EuRBPDB

Description

RBPome

Literatures

Expression

Transcripts

Gene Model

Phenotypes

GWAS

PPI

Gene Ontology

Description

Ensembl ID: ENSG00000009954 (Gene tree)
Gene ID: 9031
Gene Symbol: BAZ1B
Alias: WSTF|WBSCR9|WBSCR10
Full Name: bromodomain adjacent to zinc finger domain 1B
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Minus strand
Length: 81,901 bases
Position: chr7:73,440,398-73,522,298
Accession: 961
RBP type: non-canonical RBP
Summary: This gene encodes a member of the bromodomain protein family. The bromodomain is a structural motif characteristic of proteins involved in chromatin-dependent regulation of transcription. This gene is deleted in Williams-Beuren syndrome, a developmental disorder caused by deletion of multiple genes at 7q11.23. [provided by RefSeq, Jul 2008]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
29431736	Capturing the interactome of newly transcribed RNA	NascentRICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
29431736	Capturing the interactome of newly transcribed RNA	PolyT-RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
29431736	Capturing the interactome of newly transcribed RNA	RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & Hela	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
27453046	Comprehensive Identification of RNA-Binding Domains in Human Cells	RIC & Hela	2016 Aug 18	Castello A	DOI: 10.1016/j.molcel.2016.06.029

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
16603771	The WSTF-SNF2h chromatin remodeling complex interacts with several nuclear proteins in transcription.	J Biol Chem	2006 Jun 16	Cavellan E	-

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000466844	BAZ1B-203	827	-	-	- (aa)	-	-
ENST00000404251	BAZ1B-202	5428	-	ENSP00000385442	1483 (aa)	-	Q9UIG0
ENST00000339594	BAZ1B-201	6102	XM_017012773	ENSP00000342434	1483 (aa)	XP_016868262	Q9UIG0

Gene Model

Click here to download ENSG00000009954's gene model file

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000009954	Uric Acid	1E-12	23263486
ENSG00000009954	Triglycerides	2E-12	20864672
ENSG00000009954	Triglycerides	3E-15	19060906
ENSG00000009954	Triglycerides	1E-12	19060911
ENSG00000009954	Triglycerides	1E-16	26582766
ENSG00000009954	Triglycerides	3E-7	20139978
ENSG00000009954	Protein C	3E-8	20802025
ENSG00000009954	Hypertriglyceridemia	3E-6	20657596
ENSG00000009954	Hypertriglyceridemia	8E-9	27599772
ENSG00000009954	Migraine Disorders	3E-8	27182965
ENSG00000009954	Blood Pressure	3E-40	27790247
ENSG00000009954	Cholesterol	3E-40	27790247
ENSG00000009954	Electrocardiography	3E-40	27790247
ENSG00000009954	Glucose	3E-40	27790247
ENSG00000009954	Hematocrit	3E-40	27790247
ENSG00000009954	Cholesterol, HDL	3E-40	27790247
ENSG00000009954	Triglycerides	3E-40	27790247
ENSG00000009954	Body Mass Index	3E-40	27790247
ENSG00000009954	Atrial Fibrillation	1E-17	27790247
ENSG00000009954	Blood Pressure	1E-17	27790247
ENSG00000009954	Cholesterol	1E-17	27790247
ENSG00000009954	Coronary Disease	1E-17	27790247
ENSG00000009954	Diabetes Mellitus	1E-17	27790247
ENSG00000009954	Electrocardiography	1E-17	27790247
ENSG00000009954	Glucose	1E-17	27790247
ENSG00000009954	Heart Failure	1E-17	27790247
ENSG00000009954	Hematocrit	1E-17	27790247
ENSG00000009954	Cholesterol, HDL	1E-17	27790247
ENSG00000009954	Mortality	1E-17	27790247
ENSG00000009954	Neoplasms	1E-17	27790247
ENSG00000009954	Triglycerides	1E-17	27790247
ENSG00000009954	Body Mass Index	1E-17	27790247
ENSG00000009954	Stroke	1E-17	27790247
ENSG00000009954	C-Reactive Protein	1E-13	27286809
ENSG00000009954	Cholesterol, HDL	1E-13	27286809
ENSG00000009954	Coffee	1E-6	21490707

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000009954	rs1178979	7	73442100	C	Protein C levels	28082259	[NR] μg/mL decrease	0.06	EFO_0004633
ENSG00000009954	rs13244268	7	73497513	T	C-reactive protein levels or HDL-cholesterol levels (pleiotropy)	27286809			EFO_0004458\|EFO_0004612
ENSG00000009954	rs714052	7	73450539	G	Triglycerides	20139978	[0.076-0.170] unit decrease	0.123	EFO_0004530
ENSG00000009954	rs2074755	7	73462836	?	Age-related disease endophenotypes	27790247			EFO_0004574\|EFO_0006336\|EFO_0004530\|EFO_0006335\|EFO_0004348\|EFO_0007928\|EFO_0004468\|EFO_0004340\|EFO_0004612
ENSG00000009954	rs13231516	7	73448919	T	Triglycerides	26582766	[0.022-0.038] unit increase	0.03	EFO_0004530
ENSG00000009954	rs1178977	7	73442719	A	Urate levels	23263486	[0.034-0.06] unit increase	0.047	EFO_0004531
ENSG00000009954	rs714052	7	73450539	G	Triglycerides	19060906	[0.10-0.22] s.d. decrease	0.16	EFO_0004530
ENSG00000009954	rs714052	7	73450539	?	Hypertriglyceridemia	20657596	[1.61-3.23]	2.27	EFO_0004211
ENSG00000009954	rs17145713	7	73490480	T	Protein C levels	20802025	[0.04-0.08] ug/ml decrease	0.06	EFO_0004633
ENSG00000009954	rs1178979	7	73442100	A	Triglycerides	20864672	[0.03-0.07] unit increase	0.05	EFO_0004530
ENSG00000009954	rs2240466	7	73441939	G	Triglycerides	19060911	[NR] s.d. increase	0.14	EFO_0004530
ENSG00000009954	rs2240466	7	73441939	A	Caffeine consumption	21490707	[0.07-0.15] mg/day increase	0.1109	EFO_0004330
ENSG00000009954	rs6976930	7	73471480	G	Waist-to-hip ratio adjusted for body mass index	28448500	[0.02-0.046] unit increase	0.0326	EFO_0007788\|EFO_0008002
ENSG00000009954	rs6976930	7	73471480	G	Waist-to-hip ratio adjusted for body mass index	28448500	[0.019-0.039] unit increase	0.0294	EFO_0007788\|EFO_0008002
ENSG00000009954	rs6976930	7	73471480	G	Waist-to-hip ratio adjusted for BMI in active individuals	28448500	[0.02-0.05] unit increase	0.0351	EFO_0007788\|EFO_0008002
ENSG00000009954	rs6976930	7	73471480	G	Waist-to-hip ratio adjusted for BMI in active individuals	28448500	[0.021-0.043] unit increase	0.0319	EFO_0007788\|EFO_0008002
ENSG00000009954	rs202203062	7	73443388	?	Migraine	27182965	[1.039-1.083]	1.061	EFO_0003821
ENSG00000009954	rs6976930	7	73471480	?	Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction)	28448500			EFO_0007788\|EFO_0008002
ENSG00000009954	rs6976930	7	73471480	?	Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction)	28448500			EFO_0007788\|EFO_0008002
ENSG00000009954	rs1178977	7	73442719	A	Triglyceride levels	28334899	[0.087-0.157] unit increase	0.122	EFO_0004530
ENSG00000009954	rs7811265	7	73520180	A	High density lipoprotein cholesterol levels	29507422	unit decrease	0.034	EFO_0004612
ENSG00000009954	rs7811265	7	73520180	A	High density lipoprotein cholesterol levels	29507422	unit decrease	0.031	EFO_0004612
ENSG00000009954	rs7811265	7	73520180	A	Triglycerides	29507422	unit increase	0.11	EFO_0004530
ENSG00000009954	rs7811265	7	73520180	A	Triglycerides	29507422	unit increase	0.104	EFO_0004530
ENSG00000009954	rs7811265	7	73520180	A	Triglycerides	29507422	unit increase	0.116	EFO_0004530
ENSG00000009954	rs7811265	7	73520180	A	Triglycerides	29507422	unit increase	0.106	EFO_0004530

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000009954's network

* RBP PPI network refers to all genes directly bind to RBP

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000793	condensed chromosome	-	IEA	Component
GO:0004713	protein tyrosine kinase activity	19092802.	IDA	Function
GO:0004715	non-membrane spanning protein tyrosine kinase activity	-	IEA	Function
GO:0005515	protein binding	11980720.15543136.16514417.30021884.	IPI	Function
GO:0005524	ATP binding	-	IEA	Function
GO:0005654	nucleoplasm	-	TAS	Component
GO:0005721	pericentric heterochromatin	-	IEA	Component
GO:0006333	chromatin assembly or disassembly	-	IEA	Process
GO:0006338	chromatin remodeling	29021563.	TAS	Process
GO:0006357	regulation of transcription by RNA polymerase II	10662543.	NAS	Process
GO:0006974	cellular response to DNA damage stimulus	19092802.	IDA	Process
GO:0008270	zinc ion binding	11124022.	NAS	Function
GO:0016572	histone phosphorylation	19092802.	IDA	Process
GO:0016604	nuclear body	-	IDA	Component
GO:0018108	peptidyl-tyrosine phosphorylation	-	IEA	Process
GO:0035173	histone kinase activity	19092802.	IDA	Function
GO:0042393	histone binding	-	IEA	Function
GO:0043596	nuclear replication fork	15543136.	IDA	Component
GO:0045815	positive regulation of gene expression, epigenetic	-	TAS	Process