EuRBPDB

Basic Information
Cancer Related Information

Description

RBPome

Literatures

Expression

Transcripts

Gene Model

PPI

Gene Ontology

Description

Ensembl ID: ENSG00000006712 (Gene tree)
Gene ID: 54623
Gene Symbol: PAF1
Alias: PD2|F23149_1|FLJ11123
Full Name: PAF1 homolog, Paf1/RNA polymerase II complex component
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Minus strand
Length: 5,567 bases
Position: chr19:39,385,629-39,391,195
Accession: 25459
RBP type: non-canonical RBP
Summary: This gene encodes a subunit of the polymerase associated factor (PAF1) complex. The PAF1 complex interacts with RNA polymerase II and plays a role in transcription elongation as well as histone modifications including ubiquitylation and methylation. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Feb 2012]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & HEK293	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
29431736	Capturing the interactome of newly transcribed RNA	RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & MCF10A	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2

Literatures on RNA binding capacity

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PID	Title	Article	Time	Author	Doi
29864419	Cigarette Smoke Induces Stem Cell Features of Pancreatic Cancer Cells via PAF1.	Gastroenterology	2018 Sep	Nimmakayala RK	doi: 10.1053/j.gastro.2018.05.041
23008333	A role for the RNA pol II-associated PAF complex in AID-induced immune diversification.	J Exp Med	2012 Oct 22	Willmann KL	doi: 10.1084/jem.20112145

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Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000597365	PAF1-206	606	-	-	- (aa)	-	-
ENST00000595379	PAF1-203	281	-	ENSP00000469742	94 (aa)	-	M0QYC7
ENST00000598127	PAF1-207	558	-	-	- (aa)	-	-
ENST00000598594	PAF1-208	280	-	-	- (aa)	-	-
ENST00000595564	PAF1-204	1810	-	ENSP00000468874	485 (aa)	-	Q8N7H5
ENST00000595797	PAF1-205	760	-	-	- (aa)	-	-
ENST00000416728	PAF1-202	1383	-	ENSP00000396412	288 (aa)	-	B4DGJ5
ENST00000221265	PAF1-201	2066	-	ENSP00000221265	531 (aa)	-	Q8N7H5

Gene Model

Click here to download ENSG00000006712's gene model file

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000006712's network

CanvasJS.com

* RBP PPI network refers to all genes directly bind to RBP

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000122	negative regulation of transcription by RNA polymerase II	-	ISS	Process
GO:0000993	RNA polymerase II complex binding	21873635.	IBA	Function
GO:0000993	RNA polymerase II complex binding	15923622.	IDA	Function
GO:0001711	endodermal cell fate commitment	-	ISS	Process
GO:0003682	chromatin binding	21873635.	IBA	Function
GO:0005515	protein binding	15923622.16024656.16307923.19136632.19410543.20178742.20541477.21516116.22419161.25277244.25416956.26496610.29774127.	IPI	Function
GO:0005654	nucleoplasm	-	IDA	Component
GO:0005654	nucleoplasm	-	TAS	Component
GO:0005737	cytoplasm	22046413.	IDA	Component
GO:0006366	transcription by RNA polymerase II	-	TAS	Process
GO:0006368	transcription elongation from RNA polymerase II promoter	-	TAS	Process
GO:0006378	mRNA polyadenylation	21329879.	IMP	Process
GO:0010390	histone monoubiquitination	16307923.	IDA	Process
GO:0016020	membrane	22046413.	IDA	Component
GO:0016055	Wnt signaling pathway	-	IEA	Process
GO:0016567	protein ubiquitination	-	TAS	Process
GO:0016584	nucleosome positioning	22046413.	IMP	Process
GO:0016593	Cdc73/Paf1 complex	21873635.	IBA	Component
GO:0016593	Cdc73/Paf1 complex	16307923.20178742.	IDA	Component
GO:0019827	stem cell population maintenance	-	IEA	Process
GO:0030054	cell junction	-	IDA	Component
GO:0031062	positive regulation of histone methylation	22046413.	IMP	Process
GO:0031442	positive regulation of mRNA 3'-end processing	21329879.	IMP	Process
GO:0032968	positive regulation of transcription elongation from RNA polymerase II promoter	20178742.	IDA	Process
GO:0033523	histone H2B ubiquitination	16307923.	IDA	Process
GO:0034504	protein localization to nucleus	22046413.	IMP	Process
GO:0035327	transcriptionally active chromatin	21873635.	IBA	Component
GO:0045638	negative regulation of myeloid cell differentiation	20541477.	IDA	Process
GO:0045944	positive regulation of transcription by RNA polymerase II	20178742.	IDA	Process
GO:0071222	cellular response to lipopolysaccharide	-	ISS	Process
GO:1902808	positive regulation of cell cycle G1/S phase transition	15923622.	IMP	Process

Cancer associated literatures

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PID	Title	Article	Time	Author	Doi
28122356	hPaf1/PD2 interacts with OCT3/4 to promote self-renewal of ovarian cancer stem cells.	Oncotarget	2017 Feb 28	Karmakar S	doi: 10.18632/oncotarget.14775.
26282204	Human RNA polymerase II associated factor 1 complex promotes tumorigenesis by activating c-MYC transcription in non-small cell lung cancer.	Biochem Biophys Res Commun	2015 Oct 2	Zhi X	doi: 10.1016/j.bbrc.2015.08.017
25003666	Novel role of pancreatic differentiation 2 in facilitating self-renewal and drug resistance of pancreatic cancer stem cells.	Br J Cancer	2014 Jul 29	Vaz AP	doi: 10.1038/bjc.2014.152
22046413	Human RNA polymerase II-association factor 1 (hPaf1/PD2) regulates histone methylation and chromatin remodeling in pancreatic cancer.	PLoS One	2011	Dey P	doi: 10.1371/journal.pone.0026926
16491129	The human homologue of the RNA polymerase II-associated factor 1 (hPaf1), localized on the 19q13 amplicon, is associated with tumorigenesis.	Oncogene	2006 Jun 1	Moniaux N	-

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Expression in 33 cancers

Mutations

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Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq
UCEC	chr19	39385912	3'UTR	novel		0.5
BRCA	chr19	39385932	3'UTR	NA		0.25
STAD	chr19	39385960	3'UTR	novel		0.15
UCEC	chr19	39385969	3'UTR	novel		0.38
BRCA	chr19	39385977	3'UTR	novel		0.2
LUAD	chr19	39386023	Missense_Mutation	NA	D522N	0.18
BLCA	chr19	39386023	Missense_Mutation	NA	D522N	0.14
OV	chr19	39386039	Missense_Mutation	novel	S516R	0.14
UCEC	chr19	39386056	Missense_Mutation	novel	A511T	0.32
LUSC	chr19	39386058	Missense_Mutation	rs778486153	S510L	0.12

Showing 1 to 10 of 131 entries

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Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
KIRP	DEL	0.0451	0.054726
OV	AMP	0.3541	2.2539e-28
PAAD	AMP	0.2011	3.1883e-10
READ	DEL	0.0545	0.23023
UCS	DEL	0.125	0.12448

Survival Analysis

Cancer	P-value	Q-value
KIRC	0.028	Kaplan-Meier Survival Analysis
ACC	0.0016	Kaplan-Meier Survival Analysis
BRCA	0.017	Kaplan-Meier Survival Analysis
PAAD	0.0044	Kaplan-Meier Survival Analysis
LAML	0.00048	Kaplan-Meier Survival Analysis
LIHC	0.018	Kaplan-Meier Survival Analysis
DLBC	0.018	Kaplan-Meier Survival Analysis
LGG	0.0018	Kaplan-Meier Survival Analysis
CHOL	0.0015	Kaplan-Meier Survival Analysis
UVM	0.00082	Kaplan-Meier Survival Analysis

Drugs

EuRBPDB

Description

RBPome

Literatures

Expression

Transcripts

Gene Model

PPI

Gene Ontology

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Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742