EuRBPDB

Basic Information
Cancer Related Information

Description

RBDs

RBPome

Expression

Transcripts

Gene Model

Pathways

GWAS

PPI

Paralogs

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000011376 (Gene tree)
Gene ID: 23395
Gene Symbol: LARS2
Alias: KIAA0028|LEURS|MGC26121|mtLeuRS
Full Name: leucyl-tRNA synthetase 2, mitochondrial
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Plus strand
Length: 160,916 bases
Position: chr3:45,388,506-45,549,421
Accession: 17095
RBP type: canonical RBP
Summary: This gene encodes a class 1 aminoacyl-tRNA synthetase, mitochondrial leucyl-tRNA synthetase. Each of the twenty aminoacyl-tRNA synthetases catalyzes the aminoacylation of a specific tRNA or tRNA isoaccepting family with the cognate amino acid. [provided by RefSeq, Jul 2008]

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000265537	tRNA-synt_1g	PF09334.11	5.1e-29	1	2
ENSP00000265537	tRNA-synt_1g	PF09334.11	5.1e-29	2	2
ENSP00000408576	tRNA-synt_1g	PF09334.11	5.1e-29	1	2
ENSP00000408576	tRNA-synt_1g	PF09334.11	5.1e-29	2	2
ENSP00000495093	tRNA-synt_1g	PF09334.11	5.1e-29	1	2
ENSP00000495093	tRNA-synt_1g	PF09334.11	5.1e-29	2	2
ENSP00000495707	tRNA-synt_1g	PF09334.11	5.1e-29	1	2
ENSP00000495707	tRNA-synt_1g	PF09334.11	5.1e-29	2	2
ENSP00000412893	tRNA-synt_1g	PF09334.11	1.8e-16	1	2
ENSP00000412893	tRNA-synt_1g	PF09334.11	1.8e-16	2	2
ENSP00000412893	Anticodon_1	PF08264.13	1.5e-12	1	1
ENSP00000265537	Anticodon_1	PF08264.13	1.6e-12	1	1
ENSP00000408576	Anticodon_1	PF08264.13	1.6e-12	1	1
ENSP00000495093	Anticodon_1	PF08264.13	1.6e-12	1	1
ENSP00000495707	Anticodon_1	PF08264.13	1.6e-12	1	1
ENSP00000265537	tRNA-synt_1	PF00133.22	1.1e-44	1	3
ENSP00000265537	tRNA-synt_1	PF00133.22	1.1e-44	2	3
ENSP00000265537	tRNA-synt_1	PF00133.22	1.1e-44	3	3
ENSP00000408576	tRNA-synt_1	PF00133.22	1.1e-44	1	3
ENSP00000408576	tRNA-synt_1	PF00133.22	1.1e-44	2	3
ENSP00000408576	tRNA-synt_1	PF00133.22	1.1e-44	3	3
ENSP00000495093	tRNA-synt_1	PF00133.22	1.1e-44	1	3
ENSP00000495093	tRNA-synt_1	PF00133.22	1.1e-44	2	3
ENSP00000495093	tRNA-synt_1	PF00133.22	1.1e-44	3	3
ENSP00000495707	tRNA-synt_1	PF00133.22	1.1e-44	1	3
ENSP00000495707	tRNA-synt_1	PF00133.22	1.1e-44	2	3
ENSP00000495707	tRNA-synt_1	PF00133.22	1.1e-44	3	3
ENSP00000412893	tRNA-synt_1	PF00133.22	4.8e-31	1	3
ENSP00000412893	tRNA-synt_1	PF00133.22	4.8e-31	2	3
ENSP00000412893	tRNA-synt_1	PF00133.22	4.8e-31	3	3
ENSP00000401388	tRNA-synt_1	PF00133.22	5.2e-05	1	1

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
29431736	Capturing the interactome of newly transcribed RNA	PolyT-RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000431023	LARS2-205	1881	-	-	- (aa)	-	-
ENST00000265537	LARS2-201	4281	-	ENSP00000265537	903 (aa)	-	Q15031
ENST00000474585	LARS2-207	567	-	-	- (aa)	-	-
ENST00000415258	LARS2-203	4744	XM_005265006	ENSP00000408576	903 (aa)	XP_005265063	Q15031
ENST00000645846	LARS2-210	4211	XM_011533554	ENSP00000495093	903 (aa)	XP_011531856	Q15031
ENST00000414984	LARS2-202	2800	-	ENSP00000412893	860 (aa)	-	E9PHM2
ENST00000485461	LARS2-208	580	-	ENSP00000494606	70 (aa)	-	A0A2R8Y581
ENST00000430399	LARS2-204	566	-	ENSP00000401388	114 (aa)	-	C9JYR8
ENST00000467936	LARS2-206	804	-	-	- (aa)	-	-
ENST00000642274	LARS2-209	4139	-	ENSP00000495707	903 (aa)	-	Q15031

Gene Model

Click here to download ENSG00000011376's gene model file

Pathways

Pathway ID	Pathway Name	Source
hsa00970	Aminoacyl-tRNA biosynthesis	KEGG

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000011376	rs62243190	3	45483446	C	Macrophage inflammatory protein 1b levels	27989323	[0.38-0.54] SD units decrease	0.4572	EFO_0008219
ENSG00000011376	rs1482465	3	45526882	?	Adolescent idiopathic scoliosis	30019117			EFO_0005423

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000011376's network

* RBP PPI network refers to all genes directly bind to RBP

Paralogs

Ensembl ID	Gene Symbol	Coverage	Identiy	Paralog	Gene Symbol	Coverage	Identiy
ENSG00000011376	LARS2	60	61.905	ENSG00000126653	NSRP1	84	61.905
ENSG00000011376	LARS2	84	49.180	ENSG00000154743	TSEN2	60	49.180

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000011376	LARS2	99	62.667	ENSAPOG00000004760	lars2	99	62.667	Acanthochromis_polyacanthus
ENSG00000011376	LARS2	100	90.033	ENSAMEG00000012154	LARS2	100	90.033	Ailuropoda_melanoleuca
ENSG00000011376	LARS2	97	63.616	ENSACIG00000010901	lars2	97	63.616	Amphilophus_citrinellus
ENSG00000011376	LARS2	97	64.000	ENSAOCG00000018907	lars2	97	64.000	Amphiprion_ocellaris
ENSG00000011376	LARS2	97	62.100	ENSAPEG00000019312	lars2	97	62.100	Amphiprion_percula
ENSG00000011376	LARS2	99	62.000	ENSATEG00000023835	lars2	99	62.000	Anabas_testudineus
ENSG00000011376	LARS2	87	71.523	ENSAPLG00000013338	LARS2	99	71.523	Anas_platyrhynchos
ENSG00000011376	LARS2	99	70.000	ENSACAG00000014604	LARS2	99	70.000	Anolis_carolinensis
ENSG00000011376	LARS2	100	95.792	ENSANAG00000034662	LARS2	100	95.792	Aotus_nancymaae
ENSG00000011376	LARS2	96	63.867	ENSACLG00000013037	lars2	96	63.867	Astatotilapia_calliptera
ENSG00000011376	LARS2	96	64.656	ENSAMXG00000010970	lars2	96	64.656	Astyanax_mexicanus
ENSG00000011376	LARS2	100	88.704	ENSBTAG00000007315	LARS2	100	88.704	Bos_taurus
ENSG00000011376	LARS2	86	35.183	WBGene00003074	lars-2	83	35.183	Caenorhabditis_elegans
ENSG00000011376	LARS2	100	96.491	ENSCJAG00000001949	LARS2	100	95.460	Callithrix_jacchus
ENSG00000011376	LARS2	100	90.476	ENSCAFG00000014030	LARS2	100	90.476	Canis_familiaris
ENSG00000011376	LARS2	100	90.587	ENSCAFG00020013332	LARS2	100	90.587	Canis_lupus_dingo
ENSG00000011376	LARS2	100	89.922	ENSCHIG00000003165	LARS2	100	89.922	Capra_hircus
ENSG00000011376	LARS2	100	92.248	ENSTSYG00000011445	LARS2	100	92.248	Carlito_syrichta
ENSG00000011376	LARS2	100	85.088	ENSCAPG00000015003	LARS2	100	83.389	Cavia_aperea
ENSG00000011376	LARS2	100	83.389	ENSCPOG00000008058	LARS2	100	83.389	Cavia_porcellus
ENSG00000011376	LARS2	100	95.698	ENSCCAG00000037596	LARS2	100	95.698	Cebus_capucinus
ENSG00000011376	LARS2	100	96.678	ENSCATG00000016502	LARS2	100	96.678	Cercocebus_atys
ENSG00000011376	LARS2	100	79.825	ENSCLAG00000015249	LARS2	100	78.738	Chinchilla_lanigera
ENSG00000011376	LARS2	100	96.678	ENSCSAG00000016339	LARS2	100	96.678	Chlorocebus_sabaeus
ENSG00000011376	LARS2	64	97.468	ENSCHOG00000006316	LARS2	70	97.468	Choloepus_hoffmanni
ENSG00000011376	LARS2	100	72.807	ENSCPBG00000023173	LARS2	100	73.171	Chrysemys_picta_bellii
ENSG00000011376	LARS2	96	43.360	ENSCING00000003591	-	97	43.360	Ciona_intestinalis
ENSG00000011376	LARS2	68	60.000	ENSCSAVG00000003621	-	87	61.842	Ciona_savignyi
ENSG00000011376	LARS2	100	96.899	ENSCANG00000038394	LARS2	100	96.899	Colobus_angolensis_palliatus
ENSG00000011376	LARS2	100	86.711	ENSCGRG00001013043	Lars2	100	86.711	Cricetulus_griseus_chok1gshd
ENSG00000011376	LARS2	100	86.711	ENSCGRG00000000249	Lars2	100	86.711	Cricetulus_griseus_crigri
ENSG00000011376	LARS2	96	64.335	ENSCSEG00000005202	lars2	96	64.335	Cynoglossus_semilaevis
ENSG00000011376	LARS2	97	64.457	ENSCVAG00000019899	lars2	97	64.457	Cyprinodon_variegatus
ENSG00000011376	LARS2	90	66.049	ENSDARG00000075337	lars2	97	66.049	Danio_rerio
ENSG00000011376	LARS2	85	84.699	ENSDNOG00000005830	LARS2	99	84.699	Dasypus_novemcinctus
ENSG00000011376	LARS2	100	78.982	ENSDORG00000015812	Lars2	100	79.093	Dipodomys_ordii
ENSG00000011376	LARS2	89	43.926	FBgn0027085	LeuRS-m	88	43.926	Drosophila_melanogaster
ENSG00000011376	LARS2	100	73.684	ENSETEG00000019395	LARS2	81	83.929	Echinops_telfairi
ENSG00000011376	LARS2	91	50.060	ENSEBUG00000005332	lars2	99	50.060	Eptatretus_burgeri
ENSG00000011376	LARS2	100	92.982	ENSEASG00005008052	LARS2	100	92.470	Equus_asinus_asinus
ENSG00000011376	LARS2	100	92.982	ENSECAG00000024346	LARS2	100	92.580	Equus_caballus
ENSG00000011376	LARS2	100	77.193	ENSEEUG00000009260	LARS2	100	71.990	Erinaceus_europaeus
ENSG00000011376	LARS2	99	62.930	ENSELUG00000024462	lars2	99	62.930	Esox_lucius
ENSG00000011376	LARS2	100	88.815	ENSFCAG00000009610	LARS2	100	88.815	Felis_catus
ENSG00000011376	LARS2	100	72.677	ENSFALG00000002618	LARS2	100	72.677	Ficedula_albicollis
ENSG00000011376	LARS2	100	78.947	ENSFDAG00000020916	LARS2	100	77.187	Fukomys_damarensis
ENSG00000011376	LARS2	97	63.314	ENSFHEG00000001812	lars2	97	63.314	Fundulus_heteroclitus
ENSG00000011376	LARS2	95	54.577	ENSGMOG00000000795	lars2	100	54.577	Gadus_morhua
ENSG00000011376	LARS2	100	70.907	ENSGALG00000036309	LARS2	99	70.907	Gallus_gallus
ENSG00000011376	LARS2	97	62.942	ENSGAFG00000002235	lars2	97	62.942	Gambusia_affinis
ENSG00000011376	LARS2	96	62.644	ENSGACG00000007099	lars2	96	62.644	Gasterosteus_aculeatus
ENSG00000011376	LARS2	100	71.823	ENSGAGG00000010435	LARS2	100	71.823	Gopherus_agassizii
ENSG00000011376	LARS2	100	99.225	ENSGGOG00000015767	LARS2	100	99.225	Gorilla_gorilla
ENSG00000011376	LARS2	96	63.521	ENSHBUG00000014070	lars2	96	63.521	Haplochromis_burtoni
ENSG00000011376	LARS2	100	84.496	ENSHGLG00000016811	LARS2	100	84.496	Heterocephalus_glaber_female
ENSG00000011376	LARS2	100	84.496	ENSHGLG00100012898	LARS2	100	84.496	Heterocephalus_glaber_male
ENSG00000011376	LARS2	96	61.117	ENSHCOG00000011897	lars2	96	61.460	Hippocampus_comes
ENSG00000011376	LARS2	96	65.899	ENSIPUG00000020564	lars2	96	65.899	Ictalurus_punctatus
ENSG00000011376	LARS2	100	92.982	ENSSTOG00000012878	LARS2	100	90.587	Ictidomys_tridecemlineatus
ENSG00000011376	LARS2	100	88.261	ENSJJAG00000009780	Lars2	100	88.261	Jaculus_jaculus
ENSG00000011376	LARS2	97	63.014	ENSKMAG00000020875	lars2	97	63.014	Kryptolebias_marmoratus
ENSG00000011376	LARS2	97	63.771	ENSLBEG00000006552	lars2	97	63.771	Labrus_bergylta
ENSG00000011376	LARS2	100	67.398	ENSLACG00000005448	LARS2	100	67.398	Latimeria_chalumnae
ENSG00000011376	LARS2	96	67.890	ENSLOCG00000002048	lars2	97	67.890	Lepisosteus_oculatus
ENSG00000011376	LARS2	98	90.293	ENSLAFG00000002474	LARS2	100	90.293	Loxodonta_africana
ENSG00000011376	LARS2	100	97.231	ENSMFAG00000003225	LARS2	100	97.231	Macaca_fascicularis
ENSG00000011376	LARS2	100	97.121	ENSMMUG00000018020	LARS2	100	97.121	Macaca_mulatta
ENSG00000011376	LARS2	100	97.010	ENSMNEG00000031043	LARS2	100	97.010	Macaca_nemestrina
ENSG00000011376	LARS2	100	96.899	ENSMLEG00000033552	LARS2	100	96.899	Mandrillus_leucophaeus
ENSG00000011376	LARS2	97	63.886	ENSMAMG00000023987	lars2	97	63.886	Mastacembelus_armatus
ENSG00000011376	LARS2	96	63.825	ENSMZEG00005013585	lars2	96	63.825	Maylandia_zebra
ENSG00000011376	LARS2	94	71.462	ENSMGAG00000011621	LARS2	100	71.462	Meleagris_gallopavo
ENSG00000011376	LARS2	100	85.965	ENSMAUG00000014868	Lars2	100	85.398	Mesocricetus_auratus
ENSG00000011376	LARS2	100	93.860	ENSMICG00000049159	LARS2	100	93.023	Microcebus_murinus
ENSG00000011376	LARS2	100	87.708	ENSMOCG00000018666	Lars2	100	87.708	Microtus_ochrogaster
ENSG00000011376	LARS2	100	60.023	ENSMMOG00000008951	lars2	100	60.023	Mola_mola
ENSG00000011376	LARS2	100	80.177	ENSMODG00000011311	LARS2	100	80.177	Monodelphis_domestica
ENSG00000011376	LARS2	97	62.329	ENSMALG00000007892	lars2	97	62.329	Monopterus_albus
ENSG00000011376	LARS2	100	86.489	MGP_CAROLIEiJ_G0032858	Lars2	100	86.489	Mus_caroli
ENSG00000011376	LARS2	100	86.489	ENSMUSG00000035202	Lars2	100	86.489	Mus_musculus
ENSG00000011376	LARS2	100	87.154	MGP_PahariEiJ_G0015724	Lars2	100	87.154	Mus_pahari
ENSG00000011376	LARS2	100	86.600	MGP_SPRETEiJ_G0034006	Lars2	100	86.600	Mus_spretus
ENSG00000011376	LARS2	100	84.155	ENSMPUG00000015327	LARS2	100	84.155	Mustela_putorius_furo
ENSG00000011376	LARS2	100	91.228	ENSMLUG00000010333	LARS2	100	85.825	Myotis_lucifugus
ENSG00000011376	LARS2	100	86.957	ENSNGAG00000011444	Lars2	100	86.836	Nannospalax_galili
ENSG00000011376	LARS2	96	61.751	ENSNBRG00000022165	lars2	96	61.751	Neolamprologus_brichardi
ENSG00000011376	LARS2	100	99.123	ENSNLEG00000006048	LARS2	100	95.460	Nomascus_leucogenys
ENSG00000011376	LARS2	91	68.606	ENSMEUG00000000032	LARS2	100	68.606	Notamacropus_eugenii
ENSG00000011376	LARS2	100	83.278	ENSOPRG00000000468	LARS2	100	83.278	Ochotona_princeps
ENSG00000011376	LARS2	100	84.275	ENSODEG00000009801	LARS2	100	84.275	Octodon_degus
ENSG00000011376	LARS2	96	63.751	ENSONIG00000006802	lars2	96	63.751	Oreochromis_niloticus
ENSG00000011376	LARS2	53	72.973	ENSOANG00000031122	-	93	84.000	Ornithorhynchus_anatinus
ENSG00000011376	LARS2	99	79.867	ENSOANG00000006800	LARS2	99	79.867	Ornithorhynchus_anatinus
ENSG00000011376	LARS2	100	87.708	ENSOCUG00000001964	LARS2	100	87.708	Oryctolagus_cuniculus
ENSG00000011376	LARS2	97	63.014	ENSORLG00000004574	lars2	93	63.014	Oryzias_latipes
ENSG00000011376	LARS2	97	63.242	ENSORLG00020022619	lars2	93	63.242	Oryzias_latipes_hni
ENSG00000011376	LARS2	97	63.128	ENSORLG00015008257	lars2	94	63.128	Oryzias_latipes_hsok
ENSG00000011376	LARS2	96	64.212	ENSOMEG00000011491	lars2	96	64.212	Oryzias_melastigma
ENSG00000011376	LARS2	100	92.982	ENSOGAG00000004381	LARS2	100	89.106	Otolemur_garnettii
ENSG00000011376	LARS2	100	90.033	ENSOARG00000010595	LARS2	100	90.033	Ovis_aries
ENSG00000011376	LARS2	100	100.000	ENSPPAG00000037972	LARS2	100	99.668	Pan_paniscus
ENSG00000011376	LARS2	100	88.926	ENSPPRG00000005866	LARS2	100	88.926	Panthera_pardus
ENSG00000011376	LARS2	100	88.815	ENSPTIG00000014039	LARS2	100	88.815	Panthera_tigris_altaica
ENSG00000011376	LARS2	100	100.000	ENSPTRG00000014833	LARS2	100	99.668	Pan_troglodytes
ENSG00000011376	LARS2	100	96.788	ENSPANG00000015569	LARS2	100	96.788	Papio_anubis
ENSG00000011376	LARS2	96	64.483	ENSPKIG00000023485	lars2	96	64.483	Paramormyrops_kingsleyae
ENSG00000011376	LARS2	81	72.325	ENSPSIG00000016777	LARS2	100	72.325	Pelodiscus_sinensis
ENSG00000011376	LARS2	100	72.807	ENSPSIG00000011735	-	99	77.404	Pelodiscus_sinensis
ENSG00000011376	LARS2	96	63.855	ENSPMGG00000022738	lars2	98	63.855	Periophthalmus_magnuspinnatus
ENSG00000011376	LARS2	100	86.842	ENSPEMG00000021995	Lars2	100	83.832	Peromyscus_maniculatus_bairdii
ENSG00000011376	LARS2	99	78.707	ENSPCIG00000025139	LARS2	99	78.707	Phascolarctos_cinereus
ENSG00000011376	LARS2	97	62.215	ENSPFOG00000011593	lars2	99	62.543	Poecilia_formosa
ENSG00000011376	LARS2	97	62.400	ENSPLAG00000021668	lars2	97	62.400	Poecilia_latipinna
ENSG00000011376	LARS2	97	62.514	ENSPMEG00000023896	lars2	97	62.514	Poecilia_mexicana
ENSG00000011376	LARS2	97	62.128	ENSPREG00000009319	lars2	97	62.128	Poecilia_reticulata
ENSG00000011376	LARS2	100	99.225	ENSPPYG00000013946	LARS2	100	99.225	Pongo_abelii
ENSG00000011376	LARS2	100	84.496	ENSPCAG00000003818	LARS2	100	84.496	Procavia_capensis
ENSG00000011376	LARS2	100	93.488	ENSPCOG00000027876	LARS2	100	93.488	Propithecus_coquereli
ENSG00000011376	LARS2	100	90.351	ENSPVAG00000017735	LARS2	100	85.271	Pteropus_vampyrus
ENSG00000011376	LARS2	96	63.867	ENSPNYG00000004846	lars2	96	63.867	Pundamilia_nyererei
ENSG00000011376	LARS2	96	66.398	ENSPNAG00000021872	lars2	96	66.398	Pygocentrus_nattereri
ENSG00000011376	LARS2	100	86.932	ENSRNOG00000004760	Lars2	100	86.932	Rattus_norvegicus
ENSG00000011376	LARS2	100	97.231	ENSRBIG00000038739	LARS2	100	97.231	Rhinopithecus_bieti
ENSG00000011376	LARS2	100	97.121	ENSRROG00000043579	LARS2	100	97.121	Rhinopithecus_roxellana
ENSG00000011376	LARS2	91	36.265	YLR382C	NAM2	90	36.265	Saccharomyces_cerevisiae
ENSG00000011376	LARS2	100	95.570	ENSSBOG00000022764	LARS2	100	95.570	Saimiri_boliviensis_boliviensis
ENSG00000011376	LARS2	100	79.734	ENSSHAG00000000831	LARS2	100	79.734	Sarcophilus_harrisii
ENSG00000011376	LARS2	97	62.528	ENSSFOG00015022336	lars2	97	62.528	Scleropages_formosus
ENSG00000011376	LARS2	96	62.500	ENSSFOG00015022305	lars2	96	62.500	Scleropages_formosus
ENSG00000011376	LARS2	99	62.222	ENSSMAG00000002353	lars2	99	62.222	Scophthalmus_maximus
ENSG00000011376	LARS2	99	61.359	ENSSDUG00000016697	lars2	99	61.359	Seriola_dumerili
ENSG00000011376	LARS2	97	62.629	ENSSLDG00000016976	lars2	97	62.629	Seriola_lalandi_dorsalis
ENSG00000011376	LARS2	56	91.791	ENSSARG00000004139	-	67	84.158	Sorex_araneus
ENSG00000011376	LARS2	100	69.801	ENSSPUG00000002926	LARS2	100	69.801	Sphenodon_punctatus
ENSG00000011376	LARS2	93	60.375	ENSSPAG00000022504	LARS2	92	60.375	Stegastes_partitus
ENSG00000011376	LARS2	74	61.905	ENSSPAG00000013283	-	91	62.395	Stegastes_partitus
ENSG00000011376	LARS2	99	90.768	ENSSSCG00000011312	LARS2	99	90.768	Sus_scrofa
ENSG00000011376	LARS2	100	69.298	ENSTGUG00000014015	-	100	71.311	Taeniopygia_guttata
ENSG00000011376	LARS2	100	72.737	ENSTGUG00000005000	-	100	72.737	Taeniopygia_guttata
ENSG00000011376	LARS2	96	63.322	ENSTRUG00000012513	lars2	96	63.322	Takifugu_rubripes
ENSG00000011376	LARS2	91	64.442	ENSTNIG00000009647	lars2	100	64.442	Tetraodon_nigroviridis
ENSG00000011376	LARS2	80	80.952	ENSTBEG00000010757	LARS2	87	80.952	Tupaia_belangeri
ENSG00000011376	LARS2	100	92.982	ENSTTRG00000006813	LARS2	89	93.705	Tursiops_truncatus
ENSG00000011376	LARS2	100	89.590	ENSUAMG00000002133	LARS2	100	89.944	Ursus_americanus
ENSG00000011376	LARS2	100	89.590	ENSUMAG00000005688	LARS2	100	89.590	Ursus_maritimus
ENSG00000011376	LARS2	93	84.479	ENSVPAG00000009088	LARS2	100	84.479	Vicugna_pacos
ENSG00000011376	LARS2	100	90.698	ENSVVUG00000006969	LARS2	100	90.698	Vulpes_vulpes
ENSG00000011376	LARS2	99	67.670	ENSXETG00000014411	lars2	99	67.670	Xenopus_tropicalis
ENSG00000011376	LARS2	77	72.851	ENSXCOG00000016138	lars2	96	72.851	Xiphophorus_couchianus
ENSG00000011376	LARS2	97	62.743	ENSXMAG00000010803	lars2	97	62.743	Xiphophorus_maculatus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0002161	aminoacyl-tRNA editing activity	-	IEA	Function
GO:0004823	leucine-tRNA ligase activity	21873635.	IBA	Function
GO:0004823	leucine-tRNA ligase activity	10684970.26537577.	IDA	Function
GO:0004823	leucine-tRNA ligase activity	-	TAS	Function
GO:0005524	ATP binding	-	IEA	Function
GO:0005739	mitochondrion	21873635.	IBA	Component
GO:0005759	mitochondrial matrix	-	TAS	Component
GO:0006418	tRNA aminoacylation for protein translation	-	TAS	Process
GO:0006429	leucyl-tRNA aminoacylation	21873635.	IBA	Process
GO:0006429	leucyl-tRNA aminoacylation	10684970.	IDA	Process
GO:0032543	mitochondrial translation	21873635.	IBA	Process
GO:0106074	aminoacyl-tRNA metabolism involved in translational fidelity	-	IEA	Process

Differential Expression

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq	RBD
ACC	chr3	45547525	Missense_Mutation	novel	D903Y	0.19
BLCA	chr3	45491661	Missense_Mutation	novel	V462F	0.34
BLCA	chr3	45400242	Splice_Region	novel		0.27
BLCA	chr3	45400291	Missense_Mutation	NA	S94C	0.31	tRNA-synt_1g
BLCA	chr3	45520267	Nonsense_Mutation	NA	Q755*	0.06
BLCA	chr3	45458788	Missense_Mutation	rs759498312	E218K	0.59
BRCA	chr3	45541939	Missense_Mutation	NA	V839F	0.28
BRCA	chr3	45394608	Missense_Mutation	novel	T52K	0.12
BRCA	chr3	45520267	Nonsense_Mutation	NA	Q755*	0.15
BRCA	chr3	45520213	Splice_Site	novel	X739_splice	0.05
CESC	chr3	45516258	Missense_Mutation	novel	I676V	0.1
CESC	chr3	45400249	Missense_Mutation	rs374194205	S80L	0.32	tRNA-synt_1g
CHOL	chr3	45458814	Silent	novel	S226S	0.8
COAD	chr3	45516118	Missense_Mutation	rs398123036	T629M	0.44
COAD	chr3	45394650	Missense_Mutation	rs149789249	R66Q	0.27	tRNA-synt_1g
COAD	chr3	45491635	Missense_Mutation	novel	R453L	0.35
COAD	chr3	45500561	Frame_Shift_Del	novel	*M583Wfs51**	0.33
COAD	chr3	45394591	Missense_Mutation	NA	K46N	0.18
COAD	chr3	45516139	Missense_Mutation	rs575606480	T636M	0.37
COAD	chr3	45516171	Missense_Mutation	rs539920212	G647R	0.32
COAD	chr3	45547663	3'UTR	novel		0.26
COAD	chr3	45500561	Frame_Shift_Del	novel	*M583Wfs51**	0.28
ESCA	chr3	45516206	Silent	rs189078355	G658G	0.5
ESCA	chr3	45547399	Missense_Mutation	novel	R861G	0.58
GBM	chr3	45513148	Missense_Mutation	novel	K592Q	0.27
GBM	chr3	45476578	Silent	novel	G323G	0.14
GBM	chr3	45488753	Missense_Mutation	novel	Y394H	0.63
GBM	chr3	45491529	Missense_Mutation	novel	T418S	0.44
GBM	chr3	45513145	Missense_Mutation	novel	H591D	0.49
HNSC	chr3	45488702	Missense_Mutation	rs748873353	P377S	0.31
HNSC	chr3	45458864	Missense_Mutation	novel	I243S	0.38
KIRC	chr3	45394673	Missense_Mutation	novel	I74F	0.14	tRNA-synt_1g
KIRC	chr3	45496280	Missense_Mutation	novel	K510R	0.37
LAML	chr3	45491520	Missense_Mutation	novel	T415A	0.29
LIHC	chr3	45516216	Missense_Mutation	novel	I662V	0.35
LIHC	chr3	45476474	Missense_Mutation	novel	G289R	0.3
LUAD	chr3	45488720	Missense_Mutation	NA	D383Y	0.15
LUAD	chr3	45524014	Silent	novel	V770V	0.13
LUAD	chr3	45394585	Silent	novel	T44T	0.35
LUAD	chr3	45496340	Missense_Mutation	NA	Y530C	0.17
LUSC	chr3	45417485	Missense_Mutation	NA	I123V	0.61
LUSC	chr3	45488709	Missense_Mutation	NA	T379S	0.48
LUSC	chr3	45458875	Missense_Mutation	rs142506388	A247T	0.58
OV	chr3	45476551	Silent	NA	I314I	0.26
OV	chr3	45518066	Missense_Mutation	NA	I736M	0.23
OV	chr3	45518032	Missense_Mutation	NA	A725V	0.41
OV	chr3	45500545	Frame_Shift_Del	novel	*H576Ifs58**	0.04
OV	chr3	45491725	Frame_Shift_Ins	novel	*N483Kfs43**	0.05
OV	chr3	45516252	Nonsense_Mutation	novel	K674*	0.29
OV	chr3	45516129	Silent	novel	L633L	0.16
OV	chr3	45394574	Missense_Mutation	novel	Y41N	0.25
PAAD	chr3	45491644	Missense_Mutation	novel	G456D	0.18
PAAD	chr3	45417533	Missense_Mutation	rs150836537	A139T	0.26
PAAD	chr3	45488713	Silent	novel	S380S	0.03
PRAD	chr3	45485704	Missense_Mutation	NA	P344L	0.06
PRAD	chr3	45518044	Missense_Mutation	NA	W729L	0.24
READ	chr3	45400250	Silent	rs368047098	S80S	0.45
READ	chr3	45547648	3'UTR	novel		0.42
SKCM	chr3	45394669	Silent	rs751261319	S72S	0.38
SKCM	chr3	45516200	Silent	novel	Q656Q	0.45
SKCM	chr3	45496308	Silent	rs751609685	T519T	0.21
SKCM	chr3	45400287	Missense_Mutation	novel	P93S	0.22	tRNA-synt_1g
SKCM	chr3	45547579	3'UTR	novel		0.39
SKCM	chr3	45513145	Missense_Mutation	NA	H591Y	0.09
SKCM	chr3	45516209	Silent	NA	I659I	0.31
SKCM	chr3	45520279	Missense_Mutation	NA	L759F	0.12
SKCM	chr3	45547662	3'UTR	novel		0.14
SKCM	chr3	45417493	Silent	novel	P125P	0.28
SKCM	chr3	45541920	Silent	rs201812266	F832F	0.25
SKCM	chr3	45458746	Silent	novel	L204L	0.39
SKCM	chr3	45419700	Missense_Mutation	rs755313380	R163C	0.21
SKCM	chr3	45476514	Missense_Mutation	rs771914374	T302I	0.39
SKCM	chr3	45547511	Missense_Mutation	novel	N898I	0.2
SKCM	chr3	45547512	Silent	novel	N898N	0.21
SKCM	chr3	45476465	Splice_Region	novel		0.47
SKCM	chr3	45500503	Missense_Mutation	NA	E562K	0.58
SKCM	chr3	45476553	Missense_Mutation	rs755162646	S315L	0.37
STAD	chr3	45485746	Missense_Mutation	NA	V358D	0.16
STAD	chr3	45485700	Missense_Mutation	NA	T343A	0.35
STAD	chr3	45476542	Silent	rs761528611	H311H	0.25
STAD	chr3	45513133	Splice_Site	NA	X587_splice	0.32
STAD	chr3	45485732	Missense_Mutation	novel	Q353H	0.05
STAD	chr3	45517938	Nonsense_Mutation	rs779962003	R694*	0.39
STAD	chr3	45516253	Missense_Mutation	NA	K674T	0.08
STAD	chr3	45485696	Silent	rs773167863	C341C	0.19
STAD	chr3	45520296	Splice_Region	rs773002979	S764S	0.4
STAD	chr3	45394585	Silent	rs576608165	T44T	0.34
STAD	chr3	45394459	Silent	NA	A2A	0.08
STAD	chr3	45488712	Missense_Mutation	NA	S380N	0.11
STAD	chr3	45513222	Missense_Mutation	NA	E616D	0.09
STAD	chr3	45516247	Missense_Mutation	novel	P672L	0.22
STAD	chr3	45394480	Frame_Shift_Del	novel	*Y11Mfs5**	0.13
STAD	chr3	45417533	Missense_Mutation	rs150836537	A139T	0.59
THCA	chr3	45417532	In_Frame_Ins	novel	A138_A139insLSF	0.05
UCEC	chr3	45485742	Missense_Mutation	NA	P357S	0.34
UCEC	chr3	45419677	Missense_Mutation	novel	K155T	0.35
UCEC	chr3	45488784	Missense_Mutation	novel	G404D	0.4
UCEC	chr3	45500526	Missense_Mutation	novel	F569L	0.1
UCEC	chr3	45513170	Missense_Mutation	novel	I599T	0.25
UCEC	chr3	45488768	Nonsense_Mutation	NA	E399*	0.22
UCEC	chr3	45446966	Missense_Mutation	novel	A198T	0.25
UCEC	chr3	45394629	Missense_Mutation	novel	V59A	0.45
UCEC	chr3	45400246	Missense_Mutation	novel	K79T	0.18	tRNA-synt_1g
UCEC	chr3	45485784	Missense_Mutation	rs769300447	D371N	0.34
UCEC	chr3	45547679	3'UTR	novel		0.16
UCEC	chr3	45500444	Missense_Mutation	NA	P542L	0.2
UCEC	chr3	45547529	Silent	novel	*904*	0.23
UCEC	chr3	45491735	Silent	NA	S486S	0.5
UCEC	chr3	45476559	Missense_Mutation	novel	S317N	0.3
UCEC	chr3	45547490	Frame_Shift_Del	novel	*P892Rfs52**	0.19
UCEC	chr3	45547373	Missense_Mutation	novel	K852T	0.4
UCEC	chr3	45419712	Missense_Mutation	novel	C167S	0.26
UCEC	chr3	45458885	Missense_Mutation	novel	K250M	0.28
UCEC	chr3	45520236	Silent	novel	T744T	0.27
UCEC	chr3	45547440	Silent	novel	E874E	0.26
UCEC	chr3	45517998	Missense_Mutation	rs750021523	P714S	0.38
UCEC	chr3	45491747	Missense_Mutation	novel	K490N	0.45
UCEC	chr3	45517939	Missense_Mutation	rs751358079	R694Q	0.38
UCEC	chr3	45491568	Missense_Mutation	rs777797843	R431W	0.42
UCEC	chr3	45394483	Missense_Mutation	novel	F10L	0.18
UCEC	chr3	45491629	Missense_Mutation	rs200313557	R451Q	0.37
UCEC	chr3	45491785	Missense_Mutation	novel	N503S	0.33
UCEC	chr3	45520233	Silent	novel	F743F	0.33
UCEC	chr3	45547737	3'UTR	novel		0.33
UCEC	chr3	45516099	Missense_Mutation	rs374061060	V623I	0.31
UCEC	chr3	45394650	Missense_Mutation	rs149789249	R66Q	0.22	tRNA-synt_1g
UCEC	chr3	45491730	Missense_Mutation	rs199702518	A485T	0.36
UCEC	chr3	45516139	Missense_Mutation	rs575606480	T636M	0.33
UCEC	chr3	45417492	Missense_Mutation	novel	P125H	0.49
UCEC	chr3	45488698	Splice_Region	novel	G375G	0.27
UCEC	chr3	45516219	Missense_Mutation	rs774649299	R663W	0.48
UCEC	chr3	45547424	Missense_Mutation	novel	F869C	0.33
UCEC	chr3	45458859	Frame_Shift_Ins	novel	*F242Pfs32**	0.07
UCEC	chr3	45476543	Missense_Mutation	rs765029432	V312M	0.18
UCEC	chr3	45491753	Frame_Shift_Del	novel	*P494Hfs9**	0.38
UCEC	chr3	45500440	Splice_Site	NA	X541_splice	0.28
UCEC	chr3	45400351	Missense_Mutation	novel	F114S	0.4
UCEC	chr3	45517992	Missense_Mutation	rs764828665	P712S	0.32
UCS	chr3	45496368	Silent	novel	P539P	0.31
UCS	chr3	45541865	Missense_Mutation	novel	Y814F	0.09

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
CHOL	DEL	0.8056	0.02241
DLBC	DEL	0.1458	0.016959
GBM	DEL	0.0815	0.056565
LGG	DEL	0.078	0.00089193
LUAD	DEL	0.3353	0.0021265
PAAD	DEL	0.1739	0.030662
SARC	DEL	0.1907	0.0034746
SKCM	DEL	0.1608	0.13887
TGCT	DEL	0.2	0.08422
THYM	DEL	0.0894	0.037527

Survival Analysis

Cancer	P-value	Q-value
KIRC	0.0001	Kaplan-Meier Survival Analysis
SARC	0.0035	Kaplan-Meier Survival Analysis
TGCT	0.046	Kaplan-Meier Survival Analysis
KIRP	0.0002	Kaplan-Meier Survival Analysis
COAD	0.0063	Kaplan-Meier Survival Analysis
READ	0.0037	Kaplan-Meier Survival Analysis
UCEC	0.036	Kaplan-Meier Survival Analysis
LIHC	0.028	Kaplan-Meier Survival Analysis
UVM	0.00016	Kaplan-Meier Survival Analysis

Drugs

EuRBPDB

Description

RBDs

RBPome

Expression

Transcripts

Gene Model

Pathways

GWAS

PPI

Paralogs

Orthologs

Gene Ontology

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742