EuRBPDB

Description

RBDs

Transcripts

Gene Model

PPI

Paralogs

Orthologs

Description

Ensembl ID: ENSCAFG00000019233 (Gene tree)
Gene ID: 490030
Gene Symbol: SRL
Alias: -
Full Name: sarcalumenin
Gene Type: protein_coding
Species: Canis_familiaris
Status: putative
Strand: Plus strand
Length: 85689 bases
Position: chr6:37075124-37160812
Accession: 54070
RBP type: canonical RBP
Summary: -

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSCAFP00000039163	MMR_HSR1	PF01926.23	1.1e-08	1	1
ENSCAFP00000028358	MMR_HSR1	PF01926.23	2.9e-08	1	1

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENSCAFT00000030520	-	2634	XM_547150	ENSCAFP00000028358	877 (aa)	XP_547150	F1PZT9
ENSCAFT00000049429	-	1614	-	ENSCAFP00000039163	538 (aa)	-	J9P0U0

Gene Model

Click here to download ENSCAFG00000019233's gene model file

Protein-Protein Interaction (PPI)

Clik here to download ENSCAFG00000019233's network

Paralogs

Ensembl ID	Gene Symbol	Coverage	Identiy	Paralog	Gene Symbol	Coverage	Identiy
ENSCAFG00000019233	SRL	76	33.088	ENSCAFG00000014128	EHD1	84	33.088
ENSCAFG00000019233	SRL	65	33.714	ENSCAFG00000005348	EHD3	67	33.604
ENSCAFG00000019233	SRL	55	35.786	ENSCAFG00000009869	EHD4	55	35.786
ENSCAFG00000019233	SRL	72	32.737	ENSCAFG00000004095	EHD2	68	32.902

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSCAFG00000019233	SRL	84	96.916	ENSG00000185739	SRL	100	98.144	Homo_sapiens
ENSCAFG00000019233	SRL	85	80.786	ENSAPOG00000018093	srl	100	82.658	Acanthochromis_polyacanthus
ENSCAFG00000019233	SRL	82	76.244	ENSAPOG00000012432	SRL	98	74.720	Acanthochromis_polyacanthus
ENSCAFG00000019233	SRL	87	96.017	ENSAMEG00000010862	SRL	100	82.346	Ailuropoda_melanoleuca
ENSCAFG00000019233	SRL	83	75.225	ENSACIG00000015419	SRL	99	75.225	Amphilophus_citrinellus
ENSCAFG00000019233	SRL	84	82.119	ENSACIG00000015799	srl	100	82.119	Amphilophus_citrinellus
ENSCAFG00000019233	SRL	84	74.286	ENSAOCG00000017049	SRL	99	74.286	Amphiprion_ocellaris
ENSCAFG00000019233	SRL	81	83.410	ENSAOCG00000007574	srl	100	83.410	Amphiprion_ocellaris
ENSCAFG00000019233	SRL	85	81.004	ENSAPEG00000006911	srl	97	81.004	Amphiprion_percula
ENSCAFG00000019233	SRL	84	70.485	ENSAPEG00000006533	SRL	99	70.485	Amphiprion_percula
ENSCAFG00000019233	SRL	82	72.967	ENSATEG00000009643	SRL	52	72.967	Anabas_testudineus
ENSCAFG00000019233	SRL	82	83.032	ENSATEG00000024315	srl	97	81.223	Anabas_testudineus
ENSCAFG00000019233	SRL	82	90.508	ENSACAG00000016380	SRL	97	80.410	Anolis_carolinensis
ENSCAFG00000019233	SRL	86	80.435	ENSACLG00000027685	srl	97	82.805	Astatotilapia_calliptera
ENSCAFG00000019233	SRL	82	72.308	ENSACLG00000024674	SRL	57	72.308	Astatotilapia_calliptera
ENSCAFG00000019233	SRL	77	77.590	ENSAMXG00000038693	SRL	100	73.068	Astyanax_mexicanus
ENSCAFG00000019233	SRL	83	83.108	ENSAMXG00000018789	srl	87	83.108	Astyanax_mexicanus
ENSCAFG00000019233	SRL	84	97.788	ENSBTAG00000001078	SRL	97	69.301	Bos_taurus
ENSCAFG00000019233	SRL	85	96.288	ENSCJAG00000019750	SRL	97	96.312	Callithrix_jacchus
ENSCAFG00000019233	SRL	84	100.000	ENSCAFG00020025024	SRL	98	85.257	Canis_lupus_dingo
ENSCAFG00000019233	SRL	85	97.363	ENSCHIG00000017927	SRL	98	70.767	Capra_hircus
ENSCAFG00000019233	SRL	85	97.380	ENSTSYG00000007919	SRL	100	98.840	Carlito_syrichta
ENSCAFG00000019233	SRL	84	97.788	ENSCPOG00000012643	SRL	97	96.957	Cavia_porcellus
ENSCAFG00000019233	SRL	84	90.969	ENSCCAG00000032646	SRL	100	98.153	Cebus_capucinus
ENSCAFG00000019233	SRL	98	86.817	ENSCATG00000032227	-	97	96.095	Cercocebus_atys
ENSCAFG00000019233	SRL	84	97.566	ENSCLAG00000016242	SRL	97	96.739	Chinchilla_lanigera
ENSCAFG00000019233	SRL	99	84.022	ENSCSAG00000009635	-	90	81.538	Chlorocebus_sabaeus
ENSCAFG00000019233	SRL	72	97.143	ENSCHOG00000001618	SRL	87	97.143	Choloepus_hoffmanni
ENSCAFG00000019233	SRL	84	93.782	ENSCPBG00000026371	SRL	96	88.841	Chrysemys_picta_bellii
ENSCAFG00000019233	SRL	80	58.525	ENSCING00000005231	-	93	58.629	Ciona_intestinalis
ENSCAFG00000019233	SRL	85	96.070	ENSCANG00000035872	SRL	100	98.144	Colobus_angolensis_palliatus
ENSCAFG00000019233	SRL	98	86.389	ENSCGRG00001016630	Srl	97	96.522	Cricetulus_griseus_chok1gshd
ENSCAFG00000019233	SRL	98	86.389	ENSCGRG00000005458	Srl	97	96.522	Cricetulus_griseus_crigri
ENSCAFG00000019233	SRL	87	80.000	ENSCSEG00000016151	srl	100	80.000	Cynoglossus_semilaevis
ENSCAFG00000019233	SRL	86	70.626	ENSCSEG00000011866	SRL	93	70.626	Cynoglossus_semilaevis
ENSCAFG00000019233	SRL	86	81.522	ENSCVAG00000003513	srl	100	80.300	Cyprinodon_variegatus
ENSCAFG00000019233	SRL	82	74.558	ENSCVAG00000022465	SRL	60	74.558	Cyprinodon_variegatus
ENSCAFG00000019233	SRL	86	81.957	ENSDARG00000104587	srl	98	81.957	Danio_rerio
ENSCAFG00000019233	SRL	70	77.083	ENSDARG00000112959	CABZ01072309.1	90	83.140	Danio_rerio
ENSCAFG00000019233	SRL	84	97.118	ENSDNOG00000011643	SRL	98	66.742	Dasypus_novemcinctus
ENSCAFG00000019233	SRL	85	96.703	ENSDORG00000014807	Srl	98	96.312	Dipodomys_ordii
ENSCAFG00000019233	SRL	68	65.508	ENSEBUG00000015937	srl	88	67.816	Eptatretus_burgeri
ENSCAFG00000019233	SRL	90	98.000	ENSEASG00005000942	SRL	97	97.792	Equus_asinus_asinus
ENSCAFG00000019233	SRL	86	99.043	ENSECAG00000024219	SRL	95	99.043	Equus_caballus
ENSCAFG00000019233	SRL	85	78.814	ENSELUG00000015616	srl	97	78.814	Esox_lucius
ENSCAFG00000019233	SRL	89	99.323	ENSFCAG00000022075	SRL	96	98.458	Felis_catus
ENSCAFG00000019233	SRL	84	91.150	ENSFALG00000004328	SRL	64	91.150	Ficedula_albicollis
ENSCAFG00000019233	SRL	84	98.009	ENSFDAG00000006199	SRL	97	97.598	Fukomys_damarensis
ENSCAFG00000019233	SRL	85	80.568	ENSFHEG00000011239	srl	98	80.568	Fundulus_heteroclitus
ENSCAFG00000019233	SRL	82	75.113	ENSFHEG00000011854	SRL	98	76.018	Fundulus_heteroclitus
ENSCAFG00000019233	SRL	82	81.015	ENSGMOG00000014954	srl	99	81.015	Gadus_morhua
ENSCAFG00000019233	SRL	84	90.529	ENSGALG00000038884	SRL	96	90.529	Gallus_gallus
ENSCAFG00000019233	SRL	82	76.018	ENSGAFG00000016984	SRL	98	76.018	Gambusia_affinis
ENSCAFG00000019233	SRL	85	81.223	ENSGAFG00000000010	srl	99	81.223	Gambusia_affinis
ENSCAFG00000019233	SRL	82	80.574	ENSGACG00000011332	srl	99	80.574	Gasterosteus_aculeatus
ENSCAFG00000019233	SRL	87	89.149	ENSGAGG00000015590	SRL	59	75.084	Gopherus_agassizii
ENSCAFG00000019233	SRL	99	86.456	ENSGGOG00000011312	-	96	96.916	Gorilla_gorilla
ENSCAFG00000019233	SRL	85	70.339	ENSHBUG00000015710	SRL	57	72.088	Haplochromis_burtoni
ENSCAFG00000019233	SRL	86	80.435	ENSHBUG00000007581	srl	97	82.805	Haplochromis_burtoni
ENSCAFG00000019233	SRL	84	98.451	ENSHGLG00000015271	SRL	97	97.609	Heterocephalus_glaber_female
ENSCAFG00000019233	SRL	84	98.451	ENSHGLG00100019378	SRL	97	97.609	Heterocephalus_glaber_male
ENSCAFG00000019233	SRL	85	80.786	ENSHCOG00000008687	srl	98	83.032	Hippocampus_comes
ENSCAFG00000019233	SRL	82	71.744	ENSHCOG00000001012	SRL	50	70.640	Hippocampus_comes
ENSCAFG00000019233	SRL	86	78.925	ENSIPUG00000012513	srl	99	79.310	Ictalurus_punctatus
ENSCAFG00000019233	SRL	81	70.183	ENSIPUG00000011609	SRL	89	71.990	Ictalurus_punctatus
ENSCAFG00000019233	SRL	85	96.950	ENSSTOG00000021151	-	97	96.957	Ictidomys_tridecemlineatus
ENSCAFG00000019233	SRL	84	97.124	ENSJJAG00000016400	Srl	97	96.304	Jaculus_jaculus
ENSCAFG00000019233	SRL	82	75.964	ENSKMAG00000019537	SRL	100	75.964	Kryptolebias_marmoratus
ENSCAFG00000019233	SRL	83	81.573	ENSKMAG00000014115	srl	93	85.036	Kryptolebias_marmoratus
ENSCAFG00000019233	SRL	85	80.568	ENSLBEG00000026643	srl	97	80.568	Labrus_bergylta
ENSCAFG00000019233	SRL	84	74.066	ENSLBEG00000013811	SRL	99	73.856	Labrus_bergylta
ENSCAFG00000019233	SRL	84	85.872	ENSLACG00000002825	SRL	100	85.872	Latimeria_chalumnae
ENSCAFG00000019233	SRL	84	84.361	ENSLOCG00000002644	srl	97	84.361	Lepisosteus_oculatus
ENSCAFG00000019233	SRL	84	97.351	ENSLAFG00000006329	SRL	81	71.226	Loxodonta_africana
ENSCAFG00000019233	SRL	80	98.144	ENSMFAG00000037383	SRL	100	98.144	Macaca_fascicularis
ENSCAFG00000019233	SRL	99	85.714	ENSMNEG00000019236	-	99	94.681	Macaca_nemestrina
ENSCAFG00000019233	SRL	84	88.767	ENSMLEG00000032156	SRL	97	88.069	Mandrillus_leucophaeus
ENSCAFG00000019233	SRL	82	82.805	ENSMAMG00000023322	srl	97	80.568	Mastacembelus_armatus
ENSCAFG00000019233	SRL	82	73.128	ENSMAMG00000013756	SRL	53	73.026	Mastacembelus_armatus
ENSCAFG00000019233	SRL	86	80.435	ENSMZEG00005004548	srl	97	82.805	Maylandia_zebra
ENSCAFG00000019233	SRL	85	70.551	ENSMZEG00005004010	SRL	59	70.551	Maylandia_zebra
ENSCAFG00000019233	SRL	93	84.221	ENSMGAG00000009342	SRL	95	92.063	Meleagris_gallopavo
ENSCAFG00000019233	SRL	85	96.070	ENSMICG00000032307	SRL	97	95.879	Microcebus_murinus
ENSCAFG00000019233	SRL	84	97.124	ENSMOCG00000008208	Srl	97	96.304	Microtus_ochrogaster
ENSCAFG00000019233	SRL	82	72.527	ENSMMOG00000021572	SRL	99	72.527	Mola_mola
ENSCAFG00000019233	SRL	84	81.858	ENSMMOG00000013970	srl	100	81.858	Mola_mola
ENSCAFG00000019233	SRL	85	95.207	ENSMODG00000016380	-	51	96.026	Monodelphis_domestica
ENSCAFG00000019233	SRL	77	76.202	ENSMALG00000000670	SRL	97	75.240	Monopterus_albus
ENSCAFG00000019233	SRL	82	82.353	ENSMALG00000005039	srl	98	82.353	Monopterus_albus
ENSCAFG00000019233	SRL	85	96.078	MGP_CAROLIEiJ_G0020400	Srl	97	96.087	Mus_caroli
ENSCAFG00000019233	SRL	89	92.917	ENSMUSG00000022519	Srl	97	96.087	Mus_musculus
ENSCAFG00000019233	SRL	82	97.291	MGP_PahariEiJ_G0016108	Srl	52	92.917	Mus_pahari
ENSCAFG00000019233	SRL	89	92.917	MGP_SPRETEiJ_G0021294	Srl	97	96.087	Mus_spretus
ENSCAFG00000019233	SRL	84	99.338	ENSMPUG00000015025	SRL	98	80.410	Mustela_putorius_furo
ENSCAFG00000019233	SRL	98	85.055	ENSMLUG00000030733	SRL	100	74.886	Myotis_lucifugus
ENSCAFG00000019233	SRL	84	96.681	ENSNGAG00000019741	Srl	98	95.879	Nannospalax_galili
ENSCAFG00000019233	SRL	85	81.360	ENSNBRG00000023775	srl	97	81.360	Neolamprologus_brichardi
ENSCAFG00000019233	SRL	85	70.551	ENSNBRG00000002422	SRL	63	68.172	Neolamprologus_brichardi
ENSCAFG00000019233	SRL	84	90.265	ENSNLEG00000029051	SRL	95	90.265	Nomascus_leucogenys
ENSCAFG00000019233	SRL	88	88.347	ENSOPRG00000000477	-	81	66.798	Ochotona_princeps
ENSCAFG00000019233	SRL	84	96.239	ENSODEG00000013256	SRL	98	95.445	Octodon_degus
ENSCAFG00000019233	SRL	84	81.236	ENSONIG00000005192	srl	96	81.236	Oreochromis_niloticus
ENSCAFG00000019233	SRL	89	93.555	ENSOCUG00000025140	SRL	98	65.973	Oryctolagus_cuniculus
ENSCAFG00000019233	SRL	85	80.702	ENSORLG00000008291	srl	92	85.052	Oryzias_latipes
ENSCAFG00000019233	SRL	83	74.550	ENSORLG00000015064	SRL	99	74.115	Oryzias_latipes
ENSCAFG00000019233	SRL	83	74.775	ENSORLG00020018173	SRL	99	74.336	Oryzias_latipes_hni
ENSCAFG00000019233	SRL	85	80.659	ENSORLG00020019784	srl	79	85.013	Oryzias_latipes_hni
ENSCAFG00000019233	SRL	83	75.000	ENSORLG00015019063	SRL	99	74.558	Oryzias_latipes_hsok
ENSCAFG00000019233	SRL	85	80.044	ENSORLG00015009342	srl	94	79.521	Oryzias_latipes_hsok
ENSCAFG00000019233	SRL	85	80.263	ENSOMEG00000010006	srl	98	82.045	Oryzias_melastigma
ENSCAFG00000019233	SRL	83	72.867	ENSOMEG00000005682	SRL	53	72.767	Oryzias_melastigma
ENSCAFG00000019233	SRL	89	93.305	ENSOGAG00000029266	SRL	100	66.959	Otolemur_garnettii
ENSCAFG00000019233	SRL	88	94.328	ENSOARG00000003074	SRL	90	78.462	Ovis_aries
ENSCAFG00000019233	SRL	100	86.296	ENSPPAG00000024919	-	100	98.144	Pan_paniscus
ENSCAFG00000019233	SRL	84	98.678	ENSPPRG00000010274	SRL	100	99.536	Panthera_pardus
ENSCAFG00000019233	SRL	84	98.678	ENSPTIG00000015162	SRL	100	99.536	Panthera_tigris_altaica
ENSCAFG00000019233	SRL	100	86.296	ENSPTRG00000007712	SRL	100	98.144	Pan_troglodytes
ENSCAFG00000019233	SRL	86	95.474	ENSPANG00000013804	SRL	99	96.296	Papio_anubis
ENSCAFG00000019233	SRL	82	76.244	ENSPKIG00000024974	SRL	92	73.913	Paramormyrops_kingsleyae
ENSCAFG00000019233	SRL	85	82.096	ENSPKIG00000006405	srl	97	82.096	Paramormyrops_kingsleyae
ENSCAFG00000019233	SRL	85	89.760	ENSPSIG00000008586	SRL	51	89.760	Pelodiscus_sinensis
ENSCAFG00000019233	SRL	82	72.624	ENSPMGG00000023505	-	99	72.072	Periophthalmus_magnuspinnatus
ENSCAFG00000019233	SRL	84	82.965	ENSPMGG00000021081	srl	97	82.965	Periophthalmus_magnuspinnatus
ENSCAFG00000019233	SRL	84	97.345	ENSPEMG00000015842	Srl	97	96.522	Peromyscus_maniculatus_bairdii
ENSCAFG00000019233	SRL	78	67.661	ENSPMAG00000004786	srl	99	67.431	Petromyzon_marinus
ENSCAFG00000019233	SRL	84	96.460	ENSPCIG00000012128	SRL	99	96.460	Phascolarctos_cinereus
ENSCAFG00000019233	SRL	85	79.149	ENSPFOG00000011408	srl	97	78.723	Poecilia_formosa
ENSCAFG00000019233	SRL	82	75.566	ENSPLAG00000002932	SRL	98	74.434	Poecilia_latipinna
ENSCAFG00000019233	SRL	85	80.702	ENSPLAG00000008017	srl	99	81.004	Poecilia_latipinna
ENSCAFG00000019233	SRL	82	73.304	ENSPMEG00000005890	SRL	59	73.626	Poecilia_mexicana
ENSCAFG00000019233	SRL	85	81.004	ENSPMEG00000006745	srl	99	81.004	Poecilia_mexicana
ENSCAFG00000019233	SRL	85	80.963	ENSPREG00000007751	srl	99	82.022	Poecilia_reticulata
ENSCAFG00000019233	SRL	88	70.782	ENSPREG00000000315	SRL	98	75.566	Poecilia_reticulata
ENSCAFG00000019233	SRL	78	98.329	ENSPPYG00000007053	SRL	98	98.329	Pongo_abelii
ENSCAFG00000019233	SRL	85	94.541	ENSPCAG00000003378	-	82	92.812	Procavia_capensis
ENSCAFG00000019233	SRL	85	95.852	ENSPCOG00000023135	SRL	100	97.680	Propithecus_coquereli
ENSCAFG00000019233	SRL	84	98.675	ENSPVAG00000006586	SRL	98	73.016	Pteropus_vampyrus
ENSCAFG00000019233	SRL	85	80.786	ENSPNYG00000001200	srl	97	82.805	Pundamilia_nyererei
ENSCAFG00000019233	SRL	85	70.551	ENSPNYG00000003423	SRL	57	72.308	Pundamilia_nyererei
ENSCAFG00000019233	SRL	83	81.573	ENSPNAG00000023106	srl	95	81.573	Pygocentrus_nattereri
ENSCAFG00000019233	SRL	83	74.165	ENSPNAG00000007361	-	92	74.165	Pygocentrus_nattereri
ENSCAFG00000019233	SRL	85	97.168	ENSRNOG00000005269	Srl	51	97.168	Rattus_norvegicus
ENSCAFG00000019233	SRL	99	86.679	ENSRBIG00000042358	SRL	82	73.483	Rhinopithecus_bieti
ENSCAFG00000019233	SRL	93	90.600	ENSSBOG00000029273	SRL	97	96.312	Saimiri_boliviensis_boliviensis
ENSCAFG00000019233	SRL	85	95.624	ENSSHAG00000011715	-	55	95.815	Sarcophilus_harrisii
ENSCAFG00000019233	SRL	82	84.163	ENSSFOG00015009773	srl	98	81.917	Scleropages_formosus
ENSCAFG00000019233	SRL	82	76.697	ENSSFOG00015021327	SRL	51	75.385	Scleropages_formosus
ENSCAFG00000019233	SRL	82	73.085	ENSSMAG00000002232	SRL	50	72.088	Scophthalmus_maximus
ENSCAFG00000019233	SRL	84	81.556	ENSSMAG00000016274	srl	98	81.556	Scophthalmus_maximus
ENSCAFG00000019233	SRL	82	83.258	ENSSDUG00000010808	srl	97	83.258	Seriola_dumerili
ENSCAFG00000019233	SRL	82	74.388	ENSSDUG00000009161	SRL	98	74.388	Seriola_dumerili
ENSCAFG00000019233	SRL	82	73.961	ENSSLDG00000014601	SRL	99	74.066	Seriola_lalandi_dorsalis
ENSCAFG00000019233	SRL	85	81.579	ENSSLDG00000022024	srl	98	81.579	Seriola_lalandi_dorsalis
ENSCAFG00000019233	SRL	84	90.949	ENSSPUG00000016859	SRL	99	90.949	Sphenodon_punctatus
ENSCAFG00000019233	SRL	82	75.737	ENSSPAG00000014254	SRL	98	74.603	Stegastes_partitus
ENSCAFG00000019233	SRL	90	78.468	ENSSPAG00000019105	srl	98	81.128	Stegastes_partitus
ENSCAFG00000019233	SRL	92	94.105	ENSSSCG00000007949	SRL	99	97.768	Sus_scrofa
ENSCAFG00000019233	SRL	84	90.929	ENSTGUG00000003951	-	99	90.929	Taeniopygia_guttata
ENSCAFG00000019233	SRL	67	93.094	ENSTGUG00000016121	-	96	93.966	Taeniopygia_guttata
ENSCAFG00000019233	SRL	78	75.179	ENSTRUG00000013310	SRL	55	75.540	Takifugu_rubripes
ENSCAFG00000019233	SRL	85	81.223	ENSTRUG00000006005	srl	98	81.046	Takifugu_rubripes
ENSCAFG00000019233	SRL	85	81.360	ENSTNIG00000009739	srl	98	80.610	Tetraodon_nigroviridis
ENSCAFG00000019233	SRL	82	97.500	ENSTTRG00000002709	-	67	97.500	Tursiops_truncatus
ENSCAFG00000019233	SRL	90	99.336	ENSUAMG00000005701	SRL	56	99.336	Ursus_americanus
ENSCAFG00000019233	SRL	90	99.558	ENSUMAG00000002574	SRL	56	99.558	Ursus_maritimus
ENSCAFG00000019233	SRL	91	99.780	ENSVVUG00000016331	-	87	83.200	Vulpes_vulpes
ENSCAFG00000019233	SRL	84	88.938	ENSXETG00000017313	srl	100	88.938	Xenopus_tropicalis
ENSCAFG00000019233	SRL	78	84.561	ENSXCOG00000010424	srl	97	84.561	Xiphophorus_couchianus
ENSCAFG00000019233	SRL	82	75.566	ENSXCOG00000014584	SRL	98	75.566	Xiphophorus_couchianus
ENSCAFG00000019233	SRL	82	73.626	ENSXMAG00000027598	SRL	62	74.286	Xiphophorus_maculatus
ENSCAFG00000019233	SRL	85	81.223	ENSXMAG00000004625	srl	93	81.264	Xiphophorus_maculatus