EuRBPDB

Description

Ensembl ID: ENSG00000011007 (Gene tree)
Gene ID: 6924
Gene Symbol: ELOA
Alias: SIII|TCEB3A|TCEB3
Full Name: elongin A
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Plus strand
Length: 18,905 bases
Position: chr1:23,743,155-23,762,059
Accession: 11620
RBP type: non-canonical RBP
Summary: This gene encodes the protein elongin A, which is a subunit of the transcription factor B (SIII) complex. The SIII complex is composed of elongins A/A2, B and C. It activates elongation by RNA polymerase II by suppressing transient pausing of the polymerase at many sites within transcription units. Elongin A functions as the transcriptionally active component of the SIII complex, whereas elongins B and C are regulatory subunits. Elongin A2 is specifically expressed in the testis, and capable of forming a stable complex with elongins B and C. The von Hippel-Lindau tumor suppressor protein binds to elongins B and C, and thereby inhibits transcription elongation. [provided by RefSeq, Jul 2008]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & HEK293	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
29431736	Capturing the interactome of newly transcribed RNA	PolyT-RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
29431736	Capturing the interactome of newly transcribed RNA	RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & MCF10A	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
27453046	Comprehensive Identification of RNA-Binding Domains in Human Cells	RIC & Hela	2016 Aug 18	Castello A	DOI: 10.1016/j.molcel.2016.06.029

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
8202474	Molecular cloning of an essential subunit of RNA polymerase II elongation factor SIII.	Proc Natl Acad Sci U S A	1994 Jun 7	Garrett KP	-
9341197	Identification of elongin C sequences required for interaction with the von Hippel-Lindau tumor suppressor protein.	J Biol Chem	1997 Oct 24	Takagi Y	-

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000418390	ELOA-201	5154	-	ENSP00000395574	798 (aa)	-	Q14241
ENST00000487554	ELOA-202	501	-	-	- (aa)	-	-
ENST00000613537	ELOA-204	4924	-	ENSP00000484196	798 (aa)	-	Q14241
ENST00000609199	ELOA-203	2671	-	ENSP00000476781	772 (aa)	-	A0A024RAC6

Gene Model

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000011007	Platelet Function Tests	2.2204460E-016	-
ENSG00000011007	Psoriasis	1E-11	25574825

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000011007	rs2076346	1	23757159	?	Inflammatory skin disease	25574825			EFO_0000676

Protein-Protein Interaction (PPI)

* RBP PPI network refers to all genes directly bind to RBP

Orthologs identified by RBPome

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000011007	ELOA	100	82.262	ENSMUSG00000028668	Eloa	100	80.977	Mus_musculus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0005515	protein binding	25416956.	IPI	Function
GO:0005615	extracellular space	22664934.	HDA	Component
GO:0005654	nucleoplasm	-	TAS	Component
GO:0006357	regulation of transcription by RNA polymerase II	-	IEA	Process
GO:0006366	transcription by RNA polymerase II	-	TAS	Process
GO:0006368	transcription elongation from RNA polymerase II promoter	-	TAS	Process
GO:0070449	elongin complex	-	IEA	Component