EuRBPDB

Basic Information
Cancer Related Information

Description

RBPome

Literatures

Expression

Transcripts

Gene Model

Pathways

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000010256 (Gene tree)
Gene ID: 7384
Gene Symbol: UQCRC1
Alias: D3S3191|QCR1|UQCR1
Full Name: ubiquinol-cytochrome c reductase core protein 1
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Minus strand
Length: 11,978 bases
Position: chr3:48,598,999-48,610,976
Accession: 12585
RBP type: non-canonical RBP
Summary: (Ubiquinol-Cytochrome C Reductase Core Protein 1) is a Protein Coding gene. Among its related pathways are Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. and Metabolism. Gene Ontology (GO) annotations related to this gene include ubiquitin protein ligase binding and ubiquinol-cytochrome-c reductase activity. An important paralog of this gene is PMPCB.

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & MCF10A	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & U2OS	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
30917721	Mitochondrial respiratory chain deficiency inhibits lysosomal hydrolysis.	Autophagy	2019 Sep	Fernandez-Mosquera L	doi: 10.1080/15548627.2019.1586256

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000203407	UQCRC1-201	1985	-	ENSP00000203407	480 (aa)	-	P31930
ENST00000471189	UQCRC1-207	955	-	-	- (aa)	-	-
ENST00000493806	UQCRC1-210	567	-	-	- (aa)	-	-
ENST00000412343	UQCRC1-202	778	-	ENSP00000388660	68 (aa)	-	F8WEF1
ENST00000415995	UQCRC1-203	1387	-	ENSP00000393696	121 (aa)	-	F8WER5
ENST00000463708	UQCRC1-205	739	-	-	- (aa)	-	-
ENST00000460105	UQCRC1-204	622	-	-	- (aa)	-	-
ENST00000472438	UQCRC1-208	477	-	-	- (aa)	-	-
ENST00000467690	UQCRC1-206	931	-	-	- (aa)	-	-
ENST00000480561	UQCRC1-209	1014	-	-	- (aa)	-	-

Gene Model

Click here to download ENSG00000010256's gene model file

Pathways

Pathway ID	Pathway Name	Source
hsa00190	Oxidative phosphorylation	KEGG
hsa01100	Metabolic pathways	KEGG
hsa04260	Cardiac muscle contraction	KEGG
hsa04714	Thermogenesis	KEGG
hsa04932	Non-alcoholic fatty liver disease (NAFLD)	KEGG
hsa05010	Alzheimer disease	KEGG
hsa05012	Parkinson disease	KEGG
hsa05016	Huntington disease	KEGG

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000010256's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs identified by RBPome

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000010256	UQCRC1	100	88.750	ENSMUSG00000025651	Uqcrc1	100	88.750	Mus_musculus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0005739	mitochondrion	20833797.	HDA	Component
GO:0005739	mitochondrion	21873635.	IBA	Component
GO:0005739	mitochondrion	-	IDA	Component
GO:0005743	mitochondrial inner membrane	21873635.	IBA	Component
GO:0005743	mitochondrial inner membrane	-	TAS	Component
GO:0005746	mitochondrial respiratory chain	8407948.	TAS	Component
GO:0005750	mitochondrial respiratory chain complex III	-	IEA	Component
GO:0005829	cytosol	-	IDA	Component
GO:0006119	oxidative phosphorylation	8407948.	TAS	Process
GO:0006122	mitochondrial electron transport, ubiquinol to cytochrome c	21873635.	IBA	Process
GO:0006122	mitochondrial electron transport, ubiquinol to cytochrome c	-	TAS	Process
GO:0008121	ubiquinol-cytochrome-c reductase activity	8407948.	TAS	Function
GO:0009060	aerobic respiration	8407948.	TAS	Process
GO:0014823	response to activity	-	IEA	Process
GO:0031625	ubiquitin protein ligase binding	19725078.	IPI	Function
GO:0043279	response to alkaloid	-	IEA	Process
GO:0044877	protein-containing complex binding	-	IEA	Function
GO:0046872	metal ion binding	-	IEA	Function
GO:0055114	oxidation-reduction process	8407948.	TAS	Process

Differential Expression

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq
BLCA	chr3	48601067	Missense_Mutation	novel	E292K	0.36
BLCA	chr3	48609265	Missense_Mutation	novel	A36V	0.29
BLCA	chr3	48603610	Silent	NA	L220L	0.13
BLCA	chr3	48604655	Silent	rs746906806	P141P	0.41
BRCA	chr3	48603582	Missense_Mutation	NA	V230L	0.26
BRCA	chr3	48601003	Frame_Shift_Del	novel	*I311Lfs2**	0.23
BRCA	chr3	48601399	In_Frame_Del	novel	G252_A258del	0.17
BRCA	chr3	48600130	Missense_Mutation	novel	D412G	0.22
BRCA	chr3	48600773	Missense_Mutation	novel	S345T	0.18
CESC	chr3	48605815	Silent	NA	E84E	0.34
CESC	chr3	48604230	Splice_Region	novel		0.4
COAD	chr3	48599136	Missense_Mutation	NA	R479C	0.42
COAD	chr3	48601393	Missense_Mutation	NA	A261T	0.22
COAD	chr3	48604772	Missense_Mutation	novel	K102N	0.06
COAD	chr3	48605823	Missense_Mutation	NA	E82K	0.46
COAD	chr3	48609239	Missense_Mutation	NA	V45M	0.45
COAD	chr3	48604322	Missense_Mutation	NA	M179I	0.31
ESCA	chr3	48600072	Silent	novel	S431S	0.38
GBM	chr3	48604713	Missense_Mutation	novel	A122D	0.51
GBM	chr3	48603573	Missense_Mutation	novel	A233T	0.38
GBM	chr3	48600681	Missense_Mutation	novel	W376G	0.44
GBM	chr3	48604260	Missense_Mutation	novel	A200D	0.24
GBM	chr3	48604242	Missense_Mutation	NA	E206G	0.41
HNSC	chr3	48604270	Missense_Mutation	rs752170068	L197V	0.05
KIRP	chr3	48599679	Frame_Shift_Del	novel	*E443Afs70**	0.37
LAML	chr3	48605849	Missense_Mutation	novel	V73E	0.38
LGG	chr3	48604720	Missense_Mutation	novel	L120I	0.46
LUAD	chr3	48600111	Silent	NA	L418L	0.19
LUAD	chr3	48605854	Splice_Region	NA	V71V	0.26
LUAD	chr3	48609177	Silent	novel	S65S	0.43
LUAD	chr3	48600501	Silent	rs375476376	A398A	0.09
LUAD	chr3	48600722	Missense_Mutation	rs369826016	R362Q	0.16
MESO	chr3	48604703	Silent	novel	T125T	0.29
OV	chr3	48600743	Missense_Mutation	novel	G355D	0.13
OV	chr3	48605845	Missense_Mutation	novel	W74C	0.13
OV	chr3	48605846	Missense_Mutation	novel	W74L	0.13
OV	chr3	48609229	Frame_Shift_Ins	novel	*T48Ifs4**	0.35
PRAD	chr3	48604293	Missense_Mutation	novel	A189V	0.24
PRAD	chr3	48600718	Missense_Mutation	NA	M363I	0.13
READ	chr3	48600547	Missense_Mutation	NA	A383V	0.13
READ	chr3	48605841	Missense_Mutation	novel	D76N	0.27
SARC	chr3	48604324	Missense_Mutation	rs772081605	M179V	0.5
SKCM	chr3	48604656	Missense_Mutation	rs539038461	P141L	0.47
SKCM	chr3	48601005	Silent	NA	G312G	0.33
SKCM	chr3	48599081	3'UTR	novel		0.19
SKCM	chr3	48599157	Missense_Mutation	rs778390581	R472C	0.22
SKCM	chr3	48599158	Silent	novel	I471I	0.21
SKCM	chr3	48601053	Nonsense_Mutation	novel	W296*	0.17
SKCM	chr3	48601054	Nonsense_Mutation	novel	W296*	0.17
SKCM	chr3	48603633	Missense_Mutation	NA	R213C	0.35
SKCM	chr3	48609242	Missense_Mutation	NA	F44L	0.2
SKCM	chr3	48600697	Silent	rs761304717	F370F	0.33
STAD	chr3	48601044	Silent	rs141289289	P299P	0.3
STAD	chr3	48599683	Missense_Mutation	novel	I444L	0.28
STAD	chr3	48609163	Missense_Mutation	novel	T70K	0.39
STAD	chr3	48600089	Frame_Shift_Del	novel	*L426Wfs89**	0.33
STAD	chr3	48601354	Missense_Mutation	NA	E274K	0.3
THCA	chr3	48600517	Missense_Mutation	NA	N393I	0.39
THCA	chr3	48600992	Missense_Mutation	rs754870725	T317A	0.38
UCEC	chr3	48600697	Silent	rs761304717	F370F	0.31
UCEC	chr3	48604242	Missense_Mutation	NA	E206A	0.29
UCEC	chr3	48601001	Missense_Mutation	NA	Y314H	0.12
UCEC	chr3	48599135	Missense_Mutation	rs762451237	R479H	0.45
UCEC	chr3	48603619	Silent	rs564951346	T217T	0.13
UCEC	chr3	48599182	Missense_Mutation	novel	E463D	0.24
UCEC	chr3	48599673	Missense_Mutation	novel	K447T	0.15
UCEC	chr3	48604656	Missense_Mutation	rs539038461	P141L	0.29
UCEC	chr3	48601423	Missense_Mutation	novel	G251S	0.34
UCEC	chr3	48609169	Missense_Mutation	rs772442813	T68I	0.38
UCEC	chr3	48599126	3'UTR	rs139174123		0.42
UCEC	chr3	48599042	3'UTR	novel		0.33
UCEC	chr3	48604363	Missense_Mutation	novel	D166N	0.31
UCEC	chr3	48604729	Missense_Mutation	novel	G117R	0.09
UCEC	chr3	48603618	Missense_Mutation	rs368060850	E218K	0.11
UCEC	chr3	48604723	Frame_Shift_Del	novel	*H119Ifs49**	0.55
UCEC	chr3	48609181	Missense_Mutation	novel	S64F	0.1
UCEC	chr3	48604337	Silent	novel	E174E	0.11
UCEC	chr3	48604739	Silent	rs369997952	V113V	0.25
UCEC	chr3	48599157	Missense_Mutation	rs778390581	R472C	0.52
UCEC	chr3	48600565	Missense_Mutation	novel	M377T	0.36
UCEC	chr3	48600122	Missense_Mutation	rs370334893	R415C	0.32
UCEC	chr3	48609275	Missense_Mutation	rs11539918	R33W	0.35
UCEC	chr3	48605785	Missense_Mutation	NA	E94D	0.04
UCEC	chr3	48604321	Nonsense_Mutation	rs369886828	R180*	0.34
UCEC	chr3	48601392	Missense_Mutation	novel	A261D	0.24
UCS	chr3	48600487	Missense_Mutation	novel	L403Q	0.95
UCS	chr3	48609254	Missense_Mutation	rs759346286	Q40E	0.97

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
BRCA	DEL	0.2731	4.5968e-31
CHOL	DEL	0.8056	0.02241
DLBC	DEL	0.1458	0.016959
GBM	DEL	0.0763	0.056565
LGG	DEL	0.0819	0.00089193
LUAD	DEL	0.343	0.0021265
PAAD	DEL	0.1848	0.030662
SARC	DEL	0.2062	0.0034746
SKCM	DEL	0.1635	0.13887
TGCT	AMP	0.12	0.23596
TGCT	DEL	0.2067	0.08422
THYM	DEL	0.0894	0.037527

Survival Analysis

Cancer	P-value	Q-value
STAD	0.034	Kaplan-Meier Survival Analysis
ACC	0.026	Kaplan-Meier Survival Analysis
SKCM	0.0067	Kaplan-Meier Survival Analysis
LUSC	0.045	Kaplan-Meier Survival Analysis
KIRP	0.00011	Kaplan-Meier Survival Analysis
COAD	0.031	Kaplan-Meier Survival Analysis
CESC	0.0053	Kaplan-Meier Survival Analysis
LAML	0.0001	Kaplan-Meier Survival Analysis
DLBC	0.032	Kaplan-Meier Survival Analysis
UVM	0.017	Kaplan-Meier Survival Analysis

Drugs

EuRBPDB

Description

RBPome

Literatures

Expression

Transcripts

Gene Model

Pathways

PPI

Orthologs

Gene Ontology

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742