EuRBPDB

Basic Information
Cancer Related Information

Description

RBDs

Expression

Transcripts

Gene Model

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000011590 (Gene tree)
Gene ID: 27033
Gene Symbol: ZBTB32
Alias: TZFP|FAZF|FAXF|Rog|ZNF538
Full Name: zinc finger and BTB domain containing 32
Gene Type: protein_coding
Species: Homo_sapiens
Status: putative
Strand: Plus strand
Length: 12,557 bases
Position: chr19:35,704,492-35,717,048
Accession: 16763
RBP type: canonical RBP
Summary: ZBTB32 (Zinc Finger And BTB Domain Containing 32) is a Protein Coding gene. Diseases associated with ZBTB32 include Fanconi Anemia, Complementation Group A. Among its related pathways are Fanconi anemia pathway and Telomere C-strand (Lagging Strand) Synthesis. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and transcription corepressor activity. An important paralog of this gene is ZBTB16.

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000262630	zf-C2H2	PF00096.26	3.2e-08	1	1
ENSP00000376035	zf-C2H2	PF00096.26	3.2e-08	1	1
ENSP00000262630	zf-met	PF12874.7	0.00058	1	1
ENSP00000376035	zf-met	PF12874.7	0.00058	1	1

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000442282	ZBTB32-204	691	-	-	- (aa)	-	-
ENST00000426659	ZBTB32-203	469	-	ENSP00000466524	71 (aa)	-	K7EMJ1
ENST00000451726	ZBTB32-205	355	-	-	- (aa)	-	-
ENST00000392197	ZBTB32-202	2068	XM_017026591	ENSP00000376035	487 (aa)	XP_016882080	Q9Y2Y4
ENST00000262630	ZBTB32-201	1960	XM_011526718	ENSP00000262630	487 (aa)	XP_011525020	Q9Y2Y4
ENST00000481182	ZBTB32-206	1733	-	ENSP00000433657	302 (aa)	-	A0A0C4DGF1

Gene Model

Click here to download ENSG00000011590's gene model file

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000011590's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000011590	ZBTB32	99	79.261	ENSAMEG00000000589	ZBTB32	95	79.399	Ailuropoda_melanoleuca
ENSG00000011590	ZBTB32	100	94.366	ENSANAG00000034122	ZBTB32	96	89.079	Aotus_nancymaae
ENSG00000011590	ZBTB32	99	78.571	ENSBTAG00000023611	ZBTB32	96	76.119	Bos_taurus
ENSG00000011590	ZBTB32	100	88.732	ENSCJAG00000046270	ZBTB32	96	87.152	Callithrix_jacchus
ENSG00000011590	ZBTB32	100	81.690	ENSCAFG00020018613	ZBTB32	96	78.205	Canis_lupus_dingo
ENSG00000011590	ZBTB32	99	77.143	ENSCHIG00000004618	ZBTB32	96	76.546	Capra_hircus
ENSG00000011590	ZBTB32	99	82.857	ENSTSYG00000008895	ZBTB32	96	78.465	Carlito_syrichta
ENSG00000011590	ZBTB32	100	94.366	ENSCCAG00000000774	ZBTB32	96	88.437	Cebus_capucinus
ENSG00000011590	ZBTB32	100	98.592	ENSCATG00000019611	ZBTB32	96	95.075	Cercocebus_atys
ENSG00000011590	ZBTB32	100	98.592	ENSCSAG00000004395	ZBTB32	100	96.304	Chlorocebus_sabaeus
ENSG00000011590	ZBTB32	100	74.648	ENSCHOG00000001017	-	60	84.828	Choloepus_hoffmanni
ENSG00000011590	ZBTB32	100	95.775	ENSCANG00000031543	ZBTB32	96	94.861	Colobus_angolensis_palliatus
ENSG00000011590	ZBTB32	99	66.736	ENSCGRG00001018211	Zbtb32	94	67.097	Cricetulus_griseus_chok1gshd
ENSG00000011590	ZBTB32	100	78.615	ENSEASG00005001159	ZBTB32	96	78.678	Equus_asinus_asinus
ENSG00000011590	ZBTB32	100	78.411	ENSECAG00000005671	ZBTB32	96	78.465	Equus_caballus
ENSG00000011590	ZBTB32	100	74.438	ENSFCAG00000006380	ZBTB32	96	74.359	Felis_catus
ENSG00000011590	ZBTB32	99	96.990	ENSGGOG00000016789	ZBTB32	96	94.658	Gorilla_gorilla
ENSG00000011590	ZBTB32	100	77.465	ENSLAFG00000018739	ZBTB32	96	73.013	Loxodonta_africana
ENSG00000011590	ZBTB32	100	98.592	ENSMFAG00000034114	ZBTB32	96	95.075	Macaca_fascicularis
ENSG00000011590	ZBTB32	100	97.183	ENSMMUG00000002375	ZBTB32	96	95.075	Macaca_mulatta
ENSG00000011590	ZBTB32	100	98.592	ENSMNEG00000036607	ZBTB32	96	95.289	Macaca_nemestrina
ENSG00000011590	ZBTB32	100	97.183	ENSMLEG00000024571	ZBTB32	96	94.004	Mandrillus_leucophaeus
ENSG00000011590	ZBTB32	99	88.571	ENSMICG00000045992	ZBTB32	96	81.702	Microcebus_murinus
ENSG00000011590	ZBTB32	100	76.056	ENSMOCG00000004626	Zbtb32	95	67.591	Microtus_ochrogaster
ENSG00000011590	ZBTB32	100	70.423	MGP_CAROLIEiJ_G0029532	Zbtb32	79	96.250	Mus_caroli
ENSG00000011590	ZBTB32	100	73.239	ENSMUSG00000006310	Zbtb32	79	96.250	Mus_musculus
ENSG00000011590	ZBTB32	100	73.239	MGP_SPRETEiJ_G0030628	Zbtb32	79	96.250	Mus_spretus
ENSG00000011590	ZBTB32	100	78.873	ENSMPUG00000006234	ZBTB32	95	72.318	Mustela_putorius_furo
ENSG00000011590	ZBTB32	100	84.507	ENSMLUG00000011396	ZBTB32	95	76.170	Myotis_lucifugus
ENSG00000011590	ZBTB32	100	97.741	ENSNLEG00000011302	ZBTB32	100	97.741	Nomascus_leucogenys
ENSG00000011590	ZBTB32	97	69.565	ENSOPRG00000001316	ZBTB32	96	59.873	Ochotona_princeps
ENSG00000011590	ZBTB32	100	84.507	ENSOGAG00000004155	ZBTB32	96	80.638	Otolemur_garnettii
ENSG00000011590	ZBTB32	100	100.000	ENSPPAG00000031211	ZBTB32	100	98.973	Pan_paniscus
ENSG00000011590	ZBTB32	100	74.438	ENSPPRG00000008152	ZBTB32	96	74.359	Panthera_pardus
ENSG00000011590	ZBTB32	100	74.642	ENSPTIG00000021084	ZBTB32	96	74.573	Panthera_tigris_altaica
ENSG00000011590	ZBTB32	100	100.000	ENSPTRG00000010857	ZBTB32	100	98.563	Pan_troglodytes
ENSG00000011590	ZBTB32	100	98.592	ENSPANG00000009043	ZBTB32	96	95.717	Papio_anubis
ENSG00000011590	ZBTB32	100	74.648	ENSPEMG00000018640	Zbtb32	94	70.108	Peromyscus_maniculatus_bairdii
ENSG00000011590	ZBTB32	100	98.592	ENSPPYG00000009876	ZBTB32	100	97.536	Pongo_abelii
ENSG00000011590	ZBTB32	100	85.915	ENSPCOG00000003160	ZBTB32	96	82.128	Propithecus_coquereli
ENSG00000011590	ZBTB32	99	80.000	ENSPVAG00000012825	ZBTB32	100	76.638	Pteropus_vampyrus
ENSG00000011590	ZBTB32	99	75.714	ENSRNOG00000042465	Zbtb32	95	69.807	Rattus_norvegicus
ENSG00000011590	ZBTB32	100	97.183	ENSRBIG00000037073	ZBTB32	96	95.075	Rhinopithecus_bieti
ENSG00000011590	ZBTB32	100	94.366	ENSSBOG00000025572	-	96	88.651	Saimiri_boliviensis_boliviensis
ENSG00000011590	ZBTB32	100	91.549	ENSSBOG00000034407	-	96	72.163	Saimiri_boliviensis_boliviensis
ENSG00000011590	ZBTB32	100	80.282	ENSSSCG00000002908	ZBTB32	97	76.333	Sus_scrofa
ENSG00000011590	ZBTB32	100	76.065	ENSTBEG00000006535	ZBTB32	95	76.546	Tupaia_belangeri
ENSG00000011590	ZBTB32	100	80.282	ENSTTRG00000002232	ZBTB32	64	85.128	Tursiops_truncatus
ENSG00000011590	ZBTB32	99	79.055	ENSUAMG00000020706	ZBTB32	95	79.185	Ursus_americanus
ENSG00000011590	ZBTB32	100	81.690	ENSUMAG00000020255	-	89	85.586	Ursus_maritimus
ENSG00000011590	ZBTB32	100	78.074	ENSVVUG00000015089	ZBTB32	93	78.205	Vulpes_vulpes

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000122	negative regulation of transcription by RNA polymerase II	10572087.	TAS	Process
GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	-	ISA	Function
GO:0003677	DNA binding	-	ISS	Function
GO:0003714	transcription corepressor activity	10572087.	TAS	Function
GO:0005515	protein binding	23088713.	IPI	Function
GO:0005634	nucleus	10572087.	TAS	Component
GO:0005654	nucleoplasm	-	TAS	Component
GO:0006366	transcription by RNA polymerase II	10572087.	TAS	Process
GO:0008270	zinc ion binding	-	ISS	Function

Differential Expression

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq	RBD
BLCA	chr19	35716833	3'UTR	novel		0.22
BLCA	chr19	35715000	Missense_Mutation	NA	K125T	0.17
BLCA	chr19	35715133	Silent	rs758252504	S169S	0.38
BLCA	chr19	35715214	Silent	NA	L196L	0.3
BLCA	chr19	35716588	Missense_Mutation	novel	G434W	0.52	zf-C2H2
BLCA	chr19	35715477	Missense_Mutation	NA	G284E	0.11
BLCA	chr19	35716567	Missense_Mutation	novel	P427S	0.35
BLCA	chr19	35715365	Missense_Mutation	novel	P247S	0.21
BLCA	chr19	35716511	Missense_Mutation	novel	Q408L	0.32
BLCA	chr19	35716910	3'UTR	novel		0.4
BLCA	chr19	35715041	Missense_Mutation	novel	E139K	0.47
BLCA	chr19	35716736	Missense_Mutation	novel	S483F	0.44
BRCA	chr19	35716756	3'UTR	novel		0.1
BRCA	chr19	35714733	Missense_Mutation	rs267605433	G36E	0.4
BRCA	chr19	35716697	Missense_Mutation	NA	S470W	0.27
BRCA	chr19	35716290	Silent	NA	V394V	0.5
CESC	chr19	35714593	5'UTR	novel		0.34
CESC	chr19	35715444	Missense_Mutation	rs761180096	G273D	0.43
CESC	chr19	35716706	Missense_Mutation	novel	S473F	0.44
COAD	chr19	35715124	Silent	rs753319110	H166H	0.5
COAD	chr19	35715209	Missense_Mutation	rs150269464	R195C	0.38
COAD	chr19	35714919	Missense_Mutation	NA	R98M	0.35
COAD	chr19	35715306	Missense_Mutation	rs755206702	R227H	0.38
COAD	chr19	35715305	Missense_Mutation	rs2234366	R227C	0.26
COAD	chr19	35715288	Missense_Mutation	novel	G221D	0.37
COAD	chr19	35715290	Missense_Mutation	novel	S222A	0.19
COAD	chr19	35714963	Nonsense_Mutation	rs759629497	R113*	0.21
COAD	chr19	35715946	Frame_Shift_Del	novel	*Q323Rfs94**	0.19
DLBC	chr19	35714552	5'UTR	novel		0.54
GBM	chr19	35715108	Missense_Mutation	novel	E161A	0.07
GBM	chr19	35715825	Missense_Mutation	rs747749454	T317I	0.21
HNSC	chr19	35715493	Silent	novel	V289V	0.09
HNSC	chr19	35714725	Silent	novel	I33I	0.1
HNSC	chr19	35715242	Frame_Shift_Del	novel	*D206Efs16**	0.22
HNSC	chr19	35714987	Missense_Mutation	novel	D121N	0.36
HNSC	chr19	35716818	3'UTR	novel		0.15
KIRP	chr19	35714976	Missense_Mutation	novel	A117V	0.43
KIRP	chr19	35715011	Missense_Mutation	novel	E129K	0.1
KIRP	chr19	35715291	Missense_Mutation	novel	S222F	0.33
LAML	chr19	35715060	Missense_Mutation	novel	P145L	0.1
LIHC	chr19	35716723	Missense_Mutation	novel	P479T	0.39
LIHC	chr19	35715404	Missense_Mutation	NA	P260T	0.24
LIHC	chr19	35716567	Missense_Mutation	novel	P427S	0.13
LIHC	chr19	35716268	Missense_Mutation	NA	Q387L	0.35
LUAD	chr19	35716578	Silent	novel	C430C	0.62
LUAD	chr19	35714750	Missense_Mutation	rs369211573	A42T	0.26
LUAD	chr19	35716546	Missense_Mutation	novel	L420M	0.34
LUAD	chr19	35714765	Silent	novel	L47L	0.16
LUAD	chr19	35714753	Missense_Mutation	NA	H43D	0.19
LUAD	chr19	35714728	Silent	NA	T34T	0.22
LUAD	chr19	35716151	Missense_Mutation	novel	A348V	0.09
LUSC	chr19	35716595	Missense_Mutation	novel	G436D	0.06	zf-C2H2
LUSC	chr19	35715061	Silent	novel	P145P	0.21
LUSC	chr19	35716226	Missense_Mutation	novel	Y373C	0.31
LUSC	chr19	35715030	Missense_Mutation	novel	S135L	0.49
LUSC	chr19	35714814	Missense_Mutation	rs749111430	G63E	0.25
LUSC	chr19	35714749	Silent	novel	P41P	0.18
LUSC	chr19	35714651	Frame_Shift_Del	novel	*S10Afs11**	0.5
OV	chr19	35716600	Missense_Mutation	NA	P438T	0.26	zf-C2H2
OV	chr19	35716667	Missense_Mutation	novel	T460S	0.17
OV	chr19	35715078	Frame_Shift_Ins	novel	*E152Ifs6**	0.23
OV	chr19	35715080	Frame_Shift_Ins	novel	*E152Afs70**	0.21
PAAD	chr19	35715065	Nonsense_Mutation	novel	E147*	0.16
PRAD	chr19	35715405	Missense_Mutation	NA	P260H	0.1
READ	chr19	35715033	Missense_Mutation	novel	R136M	0.41
READ	chr19	35715436	Silent	NA	P270P	0.39
SARC	chr19	35716290	Silent	novel	V394V	0.14
SARC	chr19	35715380	Missense_Mutation	rs767265045	A252S	0.16
SKCM	chr19	35715400	Silent	NA	G258G	0.22
SKCM	chr19	35716613	Missense_Mutation	NA	S442F	0.31	zf-C2H2
SKCM	chr19	35714532	5'UTR	novel		0.04
SKCM	chr19	35715033	Missense_Mutation	novel	R136K	0.17
SKCM	chr19	35714672	Missense_Mutation	NA	R16W	0.42
SKCM	chr19	35714734	Silent	rs754384073	G36G	0.35
SKCM	chr19	35716855	3'UTR	novel		0.33
SKCM	chr19	35714937	Missense_Mutation	novel	S104F	0.46
SKCM	chr19	35715242	Missense_Mutation	novel	D206N	0.23
SKCM	chr19	35714866	Silent	NA	G80G	0.25
SKCM	chr19	35714664	Missense_Mutation	NA	G13D	0.39
SKCM	chr19	35715062	Missense_Mutation	rs370025737	G146R	0.41
SKCM	chr19	35716726	Missense_Mutation	NA	C480G	0.19
SKCM	chr19	35715247	Silent	novel	G207G	0.5
STAD	chr19	35714636	Frame_Shift_Del	novel	I6*	0.2
STAD	chr19	35716144	Missense_Mutation	NA	T346A	0.39
STAD	chr19	35716759	3'UTR	rs372821981		0.49
STAD	chr19	35716680	Silent	NA	T464T	0.3
STAD	chr19	35714699	Missense_Mutation	rs529757518	R25W	0.24
STAD	chr19	35716552	Missense_Mutation	NA	T422A	0.18
STAD	chr19	35715443	Missense_Mutation	NA	G273S	0.35
STAD	chr19	35716806	3'UTR	novel		0.38
THCA	chr19	35716665	Nonsense_Mutation	novel	W459*	0.04
UCEC	chr19	35715465	Frame_Shift_Del	NA	*T282Pfs18**	0.21
UCEC	chr19	35715257	Missense_Mutation	novel	V211M	0.29
UCEC	chr19	35715022	Missense_Mutation	NA	E132D	0.33
UCEC	chr19	35715172	Silent	novel	Q182Q	0.09
UCEC	chr19	35714830	Silent	novel	P68P	0.11
UCEC	chr19	35715022	Missense_Mutation	NA	E132D	0.29
UCEC	chr19	35715306	Missense_Mutation	rs755206702	R227H	0.38
UCEC	chr19	35715813	Missense_Mutation	rs754233028	S313F	0.31
UCEC	chr19	35716910	3'UTR	novel		0.39
UCEC	chr19	35715192	Missense_Mutation	novel	T189I	0.64
UCEC	chr19	35716279	Missense_Mutation	novel	H391D	0.29
UCEC	chr19	35716133	Missense_Mutation	novel	G342D	0.41
UCEC	chr19	35714975	Missense_Mutation	NA	A117T	0.32
UCEC	chr19	35714567	5'UTR	novel		0.18
UCEC	chr19	35715141	Missense_Mutation	novel	R172I	0.19
UCEC	chr19	35714652	Missense_Mutation	novel	P9H	0.39
UCEC	chr19	35714639	Missense_Mutation	novel	P5S	0.31
UCEC	chr19	35715219	Missense_Mutation	rs373009533	A198V	0.15
UCEC	chr19	35716653	Frame_Shift_Del	novel	*P456Rfs40**	0.12
UCEC	chr19	35715302	Silent	novel	L226L	0.25
UCEC	chr19	35715465	Frame_Shift_Del	NA	*T282Pfs18**	0.13
UCEC	chr19	35714668	Silent	rs779219197	S14S	0.37
UCEC	chr19	35716973	3'UTR	novel		0.21
UCS	chr19	35714645	Silent	novel	R7R	0.31

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
READ	DEL	0.0364	0.23023
STAD	DEL	0.1338	0.1243

Survival Analysis

Cancer	P-value	Q-value
THYM	0.034	Kaplan-Meier Survival Analysis
KIRC	0.00086	Kaplan-Meier Survival Analysis
STAD	0.022	Kaplan-Meier Survival Analysis
SARC	0.024	Kaplan-Meier Survival Analysis
HNSC	0.0001	Kaplan-Meier Survival Analysis
SKCM	0.0001	Kaplan-Meier Survival Analysis
BRCA	0.0016	Kaplan-Meier Survival Analysis
KIRP	0.012	Kaplan-Meier Survival Analysis
PAAD	0.003	Kaplan-Meier Survival Analysis
BLCA	0.0036	Kaplan-Meier Survival Analysis
CESC	0.00015	Kaplan-Meier Survival Analysis
UCEC	0.024	Kaplan-Meier Survival Analysis
LGG	0.012	Kaplan-Meier Survival Analysis
THCA	0.0072	Kaplan-Meier Survival Analysis
LUAD	0.003	Kaplan-Meier Survival Analysis
OV	0.048	Kaplan-Meier Survival Analysis

Drugs

EuRBPDB

Description

RBDs

Expression

Transcripts

Gene Model

PPI

Orthologs

Gene Ontology

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742