EuRBPDB

Description

RBDs

Transcripts

Gene Model

PPI

Orthologs

Description

Ensembl ID: ENSCGRG00001022261 (Gene tree)
Gene ID: -
Gene Symbol: Mdm2
Alias: 1700007J15Rik|Mdm-2
Full Name: transformed mouse 3T3 cell double minute 2
Gene Type: protein_coding
Species: Cricetulus_griseus_chok1gshd
Status: putative
Strand: Plus strand
Length: 18919 bases
Position: chrscaffold_7:75171690-75190608
Accession: 96952
RBP type: canonical RBP
Summary: -

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSCGRP00001024298	zf-RanBP	PF00641.18	9.9e-09	1	1

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENSCGRT00001028544	-	1437	-	ENSCGRP00001024298	478 (aa)	-	-

Gene Model

Click here to download ENSCGRG00001022261's gene model file

Protein-Protein Interaction (PPI)

Clik here to download ENSCGRG00001022261's network

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSCGRG00001022261	Mdm2	99	84.082	ENSG00000135679	MDM2	100	91.304	Homo_sapiens
ENSCGRG00001022261	Mdm2	99	31.335	ENSG00000198625	MDM4	98	47.368	Homo_sapiens
ENSCGRG00001022261	Mdm2	99	32.816	ENSAMEG00000001126	MDM4	99	32.046	Ailuropoda_melanoleuca
ENSCGRG00001022261	Mdm2	99	84.286	ENSAMEG00000008526	MDM2	99	84.286	Ailuropoda_melanoleuca
ENSCGRG00001022261	Mdm2	99	62.628	ENSAPLG00000011164	MDM2	99	62.628	Anas_platyrhynchos
ENSCGRG00001022261	Mdm2	94	58.120	ENSACAG00000004204	MDM2	85	58.190	Anolis_carolinensis
ENSCGRG00001022261	Mdm2	97	80.526	ENSANAG00000027171	-	99	90.385	Aotus_nancymaae
ENSCGRG00001022261	Mdm2	99	31.774	ENSANAG00000036891	MDM4	99	31.373	Aotus_nancymaae
ENSCGRG00001022261	Mdm2	100	32.544	ENSBTAG00000006255	MDM4	100	31.936	Bos_taurus
ENSCGRG00001022261	Mdm2	99	85.132	ENSBTAG00000010422	MDM2	99	85.132	Bos_taurus
ENSCGRG00001022261	Mdm2	99	31.164	ENSCJAG00000016986	MDM4	99	31.485	Callithrix_jacchus
ENSCGRG00001022261	Mdm2	99	83.128	ENSCJAG00000007464	-	86	83.128	Callithrix_jacchus
ENSCGRG00001022261	Mdm2	99	82.857	ENSCJAG00000042596	-	98	82.857	Callithrix_jacchus
ENSCGRG00001022261	Mdm2	55	54.478	ENSCJAG00000040017	-	99	54.478	Callithrix_jacchus
ENSCGRG00001022261	Mdm2	99	33.135	ENSCAFG00000009669	MDM4	99	32.039	Canis_familiaris
ENSCGRG00001022261	Mdm2	97	83.898	ENSCAFG00000000418	MDM2	94	83.898	Canis_familiaris
ENSCGRG00001022261	Mdm2	58	31.944	ENSCAFG00020005984	MDM4	79	31.900	Canis_lupus_dingo
ENSCGRG00001022261	Mdm2	99	84.156	ENSCAFG00020017002	MDM2	99	84.156	Canis_lupus_dingo
ENSCGRG00001022261	Mdm2	99	33.134	ENSCHIG00000010343	-	99	32.475	Capra_hircus
ENSCGRG00001022261	Mdm2	99	84.898	ENSCHIG00000019939	-	99	84.898	Capra_hircus
ENSCGRG00001022261	Mdm2	92	71.236	ENSTSYG00000031248	-	99	70.833	Carlito_syrichta
ENSCGRG00001022261	Mdm2	100	31.507	ENSTSYG00000010731	MDM4	100	30.784	Carlito_syrichta
ENSCGRG00001022261	Mdm2	95	30.185	ENSCAPG00000011380	MDM4	97	30.705	Cavia_aperea
ENSCGRG00001022261	Mdm2	97	30.938	ENSCPOG00000008227	MDM4	99	31.275	Cavia_porcellus
ENSCGRG00001022261	Mdm2	100	83.910	ENSCPOG00000004323	MDM2	100	83.910	Cavia_porcellus
ENSCGRG00001022261	Mdm2	99	83.740	ENSCCAG00000006745	-	99	90.385	Cebus_capucinus
ENSCGRG00001022261	Mdm2	99	31.349	ENSCCAG00000031000	MDM4	99	30.938	Cebus_capucinus
ENSCGRG00001022261	Mdm2	99	31.528	ENSCATG00000027086	MDM4	99	31.349	Cercocebus_atys
ENSCGRG00001022261	Mdm2	99	84.286	ENSCATG00000045264	-	99	90.385	Cercocebus_atys
ENSCGRG00001022261	Mdm2	100	31.434	ENSCLAG00000011995	MDM4	100	30.648	Chinchilla_lanigera
ENSCGRG00001022261	Mdm2	100	82.485	ENSCLAG00000009877	MDM2	98	82.485	Chinchilla_lanigera
ENSCGRG00001022261	Mdm2	99	31.528	ENSCSAG00000014561	MDM4	99	31.151	Chlorocebus_sabaeus
ENSCGRG00001022261	Mdm2	99	84.286	ENSCSAG00000004244	MDM2	99	84.286	Chlorocebus_sabaeus
ENSCGRG00001022261	Mdm2	54	33.579	ENSCHOG00000008147	-	66	33.579	Choloepus_hoffmanni
ENSCGRG00001022261	Mdm2	100	64.300	ENSCPBG00000013316	MDM2	100	64.097	Chrysemys_picta_bellii
ENSCGRG00001022261	Mdm2	99	83.878	ENSCANG00000034475	MDM2	99	88.462	Colobus_angolensis_palliatus
ENSCGRG00001022261	Mdm2	100	99.376	ENSCGRG00000017891	Mdm2	100	99.376	Cricetulus_griseus_crigri
ENSCGRG00001022261	Mdm2	99	32.745	ENSDNOG00000000842	MDM4	99	32.613	Dasypus_novemcinctus
ENSCGRG00001022261	Mdm2	99	83.265	ENSDNOG00000046929	-	96	83.265	Dasypus_novemcinctus
ENSCGRG00001022261	Mdm2	100	69.184	ENSDORG00000007222	Mdm2	100	88.462	Dipodomys_ordii
ENSCGRG00001022261	Mdm2	94	33.891	ENSDORG00000006873	Mdm4	96	32.640	Dipodomys_ordii
ENSCGRG00001022261	Mdm2	77	53.261	ENSETEG00000011245	MDM4	74	53.261	Echinops_telfairi
ENSCGRG00001022261	Mdm2	99	65.923	ENSETEG00000011183	MDM2	89	79.532	Echinops_telfairi
ENSCGRG00001022261	Mdm2	99	33.201	ENSEASG00005011431	MDM4	99	32.079	Equus_asinus_asinus
ENSCGRG00001022261	Mdm2	99	75.410	ENSEASG00005008055	-	99	75.410	Equus_asinus_asinus
ENSCGRG00001022261	Mdm2	99	33.201	ENSECAG00000004843	MDM4	99	32.079	Equus_caballus
ENSCGRG00001022261	Mdm2	99	75.102	ENSECAG00000013604	MDM2	99	75.102	Equus_caballus
ENSCGRG00001022261	Mdm2	64	42.342	ENSEEUG00000013912	MDM4	63	42.342	Erinaceus_europaeus
ENSCGRG00001022261	Mdm2	99	75.256	ENSEEUG00000013849	MDM2	99	75.256	Erinaceus_europaeus
ENSCGRG00001022261	Mdm2	98	30.485	ENSELUG00000011889	mdm4	98	30.677	Esox_lucius
ENSCGRG00001022261	Mdm2	100	32.480	ENSFCAG00000014851	MDM4	100	32.079	Felis_catus
ENSCGRG00001022261	Mdm2	99	84.898	ENSFCAG00000024456	MDM2	99	92.308	Felis_catus
ENSCGRG00001022261	Mdm2	100	84.725	ENSFDAG00000007913	-	97	84.725	Fukomys_damarensis
ENSCGRG00001022261	Mdm2	99	62.705	ENSGALG00000009942	MDM2	99	62.295	Gallus_gallus
ENSCGRG00001022261	Mdm2	86	61.176	ENSGAGG00000017565	-	80	61.176	Gopherus_agassizii
ENSCGRG00001022261	Mdm2	99	83.878	ENSGGOG00000012907	MDM2	99	90.385	Gorilla_gorilla
ENSCGRG00001022261	Mdm2	99	31.335	ENSGGOG00000012957	MDM4	99	31.683	Gorilla_gorilla
ENSCGRG00001022261	Mdm2	100	79.022	ENSHGLG00000016066	-	100	79.022	Heterocephalus_glaber_female
ENSCGRG00001022261	Mdm2	100	84.898	ENSHGLG00000000856	-	100	84.898	Heterocephalus_glaber_female
ENSCGRG00001022261	Mdm2	100	81.059	ENSHGLG00000020526	-	97	82.077	Heterocephalus_glaber_female
ENSCGRG00001022261	Mdm2	100	31.496	ENSHGLG00000007642	MDM4	100	30.385	Heterocephalus_glaber_female
ENSCGRG00001022261	Mdm2	100	31.890	ENSHGLG00100006704	-	100	30.577	Heterocephalus_glaber_male
ENSCGRG00001022261	Mdm2	83	83.659	ENSHGLG00100000441	-	100	83.529	Heterocephalus_glaber_male
ENSCGRG00001022261	Mdm2	94	31.303	ENSHCOG00000008924	mdm4	56	31.227	Hippocampus_comes
ENSCGRG00001022261	Mdm2	99	30.417	ENSIPUG00000024447	mdm4	99	30.469	Ictalurus_punctatus
ENSCGRG00001022261	Mdm2	100	84.521	ENSSTOG00000014702	-	100	84.521	Ictidomys_tridecemlineatus
ENSCGRG00001022261	Mdm2	57	30.420	ENSSTOG00000024007	-	61	30.325	Ictidomys_tridecemlineatus
ENSCGRG00001022261	Mdm2	100	31.299	ENSSTOG00000004184	MDM4	100	31.102	Ictidomys_tridecemlineatus
ENSCGRG00001022261	Mdm2	100	31.579	ENSJJAG00000017144	Mdm4	100	32.079	Jaculus_jaculus
ENSCGRG00001022261	Mdm2	99	54.601	ENSLACG00000010207	MDM2	99	55.828	Latimeria_chalumnae
ENSCGRG00001022261	Mdm2	99	32.207	ENSLAFG00000002169	MDM4	99	32.669	Loxodonta_africana
ENSCGRG00001022261	Mdm2	99	80.894	ENSLAFG00000005885	MDM2	99	80.894	Loxodonta_africana
ENSCGRG00001022261	Mdm2	90	30.000	ENSMFAG00000033606	MDM4	81	31.000	Macaca_fascicularis
ENSCGRG00001022261	Mdm2	99	84.286	ENSMFAG00000042359	MDM2	99	90.385	Macaca_fascicularis
ENSCGRG00001022261	Mdm2	99	84.286	ENSMMUG00000014193	MDM2	99	90.385	Macaca_mulatta
ENSCGRG00001022261	Mdm2	90	30.000	ENSMMUG00000011236	MDM4	81	31.000	Macaca_mulatta
ENSCGRG00001022261	Mdm2	99	84.286	ENSMNEG00000041135	MDM2	99	90.385	Macaca_nemestrina
ENSCGRG00001022261	Mdm2	90	30.508	ENSMNEG00000026547	MDM4	99	30.283	Macaca_nemestrina
ENSCGRG00001022261	Mdm2	99	31.528	ENSMLEG00000032041	MDM4	99	31.349	Mandrillus_leucophaeus
ENSCGRG00001022261	Mdm2	99	84.286	ENSMLEG00000042099	MDM2	99	90.385	Mandrillus_leucophaeus
ENSCGRG00001022261	Mdm2	91	62.584	ENSMGAG00000010513	MDM2	100	62.171	Meleagris_gallopavo
ENSCGRG00001022261	Mdm2	94	32.438	ENSMICG00000017021	MDM4	95	32.365	Microcebus_murinus
ENSCGRG00001022261	Mdm2	99	77.938	ENSMICG00000029037	-	99	88.462	Microcebus_murinus
ENSCGRG00001022261	Mdm2	99	62.910	ENSMICG00000046928	-	98	63.374	Microcebus_murinus
ENSCGRG00001022261	Mdm2	100	32.809	ENSMOCG00000002099	Mdm4	100	32.046	Microtus_ochrogaster
ENSCGRG00001022261	Mdm2	100	85.802	ENSMOCG00000008043	Mdm2	100	88.501	Microtus_ochrogaster
ENSCGRG00001022261	Mdm2	99	69.262	ENSMODG00000007219	-	99	69.262	Monodelphis_domestica
ENSCGRG00001022261	Mdm2	100	80.202	MGP_CAROLIEiJ_G0015836	Mdm2	100	80.808	Mus_caroli
ENSCGRG00001022261	Mdm2	100	31.373	MGP_CAROLIEiJ_G0014593	Mdm4	100	30.906	Mus_caroli
ENSCGRG00001022261	Mdm2	100	30.948	ENSMUSG00000054387	Mdm4	100	31.395	Mus_musculus
ENSCGRG00001022261	Mdm2	100	82.653	ENSMUSG00000020184	Mdm2	100	82.653	Mus_musculus
ENSCGRG00001022261	Mdm2	100	31.361	MGP_PahariEiJ_G0027829	Mdm4	100	31.703	Mus_pahari
ENSCGRG00001022261	Mdm2	100	81.855	MGP_PahariEiJ_G0031251	Mdm2	100	82.460	Mus_pahari
ENSCGRG00001022261	Mdm2	100	31.703	MGP_SPRETEiJ_G0015400	Mdm4	100	31.202	Mus_spretus
ENSCGRG00001022261	Mdm2	100	83.402	MGP_SPRETEiJ_G0016659	Mdm2	100	82.377	Mus_spretus
ENSCGRG00001022261	Mdm2	99	32.812	ENSMPUG00000011721	MDM4	99	31.346	Mustela_putorius_furo
ENSCGRG00001022261	Mdm2	99	83.265	ENSMPUG00000017505	MDM2	99	83.265	Mustela_putorius_furo
ENSCGRG00001022261	Mdm2	94	31.313	ENSMLUG00000007129	MDM4	95	30.120	Myotis_lucifugus
ENSCGRG00001022261	Mdm2	100	80.162	ENSMLUG00000009997	MDM2	99	80.162	Myotis_lucifugus
ENSCGRG00001022261	Mdm2	96	31.976	ENSNGAG00000012344	Mdm4	96	31.683	Nannospalax_galili
ENSCGRG00001022261	Mdm2	100	82.957	ENSNGAG00000012154	Mdm2	100	85.010	Nannospalax_galili
ENSCGRG00001022261	Mdm2	99	84.082	ENSNLEG00000003757	MDM2	99	90.385	Nomascus_leucogenys
ENSCGRG00001022261	Mdm2	99	31.335	ENSNLEG00000014271	MDM4	99	30.620	Nomascus_leucogenys
ENSCGRG00001022261	Mdm2	81	50.000	ENSMEUG00000012624	-	82	50.000	Notamacropus_eugenii
ENSCGRG00001022261	Mdm2	100	76.578	ENSOPRG00000009677	MDM2	99	78.208	Ochotona_princeps
ENSCGRG00001022261	Mdm2	94	31.743	ENSOPRG00000013878	MDM4	100	30.470	Ochotona_princeps
ENSCGRG00001022261	Mdm2	100	80.453	ENSODEG00000004028	-	100	80.453	Octodon_degus
ENSCGRG00001022261	Mdm2	100	30.695	ENSODEG00000013499	MDM4	100	31.055	Octodon_degus
ENSCGRG00001022261	Mdm2	100	66.119	ENSODEG00000000416	-	100	75.598	Octodon_degus
ENSCGRG00001022261	Mdm2	99	70.417	ENSODEG00000006648	-	99	70.417	Octodon_degus
ENSCGRG00001022261	Mdm2	94	32.851	ENSOANG00000013464	MDM4	99	32.285	Ornithorhynchus_anatinus
ENSCGRG00001022261	Mdm2	90	67.955	ENSOANG00000005942	MDM2	100	66.591	Ornithorhynchus_anatinus
ENSCGRG00001022261	Mdm2	100	82.759	ENSOCUG00000010899	-	64	84.381	Oryctolagus_cuniculus
ENSCGRG00001022261	Mdm2	100	30.874	ENSOCUG00000000005	MDM4	100	30.077	Oryctolagus_cuniculus
ENSCGRG00001022261	Mdm2	99	77.959	ENSOCUG00000011354	-	99	78.163	Oryctolagus_cuniculus
ENSCGRG00001022261	Mdm2	99	74.694	ENSOGAG00000011845	-	99	74.694	Otolemur_garnettii
ENSCGRG00001022261	Mdm2	99	75.911	ENSOGAG00000034779	MDM2	99	75.911	Otolemur_garnettii
ENSCGRG00001022261	Mdm2	99	84.490	ENSOARG00000013821	-	99	84.490	Ovis_aries
ENSCGRG00001022261	Mdm2	99	84.350	ENSOARG00000000570	-	99	84.350	Ovis_aries
ENSCGRG00001022261	Mdm2	99	32.549	ENSOARG00000002783	-	99	32.353	Ovis_aries
ENSCGRG00001022261	Mdm2	99	84.082	ENSPPAG00000032775	MDM2	99	90.385	Pan_paniscus
ENSCGRG00001022261	Mdm2	99	31.528	ENSPPAG00000030518	MDM4	99	30.814	Pan_paniscus
ENSCGRG00001022261	Mdm2	100	32.480	ENSPPRG00000025076	MDM4	100	32.079	Panthera_pardus
ENSCGRG00001022261	Mdm2	99	85.306	ENSPPRG00000000082	MDM2	99	92.308	Panthera_pardus
ENSCGRG00001022261	Mdm2	100	31.977	ENSPTIG00000011372	MDM4	100	31.599	Panthera_tigris_altaica
ENSCGRG00001022261	Mdm2	99	85.102	ENSPTIG00000016929	MDM2	99	92.308	Panthera_tigris_altaica
ENSCGRG00001022261	Mdm2	99	84.082	ENSPTRG00000005203	MDM2	99	90.385	Pan_troglodytes
ENSCGRG00001022261	Mdm2	99	31.528	ENSPTRG00000001889	MDM4	99	30.814	Pan_troglodytes
ENSCGRG00001022261	Mdm2	99	84.286	ENSPANG00000005563	MDM2	99	90.385	Papio_anubis
ENSCGRG00001022261	Mdm2	99	31.335	ENSPANG00000008555	MDM4	99	31.151	Papio_anubis
ENSCGRG00001022261	Mdm2	92	62.335	ENSPSIG00000016379	-	100	62.187	Pelodiscus_sinensis
ENSCGRG00001022261	Mdm2	99	32.094	ENSPEMG00000018483	Mdm4	98	30.888	Peromyscus_maniculatus_bairdii
ENSCGRG00001022261	Mdm2	99	32.079	ENSPCIG00000017446	MDM4	100	31.008	Phascolarctos_cinereus
ENSCGRG00001022261	Mdm2	99	70.988	ENSPCIG00000005357	-	99	70.988	Phascolarctos_cinereus
ENSCGRG00001022261	Mdm2	99	31.349	ENSPPYG00000000315	MDM4	99	31.151	Pongo_abelii
ENSCGRG00001022261	Mdm2	99	83.673	ENSPPYG00000004754	MDM2	99	83.673	Pongo_abelii
ENSCGRG00001022261	Mdm2	99	78.049	ENSPCAG00000008949	MDM2	99	78.049	Procavia_capensis
ENSCGRG00001022261	Mdm2	100	32.341	ENSPCOG00000024397	MDM4	100	32.341	Propithecus_coquereli
ENSCGRG00001022261	Mdm2	89	80.822	ENSPCOG00000018521	-	99	82.877	Propithecus_coquereli
ENSCGRG00001022261	Mdm2	100	79.878	ENSPVAG00000006202	MDM2	99	79.878	Pteropus_vampyrus
ENSCGRG00001022261	Mdm2	80	46.296	ENSPVAG00000005663	MDM4	77	45.045	Pteropus_vampyrus
ENSCGRG00001022261	Mdm2	100	84.298	ENSRNOG00000006304	Mdm2	100	84.298	Rattus_norvegicus
ENSCGRG00001022261	Mdm2	100	30.739	ENSRNOG00000009696	Mdm4	100	30.725	Rattus_norvegicus
ENSCGRG00001022261	Mdm2	99	84.286	ENSRBIG00000028561	MDM2	99	90.385	Rhinopithecus_bieti
ENSCGRG00001022261	Mdm2	99	31.141	ENSRBIG00000038824	MDM4	99	30.952	Rhinopithecus_bieti
ENSCGRG00001022261	Mdm2	99	84.082	ENSRROG00000045589	-	99	90.385	Rhinopithecus_roxellana
ENSCGRG00001022261	Mdm2	99	31.141	ENSRROG00000027771	MDM4	99	30.952	Rhinopithecus_roxellana
ENSCGRG00001022261	Mdm2	99	31.558	ENSSBOG00000036183	-	99	30.754	Saimiri_boliviensis_boliviensis
ENSCGRG00001022261	Mdm2	99	83.878	ENSSBOG00000014544	-	99	90.385	Saimiri_boliviensis_boliviensis
ENSCGRG00001022261	Mdm2	92	30.426	ENSSBOG00000020446	-	68	30.686	Saimiri_boliviensis_boliviensis
ENSCGRG00001022261	Mdm2	99	69.796	ENSSHAG00000010284	-	99	67.755	Sarcophilus_harrisii
ENSCGRG00001022261	Mdm2	84	63.196	ENSSHAG00000000124	-	100	61.893	Sarcophilus_harrisii
ENSCGRG00001022261	Mdm2	100	31.337	ENSSFOG00015001112	mdm4	100	30.739	Scleropages_formosus
ENSCGRG00001022261	Mdm2	99	79.184	ENSSARG00000005801	MDM2	100	79.388	Sorex_araneus
ENSCGRG00001022261	Mdm2	99	60.896	ENSSPUG00000000964	MDM2	99	60.204	Sphenodon_punctatus
ENSCGRG00001022261	Mdm2	99	84.082	ENSSSCG00000000488	MDM2	99	84.082	Sus_scrofa
ENSCGRG00001022261	Mdm2	99	31.827	ENSSSCG00000015284	MDM4	99	31.507	Sus_scrofa
ENSCGRG00001022261	Mdm2	92	62.472	ENSTGUG00000006836	MDM2	100	62.821	Taeniopygia_guttata
ENSCGRG00001022261	Mdm2	82	88.889	ENSTBEG00000013758	MDM2	80	88.889	Tupaia_belangeri
ENSCGRG00001022261	Mdm2	100	31.746	ENSTTRG00000012174	MDM4	100	31.746	Tursiops_truncatus
ENSCGRG00001022261	Mdm2	92	73.836	ENSTTRG00000015715	MDM2	93	74.298	Tursiops_truncatus
ENSCGRG00001022261	Mdm2	99	82.932	ENSUAMG00000018322	-	99	94.231	Ursus_americanus
ENSCGRG00001022261	Mdm2	99	32.816	ENSUAMG00000007328	MDM4	99	32.046	Ursus_americanus
ENSCGRG00001022261	Mdm2	99	31.774	ENSUMAG00000003452	MDM4	74	32.039	Ursus_maritimus
ENSCGRG00001022261	Mdm2	99	84.082	ENSUMAG00000020757	MDM2	99	84.082	Ursus_maritimus
ENSCGRG00001022261	Mdm2	94	32.773	ENSVPAG00000012034	MDM4	99	32.218	Vicugna_pacos
ENSCGRG00001022261	Mdm2	99	79.388	ENSVPAG00000007456	MDM2	99	79.388	Vicugna_pacos
ENSCGRG00001022261	Mdm2	99	33.201	ENSVVUG00000014855	MDM4	99	30.798	Vulpes_vulpes
ENSCGRG00001022261	Mdm2	99	51.324	ENSXETG00000001434	mdm2	99	50.102	Xenopus_tropicalis