EuRBPDB

Basic Information
Cancer Related Information

Description

RBDs

RBPome

PRI

Literatures

Expression

Transcripts

Gene Model

Pathways

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000005007 (Gene tree)
Gene ID: 5976
Gene Symbol: UPF1
Alias: HUPF1|KIAA0221|NORF1|pNORF1|smg-2|RENT1
Full Name: UPF1 RNA helicase and ATPase
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Plus strand
Length: 36,302 bases
Position: chr19:18,831,935-18,868,236
Accession: 9962
RBP type: canonical RBP
Summary: This gene encodes a protein that is part of a post-splicing multiprotein complex involved in both mRNA nuclear export and mRNA surveillance. mRNA surveillance detects exported mRNAs with truncated open reading frames and initiates nonsense-mediated mRNA decay (NMD). When translation ends upstream from the last exon-exon junction, this triggers NMD to degrade mRNAs containing premature stop codons. This protein is located only in the cytoplasm. When translation ends, it interacts with the protein that is a functional homolog of yeast Upf2p to trigger mRNA decapping. Use of multiple polyadenylation sites has been noted for this gene. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000262803	UPF1_Zn_bind	PF09416.10	2.6e-74	1	1
ENSP00000470142	UPF1_Zn_bind	PF09416.10	2.6e-74	1	1
ENSP00000262803	ResIII	PF04851.15	9.2e-05	1	1
ENSP00000470142	ResIII	PF04851.15	9.3e-05	1	1

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
22681889	The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts	4SURIC & HEK293	2012 May	Baltz AG	DOI: 10.1016/j.molcel.2012.05.021
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & HEK293	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
29431736	Capturing the interactome of newly transcribed RNA	PolyT-RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
29431736	Capturing the interactome of newly transcribed RNA	RIC & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
22658674	Insights into RNA biology from an atlas of mammalian mRNA-binding proteins	RIC & Hela	2012 May 31	Castello A	DOI: 10.1016/j.cell.2012.04.031
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & Hela	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & MCF10A	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & MCF7	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & U2OS	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
27453046	Comprehensive Identification of RNA-Binding Domains in Human Cells	RIC & Hela	2016 Aug 18	Castello A	DOI: 10.1016/j.molcel.2016.06.029
30352994	Discovery of RNA-binding proteins and characterization of their dynamic responses by enhanced RNA interactome capture	RIC & Jurkat	2018 Oct 23	Perez-Perri JI	DOI:10.1038/s41467-018-06557-8

Protein-RNA interaction（RNA-Binding Site）

Click here to download all RNA binding sites

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
27886048	Interactions between the HIV-1 Unspliced mRNA and Host mRNA Decay Machineries.	Viruses	2016 Nov 23	Toro-Ascuy D	-
25184677	A post-translational regulatory switch on UPF1 controls targeted mRNA degradation.	Genes Dev	2014 Sep 1	Kurosaki T	doi: 10.1101/gad.245506.114.
10999600	Characterization of the biochemical properties of the human Upf1 gene product that is involved in nonsense-mediated mRNA decay.	RNA	2000 Sep	Bhattacharya A	-
21419344	Molecular mechanisms for the RNA-dependent ATPase activity of Upf1 and its regulation by Upf2.	Mol Cell	2011 Mar 18	Chakrabarti S	doi: 10.1016/j.molcel.2011.02.010.
23881279	Plakophilin-associated RNA-binding proteins in prostate cancer and their implications in tumor progression and metastasis.	Virchows Arch	2013 Sep	Yang C	doi: 10.1007/s00428-013-1452-y
30655309	UPFront and center in RNA decay: UPF1 in nonsense-mediated mRNA decay and beyond.	RNA	2019 Apr	Kim YK	doi: 10.1261/rna.070136.118
23263869	Staufen2 functions in Staufen1-mediated mRNA decay by binding to itself and its paralog and promoting UPF1 helicase but not ATPase activity.	Proc Natl Acad Sci U S A	2013 Jan 8	Park E	doi: 10.1073/pnas.1213508110
28821679	UPF1 Governs Synaptic Plasticity through Association with a STAU2 RNA Granule.	J Neurosci	2017 Sep 20	Graber TE	doi: 10.1523/JNEUROSCI.0088-17.2017
29236296	RNA Decay Factor UPF1 Promotes Protein Decay: A Hidden Talent.	Bioessays	2018 Jan	M Plank TD	doi: 10.1002/bies.201700170
9570320	ATP is a cofactor of the Upf1 protein that modulates its translation termination and RNA binding activities.	RNA	1998 Feb	Weng Y	-
12832468	Rapid deadenylation triggered by a nonsense codon precedes decay of the RNA body in a mammalian cytoplasmic nonsense-mediated decay pathway.	Mol Cell Biol	2003 Jul	Chen CY	-
16186820	CBP80 promotes interaction of Upf1 with Upf2 during nonsense-mediated mRNA decay in mammalian cells.	Nat Struct Mol Biol	2005 Oct	Hosoda N	-
22965130	The Ighmbp2 helicase structure reveals the molecular basis for disease-causing mutations in DMSA1.	Nucleic Acids Res	2012 Nov	Lim SC	doi: 10.1093/nar/gks792
25225333	Plakophilins 1 and 3 bind to FXR1 and thereby influence the mRNA stability of desmosomal proteins.	Mol Cell Biol	2014 Dec 1	Fischer-Keso R	doi: 10.1128/MCB.00766-14
24762188	Characterization of phosphorylation- and RNA-dependent UPF1 interactors by quantitative proteomics.	J Proteome Res	2014 Jun 6	Flury V	doi: 10.1021/pr5002143
25879614	Analysis of RNA decay factor mediated RNA stability contributions on RNA abundance.	BMC Genomics	2015 Mar 6	Maekawa S	doi: 10.1186/s12864-015-1358-y.
28541562	DNA substrate recognition and processing by the full-length human UPF1 helicase.	Nucleic Acids Res	2017 Jul 7	Dehghani-Tafti S	doi: 10.1093/nar/gkx478.
22713324	Biochemical characterization of the RNA helicase UPF1 involved in nonsense-mediated mRNA decay.	Methods Enzymol	2012	Fiorini F	doi: 10.1016/B978-0-12-396546-2.00012-7.
23832275	Translation-dependent displacement of UPF1 from coding sequences causes its enrichment in 3' UTRs.	Nat Struct Mol Biol	2013 Aug	Zund D	doi: 10.1038/nsmb.2635
19704008	Human UPF1 participates in small RNA-induced mRNA downregulation.	Mol Cell Biol	2009 Nov	Jin H	doi: 10.1128/MCB.00653-09
21957477	Is there a classical nonsense-mediated decay pathway in trypanosomes?	PLoS One	2011	Delhi P	doi: 10.1371/journal.pone.0025112
21419337	UPF1 learns to relax and unwind.	Mol Cell	2011 Mar 18	Gleghorn ML	doi: 10.1016/j.molcel.2011.03.001.
21029861	Upf1 senses 3'UTR length to potentiate mRNA decay.	Cell	2010 Oct 29	Hogg JR	doi: 10.1016/j.cell.2010.10.005.
24056942	mRNA-mRNA duplexes that autoelicit Staufen1-mediated mRNA decay.	Nat Struct Mol Biol	2013 Oct	Gong C	doi: 10.1038/nsmb.2664
23619768	Functional characterization of Upf1 targets in Schizosaccharomyces pombe.	RNA Biol	2013 Jun	Matia-Gonzalez AM	doi: 10.4161/rna.24569
23524536	Staufen1 dimerizes through a conserved motif and a degenerate dsRNA-binding domain to promote mRNA decay.	Nat Struct Mol Biol	2013 Apr	Gleghorn ML	doi: 10.1038/nsmb.2528

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000598471	UPF1-206	582	-	-	- (aa)	-	-
ENST00000600868	UPF1-211	580	-	-	- (aa)	-	-
ENST00000598209	UPF1-205	551	-	-	- (aa)	-	-
ENST00000601689	UPF1-212	561	-	-	- (aa)	-	-
ENST00000596842	UPF1-204	3825	-	-	- (aa)	-	-
ENST00000600012	UPF1-208	501	-	-	- (aa)	-	-
ENST00000262803	UPF1-201	5348	XM_017027106	ENSP00000262803	1118 (aa)	XP_016882595	Q92900
ENST00000601981	UPF1-213	556	-	-	- (aa)	-	-
ENST00000594504	UPF1-203	559	-	-	- (aa)	-	-
ENST00000600689	UPF1-210	3084	-	-	- (aa)	-	-
ENST00000594243	UPF1-202	683	-	-	- (aa)	-	-
ENST00000599848	UPF1-207	5311	XM_017027105	ENSP00000470142	1129 (aa)	XP_016882594	Q92900
ENST00000600310	UPF1-209	750	-	-	- (aa)	-	-

Gene Model

Click here to download ENSG00000005007's gene model file

Pathways

Pathway ID	Pathway Name	Source
hsa03013	RNA transport	KEGG
hsa03015	mRNA surveillance pathway	KEGG

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000005007's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000005007	UPF1	100	91.192	ENSAPOG00000023773	upf1	100	91.281	Acanthochromis_polyacanthus
ENSG00000005007	UPF1	100	92.507	ENSAPOG00000010916	-	100	92.507	Acanthochromis_polyacanthus
ENSG00000005007	UPF1	100	98.323	ENSAMEG00000011474	UPF1	100	98.323	Ailuropoda_melanoleuca
ENSG00000005007	UPF1	100	91.022	ENSACIG00000019949	upf1	100	91.370	Amphilophus_citrinellus
ENSG00000005007	UPF1	92	95.024	ENSACIG00000010985	-	100	95.122	Amphilophus_citrinellus
ENSG00000005007	UPF1	100	90.706	ENSAOCG00000018519	upf1	100	91.278	Amphiprion_ocellaris
ENSG00000005007	UPF1	100	92.596	ENSAOCG00000006352	-	100	92.596	Amphiprion_ocellaris
ENSG00000005007	UPF1	100	92.596	ENSAPEG00000006292	-	100	92.596	Amphiprion_percula
ENSG00000005007	UPF1	100	90.706	ENSAPEG00000016344	upf1	100	91.278	Amphiprion_percula
ENSG00000005007	UPF1	100	92.596	ENSATEG00000016606	-	100	92.596	Anabas_testudineus
ENSG00000005007	UPF1	100	89.886	ENSATEG00000017867	upf1	100	90.677	Anabas_testudineus
ENSG00000005007	UPF1	93	98.192	ENSAPLG00000009175	UPF1	99	98.192	Anas_platyrhynchos
ENSG00000005007	UPF1	95	97.209	ENSANAG00000024107	UPF1	97	97.209	Aotus_nancymaae
ENSG00000005007	UPF1	100	92.328	ENSACLG00000022630	-	100	92.239	Astatotilapia_calliptera
ENSG00000005007	UPF1	100	90.756	ENSACLG00000007181	upf1	100	91.103	Astatotilapia_calliptera
ENSG00000005007	UPF1	100	92.959	ENSAMXG00000042187	upf1	100	93.405	Astyanax_mexicanus
ENSG00000005007	UPF1	100	99.204	ENSBTAG00000020922	UPF1	100	99.204	Bos_taurus
ENSG00000005007	UPF1	89	50.639	WBGene00004880	smg-2	99	48.029	Caenorhabditis_elegans
ENSG00000005007	UPF1	100	100.000	ENSCJAG00000019627	UPF1	100	100.000	Callithrix_jacchus
ENSG00000005007	UPF1	100	99.646	ENSCAFG00000014578	UPF1	100	99.646	Canis_familiaris
ENSG00000005007	UPF1	100	99.643	ENSCAFG00020012347	UPF1	100	99.643	Canis_lupus_dingo
ENSG00000005007	UPF1	100	99.196	ENSCHIG00000011018	UPF1	100	99.196	Capra_hircus
ENSG00000005007	UPF1	96	97.967	ENSTSYG00000008877	UPF1	99	97.967	Carlito_syrichta
ENSG00000005007	UPF1	93	98.764	ENSCAPG00000005758	UPF1	95	98.764	Cavia_aperea
ENSG00000005007	UPF1	100	96.463	ENSCPOG00000025463	UPF1	100	96.463	Cavia_porcellus
ENSG00000005007	UPF1	100	100.000	ENSCCAG00000032175	UPF1	100	100.000	Cebus_capucinus
ENSG00000005007	UPF1	95	98.411	ENSCATG00000040306	UPF1	98	98.411	Cercocebus_atys
ENSG00000005007	UPF1	96	98.336	ENSCLAG00000004037	UPF1	100	99.620	Chinchilla_lanigera
ENSG00000005007	UPF1	100	99.911	ENSCSAG00000005276	UPF1	100	99.911	Chlorocebus_sabaeus
ENSG00000005007	UPF1	100	96.797	ENSCPBG00000012513	UPF1	100	96.797	Chrysemys_picta_bellii
ENSG00000005007	UPF1	78	78.007	ENSCING00000021399	-	99	78.236	Ciona_intestinalis
ENSG00000005007	UPF1	99	71.972	ENSCSAVG00000006533	-	99	71.972	Ciona_savignyi
ENSG00000005007	UPF1	95	99.252	ENSCANG00000029819	UPF1	99	99.252	Colobus_angolensis_palliatus
ENSG00000005007	UPF1	100	98.569	ENSCGRG00001021067	Upf1	100	98.569	Cricetulus_griseus_chok1gshd
ENSG00000005007	UPF1	95	98.129	ENSCGRG00000013480	Upf1	99	98.129	Cricetulus_griseus_crigri
ENSG00000005007	UPF1	100	92.500	ENSCSEG00000016159	-	100	92.411	Cynoglossus_semilaevis
ENSG00000005007	UPF1	100	86.173	ENSCSEG00000017239	upf1	100	86.262	Cynoglossus_semilaevis
ENSG00000005007	UPF1	100	92.328	ENSCVAG00000010561	upf1	100	92.239	Cyprinodon_variegatus
ENSG00000005007	UPF1	100	92.781	ENSDARG00000016302	upf1	100	93.226	Danio_rerio
ENSG00000005007	UPF1	95	95.884	ENSDORG00000009984	Upf1	96	95.884	Dipodomys_ordii
ENSG00000005007	UPF1	85	70.941	FBgn0030354	Upf1	84	67.433	Drosophila_melanogaster
ENSG00000005007	UPF1	55	85.575	ENSEBUG00000010069	upf1	96	85.413	Eptatretus_burgeri
ENSG00000005007	UPF1	100	99.196	ENSEASG00005006549	UPF1	100	99.196	Equus_asinus_asinus
ENSG00000005007	UPF1	100	99.196	ENSECAG00000010639	UPF1	100	99.196	Equus_caballus
ENSG00000005007	UPF1	100	91.667	ENSELUG00000012916	-	100	91.585	Esox_lucius
ENSG00000005007	UPF1	100	90.240	ENSELUG00000020917	upf1	100	90.506	Esox_lucius
ENSG00000005007	UPF1	100	99.558	ENSFCAG00000009757	UPF1	100	99.558	Felis_catus
ENSG00000005007	UPF1	96	96.756	ENSFALG00000009312	UPF1	99	96.756	Ficedula_albicollis
ENSG00000005007	UPF1	97	97.067	ENSFDAG00000014816	UPF1	100	99.525	Fukomys_damarensis
ENSG00000005007	UPF1	100	88.319	ENSFHEG00000006428	upf1	100	88.319	Fundulus_heteroclitus
ENSG00000005007	UPF1	85	95.477	ENSFHEG00000016276	-	96	95.477	Fundulus_heteroclitus
ENSG00000005007	UPF1	100	91.254	ENSGMOG00000007541	upf1	100	91.696	Gadus_morhua
ENSG00000005007	UPF1	100	97.676	ENSGALG00000003220	UPF1	100	97.676	Gallus_gallus
ENSG00000005007	UPF1	62	95.389	ENSGAFG00000015443	-	88	93.026	Gambusia_affinis
ENSG00000005007	UPF1	100	92.232	ENSGAFG00000004831	upf1	100	92.143	Gambusia_affinis
ENSG00000005007	UPF1	100	97.143	ENSGAGG00000022217	UPF1	100	97.143	Gopherus_agassizii
ENSG00000005007	UPF1	93	100.000	ENSGGOG00000002608	UPF1	99	100.000	Gorilla_gorilla
ENSG00000005007	UPF1	87	100.000	ENSHBUG00000008939	upf1	95	100.000	Haplochromis_burtoni
ENSG00000005007	UPF1	90	86.207	ENSHBUG00000014694	upf1	100	86.207	Haplochromis_burtoni
ENSG00000005007	UPF1	100	99.114	ENSHGLG00000010900	UPF1	100	99.114	Heterocephalus_glaber_female
ENSG00000005007	UPF1	96	95.753	ENSHGLG00100005904	UPF1	99	95.753	Heterocephalus_glaber_male
ENSG00000005007	UPF1	100	91.518	ENSHCOG00000008918	upf1	100	93.810	Hippocampus_comes
ENSG00000005007	UPF1	100	93.405	ENSIPUG00000005108	UPF1	100	93.761	Ictalurus_punctatus
ENSG00000005007	UPF1	100	99.642	ENSSTOG00000009196	UPF1	100	99.642	Ictidomys_tridecemlineatus
ENSG00000005007	UPF1	100	98.317	ENSJJAG00000023151	Upf1	100	98.317	Jaculus_jaculus
ENSG00000005007	UPF1	100	92.685	ENSKMAG00000004962	upf1	100	92.596	Kryptolebias_marmoratus
ENSG00000005007	UPF1	100	92.246	ENSLBEG00000027848	-	100	92.246	Labrus_bergylta
ENSG00000005007	UPF1	100	89.339	ENSLBEG00000014862	upf1	100	90.485	Labrus_bergylta
ENSG00000005007	UPF1	62	97.274	ENSLACG00000008482	UPF1	100	97.274	Latimeria_chalumnae
ENSG00000005007	UPF1	100	95.000	ENSLOCG00000002072	upf1	100	95.000	Lepisosteus_oculatus
ENSG00000005007	UPF1	100	98.761	ENSLAFG00000014963	UPF1	100	98.761	Loxodonta_africana
ENSG00000005007	UPF1	100	100.000	ENSMFAG00000037748	UPF1	100	100.000	Macaca_fascicularis
ENSG00000005007	UPF1	100	100.000	ENSMMUG00000023286	UPF1	100	100.000	Macaca_mulatta
ENSG00000005007	UPF1	100	100.000	ENSMNEG00000000046	UPF1	100	100.000	Macaca_nemestrina
ENSG00000005007	UPF1	93	100.000	ENSMLEG00000028404	UPF1	100	100.000	Mandrillus_leucophaeus
ENSG00000005007	UPF1	100	91.622	ENSMAMG00000006231	-	100	92.068	Mastacembelus_armatus
ENSG00000005007	UPF1	100	89.622	ENSMAMG00000006229	upf1	100	90.589	Mastacembelus_armatus
ENSG00000005007	UPF1	100	89.719	ENSMZEG00005003489	upf1	100	90.901	Maylandia_zebra
ENSG00000005007	UPF1	100	92.328	ENSMZEG00005016386	-	100	92.239	Maylandia_zebra
ENSG00000005007	UPF1	93	97.719	ENSMGAG00000004745	UPF1	100	97.719	Meleagris_gallopavo
ENSG00000005007	UPF1	95	97.403	ENSMAUG00000011398	Upf1	97	97.403	Mesocricetus_auratus
ENSG00000005007	UPF1	100	99.553	ENSMICG00000001659	UPF1	100	99.553	Microcebus_murinus
ENSG00000005007	UPF1	100	98.406	ENSMOCG00000005699	Upf1	100	98.406	Microtus_ochrogaster
ENSG00000005007	UPF1	93	92.514	ENSMMOG00000007537	-	99	92.610	Mola_mola
ENSG00000005007	UPF1	100	90.527	ENSMMOG00000007881	upf1	100	90.982	Mola_mola
ENSG00000005007	UPF1	100	98.147	ENSMODG00000003689	UPF1	100	98.147	Monodelphis_domestica
ENSG00000005007	UPF1	100	90.706	ENSMALG00000000144	upf1	100	90.974	Monopterus_albus
ENSG00000005007	UPF1	100	91.297	ENSMALG00000018100	-	100	91.297	Monopterus_albus
ENSG00000005007	UPF1	100	98.494	MGP_CAROLIEiJ_G0031142	Upf1	100	98.494	Mus_caroli
ENSG00000005007	UPF1	100	98.494	ENSMUSG00000058301	Upf1	100	98.494	Mus_musculus
ENSG00000005007	UPF1	100	98.494	MGP_PahariEiJ_G0021607	Upf1	100	98.494	Mus_pahari
ENSG00000005007	UPF1	100	98.494	MGP_SPRETEiJ_G0032260	Upf1	100	98.494	Mus_spretus
ENSG00000005007	UPF1	100	99.643	ENSMPUG00000015516	UPF1	100	99.643	Mustela_putorius_furo
ENSG00000005007	UPF1	99	99.193	ENSMLUG00000012122	UPF1	99	99.193	Myotis_lucifugus
ENSG00000005007	UPF1	100	98.671	ENSNGAG00000024107	Upf1	100	98.671	Nannospalax_galili
ENSG00000005007	UPF1	100	89.067	ENSNBRG00000000670	upf1	100	89.413	Neolamprologus_brichardi
ENSG00000005007	UPF1	100	89.329	ENSNBRG00000022069	-	100	93.878	Neolamprologus_brichardi
ENSG00000005007	UPF1	93	94.202	ENSNLEG00000006062	UPF1	100	94.202	Nomascus_leucogenys
ENSG00000005007	UPF1	83	94.314	ENSMEUG00000014146	-	83	94.314	Notamacropus_eugenii
ENSG00000005007	UPF1	93	91.547	ENSOPRG00000014018	UPF1	100	91.547	Ochotona_princeps
ENSG00000005007	UPF1	100	97.874	ENSODEG00000012426	UPF1	100	97.874	Octodon_degus
ENSG00000005007	UPF1	100	92.417	ENSONIG00000012729	-	100	92.328	Oreochromis_niloticus
ENSG00000005007	UPF1	100	89.982	ENSONIG00000010452	upf1	100	91.166	Oreochromis_niloticus
ENSG00000005007	UPF1	100	97.350	ENSOANG00000004568	UPF1	100	97.350	Ornithorhynchus_anatinus
ENSG00000005007	UPF1	100	92.417	ENSORLG00000008453	upf1	100	92.417	Oryzias_latipes
ENSG00000005007	UPF1	100	92.246	ENSORLG00020014758	upf1	100	92.246	Oryzias_latipes_hni
ENSG00000005007	UPF1	100	92.246	ENSORLG00015010165	upf1	100	92.246	Oryzias_latipes_hsok
ENSG00000005007	UPF1	100	92.507	ENSOMEG00000003665	upf1	100	92.417	Oryzias_melastigma
ENSG00000005007	UPF1	100	99.911	ENSOGAG00000012866	UPF1	100	99.911	Otolemur_garnettii
ENSG00000005007	UPF1	96	97.240	ENSOARG00000010739	UPF1	100	97.240	Ovis_aries
ENSG00000005007	UPF1	95	99.065	ENSPPAG00000043884	UPF1	97	99.065	Pan_paniscus
ENSG00000005007	UPF1	100	99.558	ENSPPRG00000023470	UPF1	100	99.558	Panthera_pardus
ENSG00000005007	UPF1	93	97.596	ENSPTIG00000010159	UPF1	99	97.596	Panthera_tigris_altaica
ENSG00000005007	UPF1	100	100.000	ENSPTRG00000010721	UPF1	100	100.000	Pan_troglodytes
ENSG00000005007	UPF1	100	100.000	ENSPANG00000008847	UPF1	100	100.000	Papio_anubis
ENSG00000005007	UPF1	91	94.634	ENSPKIG00000006069	upf1	99	92.155	Paramormyrops_kingsleyae
ENSG00000005007	UPF1	68	97.908	ENSPSIG00000009491	UPF1	100	97.908	Pelodiscus_sinensis
ENSG00000005007	UPF1	100	89.235	ENSPMGG00000017327	upf1	100	89.343	Periophthalmus_magnuspinnatus
ENSG00000005007	UPF1	100	98.583	ENSPEMG00000001085	Upf1	100	98.583	Peromyscus_maniculatus_bairdii
ENSG00000005007	UPF1	100	86.999	ENSPMAG00000001206	upf1	100	86.436	Petromyzon_marinus
ENSG00000005007	UPF1	100	98.660	ENSPCIG00000006156	UPF1	100	98.660	Phascolarctos_cinereus
ENSG00000005007	UPF1	100	92.321	ENSPLAG00000016232	-	100	92.232	Poecilia_latipinna
ENSG00000005007	UPF1	100	89.292	ENSPLAG00000018155	-	100	89.204	Poecilia_latipinna
ENSG00000005007	UPF1	100	92.239	ENSPMEG00000016319	-	100	92.150	Poecilia_mexicana
ENSG00000005007	UPF1	100	89.840	ENSPMEG00000011443	-	100	89.750	Poecilia_mexicana
ENSG00000005007	UPF1	100	92.143	ENSPREG00000011247	-	100	92.054	Poecilia_reticulata
ENSG00000005007	UPF1	100	89.735	ENSPREG00000009940	upf1	100	89.735	Poecilia_reticulata
ENSG00000005007	UPF1	100	95.040	ENSPPYG00000009752	UPF1	100	95.040	Pongo_abelii
ENSG00000005007	UPF1	76	100.000	ENSPCAG00000012962	UPF1	76	100.000	Procavia_capensis
ENSG00000005007	UPF1	100	99.469	ENSPCOG00000023813	UPF1	100	99.469	Propithecus_coquereli
ENSG00000005007	UPF1	69	100.000	ENSPVAG00000003183	UPF1	69	100.000	Pteropus_vampyrus
ENSG00000005007	UPF1	100	92.328	ENSPNYG00000016731	-	100	92.239	Pundamilia_nyererei
ENSG00000005007	UPF1	100	89.719	ENSPNYG00000003694	upf1	100	90.901	Pundamilia_nyererei
ENSG00000005007	UPF1	100	92.959	ENSPNAG00000025614	upf1	100	93.405	Pygocentrus_nattereri
ENSG00000005007	UPF1	100	98.494	ENSRNOG00000020134	Upf1	100	98.494	Rattus_norvegicus
ENSG00000005007	UPF1	95	96.916	ENSRBIG00000013894	UPF1	98	99.781	Rhinopithecus_bieti
ENSG00000005007	UPF1	95	99.252	ENSRROG00000040935	UPF1	99	99.252	Rhinopithecus_roxellana
ENSG00000005007	UPF1	76	55.309	YMR080C	NAM7	86	55.962	Saccharomyces_cerevisiae
ENSG00000005007	UPF1	95	98.419	ENSSBOG00000023632	UPF1	98	98.419	Saimiri_boliviensis_boliviensis
ENSG00000005007	UPF1	93	98.860	ENSSHAG00000010499	UPF1	100	98.860	Sarcophilus_harrisii
ENSG00000005007	UPF1	100	94.826	ENSSFOG00015021095	upf1	99	97.214	Scleropages_formosus
ENSG00000005007	UPF1	100	92.424	ENSSMAG00000021018	-	100	92.424	Scophthalmus_maximus
ENSG00000005007	UPF1	100	88.987	ENSSMAG00000005055	upf1	100	89.789	Scophthalmus_maximus
ENSG00000005007	UPF1	100	92.602	ENSSDUG00000009629	-	100	92.602	Seriola_dumerili
ENSG00000005007	UPF1	100	89.886	ENSSDUG00000013320	upf1	100	90.853	Seriola_dumerili
ENSG00000005007	UPF1	100	90.683	ENSSLDG00000020868	upf1	100	91.143	Seriola_lalandi_dorsalis
ENSG00000005007	UPF1	100	92.602	ENSSLDG00000006878	-	100	92.602	Seriola_lalandi_dorsalis
ENSG00000005007	UPF1	100	97.051	ENSSPUG00000010538	UPF1	100	97.051	Sphenodon_punctatus
ENSG00000005007	UPF1	100	92.768	ENSSPAG00000011521	-	100	92.679	Stegastes_partitus
ENSG00000005007	UPF1	100	89.196	ENSSPAG00000000003	upf1	100	89.136	Stegastes_partitus
ENSG00000005007	UPF1	100	99.115	ENSSSCG00000039301	UPF1	100	99.115	Sus_scrofa
ENSG00000005007	UPF1	83	89.597	ENSTGUG00000001057	UPF1	100	95.428	Taeniopygia_guttata
ENSG00000005007	UPF1	100	91.429	ENSTRUG00000005131	-	100	91.429	Takifugu_rubripes
ENSG00000005007	UPF1	100	90.438	ENSTRUG00000000150	upf1	100	90.438	Takifugu_rubripes
ENSG00000005007	UPF1	100	95.353	ENSTTRG00000011544	UPF1	100	94.727	Tursiops_truncatus
ENSG00000005007	UPF1	100	99.553	ENSUAMG00000007093	UPF1	100	99.553	Ursus_americanus
ENSG00000005007	UPF1	96	97.961	ENSUMAG00000006652	UPF1	99	99.896	Ursus_maritimus
ENSG00000005007	UPF1	100	99.643	ENSVVUG00000007797	UPF1	100	99.643	Vulpes_vulpes
ENSG00000005007	UPF1	100	82.379	ENSXETG00000013602	upf1	100	82.379	Xenopus_tropicalis
ENSG00000005007	UPF1	97	89.658	ENSXCOG00000015275	-	96	89.566	Xiphophorus_couchianus
ENSG00000005007	UPF1	92	94.859	ENSXCOG00000005764	-	100	94.859	Xiphophorus_couchianus
ENSG00000005007	UPF1	100	89.911	ENSXMAG00000001703	-	100	89.821	Xiphophorus_maculatus
ENSG00000005007	UPF1	100	92.061	ENSXMAG00000002540	-	100	91.971	Xiphophorus_maculatus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000184	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	21873635.	IBA	Process
GO:0000184	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	17468741.	IDA	Process
GO:0000184	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	18369367.	IMP	Process
GO:0000184	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	10999600.	NAS	Process
GO:0000184	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	8855285.	TAS	Process
GO:0000294	nuclear-transcribed mRNA catabolic process, endonucleolytic cleavage-dependent decay	26255671.	IMP	Process
GO:0000784	nuclear chromosome, telomeric region	21829167.	IDA	Component
GO:0000785	chromatin	16488880.	IDA	Component
GO:0000932	P-body	-	IEA	Component
GO:0000956	nuclear-transcribed mRNA catabolic process	23828042.	IMP	Process
GO:0003682	chromatin binding	16488880.	IDA	Function
GO:0003723	RNA binding	22658674.22681889.	HDA	Function
GO:0003723	RNA binding	21873635.	IBA	Function
GO:0003723	RNA binding	24726324.	IDA	Function
GO:0003723	RNA binding	10999600.	NAS	Function
GO:0004004	ATP-dependent RNA helicase activity	21873635.	IBA	Function
GO:0004004	ATP-dependent RNA helicase activity	12554878.21419344.	IDA	Function
GO:0004386	helicase activity	9064659.	NAS	Function
GO:0005515	protein binding	9620853.11163187.11544179.12417715.12881429.14636577.15680326.16086026.16364915.16488880.16601204.17468741.17469741.17932509.18256688.18362360.18447585.19150429.19417104.19478851.19503078.19556969.19864460.20930030.21829167.23348841.23722113.23788676.24267889.24726324.24965446.25225333.26000482.26255671.	IPI	Function
GO:0005524	ATP binding	-	IEA	Function
GO:0005634	nucleus	18362360.	IDA	Component
GO:0005654	nucleoplasm	-	IDA	Component
GO:0005737	cytoplasm	21873635.	IBA	Component
GO:0005737	cytoplasm	9064659.	NAS	Component
GO:0005829	cytosol	-	TAS	Component
GO:0006260	DNA replication	16488880.	IMP	Process
GO:0006281	DNA repair	16488880.	IDA	Process
GO:0006406	mRNA export from nucleus	16488880.	TAS	Process
GO:0006449	regulation of translational termination	9620853.	IMP	Process
GO:0006449	regulation of translational termination	10999600.	NAS	Process
GO:0008270	zinc ion binding	-	IEA	Function
GO:0009048	dosage compensation by inactivation of X chromosome	-	IEA	Process
GO:0016032	viral process	-	IEA	Process
GO:0032201	telomere maintenance via semi-conservative replication	21829167.	IDA	Process
GO:0032204	regulation of telomere maintenance	17916692.	IMP	Process
GO:0035145	exon-exon junction complex	16601204.	IDA	Component
GO:0042162	telomeric DNA binding	17916692.21829167.	IDA	Function
GO:0044530	supraspliceosomal complex	18362360.	IDA	Component
GO:0044770	cell cycle phase transition	16488880.	IMP	Process
GO:0061014	positive regulation of mRNA catabolic process	24726324.	IDA	Process
GO:0061014	positive regulation of mRNA catabolic process	25225333.26255671.	IMP	Process
GO:0061158	3'-UTR-mediated mRNA destabilization	24726324.	IDA	Process
GO:0061158	3'-UTR-mediated mRNA destabilization	26255671.	IMP	Process
GO:0071044	histone mRNA catabolic process	16086026.	IMP	Process
GO:0071222	cellular response to lipopolysaccharide	26255671.	IDA	Process
GO:0071347	cellular response to interleukin-1	26255671.	IDA	Process

Cancer associated literatures

PID	Title	Article	Time	Author	Doi
27702662	Upregulation of SNHG6 regulates ZEB1 expression by competitively binding miR-101-3p and interacting with UPF1 in hepatocellular carcinoma.	Cancer Lett	2016 Dec 28	Chang L	doi: 10.1016/j.canlet.2016.09.034
28942451	The Human RNA Surveillance Factor UPF1 Modulates Gastric Cancer Progression by Targeting Long Non-Coding RNA MALAT1.	Cell Physiol Biochem	2017	Li L	doi: 10.1159/000479994
23881279	Plakophilin-associated RNA-binding proteins in prostate cancer and their implications in tumor progression and metastasis.	Virchows Arch	2013 Sep	Yang C	doi: 10.1007/s00428-013-1452-y
18427545	The NMD mRNA surveillance pathway downregulates aberrant E-cadherin transcripts in gastric cancer cells and in CDH1 mutation carriers.	Oncogene	2008 Jul 10	Karam R	doi: 10.1038/onc.2008.62

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq	RBD
ACC	chr19	18856060	Silent	novel	A571A	0.2
ACC	chr19	18832219	Missense_Mutation	novel	E4Q	0.62
BLCA	chr19	18853038	Missense_Mutation	novel	I342F	0.35
BLCA	chr19	18850708	Missense_Mutation	novel	S217N	0.19
BLCA	chr19	18863487	Missense_Mutation	novel	L895V	0.22
BLCA	chr19	18855009	Nonsense_Mutation	novel	Q477*	0.17
BLCA	chr19	18853275	Missense_Mutation	novel	E372K	0.11
BLCA	chr19	18857008	Silent	rs113001728	L663L	0.33
BLCA	chr19	18853065	Missense_Mutation	novel	D351N	0.3
BLCA	chr19	18857406	Silent	rs149225517	F696F	0.15
BLCA	chr19	18854612	Missense_Mutation	novel	E401Q	0.04
BLCA	chr19	18832188	5'UTR	novel		0.91
BLCA	chr19	18860859	Silent	novel	T789T	0.19
BLCA	chr19	18854654	Missense_Mutation	NA	E415K	0.25
BLCA	chr19	18853031	Silent	NA	K339K	0.37
BLCA	chr19	18865446	Splice_Site	novel	X1016_splice	0.08
BLCA	chr19	18846003	Silent	novel	Q85Q	0.23
BLCA	chr19	18857460	Silent	NA	R714R	0.57
BLCA	chr19	18832303	Missense_Mutation	NA	E32Q	0.46
BLCA	chr19	18865596	Missense_Mutation	novel	G1030R	0.19
BLCA	chr19	18866082	Frame_Shift_Del	novel	*D1103Efs21**	0.08
BLCA	chr19	18857475	Silent	novel	L719L	0.21
BLCA	chr19	18865311	Frame_Shift_Del	novel	*Q972Rfs8**	0.44
BRCA	chr19	18860078	Intron	novel		0.19
BRCA	chr19	18854899	Missense_Mutation	NA	T440M	0.41
BRCA	chr19	18867000	3'UTR	novel		0.31
BRCA	chr19	18854997	Missense_Mutation	novel	R473C	0.44
BRCA	chr19	18853087	Missense_Mutation	novel	V358A	0.26
BRCA	chr19	18856278	Missense_Mutation	NA	T612N	0.31
BRCA	chr19	18850147	Silent	NA	E178E	0.39
CESC	chr19	18865326	Missense_Mutation	NA	Q976H	0.12
CESC	chr19	18865600	Missense_Mutation	NA	R1031H	0.44
CESC	chr19	18862113	Missense_Mutation	rs748506121	N865S	0.47
CESC	chr19	18855974	Missense_Mutation	NA	E543K	0.41	UPF1_Zn_bind
CESC	chr19	18857426	Missense_Mutation	novel	G703D	0.58
CESC	chr19	18863444	Silent	rs758737674	G880G	0.27
CESC	chr19	18866870	3'UTR	novel		0.3
CESC	chr19	18856055	Missense_Mutation	novel	L570V	0.42
CESC	chr19	18854612	Missense_Mutation	novel	E401Q	0.18
CESC	chr19	18863465	Silent	rs757448554	P887P	0.27
CESC	chr19	18856196	Silent	NA	L585L	0.39
CESC	chr19	18853040	Silent	rs780792461	I342I	0.31
CESC	chr19	18857443	Silent	rs749375625	L709L	0.39
CHOL	chr19	18857443	Missense_Mutation	novel	L709V	0.41
COAD	chr19	18832309	Missense_Mutation	novel	E34K	0.11
COAD	chr19	18854607	Missense_Mutation	NA	G399D	0.47
COAD	chr19	18863450	Silent	NA	I882I	0.38
COAD	chr19	18857502	Silent	rs759452259	Y728Y	0.33
COAD	chr19	18832239	Silent	novel	S10S	0.57
COAD	chr19	18860878	Missense_Mutation	novel	A796T	0.53
COAD	chr19	18860962	Missense_Mutation	NA	L824M	0.48
COAD	chr19	18857348	Missense_Mutation	novel	L677P	0.38
COAD	chr19	18856943	Missense_Mutation	rs367803735	R642C	0.09
COAD	chr19	18862125	Missense_Mutation	NA	R869H	0.25
COAD	chr19	18865755	Missense_Mutation	NA	L1083I	0.39
COAD	chr19	18847814	Missense_Mutation	NA	R148C	0.16
COAD	chr19	18856263	Missense_Mutation	NA	R607Q	0.32
COAD	chr19	18864177	Missense_Mutation	NA	R939H	0.17
COAD	chr19	18854622	Missense_Mutation	NA	I404T	0.3
COAD	chr19	18856280	Missense_Mutation	NA	A613T	0.19
COAD	chr19	18857473	Missense_Mutation	novel	L719F	0.41
COAD	chr19	18846093	Silent	novel	T115T	0.17
COAD	chr19	18865598	Silent	novel	G1030G	0.16
COAD	chr19	18850821	Missense_Mutation	NA	R255C	0.52
COAD	chr19	18846006	Silent	rs149711534	N86N	0.3
DLBC	chr19	18854631	Missense_Mutation	novel	R407Q	0.28
ESCA	chr19	18856191	Missense_Mutation	novel	P583H	0.64
ESCA	chr19	18866107	Missense_Mutation	novel	Y1112N	0.18
ESCA	chr19	18856003	Silent	rs140049775	V552V	0.3
ESCA	chr19	18856240	Silent	rs201992127	S599S	0.65
GBM	chr19	18856209	Missense_Mutation	novel	Q589P	0.43
GBM	chr19	18852219	Missense_Mutation	novel	A299T	0.06
GBM	chr19	18855140	Frame_Shift_Del	novel	*T492Mfs7**	0.19
GBM	chr19	18865600	Missense_Mutation	NA	R1031H	0.34
GBM	chr19	18855142	Missense_Mutation	novel	V493M	0.09
GBM	chr19	18852242	Silent	rs771987109	F306F	0.55
GBM	chr19	18853031	Silent	NA	K339K	0.17
GBM	chr19	18856220	Missense_Mutation	novel	D593Y	0.14
GBM	chr19	18856990	Silent	novel	C657C	0.16
GBM	chr19	18853307	Silent	rs374139415	A382A	0.21
GBM	chr19	18846071	Missense_Mutation	novel	D108A	0.06
GBM	chr19	18863492	Missense_Mutation	novel	W896C	0.09
GBM	chr19	18857441	Missense_Mutation	NA	R708H	0.27
HNSC	chr19	18854694	Missense_Mutation	novel	S428L	0.07
HNSC	chr19	18865550	Splice_Site	novel	X1018_splice	0.25
HNSC	chr19	18847797	Missense_Mutation	novel	K142R	0.15
HNSC	chr19	18853287	Missense_Mutation	rs746623373	R376W	0.19
HNSC	chr19	18860143	Intron	novel		0.13
HNSC	chr19	18863576	Missense_Mutation	novel	F924L	0.13
HNSC	chr19	18856278	Missense_Mutation	novel	T612I	0.35
HNSC	chr19	18856019	Missense_Mutation	novel	K558E	0.21
HNSC	chr19	18852990	Nonsense_Mutation	novel	Q326*	0.23
HNSC	chr19	18846052	Missense_Mutation	novel	E102K	0.47
HNSC	chr19	18856997	Missense_Mutation	novel	P660T	0.37
HNSC	chr19	18856248	Missense_Mutation	novel	D602G	0.07
HNSC	chr19	18832308	Missense_Mutation	novel	F33L	0.28
HNSC	chr19	18857385	Silent	rs755122505	A689A	0.26
KIRC	chr19	18850104	Missense_Mutation	NA	K164R	0.13
KIRC	chr19	18864179	Missense_Mutation	NA	F940L	0.18
KIRP	chr19	18853258	Missense_Mutation	novel	R366Q	0.52
KIRP	chr19	18852999	Missense_Mutation	novel	I329V	0.33
KIRP	chr19	18850159	Missense_Mutation	novel	E182D	0.46
KIRP	chr19	18860287	Intron	novel		0.31
LAML	chr19	18853006	Missense_Mutation	novel	V331D	0.5
LGG	chr19	18857433	Silent	novel	R705R	0.32
LGG	chr19	18847786	Frame_Shift_Ins	novel	*T139Nfs64**	0.35
LGG	chr19	18860970	Silent	novel	T826T	0.18
LGG	chr19	18855008	Silent	rs576490273	A476A	0.34
LGG	chr19	18855955	Silent	rs772905706	I536I	0.38
LGG	chr19	18857440	Missense_Mutation	NA	R708C	0.44
LGG	chr19	18853041	Missense_Mutation	NA	A343T	0.14
LIHC	chr19	18850722	Missense_Mutation	novel	I222F	0.08
LIHC	chr19	18854691	Missense_Mutation	novel	K427R	0.1
LIHC	chr19	18856199	Nonsense_Mutation	NA	Q586*	0.06
LUAD	chr19	18855144	Silent	NA	V493V	0.7
LUAD	chr19	18857361	Silent	NA	V681V	0.24
LUAD	chr19	18863598	Missense_Mutation	novel	N932D	0.38
LUAD	chr19	18860402	Missense_Mutation	novel	E766V	0.31
LUAD	chr19	18864224	Missense_Mutation	NA	G955C	0.47
LUSC	chr19	18855182	Missense_Mutation	novel	G506D	0.38	UPF1_Zn_bind
LUSC	chr19	18832248	Silent	novel	L13L	0.08
LUSC	chr19	18860429	Missense_Mutation	novel	Y775C	0.14
LUSC	chr19	18857377	Missense_Mutation	novel	A687P	0.19
LUSC	chr19	18850195	Silent	rs546083993	L194L	0.33
LUSC	chr19	18865765	Missense_Mutation	rs767300705	P1086L	0.34
LUSC	chr19	18832148	5'UTR	novel		0.27
LUSC	chr19	18860924	Missense_Mutation	NA	R811H	0.31
LUSC	chr19	18832204	5'UTR	novel		0.42
LUSC	chr19	18850799	Silent	rs146140734	S247S	0.18
LUSC	chr19	18832151	5'UTR	novel		0.38
LUSC	chr19	18854618	Missense_Mutation	NA	A403T	0.42
LUSC	chr19	18854612	Missense_Mutation	novel	E401K	0.11
MESO	chr19	18854671	Missense_Mutation	novel	F420L	0.21
OV	chr19	18856232	Missense_Mutation	novel	E597K	0.09
OV	chr19	18856947	Missense_Mutation	novel	S643F	0.14
OV	chr19	18856043	Missense_Mutation	novel	P566S	0.14
OV	chr19	18866043	Splice_Site	novel	X1091_splice	0.1
OV	chr19	18852218	Silent	rs779100457	D298D	0.29
OV	chr19	18863503	Missense_Mutation	novel	L900P	0.14
OV	chr19	18864242	Missense_Mutation	novel	S961G	0.06
OV	chr19	18856204	Silent	novel	K587K	0.27
PAAD	chr19	18860112	Intron	novel		0.25
PRAD	chr19	18865612	Missense_Mutation	NA	R1035H	0.14
PRAD	chr19	18853288	Missense_Mutation	rs770535477	R376Q	0.29
PRAD	chr19	18860904	Silent	novel	I804I	0.33
PRAD	chr19	18866145	Silent	rs561916655	T1124T	0.17
READ	chr19	18856944	Missense_Mutation	NA	R642H	0.23
READ	chr19	18863444	Silent	rs758737674	G880G	0.3
READ	chr19	18856961	Missense_Mutation	NA	E648K	0.48
SARC	chr19	18857375	Missense_Mutation	rs765018756	A686V	0.06
SARC	chr19	18862137	Missense_Mutation	novel	A873V	0.09
SKCM	chr19	18860863	Silent	NA	L791L	0.21
SKCM	chr19	18860326	Missense_Mutation	NA	R741C	0.66
SKCM	chr19	18866052	Silent	NA	Y1093Y	0.33
SKCM	chr19	18854709	Missense_Mutation	NA	R433K	0.25
SKCM	chr19	18860909	Missense_Mutation	novel	P806L	0.73
SKCM	chr19	18860350	Nonsense_Mutation	NA	Q749*	0.4
SKCM	chr19	18855194	Missense_Mutation	novel	T510M	0.4	UPF1_Zn_bind
SKCM	chr19	18860883	Silent	NA	K797K	0.45
SKCM	chr19	18865590	Missense_Mutation	rs749634234	R1028C	0.42
SKCM	chr19	18855945	Missense_Mutation	NA	P533L	0.16	UPF1_Zn_bind
SKCM	chr19	18850142	Missense_Mutation	NA	G177R	0.38
SKCM	chr19	18850795	Missense_Mutation	novel	P246L	0.38
SKCM	chr19	18865343	Missense_Mutation	NA	A982V	0.24
SKCM	chr19	18857379	Silent	NA	A687A	0.4
SKCM	chr19	18850794	Missense_Mutation	NA	P246S	0.33
SKCM	chr19	18857420	Missense_Mutation	NA	V701G	0.32
SKCM	chr19	18864252	Splice_Site	NA	X964_splice	0.36
SKCM	chr19	18850138	Silent	NA	P175P	0.11
SKCM	chr19	18850157	Nonsense_Mutation	NA	E182*	0.34
SKCM	chr19	18864222	Missense_Mutation	novel	P954L	0.28
SKCM	chr19	18832254	Silent	novel	F15F	0.08
SKCM	chr19	18832272	Silent	NA	A21A	0.43
SKCM	chr19	18860426	Missense_Mutation	NA	S774F	0.31
SKCM	chr19	18860095	Intron	novel		0.5
SKCM	chr19	18832219	Missense_Mutation	NA	E4K	0.2
STAD	chr19	18854686	Silent	NA	V425V	0.18
STAD	chr19	18855228	Silent	NA	A521A	0.44
STAD	chr19	18850848	Nonsense_Mutation	novel	K264*	0.3
STAD	chr19	18846063	Missense_Mutation	NA	F105L	0.08
STAD	chr19	18856979	Missense_Mutation	NA	E654K	0.09
STAD	chr19	18856960	Silent	rs140516243	D647D	0.13
STAD	chr19	18852249	Missense_Mutation	NA	L309V	0.26
STAD	chr19	18857007	Missense_Mutation	NA	L663P	0.25
STAD	chr19	18856005	Frame_Shift_Del	novel	*L555Qfs4**	0.23
STAD	chr19	18865580	Silent	novel	G1024G	0.16
STAD	chr19	18866136	Silent	rs776035891	G1121G	0.13
STAD	chr19	18854638	Silent	rs144265702	S409S	0.16
STAD	chr19	18853306	Missense_Mutation	NA	A382V	0.28
STAD	chr19	18846084	Silent	NA	T112T	0.25
STAD	chr19	18860339	Missense_Mutation	NA	G745A	0.24
STAD	chr19	18850124	Missense_Mutation	novel	H171Y	0.07
STAD	chr19	18856880	Missense_Mutation	novel	A621T	0.41
STAD	chr19	18857431	Missense_Mutation	NA	R705W	0.11
STAD	chr19	18854899	Missense_Mutation	NA	T440M	0.17
STAD	chr19	18857431	Missense_Mutation	NA	R705W	0.38
STAD	chr19	18864250	Frame_Shift_Del	novel		0.42
STAD	chr19	18855990	Missense_Mutation	NA	T548M	0.19	UPF1_Zn_bind
STAD	chr19	18864177	Missense_Mutation	NA	R939H	0.26
THYM	chr19	18857376	Silent	rs369728050	A686A	0.13
UCEC	chr19	18856045	Silent	NA	P566P	0.43
UCEC	chr19	18853040	Silent	rs780792461	I342I	0.39
UCEC	chr19	18865311	Silent	novel	F971F	0.33
UCEC	chr19	18867072	3'UTR	rs553097705		0.4
UCEC	chr19	18847818	Missense_Mutation	NA	G149E	0.4
UCEC	chr19	18865560	Splice_Site	novel	X1018_splice	0.54
UCEC	chr19	18866062	Missense_Mutation	rs754812367	E1097K	0.51
UCEC	chr19	18852173	Frame_Shift_Del	novel	*V285Wfs36**	0.44
UCEC	chr19	18863576	Silent	novel	F924F	0.21
UCEC	chr19	18850831	Missense_Mutation	rs777433267	T258M	0.52
UCEC	chr19	18860372	Missense_Mutation	novel	P756L	0.26
UCEC	chr19	18850735	Missense_Mutation	novel	S226N	0.48
UCEC	chr19	18866596	3'UTR	novel		0.35
UCEC	chr19	18860932	Missense_Mutation	NA	L814M	0.18
UCEC	chr19	18852273	Missense_Mutation	NA	D317N	0.37
UCEC	chr19	18853262	Silent	NA	L367L	0.56
UCEC	chr19	18866083	Missense_Mutation	NA	V1104M	0.51
UCEC	chr19	18860231	Intron	novel		0.38
UCEC	chr19	18860379	Missense_Mutation	novel	F758L	0.16
UCEC	chr19	18867087	3'UTR	novel		0.36
UCEC	chr19	18853311	Missense_Mutation	novel	L384M	0.46
UCEC	chr19	18850183	Silent	rs780928893	N190N	0.49
UCEC	chr19	18856003	Silent	rs140049775	V552V	0.39
UCEC	chr19	18866119	Missense_Mutation	NA	R1116W	0.25
UCEC	chr19	18865413	Silent	rs760619362	P1005P	0.58
UCEC	chr19	18865682	Silent	novel	Q1058Q	0.13
UCEC	chr19	18857406	Silent	rs149225517	F696F	0.4
UCEC	chr19	18860373	Silent	rs779744388	P756P	0.39
UCEC	chr19	18864239	Missense_Mutation	novel	R960W	0.49
UCEC	chr19	18865428	Silent	novel	G1010G	0.14
UCEC	chr19	18866950	3'UTR	novel		0.44
UCEC	chr19	18856004	Missense_Mutation	rs763426703	V553M	0.1
UCEC	chr19	18855189	Silent	NA	G508G	0.34
UCEC	chr19	18856280	Missense_Mutation	NA	A613T	0.27
UCEC	chr19	18860859	Silent	rs766225206	T789T	0.35
UCEC	chr19	18862086	In_Frame_Del	novel	E857_D866del	0.08
UCEC	chr19	18847760	Missense_Mutation	rs753936939	D130N	0.15
UCEC	chr19	18852242	Silent	rs771987109	F306F	0.2
UCEC	chr19	18862036	Frame_Shift_Ins	novel	*Q841Sfs26**	0.38
UCEC	chr19	18866137	Missense_Mutation	rs763281916	G1122R	0.44
UCEC	chr19	18860322	Splice_Region	rs146958133	A739A	0.4
UCEC	chr19	18865698	Missense_Mutation	novel	A1064T	0.3
UCEC	chr19	18856016	Missense_Mutation	novel	A557T	0.22
UCEC	chr19	18862034	Missense_Mutation	novel	A839T	0.22
UCEC	chr19	18850715	Silent	novel	L219L	0.09
UCEC	chr19	18852242	Silent	rs771987109	F306F	0.36
UCEC	chr19	18854998	Missense_Mutation	NA	R473H	0.37
UCEC	chr19	18857406	Silent	rs149225517	F696F	0.42
UCEC	chr19	18866712	3'UTR	novel		0.55
UCEC	chr19	18850821	Missense_Mutation	NA	R255C	0.52
UCEC	chr19	18847772	Missense_Mutation	NA	V134M	0.28
UCEC	chr19	18850174	Silent	novel	G187G	0.26
UCEC	chr19	18867095	3'UTR	novel		0.27
UCEC	chr19	18856263	Missense_Mutation	NA	R607Q	0.67
UCEC	chr19	18853268	Frame_Shift_Del	novel	*D371Mfs46**	0.32
UCEC	chr19	18860212	Intron	novel		0.43
UCEC	chr19	18862139	Missense_Mutation	novel	L874M	0.37
UCEC	chr19	18846111	Silent	rs748049113	H121H	0.24
UCEC	chr19	18853082	Silent	novel	D356D	0.07
UCEC	chr19	18854921	Silent	rs137917420	S447S	0.39
UCEC	chr19	18846064	Missense_Mutation	rs758924331	E106K	0.19
UCEC	chr19	18863496	Missense_Mutation	rs374426265	H898Y	0.26
UCEC	chr19	18853040	Silent	rs780792461	I342I	0.6
UCEC	chr19	18866905	3'UTR	novel		0.45
UCEC	chr19	18865696	Missense_Mutation	novel	G1063D	0.28
UCEC	chr19	18853041	Missense_Mutation	NA	A343T	0.13
UCEC	chr19	18863464	Missense_Mutation	NA	P887L	0.3
UCEC	chr19	18850178	Missense_Mutation	novel	R189C	0.34
UCEC	chr19	18852266	Silent	rs376694927	A314A	0.52
UCEC	chr19	18850790	Missense_Mutation	novel	K244N	0.37
UCEC	chr19	18853040	Silent	rs780792461	I342I	0.35
UCEC	chr19	18860326	Missense_Mutation	NA	R741C	0.38

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
READ	DEL	0.0788	0.23023
THCA	DEL	0.012	0.090402
THYM	DEL	0.0244	0.10691

Survival Analysis

Cancer	P-value	Q-value
KIRC	0.00013	Kaplan-Meier Survival Analysis
ACC	0.00091	Kaplan-Meier Survival Analysis
BLCA	0.042	Kaplan-Meier Survival Analysis
LAML	0.00021	Kaplan-Meier Survival Analysis
LGG	0.00011	Kaplan-Meier Survival Analysis
THCA	0.033	Kaplan-Meier Survival Analysis

Drugs

EuRBPDB

Description

RBDs

RBPome

PRI

Literatures

Expression

Transcripts

Gene Model

Pathways

PPI

Orthologs

Gene Ontology

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Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742