENSP000004823682268 (aa)XP_005257324Q13085
ENST00000612926ACACA-227339--- (aa)--
ENST00000612120ACACA-225566--- (aa)--
ENST00000618053ACACA-241463-ENSP0000048206496 (aa)-A0A087WYS8
ENST00000613776ACACA-2291372--- (aa)--
ENST00000614438ACACA-232569-ENSP00000483852112 (aa)-A0A087X126
ENST00000616352ACACA-2381626-ENSP00000477912120 (aa)-A0A0C4DGT1
ENST00000612895ACACA-2269624-ENSP000004822692288 (aa)-Q13085
ENST00000615229ACACA-2361468-ENSP00000482498114 (aa)-A0A087WYK6
ENST00000614450ACACA-233591--- (aa)--
ENST00000614789ACACA-235662-ENSP0000047962142 (aa)-A0A087WVR6
ENST00000618351ACACA-242716--- (aa)--
ENST00000614482ACACA-2342177-ENSP0000048037152 (aa)-A0A087WWN5
ENST00000619546ACACA-2455315-ENSP00000483969998 (aa)-Q59FY4
ENST00000613146ACACA-2283974--- (aa)--
ENST00000617548ACACA-2391063-ENSP00000481900114 (aa)-A0A087WYK6
ENST00000614428ACACA-2319554XM_011524703ENSP000004785472346 (aa)XP_011523005Q13085
ENST00000618575ACACA-243772--- (aa)--
ENST00000612007ACACA-224451-ENSP0000048494884 (aa)-A0A087X2F8
ENST00000621960ACACA-246551-ENSP0000048369694 (aa)-A0A087X0W4
ENST00000616317ACACA-2379961XM_006721853ENSP000004833002383 (aa)XP_006721916Q13085
Gene Model
Click here to download ENSG00000278540's gene model file
Pathways
Pathway IDPathway NameSource
hsa00061Fatty acid biosynthesisKEGG
hsa00620Pyruvate metabolismKEGG
hsa00640Propanoate metabolismKEGG
hsa01100Metabolic pathwaysKEGG
hsa01212Fatty acid metabolismKEGG
hsa04152AMPK signaling pathwayKEGG
hsa04910Insulin signaling pathwayKEGG
hsa04922Glucagon signaling pathwayKEGG
Phenotypes
ensgIDTraitpValuePubmed ID
ENSG00000278540Body Mass Index8.5299839548396E-517903300
ENSG00000278540Body Mass Index6.44217335813154E-517903300
ENSG00000278540Body Mass Index4.46497968306523E-517903300
ENSG00000278540Body Mass Index4.18538902585292E-517903300
ENSG00000278540Body Mass Index6.334248366624E-517903300
ENSG00000278540Body Mass Index3.85504303518931E-517903300
ENSG00000278540Body Mass Index6.3610680108404E-517903300
ENSG00000278540Body Mass Index7.12717198981484E-517903300
ENSG00000278540Body Mass Index6.38799512154111E-517903300
ENSG00000278540Child Development Disorders, Pervasive5.5000000E-005-
ENSG00000278540Celiac Disease8E-724999842
GWAS
ensgIDSNPChromosomePositionSNP-risk TraitPubmedID95% CIOr or BEAT EFO ID
ENSG00000278540rs1822106241737159111GMacrophage inflammatory protein 1b levels27989323[0.17-0.37] SD units increase0.2695EFO_0008219
ENSG00000278540rs1851286711737365406GMacrophage inflammatory protein 1b levels27989323[0.42-0.8] SD units increase0.6071EFO_0008219
ENSG00000278540rs99060441737251740?Body mass index30595370EFO_0004340
Protein-Protein Interaction (PPI)

Clik here to download ENSG00000278540's network

* RBP PPI network refers to all genes directly bind to RBP
Gene Ontology
Go IDGo_termPubmedIDEvidenceCategory
GO:0001650fibrillar center-IDAComponent
GO:0001894tissue homeostasis-IEAProcess
GO:0003989acetyl-CoA carboxylase activity20952656.ISSFunction
GO:0003989acetyl-CoA carboxylase activity-TASFunction
GO:0004075biotin carboxylase activity-IEAFunction
GO:0005515protein binding16326698.16794074.18056116.19343720.20457939.20952656.IPIFunction
GO:0005524ATP binding-IEAFunction
GO:0005829cytosol-IDAComponent
GO:0005829cytosol-ISSComponent
GO:0005829cytosol-TASComponent
GO:0006084acetyl-CoA metabolic process-ISSProcess
GO:0006633fatty acid biosynthetic process-ISSProcess
GO:0006853carnitine shuttle-TASProcess
GO:0015629actin cytoskeleton-IDAComponent
GO:0019538protein metabolic process-IEAProcess
GO:0031325positive regulation of cellular metabolic process-TASProcess
GO:0042802identical protein binding20457939.IPIFunction
GO:0045540regulation of cholesterol biosynthetic process-TASProcess
GO:0046872metal ion binding-IEAFunction
GO:0046949fatty-acyl-CoA biosynthetic process-TASProcess
GO:0051289protein homotetramerization20952656.ISSProcess
GO:0055088lipid homeostasis-IEAProcess
GO:0071380cellular response to prostaglandin E stimulus-IEAProcess
GO:2001295malonyl-CoA biosynthetic process-IEAProcess
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