EuRBPDB

Pathway ID	Pathway Name	Source
aml01522	Endocrine resistance	KEGG
aml01524	Platinum drug resistance	KEGG
aml04068	FoxO signaling pathway	KEGG
aml04110	Cell cycle	KEGG
aml04115	p53 signaling pathway	KEGG
aml04120	Ubiquitin mediated proteolysis	KEGG
aml04144	Endocytosis	KEGG
aml04151	PI3K-Akt signaling pathway	KEGG
aml04218	Cellular senescence	KEGG
aml04625	C-type lectin receptor signaling pathway	KEGG
aml04919	Thyroid hormone signaling pathway	KEGG
aml05163	Human cytomegalovirus infection	KEGG
aml05165	Human papillomavirus infection	KEGG
aml05169	Epstein-Barr virus infection	KEGG
aml05200	Pathways in cancer	KEGG
aml05202	Transcriptional misregulation in cancer	KEGG
aml05203	Viral carcinogenesis	KEGG
aml05205	Proteoglycans in cancer	KEGG
aml05206	MicroRNAs in cancer	KEGG
aml05214	Glioma	KEGG
aml05215	Prostate cancer	KEGG
aml05218	Melanoma	KEGG
aml05219	Bladder cancer	KEGG
aml05220	Chronic myeloid leukemia	KEGG

Protein-Protein Interaction (PPI)

Clik here to download ENSAMEG00000008526's network

Paralogs

Ensembl ID	Gene Symbol	Coverage	Identiy	Paralog	Gene Symbol	Coverage	Identiy
ENSAMEG00000008526	MDM2	97	32.308	ENSAMEG00000001126	MDM4	99	31.845

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSAMEG00000008526	MDM2	99	94.929	ENSG00000135679	MDM2	100	98.901	Homo_sapiens
ENSAMEG00000008526	MDM2	93	32.213	ENSG00000198625	MDM4	93	50.000	Homo_sapiens
ENSAMEG00000008526	MDM2	99	66.735	ENSAPLG00000011164	MDM2	99	66.735	Anas_platyrhynchos
ENSAMEG00000008526	MDM2	93	60.684	ENSACAG00000004204	MDM2	85	60.256	Anolis_carolinensis
ENSAMEG00000008526	MDM2	93	90.052	ENSANAG00000027171	-	100	96.154	Aotus_nancymaae
ENSAMEG00000008526	MDM2	98	32.068	ENSANAG00000036891	MDM4	99	31.853	Aotus_nancymaae
ENSAMEG00000008526	MDM2	94	32.724	ENSBTAG00000006255	MDM4	95	33.061	Bos_taurus
ENSAMEG00000008526	MDM2	99	93.496	ENSBTAG00000010422	MDM2	100	93.496	Bos_taurus
ENSAMEG00000008526	MDM2	98	31.609	ENSCJAG00000016986	MDM4	71	49.074	Callithrix_jacchus
ENSAMEG00000008526	MDM2	98	92.402	ENSCJAG00000007464	-	86	92.402	Callithrix_jacchus
ENSAMEG00000008526	MDM2	99	91.886	ENSCJAG00000042596	-	98	91.886	Callithrix_jacchus
ENSAMEG00000008526	MDM2	54	59.108	ENSCJAG00000040017	-	100	59.108	Callithrix_jacchus
ENSAMEG00000008526	MDM2	96	96.414	ENSCAFG00000000418	MDM2	94	96.414	Canis_familiaris
ENSAMEG00000008526	MDM2	94	32.669	ENSCAFG00000009669	MDM4	96	32.056	Canis_familiaris
ENSAMEG00000008526	MDM2	56	32.000	ENSCAFG00020005984	MDM4	80	31.757	Canis_lupus_dingo
ENSAMEG00000008526	MDM2	99	96.920	ENSCAFG00020017002	MDM2	100	96.920	Canis_lupus_dingo
ENSAMEG00000008526	MDM2	98	32.819	ENSCHIG00000010343	-	99	33.141	Capra_hircus
ENSAMEG00000008526	MDM2	99	93.483	ENSCHIG00000019939	-	100	93.483	Capra_hircus
ENSAMEG00000008526	MDM2	93	31.174	ENSTSYG00000010731	MDM4	92	30.629	Carlito_syrichta
ENSAMEG00000008526	MDM2	91	73.951	ENSTSYG00000031248	-	92	96.429	Carlito_syrichta
ENSAMEG00000008526	MDM2	93	31.034	ENSCAPG00000011380	MDM4	96	32.049	Cavia_aperea
ENSAMEG00000008526	MDM2	96	32.024	ENSCPOG00000008227	MDM4	99	32.024	Cavia_porcellus
ENSAMEG00000008526	MDM2	99	88.776	ENSCPOG00000004323	MDM2	99	88.776	Cavia_porcellus
ENSAMEG00000008526	MDM2	98	31.939	ENSCCAG00000031000	MDM4	71	50.000	Cebus_capucinus
ENSAMEG00000008526	MDM2	99	92.292	ENSCCAG00000006745	-	100	96.154	Cebus_capucinus
ENSAMEG00000008526	MDM2	93	32.389	ENSCATG00000027086	MDM4	92	31.098	Cercocebus_atys
ENSAMEG00000008526	MDM2	99	94.726	ENSCATG00000045264	-	100	96.154	Cercocebus_atys
ENSAMEG00000008526	MDM2	99	89.315	ENSCLAG00000009877	MDM2	99	89.315	Chinchilla_lanigera
ENSAMEG00000008526	MDM2	97	32.227	ENSCLAG00000011995	MDM4	99	32.438	Chinchilla_lanigera
ENSAMEG00000008526	MDM2	99	94.501	ENSCSAG00000004244	MDM2	100	94.501	Chlorocebus_sabaeus
ENSAMEG00000008526	MDM2	93	32.213	ENSCSAG00000014561	MDM4	92	30.894	Chlorocebus_sabaeus
ENSAMEG00000008526	MDM2	53	32.979	ENSCHOG00000008147	-	66	32.979	Choloepus_hoffmanni
ENSAMEG00000008526	MDM2	99	68.916	ENSCPBG00000013316	MDM2	99	68.916	Chrysemys_picta_bellii
ENSAMEG00000008526	MDM2	56	31.164	ENSCANG00000032288	MDM4	80	30.903	Colobus_angolensis_palliatus
ENSAMEG00000008526	MDM2	99	94.118	ENSCANG00000034475	MDM2	100	94.231	Colobus_angolensis_palliatus
ENSAMEG00000008526	MDM2	99	84.286	ENSCGRG00001022261	Mdm2	99	84.286	Cricetulus_griseus_chok1gshd
ENSAMEG00000008526	MDM2	99	84.490	ENSCGRG00000017891	Mdm2	99	84.490	Cricetulus_griseus_crigri
ENSAMEG00000008526	MDM2	97	33.654	ENSDNOG00000000842	MDM4	92	33.402	Dasypus_novemcinctus
ENSAMEG00000008526	MDM2	99	92.886	ENSDNOG00000046929	-	96	92.886	Dasypus_novemcinctus
ENSAMEG00000008526	MDM2	93	33.197	ENSDORG00000006873	Mdm4	93	31.546	Dipodomys_ordii
ENSAMEG00000008526	MDM2	99	74.797	ENSDORG00000007222	Mdm2	99	94.231	Dipodomys_ordii
ENSAMEG00000008526	MDM2	99	72.617	ENSETEG00000011183	MDM2	99	72.617	Echinops_telfairi
ENSAMEG00000008526	MDM2	74	55.435	ENSETEG00000011245	MDM4	74	55.435	Echinops_telfairi
ENSAMEG00000008526	MDM2	99	84.254	ENSEASG00005008055	-	100	84.254	Equus_asinus_asinus
ENSAMEG00000008526	MDM2	97	32.500	ENSEASG00005011431	MDM4	99	32.308	Equus_asinus_asinus
ENSAMEG00000008526	MDM2	99	83.910	ENSECAG00000013604	MDM2	100	83.910	Equus_caballus
ENSAMEG00000008526	MDM2	97	32.500	ENSECAG00000004843	MDM4	99	32.308	Equus_caballus
ENSAMEG00000008526	MDM2	99	83.573	ENSEEUG00000013849	MDM2	100	83.573	Erinaceus_europaeus
ENSAMEG00000008526	MDM2	60	51.042	ENSEEUG00000013912	MDM4	65	46.364	Erinaceus_europaeus
ENSAMEG00000008526	MDM2	96	31.467	ENSELUG00000011889	mdm4	92	30.815	Esox_lucius
ENSAMEG00000008526	MDM2	97	31.467	ENSFCAG00000014851	MDM4	99	32.171	Felis_catus
ENSAMEG00000008526	MDM2	99	96.957	ENSFCAG00000024456	MDM2	100	98.077	Felis_catus
ENSAMEG00000008526	MDM2	93	31.148	ENSFDAG00000021356	MDM4	92	30.128	Fukomys_damarensis
ENSAMEG00000008526	MDM2	99	90.650	ENSFDAG00000007913	-	98	90.650	Fukomys_damarensis
ENSAMEG00000008526	MDM2	93	30.444	ENSGMOG00000016389	mdm4	92	30.316	Gadus_morhua
ENSAMEG00000008526	MDM2	99	66.462	ENSGALG00000009942	MDM2	99	65.644	Gallus_gallus
ENSAMEG00000008526	MDM2	88	64.350	ENSGAGG00000017565	-	85	64.350	Gopherus_agassizii
ENSAMEG00000008526	MDM2	99	94.726	ENSGGOG00000012907	MDM2	100	96.154	Gorilla_gorilla
ENSAMEG00000008526	MDM2	93	32.411	ENSGGOG00000012957	MDM4	92	32.158	Gorilla_gorilla
ENSAMEG00000008526	MDM2	97	31.214	ENSHGLG00000007642	MDM4	99	31.335	Heterocephalus_glaber_female
ENSAMEG00000008526	MDM2	99	90.650	ENSHGLG00000000856	-	99	90.650	Heterocephalus_glaber_female
ENSAMEG00000008526	MDM2	99	85.714	ENSHGLG00000016066	-	99	85.714	Heterocephalus_glaber_female
ENSAMEG00000008526	MDM2	99	88.163	ENSHGLG00000020526	-	97	88.163	Heterocephalus_glaber_female
ENSAMEG00000008526	MDM2	83	90.073	ENSHGLG00100000441	-	100	89.720	Heterocephalus_glaber_male
ENSAMEG00000008526	MDM2	97	31.407	ENSHGLG00100006704	-	99	31.528	Heterocephalus_glaber_male
ENSAMEG00000008526	MDM2	93	31.365	ENSHCOG00000008924	mdm4	92	30.882	Hippocampus_comes
ENSAMEG00000008526	MDM2	98	30.000	ENSIPUG00000024447	mdm4	92	31.042	Ictalurus_punctatus
ENSAMEG00000008526	MDM2	99	91.837	ENSSTOG00000014702	-	99	91.837	Ictidomys_tridecemlineatus
ENSAMEG00000008526	MDM2	93	32.238	ENSSTOG00000004184	MDM4	92	31.042	Ictidomys_tridecemlineatus
ENSAMEG00000008526	MDM2	56	30.584	ENSSTOG00000024007	-	62	30.314	Ictidomys_tridecemlineatus
ENSAMEG00000008526	MDM2	98	59.918	ENSLACG00000010207	MDM2	99	60.736	Latimeria_chalumnae
ENSAMEG00000008526	MDM2	98	32.824	ENSLAFG00000002169	MDM4	99	32.749	Loxodonta_africana
ENSAMEG00000008526	MDM2	99	86.992	ENSLAFG00000005885	MDM2	99	86.992	Loxodonta_africana
ENSAMEG00000008526	MDM2	99	94.726	ENSMFAG00000042359	MDM2	100	96.154	Macaca_fascicularis
ENSAMEG00000008526	MDM2	89	30.720	ENSMFAG00000033606	MDM4	95	30.290	Macaca_fascicularis
ENSAMEG00000008526	MDM2	89	30.720	ENSMMUG00000011236	MDM4	95	30.290	Macaca_mulatta
ENSAMEG00000008526	MDM2	99	94.726	ENSMMUG00000014193	MDM2	100	96.154	Macaca_mulatta
ENSAMEG00000008526	MDM2	99	94.726	ENSMNEG00000041135	MDM2	100	96.154	Macaca_nemestrina
ENSAMEG00000008526	MDM2	89	31.276	ENSMNEG00000026547	MDM4	99	30.785	Macaca_nemestrina
ENSAMEG00000008526	MDM2	99	94.726	ENSMLEG00000042099	MDM2	100	96.154	Mandrillus_leucophaeus
ENSAMEG00000008526	MDM2	93	32.389	ENSMLEG00000032041	MDM4	92	31.098	Mandrillus_leucophaeus
ENSAMEG00000008526	MDM2	90	67.111	ENSMGAG00000010513	MDM2	96	67.111	Meleagris_gallopavo
ENSAMEG00000008526	MDM2	99	85.598	ENSMICG00000029037	-	100	92.308	Microcebus_murinus
ENSAMEG00000008526	MDM2	99	72.653	ENSMICG00000046928	-	99	72.653	Microcebus_murinus
ENSAMEG00000008526	MDM2	99	85.481	ENSMOCG00000008043	Mdm2	99	86.503	Microtus_ochrogaster
ENSAMEG00000008526	MDM2	93	33.809	ENSMODG00000001605	MDM4	92	32.568	Monodelphis_domestica
ENSAMEG00000008526	MDM2	99	75.665	ENSMODG00000007219	-	99	75.665	Monodelphis_domestica
ENSAMEG00000008526	MDM2	99	78.443	MGP_CAROLIEiJ_G0015836	Mdm2	99	79.042	Mus_caroli
ENSAMEG00000008526	MDM2	99	79.839	ENSMUSG00000020184	Mdm2	99	80.444	Mus_musculus
ENSAMEG00000008526	MDM2	99	31.985	ENSMUSG00000054387	Mdm4	99	31.985	Mus_musculus
ENSAMEG00000008526	MDM2	99	80.478	MGP_PahariEiJ_G0031251	Mdm2	99	80.677	Mus_pahari
ENSAMEG00000008526	MDM2	99	79.960	MGP_SPRETEiJ_G0016659	Mdm2	99	80.972	Mus_spretus
ENSAMEG00000008526	MDM2	99	31.792	MGP_SPRETEiJ_G0015400	Mdm4	99	31.870	Mus_spretus
ENSAMEG00000008526	MDM2	99	96.509	ENSMPUG00000017505	MDM2	100	96.509	Mustela_putorius_furo
ENSAMEG00000008526	MDM2	99	89.960	ENSMLUG00000009997	MDM2	99	89.759	Myotis_lucifugus
ENSAMEG00000008526	MDM2	99	87.551	ENSNGAG00000012154	Mdm2	99	87.551	Nannospalax_galili
ENSAMEG00000008526	MDM2	95	32.558	ENSNGAG00000012344	Mdm4	96	31.589	Nannospalax_galili
ENSAMEG00000008526	MDM2	99	94.523	ENSNLEG00000003757	MDM2	100	96.154	Nomascus_leucogenys
ENSAMEG00000008526	MDM2	93	32.213	ENSNLEG00000014271	MDM4	92	31.950	Nomascus_leucogenys
ENSAMEG00000008526	MDM2	80	52.500	ENSMEUG00000012624	-	82	52.500	Notamacropus_eugenii
ENSAMEG00000008526	MDM2	99	85.336	ENSOPRG00000009677	MDM2	99	85.336	Ochotona_princeps
ENSAMEG00000008526	MDM2	99	69.796	ENSODEG00000000416	-	97	84.173	Octodon_degus
ENSAMEG00000008526	MDM2	97	31.853	ENSODEG00000013499	MDM4	99	31.853	Octodon_degus
ENSAMEG00000008526	MDM2	99	83.469	ENSODEG00000004028	-	99	83.469	Octodon_degus
ENSAMEG00000008526	MDM2	98	73.608	ENSODEG00000006648	-	99	73.608	Octodon_degus
ENSAMEG00000008526	MDM2	93	34.388	ENSOANG00000013464	MDM4	97	32.826	Ornithorhynchus_anatinus
ENSAMEG00000008526	MDM2	89	72.831	ENSOANG00000005942	MDM2	99	72.831	Ornithorhynchus_anatinus
ENSAMEG00000008526	MDM2	99	92.915	ENSOCUG00000010899	-	64	92.915	Oryctolagus_cuniculus
ENSAMEG00000008526	MDM2	98	31.226	ENSOCUG00000000005	MDM4	99	31.166	Oryctolagus_cuniculus
ENSAMEG00000008526	MDM2	98	86.299	ENSOCUG00000011354	-	99	86.299	Oryctolagus_cuniculus
ENSAMEG00000008526	MDM2	97	32.613	ENSOGAG00000011679	MDM4	98	32.347	Otolemur_garnettii
ENSAMEG00000008526	MDM2	99	83.838	ENSOGAG00000034779	MDM2	100	83.838	Otolemur_garnettii
ENSAMEG00000008526	MDM2	99	84.049	ENSOGAG00000011845	-	100	84.049	Otolemur_garnettii
ENSAMEG00000008526	MDM2	98	32.819	ENSOARG00000002783	-	99	33.141	Ovis_aries
ENSAMEG00000008526	MDM2	99	92.771	ENSOARG00000000570	-	99	92.771	Ovis_aries
ENSAMEG00000008526	MDM2	99	93.075	ENSOARG00000013821	-	100	93.075	Ovis_aries
ENSAMEG00000008526	MDM2	99	94.929	ENSPPAG00000032775	MDM2	100	96.154	Pan_paniscus
ENSAMEG00000008526	MDM2	93	32.213	ENSPPAG00000030518	MDM4	92	31.950	Pan_paniscus
ENSAMEG00000008526	MDM2	99	96.957	ENSPPRG00000000082	MDM2	99	99.138	Panthera_pardus
ENSAMEG00000008526	MDM2	97	31.467	ENSPPRG00000025076	MDM4	99	32.171	Panthera_pardus
ENSAMEG00000008526	MDM2	99	97.149	ENSPTIG00000016929	MDM2	100	98.077	Panthera_tigris_altaica
ENSAMEG00000008526	MDM2	97	32.031	ENSPTIG00000011372	MDM4	99	32.087	Panthera_tigris_altaica
ENSAMEG00000008526	MDM2	93	32.213	ENSPTRG00000001889	MDM4	92	31.950	Pan_troglodytes
ENSAMEG00000008526	MDM2	99	94.929	ENSPTRG00000005203	MDM2	100	96.154	Pan_troglodytes
ENSAMEG00000008526	MDM2	93	32.186	ENSPANG00000008555	MDM4	92	30.515	Papio_anubis
ENSAMEG00000008526	MDM2	99	94.726	ENSPANG00000005563	MDM2	100	96.154	Papio_anubis
ENSAMEG00000008526	MDM2	90	66.887	ENSPSIG00000016379	-	99	67.727	Pelodiscus_sinensis
ENSAMEG00000008526	MDM2	93	32.724	ENSPEMG00000018483	Mdm4	92	31.134	Peromyscus_maniculatus_bairdii
ENSAMEG00000008526	MDM2	93	33.130	ENSPCIG00000017446	MDM4	95	30.435	Phascolarctos_cinereus
ENSAMEG00000008526	MDM2	99	77.002	ENSPCIG00000005357	-	99	77.578	Phascolarctos_cinereus
ENSAMEG00000008526	MDM2	93	31.781	ENSPPYG00000000315	MDM4	92	31.950	Pongo_abelii
ENSAMEG00000008526	MDM2	99	94.118	ENSPPYG00000004754	MDM2	99	94.118	Pongo_abelii
ENSAMEG00000008526	MDM2	74	54.255	ENSPCAG00000007019	MDM4	70	54.255	Procavia_capensis
ENSAMEG00000008526	MDM2	99	84.211	ENSPCAG00000008949	MDM2	99	84.211	Procavia_capensis
ENSAMEG00000008526	MDM2	88	92.483	ENSPCOG00000018521	-	100	92.483	Propithecus_coquereli
ENSAMEG00000008526	MDM2	97	33.141	ENSPCOG00000024397	MDM4	71	51.402	Propithecus_coquereli
ENSAMEG00000008526	MDM2	72	56.790	ENSPVAG00000005663	MDM4	70	53.521	Pteropus_vampyrus
ENSAMEG00000008526	MDM2	99	89.024	ENSPVAG00000006202	MDM2	99	89.024	Pteropus_vampyrus
ENSAMEG00000008526	MDM2	99	31.439	ENSRNOG00000009696	Mdm4	99	31.439	Rattus_norvegicus
ENSAMEG00000008526	MDM2	99	82.449	ENSRNOG00000006304	Mdm2	99	82.449	Rattus_norvegicus
ENSAMEG00000008526	MDM2	93	31.984	ENSRBIG00000038824	MDM4	92	30.488	Rhinopithecus_bieti
ENSAMEG00000008526	MDM2	99	94.726	ENSRBIG00000028561	MDM2	100	96.154	Rhinopithecus_bieti
ENSAMEG00000008526	MDM2	93	31.984	ENSRROG00000027771	MDM4	92	30.488	Rhinopithecus_roxellana
ENSAMEG00000008526	MDM2	99	94.726	ENSRROG00000045589	-	100	96.154	Rhinopithecus_roxellana
ENSAMEG00000008526	MDM2	98	32.136	ENSSBOG00000036183	-	71	50.000	Saimiri_boliviensis_boliviensis
ENSAMEG00000008526	MDM2	99	92.872	ENSSBOG00000014544	-	100	96.154	Saimiri_boliviensis_boliviensis
ENSAMEG00000008526	MDM2	91	30.453	ENSSBOG00000020446	-	94	30.342	Saimiri_boliviensis_boliviensis
ENSAMEG00000008526	MDM2	99	75.813	ENSSHAG00000010284	-	99	73.931	Sarcophilus_harrisii
ENSAMEG00000008526	MDM2	93	32.640	ENSSHAG00000007767	MDM4	92	31.760	Sarcophilus_harrisii
ENSAMEG00000008526	MDM2	83	68.116	ENSSHAG00000000124	-	100	66.505	Sarcophilus_harrisii
ENSAMEG00000008526	MDM2	96	31.969	ENSSFOG00015001112	mdm4	92	30.801	Scleropages_formosus
ENSAMEG00000008526	MDM2	99	86.939	ENSSARG00000005801	MDM2	100	86.939	Sorex_araneus
ENSAMEG00000008526	MDM2	94	32.653	ENSSARG00000004179	MDM4	55	33.333	Sorex_araneus
ENSAMEG00000008526	MDM2	99	64.969	ENSSPUG00000000964	MDM2	99	64.358	Sphenodon_punctatus
ENSAMEG00000008526	MDM2	97	31.712	ENSSSCG00000015284	MDM4	99	32.432	Sus_scrofa
ENSAMEG00000008526	MDM2	99	94.297	ENSSSCG00000000488	MDM2	100	94.297	Sus_scrofa
ENSAMEG00000008526	MDM2	56	31.818	ENSTGUG00000017483	MDM4	84	31.541	Taeniopygia_guttata
ENSAMEG00000008526	MDM2	90	67.261	ENSTGUG00000006836	MDM2	97	67.261	Taeniopygia_guttata
ENSAMEG00000008526	MDM2	81	92.593	ENSTBEG00000013758	MDM2	81	92.593	Tupaia_belangeri
ENSAMEG00000008526	MDM2	91	82.301	ENSTTRG00000015715	MDM2	91	82.301	Tursiops_truncatus
ENSAMEG00000008526	MDM2	98	32.681	ENSTTRG00000012174	MDM4	99	32.681	Tursiops_truncatus
ENSAMEG00000008526	MDM2	99	97.576	ENSUAMG00000018322	-	100	100.000	Ursus_americanus
ENSAMEG00000008526	MDM2	97	32.759	ENSUAMG00000007328	MDM4	99	31.977	Ursus_americanus
ENSAMEG00000008526	MDM2	98	31.670	ENSUMAG00000003452	MDM4	73	35.238	Ursus_maritimus
ENSAMEG00000008526	MDM2	99	98.973	ENSUMAG00000020757	MDM2	100	98.973	Ursus_maritimus
ENSAMEG00000008526	MDM2	100	88.129	ENSVPAG00000007456	MDM2	100	88.129	Vicugna_pacos
ENSAMEG00000008526	MDM2	93	32.311	ENSVPAG00000012034	MDM4	97	31.590	Vicugna_pacos
ENSAMEG00000008526	MDM2	94	32.669	ENSVVUG00000014855	MDM4	96	32.056	Vulpes_vulpes
ENSAMEG00000008526	MDM2	99	57.058	ENSXETG00000001434	mdm2	99	55.221	Xenopus_tropicalis