EuRBPDB

Description

RBPome

Expression

Transcripts

Gene Model

Phenotypes

PPI

Gene Ontology

Description

Ensembl ID: ENSG00000005206 (Gene tree)
Gene ID: 56928
Gene Symbol: SPPL2B
Alias: IMP4|PSL1|KIAA1532
Full Name: signal peptide peptidase like 2B
Gene Type: protein_coding
Species: Homo_sapiens
Status: putative
Strand: Plus strand
Length: 26,489 bases
Position: chr19:2,328,614-2,355,102
Accession: 30627
RBP type: non-canonical RBP
Summary: This gene encodes a member of the GXGD family of aspartic proteases. The GXGD proteases are transmembrane proteins with two conserved catalytic motifs localized within the membrane-spanning regions. This enzyme localizes to endosomes, lysosomes, and the plasma membrane. It cleaves the transmembrane domain of tumor necrosis factor alpha to release the intracellular domain, which triggers cytokine expression in the innate and adaptive immunity pathways. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & HEK293	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
29431736	Capturing the interactome of newly transcribed RNA	RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & Hela	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & MCF7	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30352994	Discovery of RNA-binding proteins and characterization of their dynamic responses by enhanced RNA interactome capture	RIC & Jurkat	2018 Oct 23	Perez-Perri JI	DOI:10.1038/s41467-018-06557-8

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000613503	SPPL2B-209	3456	XM_011528138	ENSP00000478298	592 (aa)	XP_011526440	Q8TCT7
ENST00000614794	SPPL2B-211	1559	-	ENSP00000482362	291 (aa)	-	A0A087WZ50
ENST00000622308	SPPL2B-214	749	-	-	- (aa)	-	-
ENST00000614784	SPPL2B-210	1411	-	-	- (aa)	-	-
ENST00000618220	SPPL2B-212	2459	XM_017027016	ENSP00000480813	319 (aa)	XP_016882505	Q8TCT7
ENST00000586111	SPPL2B-202	390	-	-	- (aa)	-	-
ENST00000593243	SPPL2B-206	551	-	-	- (aa)	-	-
ENST00000589515	SPPL2B-205	1733	-	-	- (aa)	-	-
ENST00000585725	SPPL2B-201	583	-	-	- (aa)	-	-
ENST00000621568	SPPL2B-213	1017	-	ENSP00000482470	139 (aa)	-	A0A087WZ93
ENST00000610743	SPPL2B-207	2583	-	ENSP00000478510	511 (aa)	-	Q8TCT7
ENST00000612623	SPPL2B-208	495	-	ENSP00000477658	165 (aa)	-	A0A087WT77
ENST00000586332	SPPL2B-203	496	-	ENSP00000480311	81 (aa)	-	A0A087WWL4
ENST00000587851	SPPL2B-204	586	-	-	- (aa)	-	-

Gene Model

Click here to download ENSG00000005206's gene model file

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000005206	Parkinson Disease	6E-7	25064009

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000005206's network

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000139	Golgi membrane	-	IEA	Component
GO:0005515	protein binding	2313285.17965014.	IPI	Function
GO:0005654	nucleoplasm	-	IDA	Component
GO:0005765	lysosomal membrane	21873635.	IBA	Component
GO:0005765	lysosomal membrane	15998642.	IDA	Component
GO:0005813	centrosome	-	IDA	Component
GO:0005886	plasma membrane	16829952.19114711.21896273.	IDA	Component
GO:0005886	plasma membrane	-	TAS	Component
GO:0006509	membrane protein ectodomain proteolysis	16829951.17965014.	IDA	Process
GO:0010008	endosome membrane	15998642.	IDA	Component
GO:0010803	regulation of tumor necrosis factor-mediated signaling pathway	-	TAS	Process
GO:0015629	actin cytoskeleton	-	IDA	Component
GO:0016020	membrane	2313285.	IDA	Component
GO:0030660	Golgi-associated vesicle membrane	21873635.	IBA	Component
GO:0030660	Golgi-associated vesicle membrane	17965014.	IDA	Component
GO:0031293	membrane protein intracellular domain proteolysis	16829951.19114711.	IDA	Process
GO:0031293	membrane protein intracellular domain proteolysis	16829952.22194595.	IMP	Process
GO:0033619	membrane protein proteolysis	21873635.	IBA	Process
GO:0033619	membrane protein proteolysis	2313285.	IDA	Process
GO:0042500	aspartic endopeptidase activity, intramembrane cleaving	21873635.	IBA	Function
GO:0042500	aspartic endopeptidase activity, intramembrane cleaving	2313285.	IDA	Function
GO:0042500	aspartic endopeptidase activity, intramembrane cleaving	19114711.22194595.	IMP	Function
GO:0042500	aspartic endopeptidase activity, intramembrane cleaving	16873890.	IMP	Function
GO:0042803	protein homodimerization activity	15385547.15998642.16873890.	IDA	Function
GO:0050776	regulation of immune response	16829952.	IMP	Process
GO:0071458	integral component of cytoplasmic side of endoplasmic reticulum membrane	21873635.	IBA	Component
GO:0071458	integral component of cytoplasmic side of endoplasmic reticulum membrane	15385547.	IDA	Component
GO:0071556	integral component of lumenal side of endoplasmic reticulum membrane	21873635.	IBA	Component
GO:0071556	integral component of lumenal side of endoplasmic reticulum membrane	15385547.	IDA	Component