EuRBPDB

Description

RBDs

Transcripts

Gene Model

PPI

Paralogs

Orthologs

Description

Ensembl ID: ENSDNOG00000018444 (Gene tree)
Gene ID: 101446439
Gene Symbol: -
Alias: -
Full Name: poly(A) binding protein cytoplasmic 4
Gene Type: protein_coding
Species: Dasypus_novemcinctus
Status: putative
Strand: Minus strand
Length: 11632 bases
Position: chrJH563817.1:127995-139626
Accession: 101446439
RBP type: canonical RBP
Summary: -

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSDNOP00000022483	PABP	PF00658.18	1.3e-31	1	1
ENSDNOP00000014319	PABP	PF00658.18	1.5e-31	1	1
ENSDNOP00000022483	RRM_5	PF13893.6	1e-07	1	2
ENSDNOP00000022483	RRM_5	PF13893.6	1e-07	2	2
ENSDNOP00000014319	RRM_5	PF13893.6	1.2e-07	1	2
ENSDNOP00000014319	RRM_5	PF13893.6	1.2e-07	2	2
ENSDNOP00000022483	RRM_1	PF00076.22	2e-69	1	3
ENSDNOP00000022483	RRM_1	PF00076.22	2e-69	2	3
ENSDNOP00000022483	RRM_1	PF00076.22	2e-69	3	3
ENSDNOP00000014319	RRM_1	PF00076.22	2.5e-69	1	3
ENSDNOP00000014319	RRM_1	PF00076.22	2.5e-69	2	3
ENSDNOP00000014319	RRM_1	PF00076.22	2.5e-69	3	3

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENSDNOT00000051357	-	2032	XM_012522258	ENSDNOP00000022483	560 (aa)	XP_012377712	UPI0003CBDFF3
ENSDNOT00000018443	-	1781	-	ENSDNOP00000014319	585 (aa)	XP_004450671	UPI0003292AE3

Gene Model

Click here to download ENSDNOG00000018444's gene model file

Protein-Protein Interaction (PPI)

Clik here to download ENSDNOG00000018444's network

Paralogs

Ensembl ID	Gene Symbol	Coverage	Identiy	Paralog	Gene Symbol	Coverage	Identiy
ENSDNOG00000018444	-	99	76.667	ENSDNOG00000008718	PABPC1	99	76.491
ENSDNOG00000018444	-	52	32.911	ENSDNOG00000009552	TIAL1	74	32.911
ENSDNOG00000018444	-	54	74.016	ENSDNOG00000030926	-	99	71.852
ENSDNOG00000018444	-	54	35.246	ENSDNOG00000037231	-	50	35.246
ENSDNOG00000018444	-	56	78.595	ENSDNOG00000031077	PABPC4L	97	78.595
ENSDNOG00000018444	-	52	37.500	ENSDNOG00000000252	CELF2	65	37.500
ENSDNOG00000018444	-	98	55.615	ENSDNOG00000030956	-	99	55.615
ENSDNOG00000018444	-	97	65.385	ENSDNOG00000048450	PABPC1L	98	65.385
ENSDNOG00000018444	-	83	69.492	ENSDNOG00000006598	-	98	69.492

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSDNOG00000018444	-	100	99.464	ENSG00000090621	PABPC4	99	100.000	Homo_sapiens
ENSDNOG00000018444	-	99	81.964	ENSAPOG00000001161	pabpc4	99	81.786	Acanthochromis_polyacanthus
ENSDNOG00000018444	-	99	58.528	ENSAMEG00000015083	-	88	58.169	Ailuropoda_melanoleuca
ENSDNOG00000018444	-	99	99.483	ENSAMEG00000011535	-	98	99.483	Ailuropoda_melanoleuca
ENSDNOG00000018444	-	100	82.601	ENSACIG00000023343	pabpc4	99	83.304	Amphilophus_citrinellus
ENSDNOG00000018444	-	99	82.500	ENSAOCG00000021529	pabpc4	99	82.777	Amphiprion_ocellaris
ENSDNOG00000018444	-	99	82.500	ENSAPEG00000019196	pabpc4	99	82.777	Amphiprion_percula
ENSDNOG00000018444	-	99	81.495	ENSATEG00000007402	pabpc4	99	81.294	Anabas_testudineus
ENSDNOG00000018444	-	99	91.771	ENSAPLG00000009729	-	100	91.771	Anas_platyrhynchos
ENSDNOG00000018444	-	99	90.161	ENSACAG00000002544	PABPC4	100	90.161	Anolis_carolinensis
ENSDNOG00000018444	-	100	99.286	ENSANAG00000025079	PABPC4	99	99.286	Aotus_nancymaae
ENSDNOG00000018444	-	100	82.074	ENSACLG00000019558	pabpc4	99	82.168	Astatotilapia_calliptera
ENSDNOG00000018444	-	99	77.102	ENSAMXG00000018779	pabpc4	98	77.996	Astyanax_mexicanus
ENSDNOG00000018444	-	52	92.784	ENSBTAG00000048536	-	92	92.784	Bos_taurus
ENSDNOG00000018444	-	99	96.386	ENSBTAG00000017125	PABPC4	98	96.386	Bos_taurus
ENSDNOG00000018444	-	72	89.754	ENSCJAG00000045953	-	92	89.712	Callithrix_jacchus
ENSDNOG00000018444	-	100	99.107	ENSCJAG00000002512	-	99	99.107	Callithrix_jacchus
ENSDNOG00000018444	-	100	99.643	ENSCAFG00000003081	PABPC4	99	99.643	Canis_familiaris
ENSDNOG00000018444	-	99	99.483	ENSCAFG00020004161	PABPC4	98	99.483	Canis_lupus_dingo
ENSDNOG00000018444	-	99	75.862	ENSCHIG00000023385	-	97	75.862	Capra_hircus
ENSDNOG00000018444	-	99	99.310	ENSCHIG00000019398	-	98	99.310	Capra_hircus
ENSDNOG00000018444	-	100	99.464	ENSTSYG00000006532	PABPC4	99	99.464	Carlito_syrichta
ENSDNOG00000018444	-	100	99.107	ENSCAPG00000015984	PABPC4	99	99.107	Cavia_aperea
ENSDNOG00000018444	-	100	99.107	ENSCPOG00000009552	PABPC4	99	99.107	Cavia_porcellus
ENSDNOG00000018444	-	100	99.286	ENSCCAG00000037306	PABPC4	99	99.286	Cebus_capucinus
ENSDNOG00000018444	-	100	99.643	ENSCATG00000042164	PABPC4	99	99.643	Cercocebus_atys
ENSDNOG00000018444	-	100	99.107	ENSCLAG00000011899	PABPC4	99	99.107	Chinchilla_lanigera
ENSDNOG00000018444	-	99	99.655	ENSCSAG00000001135	PABPC4	98	99.655	Chlorocebus_sabaeus
ENSDNOG00000018444	-	85	97.855	ENSCHOG00000005327	PABPC4	80	97.855	Choloepus_hoffmanni
ENSDNOG00000018444	-	99	91.234	ENSCPBG00000001038	PABPC4	99	91.234	Chrysemys_picta_bellii
ENSDNOG00000018444	-	100	99.464	ENSCANG00000034177	PABPC4	100	99.464	Colobus_angolensis_palliatus
ENSDNOG00000018444	-	99	97.759	ENSCGRG00001018166	Pabpc4	97	97.759	Cricetulus_griseus_chok1gshd
ENSDNOG00000018444	-	99	95.172	ENSCGRG00000009777	Pabpc4	98	95.172	Cricetulus_griseus_crigri
ENSDNOG00000018444	-	100	81.195	ENSCSEG00000000130	pabpc4	99	81.643	Cynoglossus_semilaevis
ENSDNOG00000018444	-	100	82.363	ENSCVAG00000019246	pabpc4	100	82.632	Cyprinodon_variegatus
ENSDNOG00000018444	-	99	83.871	ENSDARG00000059259	pabpc4	99	84.701	Danio_rerio
ENSDNOG00000018444	-	99	96.724	ENSDORG00000011581	Pabpc4	98	96.724	Dipodomys_ordii
ENSDNOG00000018444	-	96	65.370	ENSETEG00000009172	-	99	65.385	Echinops_telfairi
ENSDNOG00000018444	-	95	97.107	ENSETEG00000018453	-	73	97.107	Echinops_telfairi
ENSDNOG00000018444	-	97	74.818	ENSEBUG00000013782	pabpc4	99	73.975	Eptatretus_burgeri
ENSDNOG00000018444	-	99	74.866	ENSEBUG00000000992	pabpc4	98	80.508	Eptatretus_burgeri
ENSDNOG00000018444	-	100	100.000	ENSEASG00005014119	PABPC4	98	100.000	Equus_asinus_asinus
ENSDNOG00000018444	-	100	100.000	ENSECAG00000009396	PABPC4	98	100.000	Equus_caballus
ENSDNOG00000018444	-	98	96.007	ENSEEUG00000002962	PABPC4	98	96.034	Erinaceus_europaeus
ENSDNOG00000018444	-	99	82.826	ENSELUG00000003195	pabpc4	98	83.481	Esox_lucius
ENSDNOG00000018444	-	100	99.643	ENSFCAG00000015254	-	99	99.643	Felis_catus
ENSDNOG00000018444	-	99	90.519	ENSFALG00000000543	PABPC4	99	90.519	Ficedula_albicollis
ENSDNOG00000018444	-	99	99.483	ENSFDAG00000020016	-	98	99.483	Fukomys_damarensis
ENSDNOG00000018444	-	99	66.946	ENSFDAG00000010581	-	97	62.931	Fukomys_damarensis
ENSDNOG00000018444	-	100	82.394	ENSFHEG00000007548	pabpc4	99	82.662	Fundulus_heteroclitus
ENSDNOG00000018444	-	99	81.705	ENSGMOG00000019025	pabpc4	98	82.562	Gadus_morhua
ENSDNOG00000018444	-	99	91.413	ENSGALG00000003800	PABPC4	99	91.413	Gallus_gallus
ENSDNOG00000018444	-	100	89.683	ENSGAFG00000018195	pabpc4	98	95.763	Gambusia_affinis
ENSDNOG00000018444	-	100	80.526	ENSGACG00000007179	pabpc4	99	81.228	Gasterosteus_aculeatus
ENSDNOG00000018444	-	99	91.234	ENSGAGG00000001888	PABPC4	99	91.234	Gopherus_agassizii
ENSDNOG00000018444	-	100	99.464	ENSGGOG00000004002	PABPC4	99	99.464	Gorilla_gorilla
ENSDNOG00000018444	-	100	82.250	ENSHBUG00000020206	pabpc4	99	82.343	Haplochromis_burtoni
ENSDNOG00000018444	-	100	99.643	ENSHGLG00000011162	PABPC4	99	99.643	Heterocephalus_glaber_female
ENSDNOG00000018444	-	100	99.643	ENSHGLG00100001580	PABPC4	99	99.643	Heterocephalus_glaber_male
ENSDNOG00000018444	-	100	81.162	ENSHCOG00000012694	pabpc4	99	81.866	Hippocampus_comes
ENSDNOG00000018444	-	98	81.703	ENSIPUG00000016620	pabpc4	99	81.770	Ictalurus_punctatus
ENSDNOG00000018444	-	100	96.786	ENSSTOG00000010416	PABPC4	99	96.786	Ictidomys_tridecemlineatus
ENSDNOG00000018444	-	99	94.310	ENSJJAG00000007781	Pabpc4	98	94.310	Jaculus_jaculus
ENSDNOG00000018444	-	99	81.560	ENSKMAG00000013597	pabpc4	98	81.019	Kryptolebias_marmoratus
ENSDNOG00000018444	-	100	81.261	ENSLBEG00000013654	pabpc4	99	80.944	Labrus_bergylta
ENSDNOG00000018444	-	99	87.389	ENSLACG00000011907	PABPC4	99	87.389	Latimeria_chalumnae
ENSDNOG00000018444	-	100	84.779	ENSLOCG00000001877	pabpc4	99	85.664	Lepisosteus_oculatus
ENSDNOG00000018444	-	99	99.483	ENSLAFG00000000151	PABPC4	98	99.483	Loxodonta_africana
ENSDNOG00000018444	-	100	99.643	ENSMFAG00000041481	PABPC4	99	99.643	Macaca_fascicularis
ENSDNOG00000018444	-	99	99.655	ENSMMUG00000007497	PABPC4	98	99.655	Macaca_mulatta
ENSDNOG00000018444	-	100	99.464	ENSMNEG00000043054	PABPC4	99	99.464	Macaca_nemestrina
ENSDNOG00000018444	-	100	99.643	ENSMLEG00000040716	PABPC4	99	99.643	Mandrillus_leucophaeus
ENSDNOG00000018444	-	99	81.786	ENSMAMG00000010025	pabpc4	98	80.877	Mastacembelus_armatus
ENSDNOG00000018444	-	100	81.898	ENSMZEG00005006141	pabpc4	89	92.473	Maylandia_zebra
ENSDNOG00000018444	-	99	87.931	ENSMGAG00000005408	PABPC4	99	87.931	Meleagris_gallopavo
ENSDNOG00000018444	-	70	96.465	ENSMAUG00000019763	-	62	100.000	Mesocricetus_auratus
ENSDNOG00000018444	-	67	89.423	ENSMAUG00000001295	-	97	89.423	Mesocricetus_auratus
ENSDNOG00000018444	-	55	80.342	ENSMAUG00000004089	-	89	80.342	Mesocricetus_auratus
ENSDNOG00000018444	-	89	95.000	ENSMICG00000016633	-	97	99.149	Microcebus_murinus
ENSDNOG00000018444	-	100	84.902	ENSMICG00000036729	-	100	85.435	Microcebus_murinus
ENSDNOG00000018444	-	100	97.340	ENSMOCG00000006763	Pabpc4	99	97.340	Microtus_ochrogaster
ENSDNOG00000018444	-	100	79.115	ENSMMOG00000002363	pabpc4	99	78.028	Mola_mola
ENSDNOG00000018444	-	56	73.312	ENSMODG00000018051	-	89	73.312	Monodelphis_domestica
ENSDNOG00000018444	-	98	88.215	ENSMODG00000017657	-	98	88.296	Monodelphis_domestica
ENSDNOG00000018444	-	99	81.673	ENSMALG00000011017	pabpc4	99	81.359	Monopterus_albus
ENSDNOG00000018444	-	100	83.274	MGP_CAROLIEiJ_G0024864	-	100	83.274	Mus_caroli
ENSDNOG00000018444	-	99	98.103	MGP_CAROLIEiJ_G0026435	-	100	100.000	Mus_caroli
ENSDNOG00000018444	-	100	97.857	ENSMUSG00000011257	Pabpc4	98	98.969	Mus_musculus
ENSDNOG00000018444	-	99	97.931	MGP_PahariEiJ_G0028765	Pabpc4	100	100.000	Mus_pahari
ENSDNOG00000018444	-	99	88.204	MGP_SPRETEiJ_G0027415	Pabpc4	100	98.969	Mus_spretus
ENSDNOG00000018444	-	96	54.731	ENSMPUG00000006836	-	90	54.545	Mustela_putorius_furo
ENSDNOG00000018444	-	99	99.655	ENSMPUG00000014414	-	98	99.655	Mustela_putorius_furo
ENSDNOG00000018444	-	100	96.429	ENSMLUG00000012068	PABPC4	99	96.429	Myotis_lucifugus
ENSDNOG00000018444	-	100	96.250	ENSNGAG00000018292	Pabpc4	99	96.250	Nannospalax_galili
ENSDNOG00000018444	-	60	86.441	ENSNBRG00000010047	-	75	86.441	Neolamprologus_brichardi
ENSDNOG00000018444	-	56	91.781	ENSNBRG00000009708	pabpc4	98	91.781	Neolamprologus_brichardi
ENSDNOG00000018444	-	100	99.643	ENSNLEG00000011928	PABPC4	99	99.643	Nomascus_leucogenys
ENSDNOG00000018444	-	83	98.762	ENSOPRG00000011984	PABPC4	86	98.762	Ochotona_princeps
ENSDNOG00000018444	-	95	89.540	ENSODEG00000017434	-	100	87.764	Octodon_degus
ENSDNOG00000018444	-	100	98.393	ENSODEG00000006592	-	99	98.393	Octodon_degus
ENSDNOG00000018444	-	53	83.333	ENSODEG00000013457	-	99	83.333	Octodon_degus
ENSDNOG00000018444	-	100	82.250	ENSONIG00000008176	pabpc4	99	82.953	Oreochromis_niloticus
ENSDNOG00000018444	-	99	91.055	ENSOANG00000010001	PABPC4	99	91.055	Ornithorhynchus_anatinus
ENSDNOG00000018444	-	96	99.287	ENSOCUG00000000562	PABPC4	88	99.287	Oryctolagus_cuniculus
ENSDNOG00000018444	-	99	90.909	ENSORLG00000017479	pabpc4	98	90.909	Oryzias_latipes
ENSDNOG00000018444	-	99	90.909	ENSORLG00020018644	pabpc4	98	90.909	Oryzias_latipes_hni
ENSDNOG00000018444	-	99	90.909	ENSORLG00015015042	pabpc4	98	90.909	Oryzias_latipes_hsok
ENSDNOG00000018444	-	99	82.143	ENSOMEG00000014410	pabpc4	98	82.042	Oryzias_melastigma
ENSDNOG00000018444	-	99	96.741	ENSOGAG00000004067	PABPC4	98	96.741	Otolemur_garnettii
ENSDNOG00000018444	-	99	99.310	ENSOARG00000020060	PABPC4	98	99.310	Ovis_aries
ENSDNOG00000018444	-	100	99.464	ENSPPAG00000043625	PABPC4	99	99.464	Pan_paniscus
ENSDNOG00000018444	-	100	99.643	ENSPPRG00000024727	PABPC4	99	99.643	Panthera_pardus
ENSDNOG00000018444	-	100	99.643	ENSPTIG00000005829	PABPC4	99	99.643	Panthera_tigris_altaica
ENSDNOG00000018444	-	100	99.464	ENSPTRG00000000573	PABPC4	99	99.464	Pan_troglodytes
ENSDNOG00000018444	-	100	99.464	ENSPANG00000009484	PABPC4	99	99.464	Papio_anubis
ENSDNOG00000018444	-	99	83.659	ENSPKIG00000025356	pabpc4	98	84.369	Paramormyrops_kingsleyae
ENSDNOG00000018444	-	99	91.234	ENSPSIG00000016892	PABPC4	99	91.234	Pelodiscus_sinensis
ENSDNOG00000018444	-	100	80.496	ENSPMGG00000009073	pabpc4	98	80.142	Periophthalmus_magnuspinnatus
ENSDNOG00000018444	-	100	90.248	ENSPEMG00000024193	-	99	90.248	Peromyscus_maniculatus_bairdii
ENSDNOG00000018444	-	100	96.786	ENSPEMG00000023569	-	99	96.786	Peromyscus_maniculatus_bairdii
ENSDNOG00000018444	-	92	71.311	ENSPMAG00000007885	pabpc4	100	69.822	Petromyzon_marinus
ENSDNOG00000018444	-	87	70.751	ENSPMAG00000002836	pabpc4	99	71.344	Petromyzon_marinus
ENSDNOG00000018444	-	98	93.298	ENSPCIG00000020674	PABPC4	99	93.048	Phascolarctos_cinereus
ENSDNOG00000018444	-	100	81.690	ENSPFOG00000002682	pabpc4	99	81.850	Poecilia_formosa
ENSDNOG00000018444	-	100	81.514	ENSPLAG00000010112	pabpc4	99	82.312	Poecilia_latipinna
ENSDNOG00000018444	-	99	82.258	ENSPMEG00000019739	pabpc4	99	82.024	Poecilia_mexicana
ENSDNOG00000018444	-	100	82.042	ENSPREG00000001589	pabpc4	99	82.312	Poecilia_reticulata
ENSDNOG00000018444	-	99	99.483	ENSPPYG00000001506	PABPC4	98	99.483	Pongo_abelii
ENSDNOG00000018444	-	99	93.966	ENSPCAG00000003341	PABPC4	98	93.966	Procavia_capensis
ENSDNOG00000018444	-	100	83.471	ENSPCOG00000025882	-	87	94.059	Propithecus_coquereli
ENSDNOG00000018444	-	100	99.643	ENSPCOG00000023725	-	99	99.643	Propithecus_coquereli
ENSDNOG00000018444	-	99	99.138	ENSPVAG00000002187	PABPC4	97	99.138	Pteropus_vampyrus
ENSDNOG00000018444	-	100	82.074	ENSPNYG00000006134	pabpc4	99	82.168	Pundamilia_nyererei
ENSDNOG00000018444	-	100	82.187	ENSPNAG00000024355	pabpc4	99	82.632	Pygocentrus_nattereri
ENSDNOG00000018444	-	99	95.345	ENSRNOG00000015642	Pabpc4	98	95.345	Rattus_norvegicus
ENSDNOG00000018444	-	99	93.448	ENSRNOG00000028592	AABR07035074.1	98	93.448	Rattus_norvegicus
ENSDNOG00000018444	-	100	99.643	ENSRBIG00000039761	PABPC4	99	99.643	Rhinopithecus_bieti
ENSDNOG00000018444	-	100	99.643	ENSRROG00000033355	PABPC4	99	99.643	Rhinopithecus_roxellana
ENSDNOG00000018444	-	100	99.107	ENSSBOG00000026193	PABPC4	99	99.107	Saimiri_boliviensis_boliviensis
ENSDNOG00000018444	-	98	91.956	ENSSHAG00000018139	PABPC4	99	91.413	Sarcophilus_harrisii
ENSDNOG00000018444	-	99	84.725	ENSSFOG00015023514	pabpc4	99	84.725	Scleropages_formosus
ENSDNOG00000018444	-	99	81.283	ENSSMAG00000009007	pabpc4	98	80.919	Scophthalmus_maximus
ENSDNOG00000018444	-	99	81.607	ENSSDUG00000012683	pabpc4	99	81.898	Seriola_dumerili
ENSDNOG00000018444	-	99	81.607	ENSSLDG00000013025	pabpc4	93	89.216	Seriola_lalandi_dorsalis
ENSDNOG00000018444	-	99	98.448	ENSSARG00000000310	PABPC4	92	98.448	Sorex_araneus
ENSDNOG00000018444	-	99	89.088	ENSSPUG00000003204	PABPC4	99	89.088	Sphenodon_punctatus
ENSDNOG00000018444	-	99	90.133	ENSSPAG00000009252	pabpc4	96	90.133	Stegastes_partitus
ENSDNOG00000018444	-	100	49.308	ENSSSCG00000036170	-	96	49.308	Sus_scrofa
ENSDNOG00000018444	-	100	99.464	ENSSSCG00000003660	-	99	99.464	Sus_scrofa
ENSDNOG00000018444	-	99	87.113	ENSTGUG00000001266	PABPC4	98	87.113	Taeniopygia_guttata
ENSDNOG00000018444	-	100	80.885	ENSTRUG00000005907	pabpc4	98	81.162	Takifugu_rubripes
ENSDNOG00000018444	-	100	76.543	ENSTNIG00000016902	pabpc4	98	76.543	Tetraodon_nigroviridis
ENSDNOG00000018444	-	99	88.276	ENSTBEG00000009035	PABPC4	97	88.276	Tupaia_belangeri
ENSDNOG00000018444	-	99	83.431	ENSTTRG00000014340	PABPC4	97	87.069	Tursiops_truncatus
ENSDNOG00000018444	-	100	99.464	ENSUAMG00000000303	PABPC4	99	99.464	Ursus_americanus
ENSDNOG00000018444	-	100	99.464	ENSUMAG00000019585	PABPC4	100	99.464	Ursus_maritimus
ENSDNOG00000018444	-	76	96.429	ENSVPAG00000010041	PABPC4	59	96.429	Vicugna_pacos
ENSDNOG00000018444	-	100	99.643	ENSVVUG00000005215	PABPC4	99	99.643	Vulpes_vulpes
ENSDNOG00000018444	-	99	82.111	ENSXETG00000010946	pabpc4	99	82.111	Xenopus_tropicalis
ENSDNOG00000018444	-	59	97.938	ENSXETG00000027221	-	98	97.938	Xenopus_tropicalis
ENSDNOG00000018444	-	100	89.153	ENSXCOG00000013190	pabpc4	96	90.094	Xiphophorus_couchianus
ENSDNOG00000018444	-	100	81.866	ENSXMAG00000019007	pabpc4	99	82.137	Xiphophorus_maculatus