EuRBPDB

Basic Information
Cancer Related Information

Description

RBPome

Expression

Transcripts

Gene Model

Pathways

PPI

Gene Ontology

Description

Ensembl ID: ENSG00000006625 (Gene tree)
Gene ID: 79017
Gene Symbol: GGCT
Alias: MGC3077|CRF21|Ggc|C7orf24|GCTG
Full Name: gamma-glutamylcyclotransferase
Gene Type: protein_coding
Species: Homo_sapiens
Status: putative
Strand: Minus strand
Length: 8,224 bases
Position: chr7:30,496,621-30,504,844
Accession: 21705
RBP type: non-canonical RBP
Summary: The protein encoded by this gene catalyzes the formation of 5-oxoproline from gamma-glutamyl dipeptides, the penultimate step in glutathione catabolism, and may play a critical role in glutathione homeostasis. The encoded protein may also play a role in cell proliferation, and the expression of this gene is a potential marker for cancer. Pseudogenes of this gene are located on the long arm of chromosome 5 and the short arm of chromosomes 2 and 20. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2010]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
29431736	Capturing the interactome of newly transcribed RNA	PolyT-RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & MCF7	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000275428	GGCT-202	1173	-	ENSP00000275428	188 (aa)	-	O75223
ENST00000409144	GGCT-203	836	-	ENSP00000386610	94 (aa)	-	O75223
ENST00000426081	GGCT-206	889	-	ENSP00000390094	119 (aa)	-	H7BZK5
ENST00000005374	GGCT-201	1032	-	ENSP00000005374	114 (aa)	-	O75223
ENST00000440082	GGCT-207	1012	-	ENSP00000408015	51 (aa)	-	A0A0B4J1Y4
ENST00000409436	GGCT-205	954	-	ENSP00000386686	166 (aa)	-	B8ZZK2
ENST00000447901	GGCT-208	784	-	ENSP00000387809	51 (aa)	-	A0A0B4J1Y4
ENST00000409390	GGCT-204	767	-	ENSP00000387235	166 (aa)	-	O75223

Gene Model

Click here to download ENSG00000006625's gene model file

Pathways

Pathway ID	Pathway Name	Source
hsa00480	Glutathione metabolism	KEGG
hsa01100	Metabolic pathways	KEGG

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000006625's network

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0001836	release of cytochrome c from mitochondria	16765912.	IMP	Process
GO:0003839	gamma-glutamylcyclotransferase activity	18515354.	IDA	Function
GO:0005829	cytosol	16765912.	IDA	Component
GO:0005829	cytosol	-	TAS	Component
GO:0006750	glutathione biosynthetic process	-	TAS	Process
GO:0042803	protein homodimerization activity	17932939.18515354.	IDA	Function
GO:0070062	extracellular exosome	19056867.	HDA	Component

Cancer associated literatures

PID	Title	Article	Time	Author	Doi
24342434	γ-Glutamylcyclotransferase as a novel immunohistochemical biomarker for the malignancy of esophageal squamous tumors.	Hum Pathol	2014 Feb	Takemura K	doi: 10.1016/j.humpath.2013.09.009
25941902	γ-Glutamylcyclotransferase Knockdown Inhibits Growth of Lung Cancer Cells Through G0/G1 Phase Arrest.	Cancer Biother Radiopharm	2015 Jun	Lin Z	doi: 10.1089/cbr.2014.1807
26828272	Gamma-glutamylcyclotransferase promotes the growth of human glioma cells by activating Notch-Akt signaling.	Biochem Biophys Res Commun	2016 Mar 18	Shen SH	doi: 10.1016/j.bbrc.2016.01.165
29307834	Prohibitin-2 is a novel regulator of p21WAF1/CIP1 induced by depletion of γ-glutamylcyclotransferase.	Biochem Biophys Res Commun	2018 Jan 29	Taniguchi K	doi: 10.1016/j.bbrc.2018.01.029

Differential Expression

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq
BLCA	chr7	30498883	Missense_Mutation	NA	Q115E	0.06
BLCA	chr7	30497119	Silent	rs201709515	I180I	0.17
BLCA	chr7	30498836	Silent	rs753110206	Y130Y	0.1
BLCA	chr7	30504722	5'UTR	novel		0.19
BRCA	chr7	30504617	Silent	novel	I31I	0.2
BRCA	chr7	30504643	Missense_Mutation	novel	G23C	0.29
BRCA	chr7	30496918	3'UTR	novel		0.09
BRCA	chr7	30497139	Missense_Mutation	novel	E174K	0.06
COAD	chr7	30497185	Missense_Mutation	NA	E158D	0.33
COAD	chr7	30498888	Missense_Mutation	NA	A113E	0.33
COAD	chr7	30498823	Missense_Mutation	NA	P135T	0.28
ESCA	chr7	30500544	Silent	novel	S93S	0.36
GBM	chr7	30504748	5'UTR	novel		0.26
GBM	chr7	30504619	Missense_Mutation	novel	I31V	0.25
GBM	chr7	30498819	Missense_Mutation	novel	S136Y	0.08
HNSC	chr7	30498892	Missense_Mutation	NA	V112L	0.07
KIRC	chr7	30498918	Missense_Mutation	NA	G103E	0.33
LGG	chr7	30498836	Silent	rs753110206	Y130Y	0.41
LUAD	chr7	30498859	Nonsense_Mutation	rs758508499	R123*	0.06
LUAD	chr7	30504735	5'UTR	novel		0.28
LUSC	chr7	30504596	Silent	NA	A38A	0.35
LUSC	chr7	30498876	Missense_Mutation	novel	G117V	0.26
LUSC	chr7	30498877	Missense_Mutation	novel	G117R	0.25
LUSC	chr7	30496978	3'UTR	novel		0.27
LUSC	chr7	30498918	Missense_Mutation	NA	G103A	0.46
LUSC	chr7	30504824	5'UTR	novel		0.12
OV	chr7	30500594	Missense_Mutation	rs766416927	D77N	0.35
PRAD	chr7	30498835	Missense_Mutation	rs765582824	E131K	0.18
READ	chr7	30500545	Missense_Mutation	rs776460145	S93Y	0.33
SKCM	chr7	30498826	Missense_Mutation	rs142543540	P134S	0.19
SKCM	chr7	30496997	3'UTR	novel		0.5
STAD	chr7	30504699	Nonsense_Mutation	NA	S4*	0.24
THCA	chr7	30498901	Missense_Mutation	novel	E109Q	0.14
UCEC	chr7	30498858	Missense_Mutation	rs371796444	R123Q	0.16
UCEC	chr7	30500612	Missense_Mutation	novel	I71V	0.07
UCEC	chr7	30497042	3'UTR	novel		0.08
UCEC	chr7	30498894	Missense_Mutation	novel	K111R	0.51
UCEC	chr7	30496931	3'UTR	novel		0.23
UCEC	chr7	30500599	Missense_Mutation	NA	P75H	0.49
UCEC	chr7	30497005	3'UTR	novel		0.36
UCEC	chr7	30496905	3'UTR	novel		0.15
UCEC	chr7	30500681	Missense_Mutation	novel	D48N	0.14
UCEC	chr7	30504811	5'UTR	novel		0.25
UCEC	chr7	30497047	3'UTR	novel		0.56
UCEC	chr7	30500661	Silent	NA	G54G	0.45
UCEC	chr7	30498858	Missense_Mutation	rs371796444	R123Q	0.33
UCEC	chr7	30497169	Nonsense_Mutation	novel	E164*	0.28
UCEC	chr7	30500545	Missense_Mutation	rs776460145	S93Y	0.26
UCEC	chr7	30500594	Missense_Mutation	rs766416927	D77N	0.37
UCEC	chr7	30500570	Missense_Mutation	novel	K85E	0.12
UCEC	chr7	30497232	Missense_Mutation	novel	I143F	0.52
UCEC	chr7	30497047	3'UTR	novel		0.04
UCEC	chr7	30497169	Nonsense_Mutation	novel	E164*	0.06
UCEC	chr7	30497167	Silent	novel	E164E	0.43

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
PRAD	AMP	0.1484	0.02772
THCA	DEL	0	0.27619

Survival Analysis

Cancer	P-value	Q-value
KIRC	0.0001	Kaplan-Meier Survival Analysis
ACC	0.00062	Kaplan-Meier Survival Analysis
HNSC	0.019	Kaplan-Meier Survival Analysis
LUSC	0.0034	Kaplan-Meier Survival Analysis
BRCA	0.0025	Kaplan-Meier Survival Analysis
ESCA	0.016	Kaplan-Meier Survival Analysis
TGCT	0.015	Kaplan-Meier Survival Analysis
KIRP	0.034	Kaplan-Meier Survival Analysis
PAAD	0.0049	Kaplan-Meier Survival Analysis
KICH	0.0018	Kaplan-Meier Survival Analysis
GBM	0.00099	Kaplan-Meier Survival Analysis
LIHC	0.004	Kaplan-Meier Survival Analysis
LGG	0.0001	Kaplan-Meier Survival Analysis
CHOL	0.049	Kaplan-Meier Survival Analysis
THCA	0.002	Kaplan-Meier Survival Analysis
OV	0.012	Kaplan-Meier Survival Analysis

Drugs

EuRBPDB

Description

RBPome

Expression

Transcripts

Gene Model

Pathways

PPI

Gene Ontology

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742