EuRBPDB

Basic Information
Cancer Related Information

Description

RBDs

Literatures

Expression

Transcripts

Gene Model

Pathways

GWAS

PPI

Paralogs

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000005075 (Gene tree)
Gene ID: 5439
Gene Symbol: POLR2J
Alias: RPB11|hRPB14|RPB11A|RPB11m|POLR2J1
Full Name: RNA polymerase II subunit J
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Minus strand
Length: 5,900 bases
Position: chr7:102,473,100-102,478,999
Accession: 9197
RBP type: canonical RBP
Summary: This gene encodes a subunit of RNA polymerase II, the polymerase responsible for synthesizing messenger RNA in eukaryotes. The product of this gene exists as a heterodimer with another polymerase subunit; together they form a core subassembly unit of the polymerase. Two similar genes are located nearby on chromosome 7q22.1 and a pseudogene is found on chromosome 7p13. [provided by RefSeq, Jul 2008]

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000292614	RNA_pol_L_2	PF13656.6	1.1e-28	1	1
ENSP00000377383	RNA_pol_L_2	PF13656.6	2.6e-28	1	1
ENSP00000292614	RNA_pol_L	PF01193.24	1.2e-09	1	1
ENSP00000377383	RNA_pol_L	PF01193.24	2.5e-09	1	1

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
9325316	RNA polymerase II subunits 2, 3, and 11 form a core subassembly with DNA binding activity.	J Biol Chem	1997 Oct 10	Kimura M	-
12036295	The thymocyte-specific MAR binding protein, SATB1, interacts in vitro with a novel variant of DNA-directed RNA polymerase II, subunit 11.	Genomics	2002 Jun	Durrin LK	-

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000393794	POLR2J-202	784	XM_005250452	ENSP00000377383	158 (aa)	XP_005250509	F6S314
ENST00000292614	POLR2J-201	932	XM_017012353	ENSP00000292614	117 (aa)	XP_016867842	P52435

Gene Model

Click here to download ENSG00000005075's gene model file

Pathways

Pathway ID	Pathway Name	Source
hsa03020	RNA polymerase	KEGG
hsa05016	Huntington disease	KEGG

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000005075	rs369574511	7	102478605	C	Breast cancer	29059683	[0.023-0.05] unit decrease	0.0364	EFO_0000305
ENSG00000005075	rs1131359	7	102473643	T	Chronotype	30696823	[0.029-0.05] unit increase	0.039267	EFO_0008328

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000005075's network

* RBP PPI network refers to all genes directly bind to RBP

Paralogs

Ensembl ID	Gene Symbol	Coverage	Identiy	Paralog	Gene Symbol	Coverage	Identiy
ENSG00000005075	POLR2J	100	98.734	ENSG00000228049	POLR2J2	100	98.734

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000005075	POLR2J	100	94.872	ENSAPOG00000019538	polr2j	100	94.872	Acanthochromis_polyacanthus
ENSG00000005075	POLR2J	100	92.126	ENSAMEG00000015480	-	100	92.126	Ailuropoda_melanoleuca
ENSG00000005075	POLR2J	93	71.818	ENSACIG00000014549	POLR2J2	91	71.818	Amphilophus_citrinellus
ENSG00000005075	POLR2J	100	94.017	ENSAOCG00000006937	polr2j	100	94.017	Amphiprion_ocellaris
ENSG00000005075	POLR2J	100	94.872	ENSAPEG00000021761	polr2j	100	94.872	Amphiprion_percula
ENSG00000005075	POLR2J	100	94.872	ENSATEG00000013312	-	100	94.872	Anabas_testudineus
ENSG00000005075	POLR2J	100	94.872	ENSATEG00000009731	polr2j	100	94.872	Anabas_testudineus
ENSG00000005075	POLR2J	86	98.020	ENSAPLG00000003744	-	100	98.020	Anas_platyrhynchos
ENSG00000005075	POLR2J	100	90.598	ENSACAG00000000251	POLR2J	100	90.598	Anolis_carolinensis
ENSG00000005075	POLR2J	100	94.872	ENSACLG00000014564	polr2j	100	94.872	Astatotilapia_calliptera
ENSG00000005075	POLR2J	100	96.581	ENSAMXG00000007517	polr2j	100	96.581	Astyanax_mexicanus
ENSG00000005075	POLR2J	62	68.493	ENSBTAG00000048046	-	61	68.493	Bos_taurus
ENSG00000005075	POLR2J	94	70.000	WBGene00012187	rpb-11	89	70.000	Caenorhabditis_elegans
ENSG00000005075	POLR2J	100	100.000	ENSCJAG00000016203	-	100	100.000	Callithrix_jacchus
ENSG00000005075	POLR2J	100	100.000	ENSCAFG00000013683	-	100	100.000	Canis_familiaris
ENSG00000005075	POLR2J	85	100.000	ENSTSYG00000029243	-	85	100.000	Carlito_syrichta
ENSG00000005075	POLR2J	100	100.000	ENSCPOG00000001401	-	100	100.000	Cavia_porcellus
ENSG00000005075	POLR2J	100	74.359	ENSCATG00000016595	-	96	84.615	Cercocebus_atys
ENSG00000005075	POLR2J	100	100.000	ENSCLAG00000005238	-	100	100.000	Chinchilla_lanigera
ENSG00000005075	POLR2J	100	100.000	ENSCSAG00000018092	-	100	100.000	Chlorocebus_sabaeus
ENSG00000005075	POLR2J	100	81.197	ENSCING00000020531	-	100	81.197	Ciona_intestinalis
ENSG00000005075	POLR2J	100	81.197	ENSCSAVG00000006948	-	100	81.197	Ciona_savignyi
ENSG00000005075	POLR2J	100	100.000	ENSCGRG00001012814	Polr2j	100	100.000	Cricetulus_griseus_chok1gshd
ENSG00000005075	POLR2J	100	84.615	ENSCGRG00000008433	Polr2j	100	84.615	Cricetulus_griseus_crigri
ENSG00000005075	POLR2J	100	94.017	ENSCSEG00000020352	polr2j	100	94.017	Cynoglossus_semilaevis
ENSG00000005075	POLR2J	100	94.017	ENSCVAG00000014267	polr2j	100	94.017	Cyprinodon_variegatus
ENSG00000005075	POLR2J	100	95.726	ENSDARG00000035146	polr2j	100	95.726	Danio_rerio
ENSG00000005075	POLR2J	100	100.000	ENSDORG00000005934	Polr2j	100	100.000	Dipodomys_ordii
ENSG00000005075	POLR2J	98	78.261	FBgn0032634	Rpb11	98	78.261	Drosophila_melanogaster
ENSG00000005075	POLR2J	100	64.103	ENSEBUG00000016100	polr2j	100	64.103	Eptatretus_burgeri
ENSG00000005075	POLR2J	100	100.000	ENSEASG00005016864	-	100	100.000	Equus_asinus_asinus
ENSG00000005075	POLR2J	100	95.726	ENSELUG00000012822	polr2j	100	95.726	Esox_lucius
ENSG00000005075	POLR2J	100	100.000	ENSFCAG00000000377	-	100	100.000	Felis_catus
ENSG00000005075	POLR2J	100	100.000	ENSFALG00000009523	POLR2J	100	100.000	Ficedula_albicollis
ENSG00000005075	POLR2J	100	100.000	ENSFDAG00000010507	-	100	100.000	Fukomys_damarensis
ENSG00000005075	POLR2J	100	94.872	ENSFHEG00000006625	polr2j	100	94.872	Fundulus_heteroclitus
ENSG00000005075	POLR2J	100	94.872	ENSGMOG00000018207	polr2j	100	94.872	Gadus_morhua
ENSG00000005075	POLR2J	100	100.000	ENSGALG00000030808	-	100	100.000	Gallus_gallus
ENSG00000005075	POLR2J	100	94.872	ENSGAFG00000019555	polr2j	100	94.872	Gambusia_affinis
ENSG00000005075	POLR2J	100	94.872	ENSGACG00000003310	polr2j	100	94.872	Gasterosteus_aculeatus
ENSG00000005075	POLR2J	97	90.265	ENSGAGG00000018304	-	96	90.265	Gopherus_agassizii
ENSG00000005075	POLR2J	85	95.000	ENSGGOG00000004519	-	80	95.000	Gorilla_gorilla
ENSG00000005075	POLR2J	100	94.872	ENSHBUG00000008467	polr2j	100	94.872	Haplochromis_burtoni
ENSG00000005075	POLR2J	100	100.000	ENSHGLG00000013598	POLR2J	100	100.000	Heterocephalus_glaber_female
ENSG00000005075	POLR2J	100	100.000	ENSHGLG00100011242	POLR2J	100	100.000	Heterocephalus_glaber_male
ENSG00000005075	POLR2J	100	94.872	ENSHCOG00000014827	polr2j	96	68.072	Hippocampus_comes
ENSG00000005075	POLR2J	100	96.581	ENSIPUG00000023960	polr2j	100	96.581	Ictalurus_punctatus
ENSG00000005075	POLR2J	100	100.000	ENSSTOG00000006377	POLR2J	100	100.000	Ictidomys_tridecemlineatus
ENSG00000005075	POLR2J	100	100.000	ENSJJAG00000013854	-	100	100.000	Jaculus_jaculus
ENSG00000005075	POLR2J	100	94.872	ENSJJAG00000018834	-	100	94.872	Jaculus_jaculus
ENSG00000005075	POLR2J	100	94.872	ENSKMAG00000014581	polr2j	79	94.872	Kryptolebias_marmoratus
ENSG00000005075	POLR2J	100	94.872	ENSLBEG00000005885	polr2j	100	94.872	Labrus_bergylta
ENSG00000005075	POLR2J	100	96.581	ENSLOCG00000001885	polr2j	89	96.581	Lepisosteus_oculatus
ENSG00000005075	POLR2J	100	100.000	ENSLAFG00000021507	-	100	100.000	Loxodonta_africana
ENSG00000005075	POLR2J	100	90.000	ENSMMUG00000012019	POLR2J	100	90.000	Macaca_mulatta
ENSG00000005075	POLR2J	100	94.872	ENSMAMG00000009374	polr2j	100	94.872	Mastacembelus_armatus
ENSG00000005075	POLR2J	100	94.872	ENSMZEG00005011932	polr2j	100	94.872	Maylandia_zebra
ENSG00000005075	POLR2J	100	100.000	ENSMGAG00000003534	POLR2J	100	100.000	Meleagris_gallopavo
ENSG00000005075	POLR2J	100	100.000	ENSMAUG00000013049	Polr2j	100	100.000	Mesocricetus_auratus
ENSG00000005075	POLR2J	80	95.745	ENSMICG00000026811	-	95	94.792	Microcebus_murinus
ENSG00000005075	POLR2J	100	100.000	ENSMOCG00000001294	Polr2j	100	100.000	Microtus_ochrogaster
ENSG00000005075	POLR2J	100	94.017	ENSMMOG00000013265	polr2j	100	94.017	Mola_mola
ENSG00000005075	POLR2J	100	91.406	ENSMODG00000013617	-	100	91.406	Monodelphis_domestica
ENSG00000005075	POLR2J	100	94.872	ENSMALG00000020749	polr2j	100	94.872	Monopterus_albus
ENSG00000005075	POLR2J	100	100.000	MGP_CAROLIEiJ_G0027851	Polr2j	100	100.000	Mus_caroli
ENSG00000005075	POLR2J	100	100.000	ENSMUSG00000039771	Polr2j	100	100.000	Mus_musculus
ENSG00000005075	POLR2J	100	100.000	MGP_PahariEiJ_G0024434	Polr2j	100	100.000	Mus_pahari
ENSG00000005075	POLR2J	100	100.000	MGP_SPRETEiJ_G0028853	Polr2j	100	100.000	Mus_spretus
ENSG00000005075	POLR2J	100	100.000	ENSMLUG00000010467	POLR2J	100	100.000	Myotis_lucifugus
ENSG00000005075	POLR2J	100	100.000	ENSNGAG00000023412	Polr2j	100	100.000	Nannospalax_galili
ENSG00000005075	POLR2J	66	90.909	ENSNBRG00000006580	polr2j	59	92.105	Neolamprologus_brichardi
ENSG00000005075	POLR2J	100	100.000	ENSODEG00000015648	-	100	100.000	Octodon_degus
ENSG00000005075	POLR2J	100	76.923	ENSODEG00000008559	-	100	76.923	Octodon_degus
ENSG00000005075	POLR2J	100	94.872	ENSONIG00000000259	polr2j	100	94.872	Oreochromis_niloticus
ENSG00000005075	POLR2J	100	97.436	ENSOANG00000020912	POLR2J	100	97.436	Ornithorhynchus_anatinus
ENSG00000005075	POLR2J	100	92.126	ENSOCUG00000023609	POLR2J	100	92.126	Oryctolagus_cuniculus
ENSG00000005075	POLR2J	100	94.872	ENSORLG00000029046	polr2j	83	94.872	Oryzias_latipes
ENSG00000005075	POLR2J	100	94.872	ENSORLG00020007625	polr2j	83	94.872	Oryzias_latipes_hni
ENSG00000005075	POLR2J	100	94.872	ENSORLG00015003457	polr2j	83	94.872	Oryzias_latipes_hsok
ENSG00000005075	POLR2J	100	94.017	ENSOMEG00000002097	polr2j	100	94.017	Oryzias_melastigma
ENSG00000005075	POLR2J	100	71.875	ENSOGAG00000008250	-	100	71.875	Otolemur_garnettii
ENSG00000005075	POLR2J	100	100.000	ENSOARG00000014204	-	98	100.000	Ovis_aries
ENSG00000005075	POLR2J	100	100.000	ENSPPRG00000012439	-	100	100.000	Panthera_pardus
ENSG00000005075	POLR2J	97	91.228	ENSPTIG00000018714	-	100	97.087	Panthera_tigris_altaica
ENSG00000005075	POLR2J	85	99.000	ENSPSIG00000010173	-	100	99.000	Pelodiscus_sinensis
ENSG00000005075	POLR2J	100	94.872	ENSPMGG00000021256	polr2j	100	94.872	Periophthalmus_magnuspinnatus
ENSG00000005075	POLR2J	100	100.000	ENSPEMG00000015733	Polr2j	100	100.000	Peromyscus_maniculatus_bairdii
ENSG00000005075	POLR2J	100	100.000	ENSPCIG00000009026	-	100	100.000	Phascolarctos_cinereus
ENSG00000005075	POLR2J	100	94.872	ENSPFOG00000012001	polr2j	99	94.872	Poecilia_formosa
ENSG00000005075	POLR2J	100	94.872	ENSPLAG00000014075	polr2j	100	94.872	Poecilia_latipinna
ENSG00000005075	POLR2J	100	94.872	ENSPMEG00000020585	polr2j	100	94.872	Poecilia_mexicana
ENSG00000005075	POLR2J	100	94.872	ENSPREG00000015255	polr2j	100	94.872	Poecilia_reticulata
ENSG00000005075	POLR2J	100	100.000	ENSPCOG00000024573	-	100	100.000	Propithecus_coquereli
ENSG00000005075	POLR2J	99	93.966	ENSPVAG00000017770	-	86	82.237	Pteropus_vampyrus
ENSG00000005075	POLR2J	100	94.872	ENSPNYG00000014832	polr2j	100	94.872	Pundamilia_nyererei
ENSG00000005075	POLR2J	100	94.017	ENSPNAG00000016595	polr2j	100	94.017	Pygocentrus_nattereri
ENSG00000005075	POLR2J	100	100.000	ENSRNOG00000001430	Polr2j	100	100.000	Rattus_norvegicus
ENSG00000005075	POLR2J	100	100.000	ENSSBOG00000025579	-	100	100.000	Saimiri_boliviensis_boliviensis
ENSG00000005075	POLR2J	59	100.000	ENSSHAG00000010443	-	81	100.000	Sarcophilus_harrisii
ENSG00000005075	POLR2J	93	94.495	ENSSFOG00015003371	polr2j	83	94.495	Scleropages_formosus
ENSG00000005075	POLR2J	100	94.872	ENSSMAG00000006729	polr2j	100	94.872	Scophthalmus_maximus
ENSG00000005075	POLR2J	100	94.872	ENSSDUG00000018490	polr2j	100	94.872	Seriola_dumerili
ENSG00000005075	POLR2J	100	94.872	ENSSLDG00000022354	polr2j	100	94.872	Seriola_lalandi_dorsalis
ENSG00000005075	POLR2J	100	100.000	ENSSPUG00000010802	-	100	100.000	Sphenodon_punctatus
ENSG00000005075	POLR2J	100	94.872	ENSSPAG00000021953	polr2j	100	94.872	Stegastes_partitus
ENSG00000005075	POLR2J	100	82.906	ENSSSCG00000003703	-	83	82.906	Sus_scrofa
ENSG00000005075	POLR2J	100	100.000	ENSSSCG00000007688	-	100	100.000	Sus_scrofa
ENSG00000005075	POLR2J	85	99.000	ENSTGUG00000004501	-	100	99.000	Taeniopygia_guttata
ENSG00000005075	POLR2J	59	100.000	ENSTGUG00000004510	-	100	100.000	Taeniopygia_guttata
ENSG00000005075	POLR2J	100	95.726	ENSTRUG00000020842	polr2j	100	95.726	Takifugu_rubripes
ENSG00000005075	POLR2J	100	94.872	ENSTNIG00000002994	polr2j	100	94.872	Tetraodon_nigroviridis
ENSG00000005075	POLR2J	91	82.243	ENSTBEG00000005797	-	76	78.151	Tupaia_belangeri
ENSG00000005075	POLR2J	100	100.000	ENSUAMG00000011310	-	100	100.000	Ursus_americanus
ENSG00000005075	POLR2J	100	100.000	ENSUMAG00000012594	-	100	100.000	Ursus_maritimus
ENSG00000005075	POLR2J	100	98.291	ENSXETG00000001108	polr2j	100	98.291	Xenopus_tropicalis
ENSG00000005075	POLR2J	100	94.872	ENSXMAG00000012422	polr2j	100	94.872	Xiphophorus_maculatus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000398	mRNA splicing, via spliceosome	-	TAS	Process
GO:0001055	RNA polymerase II activity	21873635.	IBA	Function
GO:0003677	DNA binding	-	IEA	Function
GO:0003899	DNA-directed 5'-3' RNA polymerase activity	21873635.	IBA	Function
GO:0005515	protein binding	10783144.21988832.25416956.	IPI	Function
GO:0005634	nucleus	9852112.	IDA	Component
GO:0005654	nucleoplasm	-	TAS	Component
GO:0005665	RNA polymerase II, core complex	21873635.	IBA	Component
GO:0005665	RNA polymerase II, core complex	9852112.	IDA	Component
GO:0006283	transcription-coupled nucleotide-excision repair	-	TAS	Process
GO:0006351	transcription, DNA-templated	-	TAS	Process
GO:0006366	transcription by RNA polymerase II	9852112.	IDA	Process
GO:0006366	transcription by RNA polymerase II	-	TAS	Process
GO:0006367	transcription initiation from RNA polymerase II promoter	-	TAS	Process
GO:0006368	transcription elongation from RNA polymerase II promoter	-	TAS	Process
GO:0006370	7-methylguanosine mRNA capping	-	TAS	Process
GO:0008543	fibroblast growth factor receptor signaling pathway	-	TAS	Process
GO:0016070	RNA metabolic process	-	TAS	Process
GO:0030275	LRR domain binding	10783144.	IPI	Function
GO:0035019	somatic stem cell population maintenance	-	TAS	Process
GO:0042795	snRNA transcription by RNA polymerase II	-	TAS	Process
GO:0046983	protein dimerization activity	-	IEA	Function
GO:0050434	positive regulation of viral transcription	-	TAS	Process
GO:0060964	regulation of gene silencing by miRNA	-	TAS	Process

Differential Expression

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq	RBD
BRCA	chr7	102473527	3'UTR	novel		0.04
BRCA	chr7	102474363	Missense_Mutation	rs771355970	R106W	0.07
BRCA	chr7	102473627	3'UTR	rs141765538		0.27
BRCA	chr7	102476241	Missense_Mutation	NA	P28H	0.75
BRCA	chr7	102478861	5'UTR	rs202131725		0.28
BRCA	chr7	102473532	3'UTR	novel		0.04
BRCA	chr7	102478840	Silent	novel	F7F	0.1
COAD	chr7	102473660	Nonsense_Mutation	novel	G115*	0.35
COAD	chr7	102474369	Missense_Mutation	rs746099610	R104C	0.08
COAD	chr7	102474412	Silent	rs766205098	N89N	0.14
ESCA	chr7	102478825	Silent	novel	L12L	0.24
HNSC	chr7	102478840	Missense_Mutation	novel	F7L	0.11
LUAD	chr7	102478821	Missense_Mutation	NA	E14Q	0.08
LUAD	chr7	102473210	3'UTR	novel		0.5
LUSC	chr7	102478873	5'UTR	rs565875911		0.14
LUSC	chr7	102474509	Missense_Mutation	novel	L57Q	0.28	RNA_pol_L_2
OV	chr7	102478819	Missense_Mutation	novel	E14D	0.13
PAAD	chr7	102474402	Missense_Mutation	rs772943522	D93N	0.16	RNA_pol_L_2
PRAD	chr7	102473577	3'UTR	novel		0.5
SKCM	chr7	102474362	Missense_Mutation	novel	R106L	0.09
SKCM	chr7	102474525	Missense_Mutation	NA	K52E	0.82	RNA_pol_L_2
SKCM	chr7	102478896	5'UTR	novel		0.57
SKCM	chr7	102474363	Missense_Mutation	rs771355970	R106W	0.27
STAD	chr7	102474475	Silent	novel	E68E	0.09
STAD	chr7	102473642	3'UTR	novel		0.1
STAD	chr7	102473686	Splice_Site	novel	X107_splice	0.28
STAD	chr7	102474409	Silent	NA	A90A	0.15
UCEC	chr7	102476202	Missense_Mutation	novel	T41I	0.11	RNA_pol_L_2
UCEC	chr7	102473589	3'UTR	rs530025714		0.33
UCEC	chr7	102473479	3'UTR	novel		0.39
UCEC	chr7	102473680	Missense_Mutation	rs766396668	A108V	0.29

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
ACC	DEL	0.0667	0.12261
DLBC	AMP	0.2917	0.13215
LGG	AMP	0.2943	1.5525e-07
LIHC	DEL	0.0595	0.24831
PAAD	DEL	0.0489	0.049388
PRAD	AMP	0.1362	0.012709
TGCT	AMP	0.62	0.035574
THCA	DEL	0.002	0.27619

Survival Analysis

Cancer	P-value	Q-value
THYM	0.032	Kaplan-Meier Survival Analysis
KIRC	0.0001	Kaplan-Meier Survival Analysis
SKCM	0.029	Kaplan-Meier Survival Analysis
LUSC	0.0097	Kaplan-Meier Survival Analysis
TGCT	0.043	Kaplan-Meier Survival Analysis
PAAD	0.041	Kaplan-Meier Survival Analysis
CESC	0.018	Kaplan-Meier Survival Analysis
READ	0.00034	Kaplan-Meier Survival Analysis
KICH	0.026	Kaplan-Meier Survival Analysis
LGG	0.0022	Kaplan-Meier Survival Analysis
UVM	0.00073	Kaplan-Meier Survival Analysis
OV	0.024	Kaplan-Meier Survival Analysis

Drugs

EuRBPDB

Description

RBDs

Literatures

Expression

Transcripts

Gene Model

Pathways

GWAS

PPI

Paralogs

Orthologs

Gene Ontology

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742