EuRBPDB

Basic Information
Cancer Related Information

Description

RBPome

Expression

Transcripts

Gene Model

Phenotypes

GWAS

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000011426 (Gene tree)
Gene ID: 54443
Gene Symbol: ANLN
Alias: ANILLIN|Scraps|scra
Full Name: anillin actin binding protein
Gene Type: protein_coding
Species: Homo_sapiens
Status: putative
Strand: Plus strand
Length: 63,989 bases
Position: chr7:36,389,803-36,453,791
Accession: 14082
RBP type: non-canonical RBP
Summary: This gene encodes an actin-binding protein that plays a role in cell growth and migration, and in cytokinesis. The encoded protein is thought to regulate actin cytoskeletal dynamics in podocytes, components of the glomerulus. Mutations in this gene are associated with focal segmental glomerulosclerosis 8. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Oct 2014]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
29431736	Capturing the interactome of newly transcribed RNA	PolyT-RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
29431736	Capturing the interactome of newly transcribed RNA	RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & U2OS	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000446635	ANLN-208	829	-	ENSP00000400777	276 (aa)	-	H7C1K5
ENST00000491782	ANLN-212	2078	-	-	- (aa)	-	-
ENST00000452877	ANLN-209	580	-	ENSP00000413441	26 (aa)	-	H7C3R2
ENST00000460598	ANLN-211	569	-	-	- (aa)	-	-
ENST00000441696	ANLN-207	716	-	ENSP00000397465	69 (aa)	-	H7C0Y6
ENST00000429082	ANLN-206	557	-	ENSP00000398712	73 (aa)	-	H7C167
ENST00000428612	ANLN-205	707	-	ENSP00000413522	236 (aa)	-	H7C3S1
ENST00000418118	ANLN-203	463	-	ENSP00000406584	36 (aa)	-	C9J0G4
ENST00000265748	ANLN-201	4787	XM_006715746	ENSP00000265748	1124 (aa)	XP_006715809	Q9NQW6
ENST00000495714	ANLN-213	607	-	-	- (aa)	-	-
ENST00000396068	ANLN-202	4661	XM_006715747	ENSP00000379380	1087 (aa)	XP_006715810	Q9NQW6
ENST00000457743	ANLN-210	757	-	ENSP00000399553	252 (aa)	-	H7C1C2
ENST00000424865	ANLN-204	596	-	ENSP00000404979	169 (aa)	-	C9JJT6

Gene Model

Click here to download ENSG00000011426's gene model file

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000011426	Blood Pressure	3.475e-005	19060910
ENSG00000011426	Muscle, Skeletal	4.4410000E-005	-
ENSG00000011426	Rotator Cuff	3.4690000E-005	-
ENSG00000011426	Waist-Hip Ratio	9.7920000E-007	-
ENSG00000011426	Eosinophils	9.0250000E-005	-
ENSG00000011426	Blood Pressure	1E-7	26969751
ENSG00000011426	Blood Pressure	1E-7	26969751
ENSG00000011426	Body Weight	1E-6	23251661

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000011426	rs3735398	7	36406512	?	Systolic blood pressure	26969751	[0.073-0.159] unit increase	0.116	EFO_0006335
ENSG00000011426	rs3735398	7	36406512	?	Systolic blood pressure	26969751	[0.100-0.218] unit increase	0.159	EFO_0006335
ENSG00000011426	rs10224902	7	36415868	?	Red cell distribution width	30595370			EFO_0005192
ENSG00000011426	rs55891665	7	36406903	?	Mean corpuscular hemoglobin	30595370			EFO_0004527

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000011426's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs identified by RBPome

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000011426	ANLN	99	89.163	ENSMUSG00000036777	Anln	100	83.682	Mus_musculus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000281	mitotic cytokinesis	21873635.	IBA	Process
GO:0000281	mitotic cytokinesis	10931866.	IDA	Process
GO:0000915	actomyosin contractile ring assembly	21873635.	IBA	Process
GO:0000921	septin ring assembly	10931866.	TAS	Process
GO:0002244	hematopoietic progenitor cell differentiation	-	IEA	Process
GO:0003779	actin binding	10931866.	IDA	Function
GO:0005654	nucleoplasm	-	IDA	Component
GO:0005826	actomyosin contractile ring	21873635.	IBA	Component
GO:0005826	actomyosin contractile ring	10931866.	IDA	Component
GO:0007096	regulation of exit from mitosis	10931866.	TAS	Process
GO:0015629	actin cytoskeleton	10931866.	IDA	Component
GO:0017049	GTP-Rho binding	21873635.	IBA	Function
GO:0030496	midbody	-	IDA	Component
GO:0030865	cortical cytoskeleton organization	21873635.	IBA	Process
GO:0031106	septin ring organization	21873635.	IBA	Process
GO:0032059	bleb	23870127.	IDA	Component
GO:0045296	cadherin binding	25468996.	HDA	Function
GO:0090521	glomerular visceral epithelial cell migration	24676636.	IMP	Process
GO:0099738	cell cortex region	23870127.	IDA	Component
GO:1904172	positive regulation of bleb assembly	23870127.	IMP	Process
GO:1904498	protein localization to mitotic actomyosin contractile ring	21873635.	IBA	Process

Cancer associated literatures

PID	Title	Article	Time	Author	Doi
27863473	ANLN is a prognostic biomarker independent of Ki-67 and essential for cell cycle progression in primary breast cancer.	BMC Cancer	2016 Nov 18	Magnusson K	-
26486082	The potent tumor suppressor miR-497 inhibits cancer phenotypes in nasopharyngeal carcinoma by targeting ANLN and HSPA4L.	Oncotarget	2015 Nov 3	Wang S	doi: 10.18632/oncotarget.5651.
24809965	In silico analysis of expression pattern of a Wnt/β-catenin responsive gene ANLN in gastric cancer.	Gene	2014 Jul 15	Pandi NS	doi: 10.1016/j.gene.2014.05.013
25223638	Knockdown of ANLN by lentivirus inhibits cell growth and migration in human breast cancer.	Mol Cell Biochem	2015 Jan	Zhou W	doi: 10.1007/s11010-014-2200-6
27062703	Overexpression of Anillin (ANLN) is correlated with colorectal cancer progression and poor prognosis.	Cancer Biomark	2016	Wang G	doi: 10.3233/CBM-160585.
23547718	Systematic antibody generation and validation via tissue microarray technology leading to identification of a novel protein prognostic panel in breast cancer.	BMC Cancer	2013 Apr 2	O Leary PC	doi: 10.1186/1471-2407-13-175.
19995712	NBL1 and anillin (ANLN) genes over-expression in pancreatic carcinoma.	Folia Histochem Cytobiol	2009	Olakowski M	doi: 10.2478/v10042-009-0031-1.

Differential Expression

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq
ACC	chr7	36410621	Missense_Mutation	novel	P402S	0.37
BLCA	chr7	36399132	Missense_Mutation	rs549587288	E76K	0.22
BLCA	chr7	36406390	Missense_Mutation	NA	A233S	0.19
BLCA	chr7	36407803	Missense_Mutation	novel	E315K	0.22
BLCA	chr7	36407927	Missense_Mutation	novel	S356F	0.28
BLCA	chr7	36399166	Missense_Mutation	NA	P87L	0.2
BLCA	chr7	36449708	Missense_Mutation	novel	Q1041L	0.15
BLCA	chr7	36423930	Splice_Site	novel	X864_splice	0.14
BLCA	chr7	36415770	Missense_Mutation	NA	Q470E	0.05
BLCA	chr7	36420168	Splice_Site	novel	X624_splice	0.16
BLCA	chr7	36407929	Missense_Mutation	NA	Q357E	0.42
BLCA	chr7	36426027	Missense_Mutation	novel	H921D	0.2
BRCA	chr7	36399367	Missense_Mutation	NA	R154P	0.19
BRCA	chr7	36407746	Missense_Mutation	rs77248468	P296S	0.1
BRCA	chr7	36426018	Missense_Mutation	NA	S918C	0.17
BRCA	chr7	36407850	Silent	rs148370852	S330S	0.18
BRCA	chr7	36406550	Nonsense_Mutation	NA	S286*	0.11
BRCA	chr7	36426027	Missense_Mutation	novel	H921Y	0.08
BRCA	chr7	36389838	5'UTR	novel		0.29
BRCA	chr7	36410680	Silent	NA	T421T	0.27
BRCA	chr7	36407850	Silent	rs148370852	S330S	0.14
BRCA	chr7	36417102	Silent	rs139579665	T515T	0.11
BRCA	chr7	36452705	3'UTR	novel		0.09
BRCA	chr7	36420268	Frame_Shift_Ins	novel	*E657Afs35**	0.13
BRCA	chr7	36420270	Missense_Mutation	novel	E657D	0.12
BRCA	chr7	36420268	Frame_Shift_Ins	novel	*E657Afs35**	0.18
BRCA	chr7	36420270	Missense_Mutation	novel	E657D	0.13
BRCA	chr7	36407792	Missense_Mutation	rs756975220	G311E	0.32
BRCA	chr7	36406550	Nonsense_Mutation	NA	S286*	0.29
BRCA	chr7	36410599	Silent	novel	P394P	0.23
CESC	chr7	36417132	Missense_Mutation	novel	F525L	0.36
CESC	chr7	36449805	Silent	novel	V1073V	0.08
CESC	chr7	36406390	Missense_Mutation	rs202225666	A233T	0.33
CESC	chr7	36407805	Silent	novel	E315E	0.31
CESC	chr7	36410692	Missense_Mutation	novel	Q425H	0.3
CESC	chr7	36396317	Missense_Mutation	novel	A24S	0.07
CESC	chr7	36406268	Missense_Mutation	rs139482132	S192L	0.43
CESC	chr7	36423846	Missense_Mutation	novel	L836V	0.52
COAD	chr7	36425704	Splice_Region	novel	A904A	0.27
COAD	chr7	36396279	Missense_Mutation	rs774828191	R11Q	0.33
COAD	chr7	36419306	Missense_Mutation	novel	N566H	0.08
COAD	chr7	36452581	Missense_Mutation	novel	K1119T	0.13
COAD	chr7	36422679	Silent	rs772500301	N782N	0.18
COAD	chr7	36419296	Silent	rs34371129	S562S	0.23
COAD	chr7	36424715	Silent	novel	D894D	0.07
COAD	chr7	36406532	Missense_Mutation	rs748050195	A280V	0.63
COAD	chr7	36399106	Frame_Shift_Ins	NA	*R70Tfs4**	0.21
COAD	chr7	36399364	Missense_Mutation	rs576328951	R153Q	0.09
COAD	chr7	36399333	Frame_Shift_Del	novel	*T144Hfs18**	0.38
COAD	chr7	36399176	Silent	rs146340773	S90S	0.24
COAD	chr7	36415842	Missense_Mutation	rs778648455	E494K	0.07
COAD	chr7	36421869	Missense_Mutation	rs767615862	E726K	0.16
COAD	chr7	36399157	Frame_Shift_Ins	novel	*K85Lfs45**	0.05
COAD	chr7	36420228	Nonsense_Mutation	novel	*K644Vfs3**	0.05
COAD	chr7	36452617	3'UTR	novel		0.1
COAD	chr7	36452618	3'UTR	novel		0.1
DLBC	chr7	36415857	Missense_Mutation	novel	A499T	0.2
ESCA	chr7	36420664	Missense_Mutation	rs375850531	R695W	0.42
ESCA	chr7	36406283	Missense_Mutation	novel	G197D	0.26
ESCA	chr7	36415768	Missense_Mutation	novel	C469Y	0.27
GBM	chr7	36439280	Missense_Mutation	rs747031560	R987T	0.32
GBM	chr7	36399176	Silent	rs146340773	S90S	0.51
GBM	chr7	36420628	Missense_Mutation	novel	E683K	0.2
GBM	chr7	36425717	Nonsense_Mutation	NA	R909*	0.39
GBM	chr7	36452541	Missense_Mutation	novel	L1106I	0.14
GBM	chr7	36410616	Missense_Mutation	novel	I400T	0.19
GBM	chr7	36452534	Missense_Mutation	novel	N1103K	0.05
GBM	chr7	36399385	Missense_Mutation	NA	D160V	0.25
GBM	chr7	36420247	Missense_Mutation	NA	R650G	0.52
HNSC	chr7	36420217	Missense_Mutation	novel	D640H	0.1
HNSC	chr7	36422680	Nonsense_Mutation	novel	E783*	0.09
HNSC	chr7	36424721	Frame_Shift_Ins	novel	*T899Nfs34**	0.28
HNSC	chr7	36407947	Missense_Mutation	novel	T363A	0.22
HNSC	chr7	36422664	Silent	novel	L777L	0.19
HNSC	chr7	36452727	3'UTR	novel		0.25
HNSC	chr7	36422787	Silent	novel	V818V	0.27
HNSC	chr7	36420262	Nonsense_Mutation	novel	R655*	0.12
HNSC	chr7	36399364	Missense_Mutation	NA	R153L	0.28
HNSC	chr7	36419291	Missense_Mutation	novel	S561C	0.29
HNSC	chr7	36389922	5'UTR	novel		0.12
HNSC	chr7	36439275	Missense_Mutation	novel	E985D	0.37
HNSC	chr7	36424718	Missense_Mutation	novel	K895N	0.21
KIRC	chr7	36439249	Missense_Mutation	NA	K977Q	0.38
KIRC	chr7	36419307	Nonsense_Mutation	novel	*N566Kfs8**	0.04
KIRC	chr7	36406282	Missense_Mutation	NA	G197S	0.06
KIRP	chr7	36406344	Silent	NA	N217N	0.33
KIRP	chr7	36406404	Missense_Mutation	NA	K237N	0.56
LAML	chr7	36452727	3'UTR	novel		0.15
LGG	chr7	36390029	In_Frame_Ins	novel	M1_D2insTLRRQWPPRA	0.18
LGG	chr7	36410543	Missense_Mutation	rs559978701	R376C	0.67
LGG	chr7	36422725	Missense_Mutation	rs530432252	M798V	0.43
LIHC	chr7	36407945	Missense_Mutation	novel	S362Y	0.14
LIHC	chr7	36396396	Missense_Mutation	NA	Q50L	0.51
LIHC	chr7	36396363	Missense_Mutation	NA	R39L	0.21
LIHC	chr7	36421888	Missense_Mutation	rs766163761	T732I	0.11
LIHC	chr7	36406215	Missense_Mutation	novel	M174I	0.39
LUAD	chr7	36406421	Missense_Mutation	NA	G243A	0.29
LUAD	chr7	36389908	5'UTR	novel		0.3
LUAD	chr7	36399078	Splice_Site	NA	X58_splice	0.27
LUAD	chr7	36420254	Missense_Mutation	novel	R652P	0.21
LUAD	chr7	36443848	Missense_Mutation	NA	D1022N	0.42
LUAD	chr7	36449674	Missense_Mutation	novel	G1030R	0.23
LUAD	chr7	36420668	Missense_Mutation	novel	K696T	0.17
LUAD	chr7	36406278	Silent	NA	P195P	0.07
LUAD	chr7	36420744	Missense_Mutation	NA	Q721H	0.39
LUAD	chr7	36399173	Missense_Mutation	novel	E89D	0.2
LUAD	chr7	36424695	Missense_Mutation	NA	K888E	0.25
LUAD	chr7	36399364	Missense_Mutation	NA	R153L	0.36
LUAD	chr7	36399141	Missense_Mutation	NA	V79I	0.31
LUAD	chr7	36423885	Missense_Mutation	NA	A849P	0.16
LUSC	chr7	36419251	Silent	novel	I547I	0.39
LUSC	chr7	36422751	Missense_Mutation	novel	L806F	0.44
LUSC	chr7	36426940	Missense_Mutation	novel	S932T	0.32
LUSC	chr7	36407752	Missense_Mutation	NA	K298E	0.32
LUSC	chr7	36415829	Silent	novel	T489T	0.43
LUSC	chr7	36411099	Missense_Mutation	NA	D443G	0.32
LUSC	chr7	36406375	Missense_Mutation	novel	E228Q	0.26
OV	chr7	36443764	Missense_Mutation	NA	E994Q	0.5
OV	chr7	36426949	Missense_Mutation	NA	R935Q	0.24
OV	chr7	36389951	5'UTR	novel		0.19
OV	chr7	36452662	3'UTR	novel		0.45
OV	chr7	36396379	Silent	novel	L44L	0.45
PAAD	chr7	36406546	Missense_Mutation	novel	A285T	0.17
PAAD	chr7	36424552	Missense_Mutation	novel	V871I	0.13
PAAD	chr7	36449824	Missense_Mutation	novel	L1080I	0.21
READ	chr7	36417094	Missense_Mutation	rs772690246	E513K	0.25
READ	chr7	36449730	Frame_Shift_Ins	NA	*C1050Lfs8**	0.27
READ	chr7	36420745	Splice_Site	novel	X721_splice	0.42
READ	chr7	36439220	Missense_Mutation	novel	S967Y	0.43
READ	chr7	36417102	Silent	rs139579665	T515T	0.33
READ	chr7	36424721	Missense_Mutation	NA	K896N	0.34
SARC	chr7	36452840	3'UTR	novel		0.53
SARC	chr7	36419320	Silent	novel	S570S	0.37
SKCM	chr7	36419326	Silent	novel	V572V	0.29
SKCM	chr7	36419327	Silent	rs770046058	L573L	0.27
SKCM	chr7	36439260	Silent	NA	V980V	0.36
SKCM	chr7	36399253	Missense_Mutation	novel	S116F	0.23
SKCM	chr7	36406539	Missense_Mutation	NA	L282F	0.04
SKCM	chr7	36420248	Missense_Mutation	NA	R650K	0.25
SKCM	chr7	36410615	Missense_Mutation	rs780364655	I400V	0.34
SKCM	chr7	36419295	Missense_Mutation	rs371785488	S562L	0.78
SKCM	chr7	36406239	Silent	rs748967747	S182S	0.42
SKCM	chr7	36452613	3'UTR	novel		0.41
SKCM	chr7	36452613	3'UTR	novel		0.55
SKCM	chr7	36426966	Missense_Mutation	NA	L941F	0.28
SKCM	chr7	36399364	Missense_Mutation	rs576328951	R153Q	0.42
SKCM	chr7	36421931	Missense_Mutation	novel	D746E	0.25
SKCM	chr7	36410532	Missense_Mutation	NA	P372L	0.31
SKCM	chr7	36443757	Splice_Region	rs182794031	T991T	0.54
SKCM	chr7	36439206	Splice_Region	NA	V962V	0.09
SKCM	chr7	36419474	Missense_Mutation	NA	P622S	0.38
SKCM	chr7	36407811	Silent	NA	L317L	0.15
SKCM	chr7	36396419	Frame_Shift_Del	novel		0.1
SKCM	chr7	36422726	Missense_Mutation	NA	M798T	0.4
SKCM	chr7	36406562	Missense_Mutation	NA	S290F	0.06
SKCM	chr7	36426034	Missense_Mutation	NA	S923L	0.36
SKCM	chr7	36411093	Missense_Mutation	rs754339445	R441Q	0.23
SKCM	chr7	36411086	Missense_Mutation	NA	R439C	0.22
SKCM	chr7	36410557	Silent	NA	R380R	0.17
SKCM	chr7	36422714	Missense_Mutation	NA	Q794R	0.58
STAD	chr7	36415785	Frame_Shift_Del	novel	*K476Nfs13**	0.09
STAD	chr7	36449771	Missense_Mutation	rs140729544	R1062Q	0.37
STAD	chr7	36407840	Missense_Mutation	rs564754015	T327M	0.22
STAD	chr7	36396299	Missense_Mutation	NA	N18H	0.34
STAD	chr7	36399348	Missense_Mutation	NA	K148Q	0.32
STAD	chr7	36426028	Missense_Mutation	NA	H921P	0.39
STAD	chr7	36415769	Silent	novel	C469C	0.05
STAD	chr7	36399097	Missense_Mutation	novel	P64L	0.16
STAD	chr7	36449771	Missense_Mutation	rs140729544	R1062Q	0.31
STAD	chr7	36423854	Silent	NA	A838A	0.15
STAD	chr7	36407946	Silent	novel	S362S	0.22
STAD	chr7	36415785	Frame_Shift_Del	novel	*K476Nfs13**	0.15
STAD	chr7	36452540	Silent	NA	V1105V	0.14
STAD	chr7	36422634	Splice_Region	NA	T767T	0.19
THYM	chr7	36422661	Silent	novel	E776E	0.13
UCEC	chr7	36452700	3'UTR	rs774918777		0.44
UCEC	chr7	36415863	Missense_Mutation	NA	N501H	0.33
UCEC	chr7	36399290	Missense_Mutation	novel	R128S	0.5
UCEC	chr7	36420253	Missense_Mutation	rs569378477	R652C	0.53
UCEC	chr7	36424722	Frame_Shift_Del	NA	*T899Hfs16**	0.18
UCEC	chr7	36406489	Missense_Mutation	NA	D266N	0.43
UCEC	chr7	36449664	Splice_Site	novel	X1027_splice	0.43
UCEC	chr7	36396278	Nonsense_Mutation	rs200989750	R11*	0.44
UCEC	chr7	36389932	5'UTR	rs774385405		0.42
UCEC	chr7	36410578	Missense_Mutation	novel	E387D	0.12
UCEC	chr7	36407850	Silent	rs148370852	S330S	0.46
UCEC	chr7	36407850	Silent	rs148370852	S330S	0.4
UCEC	chr7	36420295	Missense_Mutation	novel	D666Y	0.25
UCEC	chr7	36422732	Missense_Mutation	novel	S800F	0.44
UCEC	chr7	36421875	Missense_Mutation	novel	N728H	0.34
UCEC	chr7	36422795	Missense_Mutation	rs150551001	T821M	0.58
UCEC	chr7	36406492	Missense_Mutation	NA	A267T	0.26
UCEC	chr7	36389906	5'UTR	novel		0.18
UCEC	chr7	36407850	Silent	novel	S330S	0.1
UCEC	chr7	36419255	Nonsense_Mutation	novel	E549*	0.21
UCEC	chr7	36452819	3'UTR	novel		0.29
UCEC	chr7	36406184	Missense_Mutation	NA	D164V	0.29
UCEC	chr7	36424556	Missense_Mutation	novel	S872F	0.34
UCEC	chr7	36399140	Missense_Mutation	novel	E78D	0.28
UCEC	chr7	36417102	Silent	rs139579665	T515T	0.13
UCEC	chr7	36424703	Silent	novel	P890P	0.21
UCEC	chr7	36406270	Missense_Mutation	novel	A193T	0.48
UCEC	chr7	36407786	Missense_Mutation	NA	C309Y	0.42
UCEC	chr7	36399393	Missense_Mutation	novel	D163Y	0.63
UCEC	chr7	36449705	Missense_Mutation	rs151288243	R1040H	0.35
UCEC	chr7	36396298	Silent	novel	E17E	0.45
UCEC	chr7	36407850	Silent	rs148370852	S330S	0.47
UCEC	chr7	36439276	Nonsense_Mutation	novel	E986*	0.58
UCEC	chr7	36407850	Silent	rs148370852	S330S	0.4
UCEC	chr7	36419396	Missense_Mutation	rs752000697	E596K	0.11
UCEC	chr7	36427029	Splice_Site	NA	X961_splice	0.36
UCEC	chr7	36420694	Nonsense_Mutation	novel	E705*	0.32
UCEC	chr7	36449829	Silent	novel	C1081C	0.38
UCEC	chr7	36423871	Missense_Mutation	novel	V844A	0.1
UCEC	chr7	36406489	Missense_Mutation	NA	D266N	0.24
UCEC	chr7	36407850	Silent	rs148370852	S330S	0.44
UCEC	chr7	36443772	Silent	novel	V996V	0.29
UCEC	chr7	36399101	Silent	rs764261573	S65S	0.35
UCEC	chr7	36422776	Missense_Mutation	novel	A815S	0.4
UCEC	chr7	36427010	Silent	novel	T955T	0.54
UCEC	chr7	36452834	3'UTR	novel		0.43
UCEC	chr7	36439228	Missense_Mutation	NA	G970C	0.45
UCEC	chr7	36410646	Missense_Mutation	novel	R410I	0.13
UCEC	chr7	36424688	Splice_Region	rs748077424	V885V	0.36
UCEC	chr7	36449719	Missense_Mutation	novel	A1045T	0.37
UCEC	chr7	36439241	Frame_Shift_Ins	novel	*I976Nfs10**	0.38
UCEC	chr7	36411087	Missense_Mutation	rs149506588	R439H	0.45
UCEC	chr7	36407942	Missense_Mutation	novel	K361R	0.12
UCEC	chr7	36411129	Missense_Mutation	rs751746733	G453D	0.4
UCEC	chr7	36399141	Missense_Mutation	NA	V79I	0.24
UCEC	chr7	36420248	Missense_Mutation	NA	R650I	0.25
UCEC	chr7	36424562	Missense_Mutation	rs752097628	D874G	0.25
UCEC	chr7	36399364	Missense_Mutation	rs576328951	R153Q	0.24
UCEC	chr7	36406372	Nonsense_Mutation	novel	Q227*	0.24
UCEC	chr7	36420299	Missense_Mutation	rs766697251	R667H	0.16
UCEC	chr7	36439278	Missense_Mutation	novel	E986D	0.25
UCEC	chr7	36443759	Missense_Mutation	novel	I992T	0.51
UCEC	chr7	36422709	Silent	novel	S792S	0.42
UCEC	chr7	36406269	Silent	novel	S192S	0.4
UCEC	chr7	36449782	Missense_Mutation	novel	E1066K	0.34
UCEC	chr7	36410578	Missense_Mutation	novel	E387D	0.41
UCS	chr7	36419418	Missense_Mutation	novel	N603T	0.49

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
PRAD	AMP	0.1443	0.02772
THCA	DEL	0	0.27619

Survival Analysis

Cancer	P-value	Q-value
THYM	0.0015	Kaplan-Meier Survival Analysis
KIRC	0.0001	Kaplan-Meier Survival Analysis
ACC	0.0001	Kaplan-Meier Survival Analysis
HNSC	0.036	Kaplan-Meier Survival Analysis
PRAD	0.044	Kaplan-Meier Survival Analysis
BRCA	0.046	Kaplan-Meier Survival Analysis
KIRP	0.00011	Kaplan-Meier Survival Analysis
PAAD	0.00012	Kaplan-Meier Survival Analysis
PCPG	0.024	Kaplan-Meier Survival Analysis
BLCA	0.0038	Kaplan-Meier Survival Analysis
CESC	0.0086	Kaplan-Meier Survival Analysis
LAML	0.033	Kaplan-Meier Survival Analysis
KICH	0.0034	Kaplan-Meier Survival Analysis
UCEC	0.00054	Kaplan-Meier Survival Analysis
GBM	0.038	Kaplan-Meier Survival Analysis
LIHC	0.0001	Kaplan-Meier Survival Analysis
LGG	0.035	Kaplan-Meier Survival Analysis
CHOL	0.043	Kaplan-Meier Survival Analysis
UVM	0.0045	Kaplan-Meier Survival Analysis