EuRBPDB

Description

RBDs

Transcripts

Gene Model

PPI

Paralogs

Orthologs

Description

Ensembl ID: ENSCGRG00000008320 (Gene tree)
Gene ID: -
Gene Symbol: Lsm6
Alias: 1500031N17Rik|2410088K19Rik
Full Name: LSM6 homolog%2C U6 small nuclear RNA and mRNA degradation associated
Gene Type: protein_coding
Species: Cricetulus_griseus_crigri
Status: putative
Strand: Plus strand
Length: 7700 bases
Position: chrJH000229.1:1704947-1712646
Accession: 100769852
RBP type: canonical RBP
Summary: -

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSCGRP00000011429	LSM	PF01423.22	1.2e-19	1	1

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENSCGRT00000011611	-	519	XM_003500758	ENSCGRP00000011429	80 (aa)	XP_003500806	G3H9H3

Gene Model

Click here to download ENSCGRG00000008320's gene model file

Protein-Protein Interaction (PPI)

Clik here to download ENSCGRG00000008320's network

Paralogs

Ensembl ID	Gene Symbol	Coverage	Identiy	Paralog	Gene Symbol	Coverage	Identiy
ENSCGRG00000008320	Lsm6	83	43.939	ENSCGRG00000018878	-	82	43.939
ENSCGRG00000008320	Lsm6	83	51.515	ENSCGRG00000000336	-	77	51.515

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSCGRG00000008320	Lsm6	100	100.000	ENSG00000164167	LSM6	100	100.000	Homo_sapiens
ENSCGRG00000008320	Lsm6	100	95.000	ENSAPOG00000019832	lsm6	100	95.000	Acanthochromis_polyacanthus
ENSCGRG00000008320	Lsm6	100	100.000	ENSAMEG00000016671	LSM6	100	100.000	Ailuropoda_melanoleuca
ENSCGRG00000008320	Lsm6	100	95.000	ENSACIG00000016711	lsm6	100	95.000	Amphilophus_citrinellus
ENSCGRG00000008320	Lsm6	100	95.000	ENSAOCG00000002110	lsm6	52	95.000	Amphiprion_ocellaris
ENSCGRG00000008320	Lsm6	100	95.000	ENSAPEG00000023992	lsm6	100	95.000	Amphiprion_percula
ENSCGRG00000008320	Lsm6	100	95.000	ENSATEG00000012610	lsm6	100	95.000	Anabas_testudineus
ENSCGRG00000008320	Lsm6	96	100.000	ENSAPLG00000012594	LSM6	99	100.000	Anas_platyrhynchos
ENSCGRG00000008320	Lsm6	100	100.000	ENSACAG00000004004	LSM6	100	100.000	Anolis_carolinensis
ENSCGRG00000008320	Lsm6	100	86.250	ENSANAG00000021839	-	100	86.250	Aotus_nancymaae
ENSCGRG00000008320	Lsm6	100	100.000	ENSANAG00000030568	-	100	100.000	Aotus_nancymaae
ENSCGRG00000008320	Lsm6	100	95.000	ENSACLG00000025621	lsm6	100	95.000	Astatotilapia_calliptera
ENSCGRG00000008320	Lsm6	100	96.250	ENSAMXG00000038738	lsm6	100	96.250	Astyanax_mexicanus
ENSCGRG00000008320	Lsm6	100	93.750	ENSBTAG00000052085	-	100	93.750	Bos_taurus
ENSCGRG00000008320	Lsm6	100	100.000	ENSBTAG00000014060	LSM6	100	100.000	Bos_taurus
ENSCGRG00000008320	Lsm6	94	81.333	WBGene00003080	lsm-6	97	81.333	Caenorhabditis_elegans
ENSCGRG00000008320	Lsm6	100	100.000	ENSCJAG00000002482	LSM6	100	100.000	Callithrix_jacchus
ENSCGRG00000008320	Lsm6	100	100.000	ENSCAFG00000007738	LSM6	100	100.000	Canis_familiaris
ENSCGRG00000008320	Lsm6	100	100.000	ENSCAFG00020025902	LSM6	100	100.000	Canis_lupus_dingo
ENSCGRG00000008320	Lsm6	100	100.000	ENSCHIG00000010334	-	100	100.000	Capra_hircus
ENSCGRG00000008320	Lsm6	100	83.750	ENSCHIG00000024198	-	95	83.750	Capra_hircus
ENSCGRG00000008320	Lsm6	89	100.000	ENSCHIG00000012864	-	100	100.000	Capra_hircus
ENSCGRG00000008320	Lsm6	100	100.000	ENSTSYG00000026972	LSM6	100	100.000	Carlito_syrichta
ENSCGRG00000008320	Lsm6	94	84.000	ENSTSYG00000012759	-	89	84.000	Carlito_syrichta
ENSCGRG00000008320	Lsm6	81	96.923	ENSCAPG00000011179	-	100	96.923	Cavia_aperea
ENSCGRG00000008320	Lsm6	100	100.000	ENSCAPG00000008104	LSM6	100	100.000	Cavia_aperea
ENSCGRG00000008320	Lsm6	100	100.000	ENSCPOG00000032655	LSM6	100	100.000	Cavia_porcellus
ENSCGRG00000008320	Lsm6	99	98.734	ENSCCAG00000020665	-	99	98.734	Cebus_capucinus
ENSCGRG00000008320	Lsm6	100	100.000	ENSCCAG00000036437	LSM6	100	100.000	Cebus_capucinus
ENSCGRG00000008320	Lsm6	100	72.500	ENSCATG00000038799	-	100	72.500	Cercocebus_atys
ENSCGRG00000008320	Lsm6	100	100.000	ENSCATG00000002770	-	100	100.000	Cercocebus_atys
ENSCGRG00000008320	Lsm6	100	100.000	ENSCLAG00000005495	LSM6	100	100.000	Chinchilla_lanigera
ENSCGRG00000008320	Lsm6	89	80.282	ENSCLAG00000005685	-	100	80.282	Chinchilla_lanigera
ENSCGRG00000008320	Lsm6	100	100.000	ENSCSAG00000003421	LSM6	100	100.000	Chlorocebus_sabaeus
ENSCGRG00000008320	Lsm6	100	78.750	ENSCHOG00000003420	LSM6	100	78.750	Choloepus_hoffmanni
ENSCGRG00000008320	Lsm6	100	100.000	ENSCPBG00000027472	LSM6	84	100.000	Chrysemys_picta_bellii
ENSCGRG00000008320	Lsm6	95	96.053	ENSCING00000019152	-	93	96.053	Ciona_intestinalis
ENSCGRG00000008320	Lsm6	95	97.368	ENSCSAVG00000002065	-	93	97.368	Ciona_savignyi
ENSCGRG00000008320	Lsm6	100	100.000	ENSCANG00000006849	-	100	100.000	Colobus_angolensis_palliatus
ENSCGRG00000008320	Lsm6	100	71.250	ENSCANG00000035214	-	100	71.250	Colobus_angolensis_palliatus
ENSCGRG00000008320	Lsm6	100	100.000	ENSCANG00000041263	-	100	100.000	Colobus_angolensis_palliatus
ENSCGRG00000008320	Lsm6	100	100.000	ENSCGRG00001017142	Lsm6	100	100.000	Cricetulus_griseus_chok1gshd
ENSCGRG00000008320	Lsm6	100	95.000	ENSCSEG00000000423	lsm6	100	95.000	Cynoglossus_semilaevis
ENSCGRG00000008320	Lsm6	100	95.000	ENSCVAG00000001592	lsm6	100	95.000	Cyprinodon_variegatus
ENSCGRG00000008320	Lsm6	100	96.250	ENSDARG00000036995	lsm6	100	96.250	Danio_rerio
ENSCGRG00000008320	Lsm6	100	98.750	ENSDNOG00000044848	-	100	98.750	Dasypus_novemcinctus
ENSCGRG00000008320	Lsm6	86	100.000	ENSDNOG00000040186	-	74	100.000	Dasypus_novemcinctus
ENSCGRG00000008320	Lsm6	100	100.000	ENSDORG00000000933	Lsm6	100	100.000	Dipodomys_ordii
ENSCGRG00000008320	Lsm6	96	85.714	FBgn0034564	CG9344	97	85.714	Drosophila_melanogaster
ENSCGRG00000008320	Lsm6	60	100.000	ENSETEG00000013098	LSM6	100	100.000	Echinops_telfairi
ENSCGRG00000008320	Lsm6	100	98.750	ENSEBUG00000017073	lsm6	100	98.750	Eptatretus_burgeri
ENSCGRG00000008320	Lsm6	86	100.000	ENSEASG00005001533	LSM6	72	100.000	Equus_asinus_asinus
ENSCGRG00000008320	Lsm6	100	100.000	ENSECAG00000021036	LSM6	100	100.000	Equus_caballus
ENSCGRG00000008320	Lsm6	99	72.152	ENSEEUG00000002101	LSM6	100	72.152	Erinaceus_europaeus
ENSCGRG00000008320	Lsm6	100	96.250	ENSELUG00000014301	LSM6	100	96.250	Esox_lucius
ENSCGRG00000008320	Lsm6	100	100.000	ENSFCAG00000003047	LSM6	100	100.000	Felis_catus
ENSCGRG00000008320	Lsm6	100	100.000	ENSFALG00000005509	LSM6	92	100.000	Ficedula_albicollis
ENSCGRG00000008320	Lsm6	100	87.500	ENSFDAG00000019073	-	100	87.500	Fukomys_damarensis
ENSCGRG00000008320	Lsm6	100	100.000	ENSFDAG00000020913	-	100	100.000	Fukomys_damarensis
ENSCGRG00000008320	Lsm6	100	95.000	ENSFHEG00000007948	lsm6	100	95.000	Fundulus_heteroclitus
ENSCGRG00000008320	Lsm6	100	95.000	ENSGMOG00000015550	lsm6	100	95.000	Gadus_morhua
ENSCGRG00000008320	Lsm6	100	100.000	ENSGALG00000009985	LSM6	100	100.000	Gallus_gallus
ENSCGRG00000008320	Lsm6	100	95.000	ENSGAFG00000017763	lsm6	100	95.000	Gambusia_affinis
ENSCGRG00000008320	Lsm6	99	96.203	ENSGACG00000017223	lsm6	99	96.203	Gasterosteus_aculeatus
ENSCGRG00000008320	Lsm6	100	100.000	ENSGAGG00000020980	LSM6	100	100.000	Gopherus_agassizii
ENSCGRG00000008320	Lsm6	100	100.000	ENSGGOG00000001310	LSM6	100	100.000	Gorilla_gorilla
ENSCGRG00000008320	Lsm6	100	95.000	ENSHBUG00000008618	lsm6	100	95.000	Haplochromis_burtoni
ENSCGRG00000008320	Lsm6	100	100.000	ENSHGLG00000000205	LSM6	100	100.000	Heterocephalus_glaber_female
ENSCGRG00000008320	Lsm6	100	100.000	ENSHGLG00100014341	LSM6	100	100.000	Heterocephalus_glaber_male
ENSCGRG00000008320	Lsm6	100	95.000	ENSHCOG00000005591	lsm6	100	95.000	Hippocampus_comes
ENSCGRG00000008320	Lsm6	100	95.000	ENSIPUG00000004508	lsm6	100	95.000	Ictalurus_punctatus
ENSCGRG00000008320	Lsm6	100	100.000	ENSSTOG00000002678	LSM6	100	100.000	Ictidomys_tridecemlineatus
ENSCGRG00000008320	Lsm6	96	79.221	ENSJJAG00000016942	-	97	79.221	Jaculus_jaculus
ENSCGRG00000008320	Lsm6	100	100.000	ENSJJAG00000013845	-	100	100.000	Jaculus_jaculus
ENSCGRG00000008320	Lsm6	100	90.000	ENSJJAG00000011211	-	100	90.000	Jaculus_jaculus
ENSCGRG00000008320	Lsm6	100	95.000	ENSKMAG00000004105	lsm6	100	95.000	Kryptolebias_marmoratus
ENSCGRG00000008320	Lsm6	100	95.000	ENSLBEG00000018441	lsm6	100	95.000	Labrus_bergylta
ENSCGRG00000008320	Lsm6	100	100.000	ENSLACG00000006937	LSM6	100	100.000	Latimeria_chalumnae
ENSCGRG00000008320	Lsm6	100	96.250	ENSLOCG00000008852	lsm6	100	96.250	Lepisosteus_oculatus
ENSCGRG00000008320	Lsm6	100	95.000	ENSLOCG00000017683	-	100	95.000	Lepisosteus_oculatus
ENSCGRG00000008320	Lsm6	100	100.000	ENSLAFG00000001952	LSM6	100	100.000	Loxodonta_africana
ENSCGRG00000008320	Lsm6	100	100.000	ENSMFAG00000033073	LSM6	100	100.000	Macaca_fascicularis
ENSCGRG00000008320	Lsm6	100	73.750	ENSMNEG00000040412	-	100	73.750	Macaca_nemestrina
ENSCGRG00000008320	Lsm6	100	100.000	ENSMNEG00000034820	-	100	100.000	Macaca_nemestrina
ENSCGRG00000008320	Lsm6	100	100.000	ENSMLEG00000035153	LSM6	100	100.000	Mandrillus_leucophaeus
ENSCGRG00000008320	Lsm6	100	95.000	ENSMAMG00000014029	lsm6	100	95.000	Mastacembelus_armatus
ENSCGRG00000008320	Lsm6	100	95.000	ENSMZEG00005009146	lsm6	100	95.000	Maylandia_zebra
ENSCGRG00000008320	Lsm6	100	100.000	ENSMGAG00000003802	LSM6	100	100.000	Meleagris_gallopavo
ENSCGRG00000008320	Lsm6	100	100.000	ENSMAUG00000014938	Lsm6	100	100.000	Mesocricetus_auratus
ENSCGRG00000008320	Lsm6	98	91.026	ENSMICG00000047411	-	92	91.026	Microcebus_murinus
ENSCGRG00000008320	Lsm6	100	100.000	ENSMICG00000042599	LSM6	100	100.000	Microcebus_murinus
ENSCGRG00000008320	Lsm6	100	100.000	ENSMOCG00000020049	Lsm6	100	100.000	Microtus_ochrogaster
ENSCGRG00000008320	Lsm6	100	88.750	ENSMMOG00000007379	-	100	88.750	Mola_mola
ENSCGRG00000008320	Lsm6	100	95.000	ENSMMOG00000005470	lsm6	100	95.000	Mola_mola
ENSCGRG00000008320	Lsm6	100	100.000	ENSMODG00000000526	LSM6	100	100.000	Monodelphis_domestica
ENSCGRG00000008320	Lsm6	100	95.000	ENSMALG00000002419	lsm6	100	95.000	Monopterus_albus
ENSCGRG00000008320	Lsm6	100	100.000	MGP_CAROLIEiJ_G0031245	Lsm6	100	100.000	Mus_caroli
ENSCGRG00000008320	Lsm6	100	100.000	ENSMUSG00000031683	Lsm6	100	100.000	Mus_musculus
ENSCGRG00000008320	Lsm6	100	100.000	MGP_PahariEiJ_G0022851	Lsm6	100	100.000	Mus_pahari
ENSCGRG00000008320	Lsm6	100	100.000	MGP_SPRETEiJ_G0032365	Lsm6	100	100.000	Mus_spretus
ENSCGRG00000008320	Lsm6	99	100.000	ENSMPUG00000006936	LSM6	92	100.000	Mustela_putorius_furo
ENSCGRG00000008320	Lsm6	100	100.000	ENSMLUG00000026355	LSM6	100	100.000	Myotis_lucifugus
ENSCGRG00000008320	Lsm6	100	100.000	ENSNGAG00000019116	Lsm6	100	100.000	Nannospalax_galili
ENSCGRG00000008320	Lsm6	100	95.000	ENSNBRG00000004887	lsm6	100	95.000	Neolamprologus_brichardi
ENSCGRG00000008320	Lsm6	100	100.000	ENSNLEG00000005584	LSM6	100	100.000	Nomascus_leucogenys
ENSCGRG00000008320	Lsm6	100	98.750	ENSOPRG00000011199	LSM6	100	98.750	Ochotona_princeps
ENSCGRG00000008320	Lsm6	100	98.750	ENSODEG00000002307	-	100	98.750	Octodon_degus
ENSCGRG00000008320	Lsm6	96	88.312	ENSODEG00000018684	-	100	88.312	Octodon_degus
ENSCGRG00000008320	Lsm6	100	97.500	ENSODEG00000020420	-	100	97.500	Octodon_degus
ENSCGRG00000008320	Lsm6	100	96.250	ENSODEG00000019419	-	100	96.250	Octodon_degus
ENSCGRG00000008320	Lsm6	100	95.000	ENSONIG00000010005	lsm6	100	95.000	Oreochromis_niloticus
ENSCGRG00000008320	Lsm6	98	74.359	ENSOANG00000006894	-	100	74.359	Ornithorhynchus_anatinus
ENSCGRG00000008320	Lsm6	98	74.359	ENSOANG00000006895	-	100	74.359	Ornithorhynchus_anatinus
ENSCGRG00000008320	Lsm6	100	93.750	ENSORLG00000024158	lsm6	100	93.750	Oryzias_latipes
ENSCGRG00000008320	Lsm6	100	93.750	ENSORLG00020017383	lsm6	100	93.750	Oryzias_latipes_hni
ENSCGRG00000008320	Lsm6	100	93.750	ENSORLG00015016903	lsm6	100	93.750	Oryzias_latipes_hsok
ENSCGRG00000008320	Lsm6	100	95.000	ENSOMEG00000000074	lsm6	100	95.000	Oryzias_melastigma
ENSCGRG00000008320	Lsm6	100	100.000	ENSOGAG00000026665	-	100	100.000	Otolemur_garnettii
ENSCGRG00000008320	Lsm6	100	100.000	ENSOGAG00000033153	-	100	100.000	Otolemur_garnettii
ENSCGRG00000008320	Lsm6	86	100.000	ENSOARG00000008509	-	88	100.000	Ovis_aries
ENSCGRG00000008320	Lsm6	99	93.671	ENSOARG00000011641	-	92	93.671	Ovis_aries
ENSCGRG00000008320	Lsm6	100	100.000	ENSPPAG00000037929	LSM6	100	100.000	Pan_paniscus
ENSCGRG00000008320	Lsm6	100	100.000	ENSPPRG00000012806	LSM6	100	100.000	Panthera_pardus
ENSCGRG00000008320	Lsm6	100	100.000	ENSPTIG00000019769	LSM6	100	100.000	Panthera_tigris_altaica
ENSCGRG00000008320	Lsm6	100	100.000	ENSPTRG00000016488	LSM6	100	100.000	Pan_troglodytes
ENSCGRG00000008320	Lsm6	100	100.000	ENSPANG00000006552	LSM6	100	100.000	Papio_anubis
ENSCGRG00000008320	Lsm6	100	96.250	ENSPKIG00000016176	lsm6	100	96.250	Paramormyrops_kingsleyae
ENSCGRG00000008320	Lsm6	100	100.000	ENSPSIG00000016942	LSM6	100	100.000	Pelodiscus_sinensis
ENSCGRG00000008320	Lsm6	100	95.000	ENSPMGG00000018004	lsm6	100	95.000	Periophthalmus_magnuspinnatus
ENSCGRG00000008320	Lsm6	100	100.000	ENSPEMG00000012410	Lsm6	100	100.000	Peromyscus_maniculatus_bairdii
ENSCGRG00000008320	Lsm6	100	98.750	ENSPMAG00000006949	lsm6	100	98.750	Petromyzon_marinus
ENSCGRG00000008320	Lsm6	100	100.000	ENSPCIG00000023469	LSM6	80	100.000	Phascolarctos_cinereus
ENSCGRG00000008320	Lsm6	100	95.000	ENSPFOG00000008881	lsm6	100	95.000	Poecilia_formosa
ENSCGRG00000008320	Lsm6	100	95.000	ENSPLAG00000003202	lsm6	100	95.000	Poecilia_latipinna
ENSCGRG00000008320	Lsm6	100	95.000	ENSPMEG00000004000	lsm6	100	95.000	Poecilia_mexicana
ENSCGRG00000008320	Lsm6	100	95.000	ENSPREG00000023235	lsm6	100	95.000	Poecilia_reticulata
ENSCGRG00000008320	Lsm6	100	100.000	ENSPPYG00000015105	LSM6	100	100.000	Pongo_abelii
ENSCGRG00000008320	Lsm6	100	100.000	ENSPCOG00000013899	LSM6	100	100.000	Propithecus_coquereli
ENSCGRG00000008320	Lsm6	100	95.000	ENSPNYG00000012614	lsm6	100	95.000	Pundamilia_nyererei
ENSCGRG00000008320	Lsm6	100	96.250	ENSPNAG00000018779	lsm6	100	96.250	Pygocentrus_nattereri
ENSCGRG00000008320	Lsm6	100	100.000	ENSRNOG00000030374	Lsm6	100	100.000	Rattus_norvegicus
ENSCGRG00000008320	Lsm6	100	100.000	ENSRNOG00000049370	LOC100360750	100	100.000	Rattus_norvegicus
ENSCGRG00000008320	Lsm6	100	100.000	ENSRBIG00000027878	LSM6	100	100.000	Rhinopithecus_bieti
ENSCGRG00000008320	Lsm6	100	100.000	ENSRROG00000024868	LSM6	100	100.000	Rhinopithecus_roxellana
ENSCGRG00000008320	Lsm6	95	41.250	YDR378C	-	93	45.000	Saccharomyces_cerevisiae
ENSCGRG00000008320	Lsm6	100	73.750	ENSSBOG00000028103	-	100	73.750	Saimiri_boliviensis_boliviensis
ENSCGRG00000008320	Lsm6	100	100.000	ENSSBOG00000021229	-	100	100.000	Saimiri_boliviensis_boliviensis
ENSCGRG00000008320	Lsm6	100	96.250	ENSSFOG00015016480	lsm6	100	96.250	Scleropages_formosus
ENSCGRG00000008320	Lsm6	100	95.000	ENSSMAG00000004550	lsm6	100	95.000	Scophthalmus_maximus
ENSCGRG00000008320	Lsm6	100	95.000	ENSSDUG00000020459	lsm6	50	95.000	Seriola_dumerili
ENSCGRG00000008320	Lsm6	86	97.101	ENSSLDG00000004136	-	59	97.101	Seriola_lalandi_dorsalis
ENSCGRG00000008320	Lsm6	100	95.000	ENSSLDG00000020533	lsm6	83	95.000	Seriola_lalandi_dorsalis
ENSCGRG00000008320	Lsm6	60	100.000	ENSSARG00000000689	LSM6	100	100.000	Sorex_araneus
ENSCGRG00000008320	Lsm6	100	100.000	ENSSPUG00000008657	LSM6	100	100.000	Sphenodon_punctatus
ENSCGRG00000008320	Lsm6	100	95.000	ENSSPAG00000003246	lsm6	100	95.000	Stegastes_partitus
ENSCGRG00000008320	Lsm6	100	100.000	ENSSSCG00000035973	LSM6	100	100.000	Sus_scrofa
ENSCGRG00000008320	Lsm6	100	100.000	ENSTGUG00000002663	LSM6	100	100.000	Taeniopygia_guttata
ENSCGRG00000008320	Lsm6	100	95.000	ENSTRUG00000023398	lsm6	100	95.000	Takifugu_rubripes
ENSCGRG00000008320	Lsm6	100	95.000	ENSTNIG00000017725	lsm6	100	95.000	Tetraodon_nigroviridis
ENSCGRG00000008320	Lsm6	100	100.000	ENSTTRG00000004609	LSM6	100	100.000	Tursiops_truncatus
ENSCGRG00000008320	Lsm6	98	91.026	ENSUAMG00000014213	LSM6	64	91.026	Ursus_americanus
ENSCGRG00000008320	Lsm6	98	91.026	ENSUMAG00000015727	LSM6	64	91.026	Ursus_maritimus
ENSCGRG00000008320	Lsm6	100	100.000	ENSVPAG00000006922	LSM6	100	100.000	Vicugna_pacos
ENSCGRG00000008320	Lsm6	100	100.000	ENSVVUG00000009254	LSM6	68	100.000	Vulpes_vulpes
ENSCGRG00000008320	Lsm6	100	100.000	ENSXETG00000023683	lsm6	100	100.000	Xenopus_tropicalis
ENSCGRG00000008320	Lsm6	100	95.000	ENSXMAG00000009606	lsm6	100	95.000	Xiphophorus_maculatus