EuRBPDB

Basic Information
Cancer Related Information

Description

RBPome

Expression

Transcripts

Gene Model

Pathways

Phenotypes

GWAS

PPI

Gene Ontology

Description

Ensembl ID: ENSG00000011485 (Gene tree)
Gene ID: 5536
Gene Symbol: PPP5C
Alias: PP5|PPP5
Full Name: protein phosphatase 5 catalytic subunit
Gene Type: protein_coding
Species: Homo_sapiens
Status: putative
Strand: Plus strand
Length: 45,988 bases
Position: chr19:46,346,994-46,392,981
Accession: 9322
RBP type: non-canonical RBP
Summary: This gene encodes a serine/threonine phosphatase which is a member of the protein phosphatase catalytic subunit family. Proteins in this family participate in pathways regulated by reversible phosphorylation at serine and threonine residues; many of these pathways are involved in the regulation of cell growth and differentiation. The product of this gene has been shown to participate in signaling pathways in response to hormones or cellular stress, and elevated levels of this protein may be associated with breast cancer development. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2011]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & MCF10A	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000491003	PPP5C-208	878	-	-	- (aa)	-	-
ENST00000493347	PPP5C-210	431	-	-	- (aa)	-	-
ENST00000527623	PPP5C-213	1215	-	-	- (aa)	-	-
ENST00000486994	PPP5C-206	2209	-	-	- (aa)	-	-
ENST00000492109	PPP5C-209	848	-	-	- (aa)	-	-
ENST00000525507	PPP5C-211	1300	-	-	- (aa)	-	-
ENST00000532058	PPP5C-214	1970	-	-	- (aa)	-	-
ENST00000012443	PPP5C-201	2109	XM_017026935	ENSP00000012443	499 (aa)	XP_016882424	P53041
ENST00000487483	PPP5C-207	4675	-	-	- (aa)	-	-
ENST00000527193	PPP5C-212	548	-	-	- (aa)	-	-
ENST00000467502	PPP5C-203	1235	-	-	- (aa)	-	-
ENST00000595055	PPP5C-215	556	-	-	- (aa)	-	-
ENST00000478046	PPP5C-205	1886	-	ENSP00000434329	485 (aa)	-	H0YDU8
ENST00000467902	PPP5C-204	399	-	-	- (aa)	-	-
ENST00000391919	PPP5C-202	1929	-	ENSP00000375786	371 (aa)	-	A8MU39

Gene Model

Click here to download ENSG00000011485's gene model file

Pathways

Pathway ID	Pathway Name	Source
hsa04010	MAPK signaling pathway	KEGG

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000011485	Crohn Disease	9E-12	26192919
ENSG00000011485	Inflammatory Bowel Diseases	2E-8	26192919
ENSG00000011485	Crohn Disease	4E-7	28067908
ENSG00000011485	Crohn Disease	2E-10	23128233

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000011485	rs534666677	19	46351484	T	Neuroticism	29255261	z score increase	5.523	EFO_0007660
ENSG00000011485	rs61747094	19	46375732	A	Basophil percentage of white cells	27863252	[0.015-0.03] unit decrease	0.02259245	EFO_0007992
ENSG00000011485	rs8106745	19	46388911	?	Age at menopause	30595370			EFO_0004704
ENSG00000011485	rs62136106	19	46365128	?	Red blood cell count	30595370			EFO_0004305
ENSG00000011485	rs4803936	19	46375372	?	Eosinophil counts	30595370			EFO_0004842

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000011485's network

* RBP PPI network refers to all genes directly bind to RBP

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000165	MAPK cascade	-	TAS	Process
GO:0000278	mitotic cell cycle	7925273.	TAS	Process
GO:0004721	phosphoprotein phosphatase activity	9383998.	ISS	Function
GO:0004721	phosphoprotein phosphatase activity	28386764.	TAS	Function
GO:0004722	protein serine/threonine phosphatase activity	21873635.	IBA	Function
GO:0004722	protein serine/threonine phosphatase activity	15546861.	ISS	Function
GO:0004722	protein serine/threonine phosphatase activity	15546861.16262633.	TAS	Function
GO:0005515	protein binding	9383998.11504734.14764652.16531226.16790549.19875381.21360678.25036637.26496610.27353360.28330616.	IPI	Function
GO:0005524	ATP binding	23184943.	IDA	Function
GO:0005634	nucleus	21873635.	IBA	Component
GO:0005654	nucleoplasm	-	TAS	Component
GO:0005829	cytosol	21873635.	IBA	Component
GO:0005829	cytosol	-	IDA	Component
GO:0005829	cytosol	-	TAS	Component
GO:0005886	plasma membrane	-	IEA	Component
GO:0006281	DNA repair	-	IEA	Process
GO:0006351	transcription, DNA-templated	7925273.	TAS	Process
GO:0006470	protein dephosphorylation	7925273.	TAS	Process
GO:0008289	lipid binding	-	IEA	Function
GO:0010288	response to lead ion	-	ISS	Process
GO:0016791	phosphatase activity	15546861.	IDA	Function
GO:0032991	protein-containing complex	23184943.	IDA	Component
GO:0035970	peptidyl-threonine dephosphorylation	16262633.	TAS	Process
GO:0042802	identical protein binding	21360678.	IPI	Function
GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling	12761501.	HMP	Process
GO:0043231	intracellular membrane-bounded organelle	-	IDA	Component
GO:0043531	ADP binding	23184943.	IDA	Function
GO:0046872	metal ion binding	-	IEA	Function
GO:0048156	tau protein binding	28386764.	NAS	Function
GO:0051879	Hsp90 protein binding	15713458.	IPI	Function
GO:0070262	peptidyl-serine dephosphorylation	16262633.	TAS	Process
GO:0101031	chaperone complex	29127155.	IDA	Component
GO:1904550	response to arachidonic acid	15546861.	ISS	Process

Cancer associated literatures

PID	Title	Article	Time	Author	Doi
18280813	Elevated levels of Ser/Thr protein phosphatase 5 (PP5) in human breast cancer.	Biochim Biophys Acta	2008 Apr	Golden T	doi: 10.1016/j.bbadis.2008.01.004
24327656	The molecular chaperone Hsp70 activates protein phosphatase 5 (PP5) by binding the tetratricopeptide repeat (TPR) domain.	J Biol Chem	2014 Jan 31	Connarn JN	doi: 10.1074/jbc.M113.519421
28534961	Disruption of serine/threonine protein phosphatase 5 inhibits tumorigenesis of urinary bladder cancer cells.	Int J Oncol	2017 Jul	Chen M	doi: 10.3892/ijo.2017.3997
30280322	Interactions of cantharidin-like inhibitors with human protein phosphatase-5 in a Mg2+ system: molecular dynamics and quantum calculations.	J Mol Model	2018 Oct 2	Assis LC	doi: 10.1007/s00894-018-3837-y.

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq
ACC	chr19	46353912	Missense_Mutation	novel	I96F	0.46
BLCA	chr19	46388576	Silent	novel	R400R	0.08
BLCA	chr19	46387522	Intron	novel		0.59
BLCA	chr19	46390124	Missense_Mutation	novel	T477S	0.47
BLCA	chr19	46387193	Silent	rs371076132	F335F	0.56
BLCA	chr19	46353868	Missense_Mutation	rs776101874	A81V	0.6
BLCA	chr19	46347047	5'UTR	novel		0.5
BLCA	chr19	46388725	Missense_Mutation	novel	N450S	0.09
BLCA	chr19	46387124	Missense_Mutation	novel	I312M	0.14
BLCA	chr19	46390287	Missense_Mutation	novel	H481Y	0.57
BLCA	chr19	46388698	Missense_Mutation	rs753540087	R441H	0.24
BRCA	chr19	46383379	Intron	novel		0.31
BRCA	chr19	46375675	Missense_Mutation	NA	Q145H	0.13
BRCA	chr19	46387166	Silent	NA	Q326Q	0.12
BRCA	chr19	46390080	Missense_Mutation	NA	I462T	0.38
BRCA	chr19	46383425	Silent	NA	V216V	0.27
BRCA	chr19	46387418	Missense_Mutation	NA	R367Q	0.27
BRCA	chr19	46353745	Splice_Region	novel		0.2
BRCA	chr19	46388690	Silent	rs752596841	H438H	0.26
CESC	chr19	46347172	Missense_Mutation	NA	K26E	0.53
CESC	chr19	46353964	Missense_Mutation	rs749045957	R113Q	0.23
CESC	chr19	46384906	Nonsense_Mutation	novel	R301*	0.06
CESC	chr19	46383862	Missense_Mutation	NA	S261L	0.1
CESC	chr19	46387172	Silent	NA	Y328Y	0.35
CESC	chr19	46387435	Nonsense_Mutation	novel	R373*	0.42
CESC	chr19	46390103	Missense_Mutation	novel	R470W	0.33
CESC	chr19	46390778	3'UTR	novel		0.56
CESC	chr19	46375669	Silent	novel	V143V	0.31
CHOL	chr19	46388682	Missense_Mutation	novel	V436M	0.42
COAD	chr19	46353837	Missense_Mutation	NA	A71T	0.19
COAD	chr19	46387133	Silent	NA	F315F	0.42
COAD	chr19	46353765	Missense_Mutation	NA	A47T	0.27
COAD	chr19	46375696	Silent	rs775576018	I152I	0.36
COAD	chr19	46347135	Frame_Shift_Ins	rs766639242	*R16Pfs7**	0.32
COAD	chr19	46387429	Missense_Mutation	NA	R371W	0.31
COAD	chr19	46390104	Missense_Mutation	rs148346594	R470Q	0.3
COAD	chr19	46376500	Missense_Mutation	NA	T187A	0.4
COAD	chr19	46347136	Frame_Shift_Del	NA	*R16Gfs10**	0.35
COAD	chr19	46353765	Missense_Mutation	NA	A47T	0.24
COAD	chr19	46387193	Silent	rs371076132	F335F	0.11
COAD	chr19	46390308	Missense_Mutation	novel	A488T	0.08
COAD	chr19	46383866	Silent	novel	E262E	0.24
COAD	chr19	46387101	Missense_Mutation	novel	E305K	0.34
DLBC	chr19	46375702	Silent	NA	G154G	0.6
GBM	chr19	46387442	In_Frame_Ins	novel	P375_P376insITTS	0.17
GBM	chr19	46387444	Frame_Shift_Ins	novel	*P376Hfs8**	0.05
GBM	chr19	46387499	Intron	novel		0.55
GBM	chr19	46375604	Missense_Mutation	novel	V122M	0.12
HNSC	chr19	46353829	Missense_Mutation	novel	R68L	0.25
HNSC	chr19	46376566	Missense_Mutation	novel	A209T	0.18
HNSC	chr19	46388621	Missense_Mutation	novel	L415F	0.14
HNSC	chr19	46387499	Intron	novel		0.43
HNSC	chr19	46388658	Missense_Mutation	NA	E428K	0.21
HNSC	chr19	46376562	Silent	novel	K207K	0.31
KIRC	chr19	46384879	Missense_Mutation	novel	L292V	0.08
KIRP	chr19	46384862	Missense_Mutation	novel	L286H	0.23
KIRP	chr19	46388225	Intron	novel		0.38
LIHC	chr19	46390319	Silent	novel	N491N	0.26
LIHC	chr19	46390364	3'UTR	novel		0.26
LIHC	chr19	46347203	Missense_Mutation	NA	N36S	0.17
LIHC	chr19	46353984	Missense_Mutation	NA	E120Q	0.19
LIHC	chr19	46390130	Missense_Mutation	novel	V479L	0.26
LIHC	chr19	46388415	Missense_Mutation	novel	M381I	0.35
LIHC	chr19	46353791	Silent	rs374930457	I55I	0.28
LIHC	chr19	46388164	Intron	novel		0.36
LIHC	chr19	46387431	Silent	NA	R371R	0.29
LUAD	chr19	46353886	Missense_Mutation	novel	R87L	0.11
LUAD	chr19	46353887	Silent	novel	R87R	0.12
LUAD	chr19	46375697	Missense_Mutation	NA	A153S	0.31
LUAD	chr19	46387419	Silent	novel	R367R	0.5
LUAD	chr19	46353869	Silent	novel	A81A	0.29
LUAD	chr19	46347136	Frame_Shift_Del	NA	*R16Gfs10**	1
LUSC	chr19	46390291	Missense_Mutation	novel	P482L	0.23
LUSC	chr19	46375741	Silent	rs144237776	I167I	0.26
MESO	chr19	46387621	Intron	novel		0.23
OV	chr19	46383829	Missense_Mutation	novel	L250H	0.06
OV	chr19	46388626	Missense_Mutation	novel	E417V	0.05
OV	chr19	46387189	Missense_Mutation	novel	V334A	0.3
PAAD	chr19	46375741	Silent	rs144237776	I167I	0.11
PRAD	chr19	46347133	Frame_Shift_Del	novel	*E13Gfs6**	0.58
PRAD	chr19	46388697	Missense_Mutation	rs376107784	R441C	0.35
READ	chr19	46383843	Missense_Mutation	rs758489583	E255K	0.17
READ	chr19	46387193	Silent	rs371076132	F335F	0.27
READ	chr19	46347136	Frame_Shift_Del	NA	*R16Gfs10**	0.25
READ	chr19	46383435	Missense_Mutation	novel	L220V	0.5
READ	chr19	46353937	Missense_Mutation	novel	A104D	0.56
SARC	chr19	46388582	Silent	novel	V402V	0.43
SARC	chr19	46376567	Missense_Mutation	rs199770924	A209V	0.27
SARC	chr19	46376568	Silent	novel	A209A	0.26
SKCM	chr19	46375720	Silent	rs754692842	S160S	0.29
SKCM	chr19	46387514	Intron	novel		0.31
SKCM	chr19	46388691	Missense_Mutation	rs775331289	G439R	0.3
SKCM	chr19	46388692	Missense_Mutation	novel	G439E	0.3
SKCM	chr19	46388711	Silent	novel	V445V	0.34
SKCM	chr19	46383777	Splice_Region	novel		0.56
SKCM	chr19	46383818	Silent	novel	Q246Q	0.16
SKCM	chr19	46353766	Missense_Mutation	NA	A47V	0.25
SKCM	chr19	46388615	Silent	rs777439537	A413A	0.19
STAD	chr19	46383797	Silent	NA	V239V	0.31
STAD	chr19	46387185	Missense_Mutation	NA	E333K	0.24
STAD	chr19	46353919	Missense_Mutation	NA	G98D	0.62
STAD	chr19	46390097	Missense_Mutation	NA	D468N	0.21
STAD	chr19	46353983	Silent	NA	Y119Y	0.13
STAD	chr19	46353867	Missense_Mutation	NA	A81T	0.3
STAD	chr19	46388679	Missense_Mutation	rs767506672	E435K	0.1
STAD	chr19	46387379	Missense_Mutation	NA	G354D	0.26
STAD	chr19	46376473	Missense_Mutation	NA	G178R	0.25
STAD	chr19	46347136	Frame_Shift_Del	NA	*R16Gfs10**	0.63
STAD	chr19	46383851	Silent	rs781056485	N257N	0.24
UCEC	chr19	46387429	Missense_Mutation	NA	R371W	0.3
UCEC	chr19	46383843	Missense_Mutation	rs758489583	E255K	0.32
UCEC	chr19	46383821	Silent	rs762149325	F247F	0.36
UCEC	chr19	46387234	Missense_Mutation	novel	L349R	0.37
UCEC	chr19	46390372	3'UTR	novel		0.68
UCEC	chr19	46384828	Nonsense_Mutation	novel	R275*	0.39
UCEC	chr19	46390356	3'UTR	rs752209870		0.42
UCEC	chr19	46390478	3'UTR	novel		0.1
UCEC	chr19	46387172	Silent	NA	Y328Y	0.26
UCEC	chr19	46387502	Intron	novel		0.27
UCEC	chr19	46390352	3'UTR	rs559037718		0.34
UCEC	chr19	46375702	Silent	NA	G154G	0.5
UCEC	chr19	46387445	Missense_Mutation	novel	P376L	0.41
UCEC	chr19	46388714	Missense_Mutation	novel	F446L	0.33
UCEC	chr19	46375666	Silent	rs372807877	I142I	0.39
UCEC	chr19	46390515	3'UTR	novel		0.14
UCEC	chr19	46353968	Silent	rs770696659	A114A	0.43
UCEC	chr19	46390450	3'UTR	novel		0.55
UCEC	chr19	46347137	Missense_Mutation	rs150667064	P14H	0.43
UCEC	chr19	46387418	Missense_Mutation	NA	R367Q	0.38
UCEC	chr19	46390332	Silent	novel	L496L	0.36
UCEC	chr19	46375721	Missense_Mutation	rs780928951	V161M	0.07
UCEC	chr19	46390323	Silent	NA	L493L	0.33
UCEC	chr19	46387184	Silent	novel	S332S	0.15
UCEC	chr19	46390322	Silent	rs146393311	T492T	0.43
UCEC	chr19	46388718	Missense_Mutation	NA	A448T	0.32
UCEC	chr19	46375721	Missense_Mutation	rs780928951	V161M	0.45
UCEC	chr19	46388575	Missense_Mutation	NA	R400Q	0.21
UCEC	chr19	46376475	Silent	novel	G178G	0.29
UCEC	chr19	46347213	Missense_Mutation	NA	F39L	0.34
UCEC	chr19	46384906	Nonsense_Mutation	novel	R301*	0.1
UCEC	chr19	46388556	Missense_Mutation	novel	G394W	0.48
UCEC	chr19	46387396	Missense_Mutation	rs780293038	G360S	0.44

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
CESC	DEL	0.0881	0.027508
KIRP	DEL	0.0486	0.054726
LUAD	DEL	0.25	1.5526e-05
LUSC	DEL	0.2116	1.1877e-06
OV	DEL	0.4732	2.441e-17
PAAD	DEL	0.0707	0.035089
READ	DEL	0.0727	0.23023
TGCT	DEL	0.2867	0.0046229
UCS	DEL	0.2143	0.12448

Survival Analysis

Cancer	P-value	Q-value
SARC	0.047	Kaplan-Meier Survival Analysis
MESO	0.00015	Kaplan-Meier Survival Analysis
SKCM	0.024	Kaplan-Meier Survival Analysis
PRAD	0.026	Kaplan-Meier Survival Analysis
PAAD	0.034	Kaplan-Meier Survival Analysis
CESC	0.048	Kaplan-Meier Survival Analysis
LAML	0.034	Kaplan-Meier Survival Analysis
UCEC	0.024	Kaplan-Meier Survival Analysis
LIHC	0.00041	Kaplan-Meier Survival Analysis
LGG	0.00058	Kaplan-Meier Survival Analysis
THCA	0.02	Kaplan-Meier Survival Analysis
LUAD	0.027	Kaplan-Meier Survival Analysis
UVM	0.00013	Kaplan-Meier Survival Analysis

Drugs

EuRBPDB

Description

RBPome

Expression

Transcripts

Gene Model

Pathways

Phenotypes

GWAS

PPI

Gene Ontology

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742