EuRBPDB

Description

Ensembl ID: ENSG00000005810 (Gene tree)
Gene ID: 23077
Gene Symbol: MYCBP2
Alias: PAM|KIAA0916|FLJ10106|PHR1
Full Name: MYC binding protein 2
Gene Type: protein_coding
Species: Homo_sapiens
Status: putative
Strand: Minus strand
Length: 282,396 bases
Position: chr13:77,044,655-77,327,050
Accession: 23386
RBP type: non-canonical RBP
Summary: This gene encodes an E3 ubiquitin-protein ligase and member of the PHR (Phr1/MYCBP2, highwire and RPM-1) family of proteins. The encoded protein plays a role in axon guidance and synapse formation in the developing nervous system. In mammalian cells, this protein regulates the cAMP and mTOR signaling pathways, and may additionally regulate autophagy. Reduced expression of this gene has been observed in acute lymphoblastic leukemia patients and a mutation in this gene has been identified in patients with a rare inherited vision defect. [provided by RefSeq, Mar 2017]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & U2OS	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000429715	MYCBP2-202	3660	-	ENSP00000413907	1061 (aa)	-	H7C3U4
ENST00000466564	MYCBP2-204	364	-	ENSP00000481482	83 (aa)	-	A0A087WY34
ENST00000498073	MYCBP2-210	1041	-	-	- (aa)	-	-
ENST00000357337	MYCBP2-201	14736	XM_005266299	ENSP00000349892	4640 (aa)	XP_005266356	O75592
ENST00000486679	MYCBP2-208	545	-	-	- (aa)	-	-
ENST00000462987	MYCBP2-203	463	-	-	- (aa)	-	-
ENST00000474882	MYCBP2-205	393	-	-	- (aa)	-	-
ENST00000485061	MYCBP2-207	566	-	-	- (aa)	-	-
ENST00000482517	MYCBP2-206	1581	-	-	- (aa)	-	-
ENST00000612956	MYCBP2-212	1542	-	ENSP00000483488	275 (aa)	-	A0A0C4DGY7
ENST00000491491	MYCBP2-209	649	-	-	- (aa)	-	-
ENST00000544440	MYCBP2-211	14664	XM_011535004	ENSP00000444596	4640 (aa)	XP_011533306	O75592

Gene Model

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000005810	Intelligence Tests	4.8295800E-005	-
ENSG00000005810	Intelligence Tests	4.8295800E-005	-
ENSG00000005810	Pre-Eclampsia	1E-6	23551011

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000005810	rs7322722	13	77305241	?	Preeclampsia	23551011	[1.90-4.52]	2.93	EFO_0000668
ENSG00000005810	rs9573999	13	77122121	C	Morning person	30696823		1.1128422	EFO_0008328
ENSG00000005810	rs9574021	13	77239199	A	Morning person	30696823		1.1135	EFO_0008328

Protein-Protein Interaction (PPI)

* RBP PPI network refers to all genes directly bind to RBP

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0005085	guanyl-nucleotide exchange factor activity	26304119.	IDA	Function
GO:0005515	protein binding	15161933.22357847.24136289.26496610.	IPI	Function
GO:0005634	nucleus	21873635.	IBA	Component
GO:0005634	nucleus	26304119.	IDA	Component
GO:0005737	cytoplasm	-	IEA	Component
GO:0008270	zinc ion binding	29643511.	IDA	Function
GO:0008536	Ran GTPase binding	26304119.	IDA	Function
GO:0015630	microtubule cytoskeleton	-	IEA	Component
GO:0016020	membrane	19946888.	HDA	Component
GO:0016567	protein ubiquitination	29643511.	IDA	Process
GO:0016567	protein ubiquitination	-	IEA	Process
GO:0021785	branchiomotor neuron axon guidance	-	IEA	Process
GO:0021952	central nervous system projection neuron axonogenesis	-	ISS	Process
GO:0030424	axon	-	IEA	Component
GO:0031398	positive regulation of protein ubiquitination	20534529.	IDA	Process
GO:0032880	regulation of protein localization	-	IEA	Process
GO:0032922	circadian regulation of gene expression	20534529.	IMP	Process
GO:0042177	negative regulation of protein catabolic process	-	IEA	Process
GO:0042803	protein homodimerization activity	-	IEA	Function
GO:0043231	intracellular membrane-bounded organelle	-	IDA	Component
GO:0050905	neuromuscular process	-	ISS	Process
GO:0051493	regulation of cytoskeleton organization	-	IEA	Process
GO:0061630	ubiquitin protein ligase activity	29643511.	IDA	Function
GO:1902667	regulation of axon guidance	-	ISS	Process