EuRBPDB

Description

Ensembl ID: ENSG00000005700 (Gene tree)
Gene ID: 25998
Gene Symbol: IBTK
Alias: DKFZP564B116|BTBD26|BTKI
Full Name: inhibitor of Bruton tyrosine kinase
Gene Type: protein_coding
Species: Homo_sapiens
Status: putative
Strand: Minus strand
Length: 77,772 bases
Position: chr6:82,169,983-82,247,754
Accession: 17853
RBP type: non-canonical RBP
Summary: Bruton tyrosine kinase (BTK) is a protein tyrosine kinase that is expressed in B cells, macrophages, and neutrophils. The protein encoded by this gene binds to BTK and downregulates BTK's kinase activity. In addition, the encoded protein disrupts BTK-mediated calcium mobilization and negatively regulates the activation of nuclear factor-kappa-B-driven transcription. This gene has a pseudogene on chromosome 18. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2014]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
29431736	Capturing the interactome of newly transcribed RNA	RIC & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & MCF7	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000610980	IBTK-210	5195	-	ENSP00000478891	1152 (aa)	-	E9PDR5
ENST00000445419	IBTK-203	3663	-	-	- (aa)	-	-
ENST00000508381	IBTK-208	2520	-	-	- (aa)	-	-
ENST00000471036	IBTK-204	721	-	ENSP00000424634	128 (aa)	-	H0Y9N7
ENST00000306270	IBTK-201	6054	XM_006715453	ENSP00000305721	1353 (aa)	XP_006715516	Q9P2D0
ENST00000505222	IBTK-207	5547	-	-	- (aa)	-	-
ENST00000503400	IBTK-205	5239	-	ENSP00000422136	238 (aa)	-	D6R9F4
ENST00000510291	IBTK-209	4109	XM_006715454	ENSP00000426405	1338 (aa)	XP_006715517	E7EPI0
ENST00000369751	IBTK-202	4437	-	-	- (aa)	-	-
ENST00000503631	IBTK-206	3560	-	ENSP00000422762	1152 (aa)	-	E9PDR5

Gene Model

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000005700	Arteries	1.3120000E-005	-
ENSG00000005700	Arteries	1.5440000E-005	-
ENSG00000005700	Arteries	1.5440000E-005	-
ENSG00000005700	Arteries	6.2110000E-005	-
ENSG00000005700	Arteries	9.7740000E-005	-
ENSG00000005700	Arteries	1.5440000E-005	-
ENSG00000005700	Arteries	2.0910000E-005	-

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000005700	rs4706938	6	82200530	?	DNA methylation variation (age effect)	30348214			GO_0006306

Protein-Protein Interaction (PPI)

* RBP PPI network refers to all genes directly bind to RBP

Orthologs identified by RBPome

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000005700	IBTK	100	85.820	ENSMUSG00000035941	Ibtk	97	90.377	Mus_musculus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0001933	negative regulation of protein phosphorylation	11577348.	IDA	Process
GO:0005654	nucleoplasm	-	IDA	Component
GO:0005737	cytoplasm	11577348.	IDA	Component
GO:0016020	membrane	-	IEA	Component
GO:0019901	protein kinase binding	11577348.	IDA	Function
GO:0030292	protein tyrosine kinase inhibitor activity	11577348.	IDA	Function
GO:0051209	release of sequestered calcium ion into cytosol	11577348.	IDA	Process
GO:0061099	negative regulation of protein tyrosine kinase activity	-	IEA	Process