EuRBPDB

  • Home
  • Cancer
  • Family
  • Species
  • RBPredictor
  • Search
  • Download
  • Submit
  • Help
  • Contact

  • Description
  • RBDs
  • Transcripts
  • Gene Model
  • Pathways
  • PPI
  • Paralogs
  • Orthologs
Description
Ensembl ID
ENSCHIG00000004808 (Gene tree)
Gene ID
102186668
Gene Symbol
HRAS
Alias
HRAS1
Full Name
HRas proto-oncogene%2C GTPase
Gene Type
protein_coding
Species
Capra_hircus
Status
putative
Strand
Plus strand
Length
2701 bases
Position
chr29:45894519-45897219
Accession
102186668
RBP type
canonical RBP
Summary
-
RNA binding domains(RBDs)
Protein IDDomain Pfam IDE-value Domain number Total number
ENSCHIP00000002188MMR_HSR1PF01926.232.6e-0511
ENSCHIP00000002180MMR_HSR1PF01926.233.2e-0511
Transcripts
Transcript IDNameLengthRefSeq ID Protein IDLengthRefSeq IDUniportKB ID
ENSCHIT00000006681HRAS-201791XM_018043553ENSCHIP00000002180189 (aa)XP_017899042UPI0005FBDF0E
ENSCHIT00000006703HRAS-202753XM_018043555ENSCHIP00000002188170 (aa)XP_017899044UPI0005FAC22E
Gene Model
Click here to download ENSCHIG00000004808's gene model file
Pathways
Pathway IDPathway NameSource
chx01521EGFR tyrosine kinase inhibitor resistanceKEGG
chx01522Endocrine resistanceKEGG
chx04010MAPK signaling pathwayKEGG
chx04012ErbB signaling pathwayKEGG
chx04014Ras signaling pathwayKEGG
chx04015Rap1 signaling pathwayKEGG
chx04062Chemokine signaling pathwayKEGG
chx04068FoxO signaling pathwayKEGG
chx04071Sphingolipid signaling pathwayKEGG
chx04072Phospholipase D signaling pathwayKEGG
chx04137Mitophagy - animalKEGG
chx04140Autophagy - animalKEGG
chx04144EndocytosisKEGG
chx04150mTOR signaling pathwayKEGG
chx04151PI3K-Akt signaling pathwayKEGG
chx04210ApoptosisKEGG
chx04211Longevity regulating pathwayKEGG
chx04213Longevity regulating pathway - multiple speciesKEGG
chx04218Cellular senescenceKEGG
chx04360Axon guidanceKEGG
chx04370VEGF signaling pathwayKEGG
chx04371Apelin signaling pathwayKEGG
chx04510Focal adhesionKEGG
chx04540Gap junctionKEGG
chx04550Signaling pathways regulating pluripotency of stem cellsKEGG
chx04625C-type lectin receptor signaling pathwayKEGG
chx04630JAK-STAT signaling pathwayKEGG
chx04650Natural killer cell mediated cytotoxicityKEGG
chx04660T cell receptor signaling pathwayKEGG
chx04662B cell receptor signaling pathwayKEGG
chx04664Fc epsilon RI signaling pathwayKEGG
chx04714ThermogenesisKEGG
chx04720Long-term potentiationKEGG
chx04722Neurotrophin signaling pathwayKEGG
chx04725Cholinergic synapseKEGG
chx04726Serotonergic synapseKEGG
chx04730Long-term depressionKEGG
chx04810Regulation of actin cytoskeletonKEGG
chx04910Insulin signaling pathwayKEGG
chx04912GnRH signaling pathwayKEGG
chx04915Estrogen signaling pathwayKEGG
chx04916MelanogenesisKEGG
chx04917Prolactin signaling pathwayKEGG
chx04919Thyroid hormone signaling pathwayKEGG
chx04921Oxytocin signaling pathwayKEGG
chx04926Relaxin signaling pathwayKEGG
chx04933AGE-RAGE signaling pathway in diabetic complicationsKEGG
chx05034AlcoholismKEGG
chx05160Hepatitis CKEGG
chx05161Hepatitis BKEGG
chx05163Human cytomegalovirus infectionKEGG
chx05165Human papillomavirus infectionKEGG
chx05166Human T-cell leukemia virus 1 infectionKEGG
chx05167Kaposi sarcoma-associated herpesvirus infectionKEGG
chx05170Human immunodeficiency virus 1 infectionKEGG
chx05200Pathways in cancerKEGG
chx05203Viral carcinogenesisKEGG
chx05205Proteoglycans in cancerKEGG
chx05206MicroRNAs in cancerKEGG
chx05210Colorectal cancerKEGG
chx05211Renal cell carcinomaKEGG
chx05213Endometrial cancerKEGG
chx05214GliomaKEGG
chx05215Prostate cancerKEGG
chx05216Thyroid cancerKEGG
chx05218MelanomaKEGG
chx05219Bladder cancerKEGG
chx05220Chronic myeloid leukemiaKEGG
chx05221Acute myeloid leukemiaKEGG
chx05223Non-small cell lung cancerKEGG
chx05224Breast cancerKEGG
chx05225Hepatocellular carcinomaKEGG
chx05226Gastric cancerKEGG
chx05230Central carbon metabolism in cancerKEGG
chx05231Choline metabolism in cancerKEGG
Protein-Protein Interaction (PPI)

Clik here to download ENSCHIG00000004808's network
Paralogs
Ensembl IDGene SymbolCoverageIdentiy ParalogGene SymbolCoverageIdentiy
ENSCHIG00000004808HRAS9984.574ENSCHIG00000023175NRAS9984.574
ENSCHIG00000004808HRAS9630.808ENSCHIG00000001138RAB7A6632.117
ENSCHIG00000004808HRAS9736.559ENSCHIG00000000158RAB39B8736.559
ENSCHIG00000004808HRAS8732.000ENSCHIG00000016452RAB6B7531.646
ENSCHIG00000004808HRAS9534.615ENSCHIG00000015549RAB1B8534.615
ENSCHIG00000004808HRAS8632.215ENSCHIG00000023957RAB6A7531.646
ENSCHIG00000004808HRAS9236.464ENSCHIG00000020393RAB33B7936.464
ENSCHIG00000004808HRAS8841.071ENSCHIG00000011004RERG8441.071
ENSCHIG00000004808HRAS9985.714ENSCHIG00000026575KRAS9985.714
ENSCHIG00000004808HRAS8535.802ENSCHIG00000017531-7235.333
ENSCHIG00000004808HRAS9332.584ENSCHIG00000010333RAB5B8032.584
ENSCHIG00000004808HRAS9335.028ENSCHIG00000014060RAB1A8435.028
ENSCHIG00000004808HRAS8930.921ENSCHIG00000008749RAB189631.313
ENSCHIG00000004808HRAS8434.459ENSCHIG00000002776RAB9B7632.680
ENSCHIG00000004808HRAS9531.319ENSCHIG00000017305RAB22A9031.333
ENSCHIG00000004808HRAS8559.310ENSCHIG00000025837MRAS8056.886
ENSCHIG00000004808HRAS8933.143ENSCHIG00000025288RAB157432.515
ENSCHIG00000004808HRAS8733.333ENSCHIG00000025419-7731.138
ENSCHIG00000004808HRAS8539.506ENSCHIG00000022271-7939.506
ENSCHIG00000004808HRAS8436.806ENSCHIG00000022426-6735.333
ENSCHIG00000004808HRAS8537.654ENSCHIG00000012183-6936.667
ENSCHIG00000004808HRAS8632.121ENSCHIG00000026983RAB147131.373
ENSCHIG00000004808HRAS8533.557ENSCHIG00000001895RAB9A7532.026
ENSCHIG00000004808HRAS9531.868ENSCHIG00000000146RAB318431.176
ENSCHIG00000004808HRAS8637.415ENSCHIG00000017350RHEB8036.486
ENSCHIG00000004808HRAS9232.000ENSCHIG00000009815RAB235632.090
ENSCHIG00000004808HRAS8535.802ENSCHIG00000020374RAB2A7035.333
ENSCHIG00000004808HRAS9431.111ENSCHIG00000012960RAB5C8131.111
ENSCHIG00000004808HRAS9431.720ENSCHIG00000018911RAB258130.636
ENSCHIG00000004808HRAS9533.333ENSCHIG00000020601RAB308934.254
Orthologs
Ensembl IDGene SymbolCoverageIdentiy OrthologGene SymbolCoverageIdentiy Species
ENSCHIG00000004808HRAS9998.225ENSG00000174775HRAS9998.225Homo_sapiens
ENSCHIG00000004808HRAS10093.122ENSAPOG00000023684hrasb10093.122Acanthochromis_polyacanthus
ENSCHIG00000004808HRAS10098.942ENSAMEG00000010515HRAS7598.942Ailuropoda_melanoleuca
ENSCHIG00000004808HRAS10093.122ENSACIG00000000699hrasb10093.122Amphilophus_citrinellus
ENSCHIG00000004808HRAS10093.122ENSAOCG00000011843hrasb10093.122Amphiprion_ocellaris
ENSCHIG00000004808HRAS10093.122ENSAPEG00000009546hrasb10093.122Amphiprion_percula
ENSCHIG00000004808HRAS10093.122ENSATEG00000020001hrasb10093.122Anabas_testudineus
ENSCHIG00000004808HRAS8998.013ENSAPLG00000012248HRAS10098.171Anas_platyrhynchos
ENSCHIG00000004808HRAS10093.651ENSACAG00000014920HRAS10093.651Anolis_carolinensis
ENSCHIG00000004808HRAS9998.817ENSANAG00000034201HRAS9998.817Aotus_nancymaae
ENSCHIG00000004808HRAS10092.593ENSACLG00000001181hrasb10092.593Astatotilapia_calliptera
ENSCHIG00000004808HRAS10092.063ENSAMXG00000033907hrasb10092.063Astyanax_mexicanus
ENSCHIG00000004808HRAS10092.593ENSAMXG00000035885hrasa10092.593Astyanax_mexicanus
ENSCHIG00000004808HRAS10098.942ENSBTAG00000046644HRAS10098.942Bos_taurus
ENSCHIG00000004808HRAS8982.119WBGene00002335let-609281.065Caenorhabditis_elegans
ENSCHIG00000004808HRAS9998.817ENSCJAG00000012199HRAS9998.817Callithrix_jacchus
ENSCHIG00000004808HRAS9992.308ENSCAFG00000031029HRAS6099.333Canis_familiaris
ENSCHIG00000004808HRAS10098.824ENSCAFG00020007059HRAS10098.824Canis_lupus_dingo
ENSCHIG00000004808HRAS9998.225ENSTSYG00000003745HRAS9998.225Carlito_syrichta
ENSCHIG00000004808HRAS10095.767ENSCAPG00000000745HRAS10095.767Cavia_aperea
ENSCHIG00000004808HRAS10095.767ENSCPOG00000000101HRAS10095.767Cavia_porcellus
ENSCHIG00000004808HRAS9998.817ENSCCAG00000031453HRAS9998.817Cebus_capucinus
ENSCHIG00000004808HRAS9998.817ENSCATG00000031194HRAS9998.817Cercocebus_atys
ENSCHIG00000004808HRAS10095.767ENSCLAG00000002823HRAS10095.767Chinchilla_lanigera
ENSCHIG00000004808HRAS10096.296ENSCSAG00000011033HRAS10096.296Chlorocebus_sabaeus
ENSCHIG00000004808HRAS10093.651ENSCPBG00000013941-10093.651Chrysemys_picta_bellii
ENSCHIG00000004808HRAS9998.817ENSCANG00000017827HRAS9998.817Colobus_angolensis_palliatus
ENSCHIG00000004808HRAS9998.810ENSCGRG00001018735Hras10096.296Cricetulus_griseus_chok1gshd
ENSCHIG00000004808HRAS9998.810ENSCGRG00000010918Hras10096.296Cricetulus_griseus_crigri
ENSCHIG00000004808HRAS10093.122ENSCSEG00000007927hrasb10093.122Cynoglossus_semilaevis
ENSCHIG00000004808HRAS10092.593ENSCVAG00000008670hrasb10092.593Cyprinodon_variegatus
ENSCHIG00000004808HRAS10093.122ENSDARG00000098497hrasa10093.122Danio_rerio
ENSCHIG00000004808HRAS10092.063ENSDARG00000005651hrasb10096.528Danio_rerio
ENSCHIG00000004808HRAS8990.066ENSDARG00000013161zgc:555588988.623Danio_rerio
ENSCHIG00000004808HRAS9992.308ENSDNOG00000015293HRAS9992.308Dasypus_novemcinctus
ENSCHIG00000004808HRAS10096.296ENSDORG00000028079Hras10096.296Dipodomys_ordii
ENSCHIG00000004808HRAS8986.093FBgn0003205Ras85D9680.663Drosophila_melanogaster
ENSCHIG00000004808HRAS10093.651ENSETEG00000019899HRAS10093.651Echinops_telfairi
ENSCHIG00000004808HRAS10089.418ENSEBUG00000004670hrasb10089.418Eptatretus_burgeri
ENSCHIG00000004808HRAS10097.884ENSECAG00000008473HRAS10097.884Equus_caballus
ENSCHIG00000004808HRAS9196.129ENSEEUG00000014548HRAS9096.129Erinaceus_europaeus
ENSCHIG00000004808HRAS10093.122ENSELUG00000004712HRAS10093.122Esox_lucius
ENSCHIG00000004808HRAS10098.824ENSFCAG00000002990HRAS10098.824Felis_catus
ENSCHIG00000004808HRAS10094.180ENSFALG00000012145HRAS10094.180Ficedula_albicollis
ENSCHIG00000004808HRAS10098.235ENSFDAG00000006760HRAS10096.296Fukomys_damarensis
ENSCHIG00000004808HRAS10092.063ENSFHEG00000010055hrasb10092.063Fundulus_heteroclitus
ENSCHIG00000004808HRAS9494.382ENSGMOG00000010196hrasb9694.382Gadus_morhua
ENSCHIG00000004808HRAS10094.180ENSGALG00000029260H-RAS10094.180Gallus_gallus
ENSCHIG00000004808HRAS10093.122ENSGAFG00000021814hrasb10093.122Gambusia_affinis
ENSCHIG00000004808HRAS10093.122ENSGACG00000011340hrasb10093.122Gasterosteus_aculeatus
ENSCHIG00000004808HRAS10093.651ENSGAGG00000019886-10093.651Gopherus_agassizii
ENSCHIG00000004808HRAS9997.633ENSGGOG00000015438HRAS9997.633Gorilla_gorilla
ENSCHIG00000004808HRAS10092.593ENSHBUG00000011998hrasb10092.593Haplochromis_burtoni
ENSCHIG00000004808HRAS10095.767ENSHGLG00000004508HRAS10095.767Heterocephalus_glaber_female
ENSCHIG00000004808HRAS10095.767ENSHGLG00100012888HRAS10095.767Heterocephalus_glaber_male
ENSCHIG00000004808HRAS10092.063ENSIPUG00000022502hrasb10092.063Ictalurus_punctatus
ENSCHIG00000004808HRAS10092.593ENSIPUG00000006053hras10092.593Ictalurus_punctatus
ENSCHIG00000004808HRAS10096.296ENSSTOG00000021206HRAS10096.296Ictidomys_tridecemlineatus
ENSCHIG00000004808HRAS10087.302ENSJJAG00000011743-10087.302Jaculus_jaculus
ENSCHIG00000004808HRAS9998.214ENSJJAG00000022529-10096.296Jaculus_jaculus
ENSCHIG00000004808HRAS10093.122ENSKMAG00000001922Ha-ras10093.122Kryptolebias_marmoratus
ENSCHIG00000004808HRAS10093.122ENSLBEG00000001905hrasb10093.122Labrus_bergylta
ENSCHIG00000004808HRAS10092.593ENSLACG00000018427HRAS10092.593Latimeria_chalumnae
ENSCHIG00000004808HRAS10092.063ENSLOCG00000000684hrasb10092.063Lepisosteus_oculatus
ENSCHIG00000004808HRAS9998.817ENSMFAG00000039003HRAS9998.817Macaca_fascicularis
ENSCHIG00000004808HRAS9998.817ENSMMUG00000021659HRAS9998.817Macaca_mulatta
ENSCHIG00000004808HRAS9998.817ENSMNEG00000039358HRAS9998.817Macaca_nemestrina
ENSCHIG00000004808HRAS9998.817ENSMLEG00000042070HRAS9998.817Mandrillus_leucophaeus
ENSCHIG00000004808HRAS10093.122ENSMAMG00000004359hrasb10093.122Mastacembelus_armatus
ENSCHIG00000004808HRAS10092.593ENSMZEG00005017583hrasb10092.593Maylandia_zebra
ENSCHIG00000004808HRAS9998.214ENSMAUG00000020006Hras10096.296Mesocricetus_auratus
ENSCHIG00000004808HRAS9998.225ENSMICG00000006472HRAS9998.225Microcebus_murinus
ENSCHIG00000004808HRAS9998.214ENSMOCG00000000744Hras10096.296Microtus_ochrogaster
ENSCHIG00000004808HRAS8897.333ENSMODG00000016580HRAS7197.333Monodelphis_domestica
ENSCHIG00000004808HRAS10093.122ENSMALG00000011273hrasb10093.122Monopterus_albus
ENSCHIG00000004808HRAS10095.767MGP_CAROLIEiJ_G0030681Hras10095.767Mus_caroli
ENSCHIG00000004808HRAS9997.633ENSMUSG00000025499Hras10096.296Mus_musculus
ENSCHIG00000004808HRAS9998.214MGP_PahariEiJ_G0013880Hras10095.767Mus_pahari
ENSCHIG00000004808HRAS10085.714MGP_SPRETEiJ_G0031792-10085.714Mus_spretus
ENSCHIG00000004808HRAS9998.225ENSNGAG00000022044Hras10096.296Nannospalax_galili
ENSCHIG00000004808HRAS10096.296ENSNLEG00000008300HRAS10096.296Nomascus_leucogenys
ENSCHIG00000004808HRAS9997.619ENSODEG00000015703HRAS10095.767Octodon_degus
ENSCHIG00000004808HRAS10093.122ENSONIG00000014560hrasb10093.122Oreochromis_niloticus
ENSCHIG00000004808HRAS10092.593ENSORLG00000018912hrasb10092.593Oryzias_latipes
ENSCHIG00000004808HRAS9685.366ENSORLG00000024443zgc:555589089.222Oryzias_latipes
ENSCHIG00000004808HRAS10092.593ENSORLG00020008129hras10092.593Oryzias_latipes_hni
ENSCHIG00000004808HRAS8990.728ENSORLG00020013690zgc:555589089.222Oryzias_latipes_hni
ENSCHIG00000004808HRAS8990.728ENSORLG00015003353zgc:555589089.222Oryzias_latipes_hsok
ENSCHIG00000004808HRAS8991.391ENSOMEG00000016685zgc:555589089.820Oryzias_melastigma
ENSCHIG00000004808HRAS10093.122ENSOMEG00000018719hrasb10093.122Oryzias_melastigma
ENSCHIG00000004808HRAS10094.709ENSOGAG00000024846HRAS10094.709Otolemur_garnettii
ENSCHIG00000004808HRAS88100.000ENSOARG00000007365HRAS99100.000Ovis_aries
ENSCHIG00000004808HRAS9998.225ENSPPAG00000028620HRAS9998.225Pan_paniscus
ENSCHIG00000004808HRAS8899.333ENSPPRG00000008185HRAS8899.333Panthera_pardus
ENSCHIG00000004808HRAS7899.248ENSPTIG00000006043HRAS10099.248Panthera_tigris_altaica
ENSCHIG00000004808HRAS9998.225ENSPTRG00000034469HRAS9998.225Pan_troglodytes
ENSCHIG00000004808HRAS9998.817ENSPANG00000008022-9998.817Papio_anubis
ENSCHIG00000004808HRAS10095.767ENSPANG00000016633-10095.767Papio_anubis
ENSCHIG00000004808HRAS9992.553ENSPKIG00000013507hrasb10092.063Paramormyrops_kingsleyae
ENSCHIG00000004808HRAS10093.122ENSPKIG00000000303HRAS10093.122Paramormyrops_kingsleyae
ENSCHIG00000004808HRAS10093.122ENSPSIG00000014690HRAS9993.122Pelodiscus_sinensis
ENSCHIG00000004808HRAS7891.729ENSPMGG00000014517zgc:555589491.729Periophthalmus_magnuspinnatus
ENSCHIG00000004808HRAS9693.923ENSPMGG00000005812HRAS8893.923Periophthalmus_magnuspinnatus
ENSCHIG00000004808HRAS9998.214ENSPEMG00000013973-10096.296Peromyscus_maniculatus_bairdii
ENSCHIG00000004808HRAS10087.302ENSPMAG00000004548hrasb9887.302Petromyzon_marinus
ENSCHIG00000004808HRAS10094.180ENSPCIG00000008359HRAS10094.180Phascolarctos_cinereus
ENSCHIG00000004808HRAS10093.122ENSPFOG00000002595hrasb10093.122Poecilia_formosa
ENSCHIG00000004808HRAS10092.063ENSPLAG00000003379hrasb10092.063Poecilia_latipinna
ENSCHIG00000004808HRAS10093.122ENSPMEG00000020891hrasb10093.122Poecilia_mexicana
ENSCHIG00000004808HRAS10093.122ENSPREG00000019341hrasb10093.122Poecilia_reticulata
ENSCHIG00000004808HRAS9998.817ENSPPYG00000002868HRAS9998.817Pongo_abelii
ENSCHIG00000004808HRAS9998.225ENSPCOG00000021838HRAS9998.225Propithecus_coquereli
ENSCHIG00000004808HRAS10092.593ENSPNYG00000015124hrasb10092.593Pundamilia_nyererei
ENSCHIG00000004808HRAS10093.122ENSPNAG00000014085hrasa10093.122Pygocentrus_nattereri
ENSCHIG00000004808HRAS10092.063ENSPNAG00000000584hrasb10092.063Pygocentrus_nattereri
ENSCHIG00000004808HRAS10096.296ENSRNOG00000016611Hras10096.296Rattus_norvegicus
ENSCHIG00000004808HRAS9998.817ENSRBIG00000034835HRAS9998.817Rhinopithecus_bieti
ENSCHIG00000004808HRAS9998.817ENSRROG00000041325HRAS9998.817Rhinopithecus_roxellana
ENSCHIG00000004808HRAS9998.817ENSSBOG00000023272HRAS9998.817Saimiri_boliviensis_boliviensis
ENSCHIG00000004808HRAS9655.135ENSSHAG00000004318-8158.537Sarcophilus_harrisii
ENSCHIG00000004808HRAS10092.593ENSSFOG00015003051hrasb10092.593Scleropages_formosus
ENSCHIG00000004808HRAS10092.593ENSSFOG00015011157-10092.593Scleropages_formosus
ENSCHIG00000004808HRAS10093.122ENSSMAG00000008745hrasb10093.122Scophthalmus_maximus
ENSCHIG00000004808HRAS10093.122ENSSDUG00000019086hrasb10093.122Seriola_dumerili
ENSCHIG00000004808HRAS10093.122ENSSLDG00000012627hrasb10093.122Seriola_lalandi_dorsalis
ENSCHIG00000004808HRAS10093.651ENSSPUG00000005243HRAS10093.651Sphenodon_punctatus
ENSCHIG00000004808HRAS10092.593ENSSPAG00000007357hrasb10092.593Stegastes_partitus
ENSCHIG00000004808HRAS10098.413ENSSSCG00000031513HRAS10098.413Sus_scrofa
ENSCHIG00000004808HRAS10094.180ENSTGUG00000009877HRAS10094.180Taeniopygia_guttata
ENSCHIG00000004808HRAS10092.063ENSTRUG00000024825hrasb10092.063Takifugu_rubripes
ENSCHIG00000004808HRAS10092.063ENSTNIG00000011385hrasb10092.063Tetraodon_nigroviridis
ENSCHIG00000004808HRAS10098.413ENSTTRG00000011120HRAS10098.413Tursiops_truncatus
ENSCHIG00000004808HRAS10098.942ENSUAMG00000027527-10098.942Ursus_americanus
ENSCHIG00000004808HRAS10098.942ENSUMAG00000005506-10098.942Ursus_maritimus
ENSCHIG00000004808HRAS10097.884ENSVVUG00000017151HRAS10097.884Vulpes_vulpes
ENSCHIG00000004808HRAS10093.651ENSXETG00000006040hras10093.651Xenopus_tropicalis
ENSCHIG00000004808HRAS9495.480ENSXCOG00000020608hrasb9493.893Xiphophorus_couchianus
ENSCHIG00000004808HRAS10093.122ENSXMAG00000015132hrasb10093.122Xiphophorus_maculatus

Copyright © , Bioinformatics Center, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, China. All Rights Reserved.

Any comment and suggestion, please contact us