EuRBPDB

Description

RBDs

Transcripts

Gene Model

Pathways

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSDARG00000068729 (Gene tree)
Gene ID: 100001092
Gene Symbol: eif2ak2
Alias: PKR
Full Name: eukaryotic translation initiation factor 2-alpha kinase 2
Gene Type: protein_coding
Species: Danio_rerio
Status: putative
Strand: Minus strand
Length: 26180 bases
Position: chr13:50207943-50234122
Accession: ZDB-GENE-080422-1
RBP type: canonical RBP
Summary: -

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSDARP00000133369	dsrm	PF00035.26	1.7e-37	1	3
ENSDARP00000133369	dsrm	PF00035.26	1.7e-37	2	3
ENSDARP00000133369	dsrm	PF00035.26	1.7e-37	3	3

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENSDART00000164338	-	2075	-	ENSDARP00000133369	682 (aa)	-	A0A0R4IHF6

Gene Model

Click here to download ENSDARG00000068729's gene model file

Pathways

Pathway ID	Pathway Name	Source
dre04141	Protein processing in endoplasmic reticulum	KEGG
dre04217	Necroptosis	KEGG
dre05168	Herpes simplex virus 1 infection	KEGG

Protein-Protein Interaction (PPI)

Clik here to download ENSDARG00000068729's network

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSDARG00000068729	eif2ak2	99	42.047	ENSAPOG00000010636	-	99	42.340	Acanthochromis_polyacanthus
ENSDARG00000068729	eif2ak2	99	42.559	ENSAPOG00000010706	eif2ak2	98	41.457	Acanthochromis_polyacanthus
ENSDARG00000068729	eif2ak2	93	39.374	ENSAPOG00000010662	eif2ak2	96	39.309	Acanthochromis_polyacanthus
ENSDARG00000068729	eif2ak2	96	42.254	ENSACIG00000007027	eif2ak2	83	51.429	Amphilophus_citrinellus
ENSDARG00000068729	eif2ak2	97	40.741	ENSACIG00000006536	eif2ak2	96	47.222	Amphilophus_citrinellus
ENSDARG00000068729	eif2ak2	98	44.633	ENSACIG00000006777	eif2ak2	98	47.000	Amphilophus_citrinellus
ENSDARG00000068729	eif2ak2	63	48.239	ENSACIG00000006955	-	94	47.183	Amphilophus_citrinellus
ENSDARG00000068729	eif2ak2	78	37.838	ENSACIG00000006710	-	95	37.838	Amphilophus_citrinellus
ENSDARG00000068729	eif2ak2	94	40.351	ENSAOCG00000003397	eif2ak2	97	39.706	Amphiprion_ocellaris
ENSDARG00000068729	eif2ak2	99	42.616	ENSAOCG00000003414	-	99	41.958	Amphiprion_ocellaris
ENSDARG00000068729	eif2ak2	94	40.351	ENSAPEG00000023879	eif2ak2	97	39.706	Amphiprion_percula
ENSDARG00000068729	eif2ak2	99	41.193	ENSAPEG00000023675	eif2ak2	94	49.521	Amphiprion_percula
ENSDARG00000068729	eif2ak2	96	41.799	ENSATEG00000015425	eif2ak2	97	49.481	Anabas_testudineus
ENSDARG00000068729	eif2ak2	99	43.447	ENSATEG00000015535	eif2ak2	98	43.429	Anabas_testudineus
ENSDARG00000068729	eif2ak2	97	42.623	ENSATEG00000015063	eif2ak2	91	52.158	Anabas_testudineus
ENSDARG00000068729	eif2ak2	83	40.998	ENSACLG00000023843	-	96	41.432	Astatotilapia_calliptera
ENSDARG00000068729	eif2ak2	87	61.905	ENSAMXG00000003716	eif2ak2	91	61.538	Astyanax_mexicanus
ENSDARG00000068729	eif2ak2	96	33.671	ENSCSEG00000012878	eif2ak2	96	33.382	Cynoglossus_semilaevis
ENSDARG00000068729	eif2ak2	93	40.091	ENSCSEG00000012820	-	99	39.454	Cynoglossus_semilaevis
ENSDARG00000068729	eif2ak2	63	43.571	ENSCVAG00000003185	-	89	44.074	Cyprinodon_variegatus
ENSDARG00000068729	eif2ak2	99	41.908	ENSCVAG00000014725	eif2ak2	99	48.852	Cyprinodon_variegatus
ENSDARG00000068729	eif2ak2	99	44.574	ENSELUG00000018164	eif2ak2	87	56.393	Esox_lucius
ENSDARG00000068729	eif2ak2	83	40.881	ENSGMOG00000018813	eif2ak2	95	50.612	Gadus_morhua
ENSDARG00000068729	eif2ak2	90	42.857	ENSGMOG00000018784	eif2ak2	98	45.745	Gadus_morhua
ENSDARG00000068729	eif2ak2	78	45.635	ENSGAFG00000005231	-	92	45.489	Gambusia_affinis
ENSDARG00000068729	eif2ak2	94	37.607	ENSHBUG00000022151	-	93	39.209	Haplochromis_burtoni
ENSDARG00000068729	eif2ak2	79	48.131	ENSHBUG00000022216	-	85	48.131	Haplochromis_burtoni
ENSDARG00000068729	eif2ak2	99	35.725	ENSHCOG00000010443	-	99	36.164	Hippocampus_comes
ENSDARG00000068729	eif2ak2	98	51.622	ENSIPUG00000019933	eif2ak2	97	51.475	Ictalurus_punctatus
ENSDARG00000068729	eif2ak2	97	47.644	ENSMAMG00000017342	eif2ak2	99	49.711	Mastacembelus_armatus
ENSDARG00000068729	eif2ak2	82	50.909	ENSMAMG00000017311	eif2ak2	93	49.091	Mastacembelus_armatus
ENSDARG00000068729	eif2ak2	94	38.926	ENSMZEG00005009773	eif2ak2	95	40.217	Maylandia_zebra
ENSDARG00000068729	eif2ak2	85	46.479	ENSMZEG00005009825	eif2ak2	86	46.479	Maylandia_zebra
ENSDARG00000068729	eif2ak2	82	50.523	ENSMMOG00000000711	-	90	50.523	Mola_mola
ENSDARG00000068729	eif2ak2	97	41.176	ENSMALG00000005115	eif2ak2	82	41.176	Monopterus_albus
ENSDARG00000068729	eif2ak2	98	45.652	ENSMALG00000005083	eif2ak2	99	45.652	Monopterus_albus
ENSDARG00000068729	eif2ak2	99	41.354	ENSNBRG00000012219	-	99	40.922	Neolamprologus_brichardi
ENSDARG00000068729	eif2ak2	97	35.928	ENSNBRG00000019433	-	93	49.825	Neolamprologus_brichardi
ENSDARG00000068729	eif2ak2	97	38.302	ENSNBRG00000011967	eif2ak2	94	47.018	Neolamprologus_brichardi
ENSDARG00000068729	eif2ak2	69	42.268	ENSONIG00000010933	-	92	42.348	Oreochromis_niloticus
ENSDARG00000068729	eif2ak2	99	38.791	ENSORLG00000012432	eif2ak2	98	41.270	Oryzias_latipes
ENSDARG00000068729	eif2ak2	100	39.455	ENSORLG00000018980	-	100	39.714	Oryzias_latipes
ENSDARG00000068729	eif2ak2	99	36.510	ENSORLG00020014073	eif2ak2	99	36.242	Oryzias_latipes_hni
ENSDARG00000068729	eif2ak2	100	39.024	ENSORLG00020014108	-	100	39.000	Oryzias_latipes_hni
ENSDARG00000068729	eif2ak2	100	39.199	ENSORLG00015023149	eif2ak2	100	39.742	Oryzias_latipes_hsok
ENSDARG00000068729	eif2ak2	99	35.452	ENSORLG00015023155	eif2ak2	96	43.189	Oryzias_latipes_hsok
ENSDARG00000068729	eif2ak2	99	39.189	ENSOMEG00000019857	eif2ak2	98	42.809	Oryzias_melastigma
ENSDARG00000068729	eif2ak2	97	41.765	ENSOMEG00000019925	-	96	41.765	Oryzias_melastigma
ENSDARG00000068729	eif2ak2	99	45.007	ENSPKIG00000024036	eif2ak2	99	44.863	Paramormyrops_kingsleyae
ENSDARG00000068729	eif2ak2	99	40.525	ENSPMGG00000001652	eif2ak2	96	50.667	Periophthalmus_magnuspinnatus
ENSDARG00000068729	eif2ak2	73	41.060	ENSPMGG00000001624	-	100	40.656	Periophthalmus_magnuspinnatus
ENSDARG00000068729	eif2ak2	98	40.356	ENSPLAG00000023307	-	96	49.658	Poecilia_latipinna
ENSDARG00000068729	eif2ak2	96	38.336	ENSPMEG00000013631	eif2ak2	99	38.003	Poecilia_mexicana
ENSDARG00000068729	eif2ak2	99	42.957	ENSPMEG00000013612	-	99	42.577	Poecilia_mexicana
ENSDARG00000068729	eif2ak2	79	41.339	ENSPREG00000007905	-	87	41.339	Poecilia_reticulata
ENSDARG00000068729	eif2ak2	97	39.021	ENSPNYG00000014220	-	85	48.227	Pundamilia_nyererei
ENSDARG00000068729	eif2ak2	97	38.122	ENSPNYG00000014187	eif2ak2	95	39.683	Pundamilia_nyererei
ENSDARG00000068729	eif2ak2	81	37.916	ENSPNYG00000023883	-	98	37.581	Pundamilia_nyererei
ENSDARG00000068729	eif2ak2	99	52.555	ENSPNAG00000000508	eif2ak2	99	52.555	Pygocentrus_nattereri
ENSDARG00000068729	eif2ak2	93	39.196	ENSSMAG00000010296	-	96	46.479	Scophthalmus_maximus
ENSDARG00000068729	eif2ak2	98	43.768	ENSSDUG00000002837	eif2ak2	98	44.206	Seriola_dumerili
ENSDARG00000068729	eif2ak2	97	37.303	ENSSDUG00000002922	eif2ak2	98	37.356	Seriola_dumerili
ENSDARG00000068729	eif2ak2	98	43.201	ENSSLDG00000024893	-	98	43.634	Seriola_lalandi_dorsalis
ENSDARG00000068729	eif2ak2	97	37.446	ENSSLDG00000024886	-	98	37.892	Seriola_lalandi_dorsalis
ENSDARG00000068729	eif2ak2	85	38.415	ENSSLDG00000024867	eif2ak2	99	38.415	Seriola_lalandi_dorsalis
ENSDARG00000068729	eif2ak2	98	44.492	ENSSLDG00000024874	eif2ak2	99	44.714	Seriola_lalandi_dorsalis
ENSDARG00000068729	eif2ak2	96	36.711	ENSSPAG00000007629	-	93	36.589	Stegastes_partitus
ENSDARG00000068729	eif2ak2	96	39.896	ENSTRUG00000022205	-	96	39.896	Takifugu_rubripes
ENSDARG00000068729	eif2ak2	80	44.727	ENSXETG00000009025	pkr2	87	43.369	Xenopus_tropicalis
ENSDARG00000068729	eif2ak2	85	36.142	ENSXCOG00000006961	-	96	36.062	Xiphophorus_couchianus
ENSDARG00000068729	eif2ak2	93	42.169	ENSXMAG00000006521	eif2ak2	99	42.018	Xiphophorus_maculatus
ENSDARG00000068729	eif2ak2	98	37.537	ENSXMAG00000006536	eif2ak2	96	42.349	Xiphophorus_maculatus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0003723	RNA binding	-	IEA	Function
GO:0003725	double-stranded RNA binding	-	IEA	Function
GO:0004672	protein kinase activity	21873635.	IBA	Function
GO:0004672	protein kinase activity	18312693.	IDA	Function
GO:0004672	protein kinase activity	-	IEA	Function
GO:0004674	protein serine/threonine kinase activity	-	IEA	Function
GO:0004694	eukaryotic translation initiation factor 2alpha kinase activity	21873635.	IBA	Function
GO:0005524	ATP binding	-	IEA	Function
GO:0006468	protein phosphorylation	-	IEA	Process
GO:0008168	methyltransferase activity	-	IEA	Function
GO:0008285	negative regulation of cell proliferation	-	IEA	Process
GO:0009615	response to virus	-	IEA	Process
GO:0009636	response to toxic substance	-	IEA	Process
GO:0010998	regulation of translational initiation by eIF2 alpha phosphorylation	-	IEA	Process
GO:0016301	kinase activity	-	IEA	Function
GO:0016310	phosphorylation	-	IEA	Process
GO:0016740	transferase activity	-	IEA	Function
GO:0022626	cytosolic ribosome	21873635.	IBA	Component
GO:0032259	methylation	-	IEA	Process
GO:0042981	regulation of apoptotic process	-	IEA	Process
GO:0045071	negative regulation of viral genome replication	-	IEA	Process