EuRBPDB

Basic Information
Cancer Related Information

Description

RBDs

RBPome

Literatures

Expression

Transcripts

Gene Model

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000006047 (Gene tree)
Gene ID: 51087
Gene Symbol: YBX2
Alias: MSY2|CSDA3|Contrin
Full Name: Y-box binding protein 2
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Minus strand
Length: 6,364 bases
Position: chr17:7,288,252-7,294,615
Accession: 17948
RBP type: canonical RBP
Summary: This gene encodes a nucleic acid binding protein which is highly expressed in germ cells. The encoded protein binds to a Y-box element in the promoters of certain genes but also binds to mRNA transcribed from these genes. Pseudogenes for this gene are located on chromosome 10 and 15. [provided by RefSeq, Feb 2012]

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000007699	CSD	PF00313.22	3.9e-25	1	1

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & MCF7	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30352994	Discovery of RNA-binding proteins and characterization of their dynamic responses by enhanced RNA interactome capture	RIC & Jurkat	2018 Oct 23	Perez-Perri JI	DOI:10.1038/s41467-018-06557-8

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
16479255	Expression of Y-box-binding protein dbpC/contrin, a potentially new cancer/testis antigen.	Br J Cancer	2006 Mar 13	Kohno Y	-
26577303	Postovulatory aging affects dynamics of mRNA, expression and localization of maternal effect proteins, spindle integrity and pericentromeric proteins in mouse oocytes.	Hum Reprod	2016 Jan	Trapphoff T	doi: 10.1093/humrep/dev279
18606161	CDC2A (CDK1)-mediated phosphorylation of MSY2 triggers maternal mRNA degradation during mouse oocyte maturation.	Dev Biol	2008 Sep 1	Medvedev S	doi: 10.1016/j.ydbio.2008.06.016
17035640	In the absence of the mouse DNA/RNA-binding protein MSY2, messenger RNA instability leads to spermatogenic arrest.	Biol Reprod	2007 Jan	Yang J	-
26358877	Sculpting the Transcriptome During the Oocyte-to-Embryo Transition in Mouse.	Curr Top Dev Biol	2015	Svoboda P	doi: 10.1016/bs.ctdb.2015.06.004
28970281	RNA Binding Protein Ybx2 Regulates RNA Stability During Cold-Induced Brown Fat Activation.	Diabetes	2017 Dec	Xu D	doi: 10.2337/db17-0655
10100484	Contrin, the human homologue of a germ-cell Y-box-binding protein: cloning, expression, and chromosomal localization.	J Androl	1999 Jan-Feb	Tekur S	-
12648488	Requirement for RNA-binding activity of MSY2 for cytoplasmic localization and retention in mouse oocytes.	Dev Biol	2003 Mar 15	Yu J	-
12297523	RNA-binding properties and translation repression in vitro by germ cell-specific MSY2 protein.	Biol Reprod	2002 Oct	Yu J	-
11564883	MSY2 and MSY4 bind a conserved sequence in the 3' untranslated region of protamine 1 mRNA in vitro and in vivo.	Mol Cell Biol	2001 Oct	Giorgini F	-
16413673	Deletion of the DNA/RNA-binding protein MSY2 leads to post-meiotic arrest.	Mol Cell Endocrinol	2006 May 16	Yang J	-
10772793	A sequence-specific RNA binding complex expressed in murine germ cells contains MSY2 and MSY4.	Dev Biol	2000 May 1	Davies HG	-
15824319	Absence of the DNA-/RNA-binding protein MSY2 results in male and female infertility.	Proc Natl Acad Sci U S A	2005 Apr 19	Yang J	-
15665108	The DNA/RNA-binding protein MSY2 marks specific transcripts for cytoplasmic storage in mouse male germ cells.	Proc Natl Acad Sci U S A	2005 Feb 1	Yang J	-
23136299	Maternally recruited DCP1A and DCP2 contribute to messenger RNA degradation during oocyte maturation and genome activation in mouse.	Biol Reprod	2013 Jan 10	Ma J	doi: 10.1095/biolreprod.112.105312
20075394	P-body loss is concomitant with formation of a messenger RNA storage domain in mouse oocytes.	Biol Reprod	2010 May	Flemr M	doi: 10.1095/biolreprod.109.082057
19597149	MIWI-independent small RNAs (MSY-RNAs) bind to the RNA-binding protein, MSY2, in male germ cells.	Proc Natl Acad Sci U S A	2009 Jul 28	Xu M	doi: 10.1073/pnas.0903944106
18380784	MSY2 and polypyrimidine tract binding protein 2 stabilize mRNAs in the mammalian testis.	Int J Androl	2008 Sep	Xu M	doi: 10.1111/j.1365-2605.2008.00885.x
21613634	Absence of MSY2 in mouse oocytes perturbs oocyte growth and maturation, RNA stability, and the transcriptome.	Biol Reprod	2011 Sep	Medvedev S	doi: 10.1095/biolreprod.111.091710
27929740	Role for PADI6 in securing the mRNA-MSY2 complex to the oocyte cytoplasmic lattices.	Cell Cycle	2017 Feb 16	Liu X	doi: 10.1080/15384101.2016.1261225
27483469	CFTR Deletion in Mouse Testis Induces VDAC1 Mediated Inflammatory Pathway Critical for Spermatogenesis.	PLoS One	2016 Aug 2	Yan C	doi: 10.1371/journal.pone.0158994
26134871	Mobilization of Dormant Cnot7 mRNA Promotes Deadenylation of Maternal Transcripts During Mouse Oocyte Maturation.	Biol Reprod	2015 Aug	Ma J	doi: 10.1095/biolreprod.115.130344
30295753	Murine PAIP1 stimulates translation of spermiogenic mRNAs stored by YBX2 via its interaction with YBX2.	Biol Reprod	2019 Feb 1	He Y	doi: 10.1093/biolre/ioy213.
26644857	Comparison of Protamine 1 to Protamine 2 mRNA Ratio and YBX2 gene mRNA Content in Testicular Tissue of Fertile and Azoospermic Men.	Int J Fertil Steril	2015 Oct-Dec	Moghbelinejad S	-
10076007	The mouse Y-box protein, MSY2, is associated with a kinase on non-polysomal mouse testicular mRNAs.	Nucleic Acids Res	1999 Apr 1	Herbert TP	-

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000571127	YBX2-204	791	-	-	- (aa)	-	-
ENST00000571834	YBX2-207	2195	-	-	- (aa)	-	-
ENST00000570627	YBX2-202	653	-	-	- (aa)	-	-
ENST00000571464	YBX2-205	640	-	ENSP00000459587	164 (aa)	-	I3L2D6
ENST00000571485	YBX2-206	4553	-	-	- (aa)	-	-
ENST00000007699	YBX2-201	1590	XM_017024713	ENSP00000007699	364 (aa)	XP_016880202	Q9Y2T7
ENST00000570720	YBX2-203	606	-	-	- (aa)	-	-

Gene Model

Click here to download ENSG00000006047's gene model file

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000006047's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000006047	YBX2	54	85.204	ENSAMEG00000016564	YBX2	87	84.896	Ailuropoda_melanoleuca
ENSG00000006047	YBX2	99	87.730	ENSANAG00000019540	YBX2	86	88.926	Aotus_nancymaae
ENSG00000006047	YBX2	99	87.117	ENSBTAG00000009126	YBX2	84	89.935	Bos_taurus
ENSG00000006047	YBX2	99	84.049	ENSCJAG00000042146	-	97	86.429	Callithrix_jacchus
ENSG00000006047	YBX2	99	83.436	ENSCJAG00000016581	-	84	87.662	Callithrix_jacchus
ENSG00000006047	YBX2	95	63.462	ENSCAFG00000005162	-	89	72.374	Canis_familiaris
ENSG00000006047	YBX2	99	84.756	ENSCAFG00000016128	-	84	88.997	Canis_familiaris
ENSG00000006047	YBX2	99	87.117	ENSCAFG00020008884	YBX2	84	85.669	Canis_lupus_dingo
ENSG00000006047	YBX2	99	85.890	ENSCHIG00000016407	YBX2	84	89.610	Capra_hircus
ENSG00000006047	YBX2	99	85.276	ENSTSYG00000030765	YBX2	92	83.571	Carlito_syrichta
ENSG00000006047	YBX2	99	85.890	ENSCAPG00000011432	YBX2	100	89.011	Cavia_aperea
ENSG00000006047	YBX2	99	86.420	ENSCPOG00000009543	YBX2	96	88.768	Cavia_porcellus
ENSG00000006047	YBX2	99	88.957	ENSCCAG00000025671	YBX2	83	90.909	Cebus_capucinus
ENSG00000006047	YBX2	99	91.358	ENSCATG00000036919	YBX2	84	92.532	Cercocebus_atys
ENSG00000006047	YBX2	99	87.117	ENSCLAG00000010306	YBX2	96	89.493	Chinchilla_lanigera
ENSG00000006047	YBX2	99	91.358	ENSCSAG00000011857	YBX2	84	92.532	Chlorocebus_sabaeus
ENSG00000006047	YBX2	72	64.662	ENSCPBG00000022288	YBX2	83	67.279	Chrysemys_picta_bellii
ENSG00000006047	YBX2	99	89.571	ENSCANG00000007129	YBX2	97	91.241	Colobus_angolensis_palliatus
ENSG00000006047	YBX2	99	86.503	ENSCGRG00001000751	Ybx2	96	88.768	Cricetulus_griseus_chok1gshd
ENSG00000006047	YBX2	99	86.503	ENSCGRG00000007683	Ybx2	99	88.768	Cricetulus_griseus_crigri
ENSG00000006047	YBX2	99	84.049	ENSDNOG00000013746	YBX2	97	77.124	Dasypus_novemcinctus
ENSG00000006047	YBX2	99	85.890	ENSDORG00000010882	Ybx2	95	89.051	Dipodomys_ordii
ENSG00000006047	YBX2	56	47.143	ENSEBUG00000009872	YBX2	60	46.766	Eptatretus_burgeri
ENSG00000006047	YBX2	95	85.806	ENSEASG00005018928	YBX2	83	85.000	Equus_asinus_asinus
ENSG00000006047	YBX2	99	82.317	ENSECAG00000009996	YBX2	79	83.172	Equus_caballus
ENSG00000006047	YBX2	99	87.730	ENSFCAG00000018097	YBX2	85	89.610	Felis_catus
ENSG00000006047	YBX2	68	64.542	ENSGAGG00000016159	YBX2	87	70.518	Gopherus_agassizii
ENSG00000006047	YBX2	100	96.986	ENSGGOG00000007399	YBX2	100	96.986	Gorilla_gorilla
ENSG00000006047	YBX2	99	85.890	ENSHGLG00000014186	YBX2	84	89.286	Heterocephalus_glaber_female
ENSG00000006047	YBX2	99	87.730	ENSSTOG00000008630	YBX2	99	89.493	Ictidomys_tridecemlineatus
ENSG00000006047	YBX2	99	87.117	ENSJJAG00000013072	Ybx2	96	89.493	Jaculus_jaculus
ENSG00000006047	YBX2	99	87.730	ENSLAFG00000014006	YBX2	84	90.584	Loxodonta_africana
ENSG00000006047	YBX2	99	91.358	ENSMFAG00000039921	YBX2	84	92.532	Macaca_fascicularis
ENSG00000006047	YBX2	99	91.358	ENSMNEG00000045221	YBX2	84	92.532	Macaca_nemestrina
ENSG00000006047	YBX2	99	90.798	ENSMLEG00000039452	YBX2	97	92.701	Mandrillus_leucophaeus
ENSG00000006047	YBX2	99	65.432	ENSMLEG00000029266	-	84	73.239	Mandrillus_leucophaeus
ENSG00000006047	YBX2	99	86.503	ENSMAUG00000022062	Ybx2	84	89.610	Mesocricetus_auratus
ENSG00000006047	YBX2	99	85.276	ENSMICG00000012453	YBX2	97	88.686	Microcebus_murinus
ENSG00000006047	YBX2	99	87.117	ENSMOCG00000013958	Ybx2	96	89.493	Microtus_ochrogaster
ENSG00000006047	YBX2	83	86.029	ENSMODG00000017596	YBX2	78	83.860	Monodelphis_domestica
ENSG00000006047	YBX2	99	87.654	MGP_CAROLIEiJ_G0016606	Ybx2	96	89.493	Mus_caroli
ENSG00000006047	YBX2	99	87.654	ENSMUSG00000018554	Ybx2	96	89.493	Mus_musculus
ENSG00000006047	YBX2	99	87.654	MGP_PahariEiJ_G0017737	Ybx2	96	89.493	Mus_pahari
ENSG00000006047	YBX2	99	87.654	MGP_SPRETEiJ_G0017442	Ybx2	96	89.493	Mus_spretus
ENSG00000006047	YBX2	99	78.395	ENSMPUG00000010386	YBX2	93	83.333	Mustela_putorius_furo
ENSG00000006047	YBX2	99	85.185	ENSMLUG00000004686	YBX2	90	82.143	Myotis_lucifugus
ENSG00000006047	YBX2	99	84.049	ENSNGAG00000011707	Ybx2	85	87.987	Nannospalax_galili
ENSG00000006047	YBX2	99	91.358	ENSNLEG00000008063	-	100	93.464	Nomascus_leucogenys
ENSG00000006047	YBX2	97	81.761	ENSMEUG00000006947	YBX2	90	79.221	Notamacropus_eugenii
ENSG00000006047	YBX2	99	82.209	ENSOPRG00000013773	YBX2	100	85.135	Ochotona_princeps
ENSG00000006047	YBX2	99	85.276	ENSODEG00000017530	YBX2	96	88.406	Octodon_degus
ENSG00000006047	YBX2	99	85.890	ENSOCUG00000015064	YBX2	95	80.263	Oryctolagus_cuniculus
ENSG00000006047	YBX2	99	85.276	ENSOGAG00000004392	YBX2	100	88.686	Otolemur_garnettii
ENSG00000006047	YBX2	99	86.503	ENSOARG00000011562	YBX2	78	87.986	Ovis_aries
ENSG00000006047	YBX2	99	100.000	ENSPPAG00000041892	YBX2	100	99.336	Pan_paniscus
ENSG00000006047	YBX2	99	87.037	ENSPPRG00000000782	YBX2	85	90.909	Panthera_pardus
ENSG00000006047	YBX2	99	100.000	ENSPTRG00000008673	YBX2	100	98.630	Pan_troglodytes
ENSG00000006047	YBX2	99	100.000	ENSPTRG00000051288	-	85	99.265	Pan_troglodytes
ENSG00000006047	YBX2	99	89.571	ENSPANG00000024250	YBX2	84	92.131	Papio_anubis
ENSG00000006047	YBX2	99	62.346	ENSPANG00000032747	-	74	67.208	Papio_anubis
ENSG00000006047	YBX2	75	66.312	ENSPSIG00000012364	YBX2	99	70.922	Pelodiscus_sinensis
ENSG00000006047	YBX2	97	83.019	ENSPCIG00000028819	YBX2	85	82.449	Phascolarctos_cinereus
ENSG00000006047	YBX2	99	85.185	ENSPCAG00000008019	YBX2	84	88.636	Procavia_capensis
ENSG00000006047	YBX2	99	84.663	ENSPCOG00000006030	YBX2	84	88.636	Propithecus_coquereli
ENSG00000006047	YBX2	99	83.333	ENSPVAG00000005050	YBX2	84	78.317	Pteropus_vampyrus
ENSG00000006047	YBX2	99	86.503	ENSRNOG00000017117	Ybx2	84	89.610	Rattus_norvegicus
ENSG00000006047	YBX2	99	90.798	ENSRBIG00000040919	YBX2	85	92.208	Rhinopithecus_bieti
ENSG00000006047	YBX2	99	90.798	ENSRROG00000041728	YBX2	99	81.518	Rhinopithecus_roxellana
ENSG00000006047	YBX2	99	88.957	ENSSBOG00000029566	YBX2	97	90.511	Saimiri_boliviensis_boliviensis
ENSG00000006047	YBX2	97	82.390	ENSSHAG00000007786	YBX2	95	78.758	Sarcophilus_harrisii
ENSG00000006047	YBX2	99	85.890	ENSSARG00000000488	YBX2	84	89.286	Sorex_araneus
ENSG00000006047	YBX2	82	58.940	ENSSPUG00000018250	YBX2	99	64.026	Sphenodon_punctatus
ENSG00000006047	YBX2	99	87.654	ENSSSCG00000017938	YBX2	84	89.935	Sus_scrofa
ENSG00000006047	YBX2	99	82.099	ENSTBEG00000001266	YBX2	89	86.601	Tupaia_belangeri
ENSG00000006047	YBX2	57	97.938	ENSTTRG00000009780	YBX2	56	97.938	Tursiops_truncatus
ENSG00000006047	YBX2	99	86.503	ENSUAMG00000014725	YBX2	100	83.088	Ursus_americanus
ENSG00000006047	YBX2	85	87.857	ENSUMAG00000015222	YBX2	89	83.200	Ursus_maritimus
ENSG00000006047	YBX2	99	62.963	ENSVPAG00000003104	-	100	71.825	Vicugna_pacos
ENSG00000006047	YBX2	95	80.128	ENSVVUG00000012111	-	77	79.377	Vulpes_vulpes
ENSG00000006047	YBX2	99	85.276	ENSVVUG00000027830	-	100	83.150	Vulpes_vulpes

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	-	ISA	Function
GO:0001650	fibrillar center	-	IDA	Component
GO:0003677	DNA binding	-	IEA	Function
GO:0003723	RNA binding	-	IEA	Function
GO:0005634	nucleus	10100484.	TAS	Component
GO:0005737	cytoplasm	-	IEA	Component
GO:0006357	regulation of transcription by RNA polymerase II	-	IEA	Process
GO:0006366	transcription by RNA polymerase II	10100484.	TAS	Process
GO:0007283	spermatogenesis	10100484.	TAS	Process
GO:0009386	translational attenuation	10100484.	TAS	Process
GO:0048599	oocyte development	-	IEA	Process
GO:0120162	positive regulation of cold-induced thermogenesis	28970281.	ISS	Process

Differential Expression

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq	RBD
BLCA	chr17	7289719	Silent	NA	F285F	0.65
BLCA	chr17	7290463	Missense_Mutation	rs771681443	R178C	0.17
CESC	chr17	7293480	Silent	NA	I110I	0.27
COAD	chr17	7291145	Missense_Mutation	rs766316395	R136H	0.41	CSD
COAD	chr17	7290451	Nonsense_Mutation	novel	R182*	0.33
COAD	chr17	7289622	Missense_Mutation	rs752018878	R318C	0.2
COAD	chr17	7290480	Missense_Mutation	novel	R172H	0.32
COAD	chr17	7291108	Silent	NA	V148V	0.31
ESCA	chr17	7290283	Missense_Mutation	NA	P238S	0.26
ESCA	chr17	7290472	Missense_Mutation	novel	P175S	0.41
GBM	chr17	7290045	Missense_Mutation	novel	E257D	0.24
GBM	chr17	7289644	Missense_Mutation	novel	D310E	0.12
GBM	chr17	7292054	Missense_Mutation	novel	D114V	0.11	CSD
GBM	chr17	7291139	Missense_Mutation	NA	V138A	0.43	CSD
HNSC	chr17	7289598	Nonsense_Mutation	novel	Q326*	0.19
HNSC	chr17	7289599	Silent	novel	F325F	0.19
HNSC	chr17	7290280	Missense_Mutation	rs756053394	R239W	0.18
KIRP	chr17	7290013	Missense_Mutation	novel	G268V	0.42
LGG	chr17	7288802	Missense_Mutation	novel	T361P	0.09
LIHC	chr17	7290465	Missense_Mutation	novel	R177Q	0.29
LIHC	chr17	7289541	Missense_Mutation	rs373353478	A345T	0.11
LUAD	chr17	7289995	Frame_Shift_Del	novel	*P274Rfs126**	0.26
LUAD	chr17	7290337	In_Frame_Del	novel	Q218_R219del	0.29
LUAD	chr17	7290404	Silent	novel	A197A	0.41
LUAD	chr17	7289626	Silent	NA	P316P	0.24
LUAD	chr17	7291143	Missense_Mutation	NA	S137C	0.33	CSD
LUSC	chr17	7290462	Missense_Mutation	novel	R178H	0.69
LUSC	chr17	7290361	Missense_Mutation	rs768696219	R212W	0.59
OV	chr17	7289970	Splice_Region	novel	R282R	0.11
OV	chr17	7289630	Missense_Mutation	novel	E315G	0.56
OV	chr17	7289577	Missense_Mutation	novel	P333A	0.81
PAAD	chr17	7292026	Missense_Mutation	novel	Q123H	0.17	CSD
PCPG	chr17	7289994	Silent	rs774610299	P274P	0.2
READ	chr17	7290532	Missense_Mutation	NA	A155T	0.34	CSD
SARC	chr17	7290318	Frame_Shift_Del	novel	*P226Hfs22**	0.15
SARC	chr17	7288387	3'UTR	novel		0.37
SKCM	chr17	7290433	Missense_Mutation	NA	P188S	0.4
SKCM	chr17	7289615	Missense_Mutation	rs535139132	R320Q	0.71
SKCM	chr17	7290029	Missense_Mutation	NA	G263R	0.3
SKCM	chr17	7290432	Missense_Mutation	NA	P188L	0.28
SKCM	chr17	7290524	Silent	novel	A157A	0.52
SKCM	chr17	7290454	Missense_Mutation	NA	R181C	0.81
SKCM	chr17	7290433	Missense_Mutation	NA	P188S	0.93
SKCM	chr17	7290319	Missense_Mutation	NA	P226S	0.1
SKCM	chr17	7290283	Missense_Mutation	NA	P238S	0.21
SKCM	chr17	7292028	Nonsense_Mutation	NA	Q123*	0.31	CSD
STAD	chr17	7290318	Frame_Shift_Del	novel	*P226Hfs22**	0.16
STAD	chr17	7290439	Frame_Shift_Del	NA	*R186Gfs62**	0.41
STAD	chr17	7290318	Frame_Shift_Del	novel	*P226Hfs22**	0.3
STAD	chr17	7290318	Frame_Shift_Del	novel	*P226Hfs22**	0.06
STAD	chr17	7290318	Frame_Shift_Del	novel	*P226Hfs22**	0.11
STAD	chr17	7291093	In_Frame_Del	novel	K153del	0.32	CSD
STAD	chr17	7289616	Nonsense_Mutation	novel	R320*	0.23
STAD	chr17	7290317	Frame_Shift_Ins	NA	*P227Tfs25**	0.24
THCA	chr17	7290298	Missense_Mutation	novel	R233W	0.23
UCEC	chr17	7290339	Missense_Mutation	novel	R219Q	0.55
UCEC	chr17	7290483	Missense_Mutation	novel	S171I	0.5
UCEC	chr17	7290450	Missense_Mutation	rs765004337	R182Q	0.44
UCEC	chr17	7290536	Splice_Site	novel	X154_splice	0.44
UCEC	chr17	7290005	Nonsense_Mutation	NA	R271*	0.3
UCEC	chr17	7290333	Missense_Mutation	rs767209415	R221Q	0.38
UCEC	chr17	7290381	Missense_Mutation	novel	G205E	0.35
UCEC	chr17	7291154	Missense_Mutation	novel	K133T	0.14	CSD
UCEC	chr17	7290505	Missense_Mutation	NA	G164W	0.59
UCEC	chr17	7290401	Missense_Mutation	novel	E198D	0.38
UCEC	chr17	7291160	Missense_Mutation	novel	P131H	0.3	CSD
UCEC	chr17	7288539	3'UTR	novel		0.41
UCEC	chr17	7290489	Missense_Mutation	novel	K169T	0.51
UCEC	chr17	7290330	Missense_Mutation	rs759095121	R222Q	0.11
UCEC	chr17	7291149	Silent	novel	L135L	0.1
UCEC	chr17	7288336	3'UTR	novel		0.29
UCEC	chr17	7289994	Silent	rs774610299	P274P	0.51
UCEC	chr17	7289705	Missense_Mutation	rs778498956	R290H	0.44
UCEC	chr17	7291096	Missense_Mutation	NA	E152D	0.14	CSD
UCEC	chr17	7289576	Missense_Mutation	novel	P333L	0.35
UCEC	chr17	7290259	Missense_Mutation	rs766006670	P246S	0.2
UCEC	chr17	7290532	Missense_Mutation	NA	A155T	0.24	CSD
UCEC	chr17	7290318	Frame_Shift_Del	novel	*P226Hfs22**	0.45
UCEC	chr17	7289718	Missense_Mutation	NA	R286S	0.21
UCEC	chr17	7291096	Missense_Mutation	NA	E152D	0.38	CSD
UCS	chr17	7289621	Missense_Mutation	rs142210139	R318H	0.32

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
DLBC	DEL	0.2083	0.18166
LAML	DEL	0.0785	0.12511
LIHC	DEL	0.573	3.9592e-10
THCA	DEL	0.016	0.221

Survival Analysis

Cancer	P-value	Q-value
STAD	0.012	Kaplan-Meier Survival Analysis
MESO	0.046	Kaplan-Meier Survival Analysis
ACC	0.00016	Kaplan-Meier Survival Analysis
BRCA	0.023	Kaplan-Meier Survival Analysis
ESCA	0.034	Kaplan-Meier Survival Analysis
BLCA	0.03	Kaplan-Meier Survival Analysis
CESC	0.0052	Kaplan-Meier Survival Analysis
LAML	0.0091	Kaplan-Meier Survival Analysis
UCEC	0.00011	Kaplan-Meier Survival Analysis
GBM	0.02	Kaplan-Meier Survival Analysis
LGG	0.0034	Kaplan-Meier Survival Analysis

Drugs

EuRBPDB

Description

RBDs

RBPome

Literatures

Expression

Transcripts

Gene Model

PPI

Orthologs

Gene Ontology

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Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742