EuRBPDB

Basic Information
Cancer Related Information

Description

RBPome

Literatures

Expression

Transcripts

Gene Model

Pathways

PPI

Gene Ontology

Description

Ensembl ID: ENSG00000014216 (Gene tree)
Gene ID: 823
Gene Symbol: CAPN1
Alias: muCANP|muCL|CANP|CANPL1
Full Name: calpain 1
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Plus strand
Length: 31,441 bases
Position: chr11:65,180,566-65,212,006
Accession: 1476
RBP type: non-canonical RBP
Summary: The calpains, calcium-activated neutral proteases, are nonlysosomal, intracellular cysteine proteases. The mammalian calpains include ubiquitous, stomach-specific, and muscle-specific proteins. The ubiquitous enzymes consist of heterodimers with distinct large, catalytic subunits associated with a common small, regulatory subunit. This gene encodes the large subunit of the ubiquitous enzyme, calpain 1. Several transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Nov 2010]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & MCF10A	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & U2OS	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
30508278	Characterizations of HSP90-Interacting Complex in Renal Cells Using Tandem Affinity Purification and Its Potential Role in Kidney Stone Formation.	Proteomics	2018 Dec	Manissorn J	doi: 10.1002/pmic.201800004.

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000526966	CAPN1-206	550	-	ENSP00000431528	161 (aa)	-	E9PJA6
ENST00000529133	CAPN1-217	593	-	ENSP00000432512	191 (aa)	-	E9PQB3
ENST00000524773	CAPN1-202	2960	-	ENSP00000434176	714 (aa)	-	P07384
ENST00000527887	CAPN1-212	348	-	-	- (aa)	-	-
ENST00000530495	CAPN1-219	572	-	-	- (aa)	-	-
ENST00000533909	CAPN1-227	573	-	ENSP00000435198	148 (aa)	-	E9PLC9
ENST00000533820	CAPN1-226	3083	-	ENSP00000435272	714 (aa)	-	P07384
ENST00000526468	CAPN1-204	690	-	ENSP00000433366	191 (aa)	-	E9PL37
ENST00000528739	CAPN1-216	341	-	-	- (aa)	-	-
ENST00000528165	CAPN1-214	2828	-	-	- (aa)	-	-
ENST00000527469	CAPN1-209	584	-	-	- (aa)	-	-
ENST00000527739	CAPN1-211	582	-	ENSP00000433823	161 (aa)	-	E9PJA6
ENST00000279247	CAPN1-201	3007	-	ENSP00000279247	714 (aa)	-	P07384
ENST00000533129	CAPN1-224	2792	XM_006718698	ENSP00000431686	714 (aa)	XP_006718761	P07384
ENST00000525013	CAPN1-203	643	-	-	- (aa)	-	-
ENST00000526954	CAPN1-205	754	-	ENSP00000436002	201 (aa)	-	E9PRM1
ENST00000530567	CAPN1-220	1415	-	-	- (aa)	-	-
ENST00000530442	CAPN1-218	577	-	-	- (aa)	-	-
ENST00000534373	CAPN1-228	581	-	ENSP00000431793	135 (aa)	-	E9PJJ3
ENST00000527323	CAPN1-208	3086	XM_011545292	ENSP00000431984	714 (aa)	XP_011543594	P07384
ENST00000528396	CAPN1-215	571	-	ENSP00000435847	163 (aa)	-	E9PSA6
ENST00000532285	CAPN1-222	568	-	ENSP00000436693	63 (aa)	-	E9PIA9
ENST00000527897	CAPN1-213	879	-	-	- (aa)	-	-
ENST00000527189	CAPN1-207	558	-	-	- (aa)	-	-
ENST00000533079	CAPN1-223	878	-	-	- (aa)	-	-
ENST00000533704	CAPN1-225	643	-	-	- (aa)	-	-
ENST00000527699	CAPN1-210	564	-	ENSP00000431172	152 (aa)	-	E9PMC6
ENST00000531068	CAPN1-221	496	-	ENSP00000435092	122 (aa)	-	E9PLX0

Gene Model

Click here to download ENSG00000014216's gene model file

Pathways

Pathway ID	Pathway Name	Source
hsa04141	Protein processing in endoplasmic reticulum	KEGG
hsa04210	Apoptosis	KEGG
hsa04217	Necroptosis	KEGG
hsa04218	Cellular senescence	KEGG
hsa05010	Alzheimer disease	KEGG

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000014216's network

* RBP PPI network refers to all genes directly bind to RBP

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0004198	calcium-dependent cysteine-type endopeptidase activity	21873635.	IBA	Function
GO:0004198	calcium-dependent cysteine-type endopeptidase activity	2407243.16411745.	IDA	Function
GO:0004198	calcium-dependent cysteine-type endopeptidase activity	-	ISS	Function
GO:0004198	calcium-dependent cysteine-type endopeptidase activity	17526495.	TAS	Function
GO:0005509	calcium ion binding	9271093.	IDA	Function
GO:0005515	protein binding	9407132.19712109.21988832.22805611.	IPI	Function
GO:0005576	extracellular region	-	TAS	Component
GO:0005737	cytoplasm	21873635.	IBA	Component
GO:0005739	mitochondrion	-	IEA	Component
GO:0005764	lysosome	-	IEA	Component
GO:0005829	cytosol	8769305.12150984.14559243.21531719.	IDA	Component
GO:0005829	cytosol	-	TAS	Component
GO:0005886	plasma membrane	8769305.12150984.	IDA	Component
GO:0005886	plasma membrane	-	TAS	Component
GO:0005925	focal adhesion	21423176.	HDA	Component
GO:0006508	proteolysis	21873635.	IBA	Process
GO:0006508	proteolysis	2400579.2407243.16411745.21531719.	IDA	Process
GO:0006508	proteolysis	-	ISS	Process
GO:0008284	positive regulation of cell proliferation	8702541.	TAS	Process
GO:0016020	membrane	14559243.	IDA	Component
GO:0016241	regulation of macroautophagy	17264674.	NAS	Process
GO:0022617	extracellular matrix disassembly	-	TAS	Process
GO:0032801	receptor catabolic process	-	IEA	Process
GO:0043312	neutrophil degranulation	-	TAS	Process
GO:0050790	regulation of catalytic activity	8954105.9271093.	IDA	Process
GO:0060056	mammary gland involution	-	IEA	Process
GO:0070062	extracellular exosome	19056867.19199708.23533145.	HDA	Component
GO:0070268	cornification	-	TAS	Process
GO:0097264	self proteolysis	8769305.8954105.	IDA	Process
GO:1904813	ficolin-1-rich granule lumen	-	TAS	Component
GO:2000310	regulation of NMDA receptor activity	17526495.	TAS	Process

Cancer associated literatures

PID	Title	Article	Time	Author	Doi
27456359	Gene/protein expression of CAPN1/2-CAST system members is associated with ERK1/2 kinases activity as well as progression and clinical outcome in human laryngeal cancer.	Tumour Biol	2016 Oct	Starska K	-
19946330	Calpain regulates sensitivity to trastuzumab and survival in HER2-positive breast cancer.	Oncogene	2010 Mar 4	Kulkarni S	doi: 10.1038/onc.2009.422
24691096	Proteolysis of the human DNA polymerase delta smallest subunit p12 by ??-calpain in calcium-triggered apoptotic HeLa cells.	PLoS One	2014 Apr 1	Fan X	doi: 10.1371/journal.pone.0093642
12393869	The role of calpain in the proteolytic cleavage of E-cadherin in prostate and mammary epithelial cells.	J Biol Chem	2003 Jan 10	Rios-Doria J	-
21305563	Calpain activity is increased in skeletal muscle from gastric cancer patients with no or minimal weight loss.	Muscle Nerve	2011 Mar	Smith IJ	doi: 10.1002/mus.21893
18726991	Calpain-mediated androgen receptor breakdown in apoptotic prostate cancer cells.	J Cell Physiol	2008 Dec	Yang H	doi: 10.1002/jcp.21565.
26496999	Calpain-1 is associated with adverse relapse free survival in breast cancer: a confirmatory study.	Histopathology	2016 Jun	Pu X	doi: 10.1111/his.12896
28498452	Calpain and AR-V7: Two potential therapeutic targets to overcome acquired docetaxel resistance in castration-resistant prostate cancer cells.	Oncol Rep	2017 Jun	Liu L	doi: 10.3892/or.2017.5623
28536704	Calpain-1 Expression in Triple-Negative Breast Cancer: A Potential Prognostic Factor Independent of the Proliferative/Apoptotic Index.	Biomed Res Int	2017	Al-Bahlani SM	doi: 10.1155/2017/9290425

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq
BLCA	chr11	65210059	Missense_Mutation	novel	M635I	0.15
BLCA	chr11	65204783	Silent	NA	A422A	0.31
BLCA	chr11	65213951	3'Flank	novel		0.14
BLCA	chr11	65214054	3'Flank	novel		0.35
BLCA	chr11	65214047	3'Flank	novel		0.65
BLCA	chr11	65204856	Missense_Mutation	NA	E447Q	0.63
BLCA	chr11	65183508	Silent	novel	L124L	0.21
BLCA	chr11	65214244	3'Flank	NA		0.2
BLCA	chr11	65210833	Silent	novel	D693D	0.04
BLCA	chr11	65183487	Silent	novel	L117L	0.16
BLCA	chr11	65182932	Silent	novel	S77S	0.38
BLCA	chr11	65210385	Silent	rs747653455	S664S	0.31
BRCA	chr11	65210833	Missense_Mutation	NA	D693E	0.27
BRCA	chr11	65211341	3'UTR	novel		0.37
BRCA	chr11	65206516	Silent	rs745365536	A469A	0.61
BRCA	chr11	65213930	3'Flank	NA		0.41
BRCA	chr11	65206526	Missense_Mutation	rs762252249	R473C	0.26
BRCA	chr11	65185951	Missense_Mutation	NA	V164A	0.29
BRCA	chr11	65206553	Missense_Mutation	novel	E482K	0.22
BRCA	chr11	65206636	Silent	rs559519689	F509F	0.09
BRCA	chr11	65204821	Missense_Mutation	NA	G435D	0.31
BRCA	chr11	65211298	3'UTR	rs532348209		0.11
BRCA	chr11	65186174	Missense_Mutation	NA	N199H	0.81
CESC	chr11	65180992	5'Flank	NA		0.42
CESC	chr11	65186261	Frame_Shift_Ins	novel	*R228Pfs27**	0.12
CESC	chr11	65187279	Missense_Mutation	NA	S275C	0.5
CESC	chr11	65188691	Silent	NA	L370L	0.48
CESC	chr11	65206570	Missense_Mutation	NA	F487L	0.41
CESC	chr11	65180926	5'Flank	novel		0.44
CESC	chr11	65204807	Silent	novel	R430R	0.37
CESC	chr11	65214061	3'Flank	rs370245841		0.31
CESC	chr11	65182828	Missense_Mutation	NA	E43Q	0.23
CESC	chr11	65188616	Silent	novel	F345F	0.27
CESC	chr11	65182914	Silent	NA	K71K	0.21
CESC	chr11	65206790	Missense_Mutation	novel	D526N	0.5
CHOL	chr11	65182808	Missense_Mutation	novel	K36T	0.53
COAD	chr11	65204819	Silent	NA	F434F	0.3
COAD	chr11	65209358	Missense_Mutation	novel	S589P	0.12
COAD	chr11	65186262	Missense_Mutation	rs748491783	R228H	0.2
COAD	chr11	65209364	Missense_Mutation	rs750102134	R591C	0.18
COAD	chr11	65206516	Silent	rs745365536	A469A	0.55
COAD	chr11	65204728	Missense_Mutation	rs769161725	T404M	0.52
COAD	chr11	65183134	Silent	novel	L92L	0.2
COAD	chr11	65214181	3'Flank	rs368350491		0.22
COAD	chr11	65186255	Missense_Mutation	novel	E226K	0.14
COAD	chr11	65211328	3'UTR	rs377011922		0.24
COAD	chr11	65214010	3'Flank	rs781736957		0.37
COAD	chr11	65210056	Silent	NA	S634S	0.2
ESCA	chr11	65186252	Missense_Mutation	novel	Y225H	0.38
ESCA	chr11	65214058	3'Flank	novel		0.16
ESCA	chr11	65214009	3'Flank	NA		0.15
ESCA	chr11	65181028	5'Flank	novel		0.62
ESCA	chr11	65211452	3'UTR	novel		0.41
ESCA	chr11	65214183	3'Flank	novel		0.05
GBM	chr11	65183179	Missense_Mutation	NA	I107V	0.34
GBM	chr11	65206490	Missense_Mutation	novel	K461Q	0.42
GBM	chr11	65186262	Missense_Mutation	rs748491783	R228H	0.23
GBM	chr11	65206509	Missense_Mutation	novel	A467V	0.14
HNSC	chr11	65206489	Missense_Mutation	novel	L460F	0.07
HNSC	chr11	65210855	Missense_Mutation	novel	T701A	0.32
HNSC	chr11	65211285	Silent	novel	*715*	0.38
KIRC	chr11	65204785	Frame_Shift_Del	novel	*L423Pfs39**	0.27
KIRP	chr11	65206647	Missense_Mutation	NA	F513C	0.23
LGG	chr11	65213945	3'Flank	novel		0.19
LUAD	chr11	65214386	3'Flank	novel		0.15
LUAD	chr11	65188583	Splice_Region	novel		0.19
LUAD	chr11	65186268	Missense_Mutation	novel	A230V	0.42
LUAD	chr11	65206653	Missense_Mutation	NA	S515L	0.18
LUAD	chr11	65206570	Silent	novel	F487F	0.32
LUAD	chr11	65214005	3'Flank	novel		0.31
LUSC	chr11	65188668	Missense_Mutation	novel	I363F	0.21
LUSC	chr11	65210386	Missense_Mutation	NA	E665K	0.14
LUSC	chr11	65204824	Missense_Mutation	NA	R436L	0.85
LUSC	chr11	65188655	Silent	novel	L358L	0.1
LUSC	chr11	65186293	Silent	novel	I238I	0.29
MESO	chr11	65180891	5'Flank	novel		0.08
OV	chr11	65210072	Missense_Mutation	novel	M640L	0.45
OV	chr11	65206606	Silent	novel	S499S	0.14
PAAD	chr11	65204781	Missense_Mutation	NA	A422T	0.22
PRAD	chr11	65206644	Missense_Mutation	rs756980532	R512H	0.37
READ	chr11	65187223	Silent	rs534960869	S256S	0.34
READ	chr11	65214010	3'Flank	rs781736957		0.26
READ	chr11	65214430	3'Flank	rs368014225		0.19
READ	chr11	65210849	Missense_Mutation	novel	V699F	0.07
SARC	chr11	65214071	3'Flank	novel		0.07
SKCM	chr11	65214012	3'Flank	NA		0.25
SKCM	chr11	65214169	3'Flank	NA		0.6
SKCM	chr11	65188670	Silent	NA	I363I	0.42
SKCM	chr11	65211293	3'UTR	rs779071796		0.58
SKCM	chr11	65209359	Missense_Mutation	rs761412242	S589L	0.29
SKCM	chr11	65210344	Missense_Mutation	novel	L651F	0.5
SKCM	chr11	65206673	Missense_Mutation	NA	V522M	0.18
SKCM	chr11	65214353	3'Flank	NA		0.35
SKCM	chr11	65204802	Missense_Mutation	rs777787068	R429C	0.14
SKCM	chr11	65183564	Missense_Mutation	NA	N143I	0.22
STAD	chr11	65210403	Silent	novel	V670V	0.29
STAD	chr11	65214010	3'Flank	rs781736957		0.45
STAD	chr11	65204819	Silent	NA	F434F	0.29
STAD	chr11	65213963	3'Flank	rs779955818		0.29
STAD	chr11	65204800	Missense_Mutation	NA	R428H	0.3
STAD	chr11	65204800	Missense_Mutation	NA	R428H	0.43
STAD	chr11	65185991	Silent	rs200853785	F177F	0.21
STAD	chr11	65183176	Missense_Mutation	novel	D106N	0.08
STAD	chr11	65204781	Missense_Mutation	NA	A422T	0.36
STAD	chr11	65206551	Missense_Mutation	rs763471308	R481Q	0.29
STAD	chr11	65206526	Missense_Mutation	rs762252249	R473C	0.23
STAD	chr11	65210400	Silent	rs377531394	A669A	0.45
STAD	chr11	65214367	3'Flank	rs370845248		0.27
STAD	chr11	65209879	Missense_Mutation	NA	E609K	0.21
STAD	chr11	65206516	Silent	rs745365536	A469A	0.04
STAD	chr11	65210403	Silent	novel	V670V	0.17
STAD	chr11	65182737	Silent	novel	T12T	0.38
STAD	chr11	65211342	3'UTR	novel		0.29
TGCT	chr11	65188680	Frame_Shift_Ins	novel	*L370Hfs36**	0.14
THCA	chr11	65214341	3'Flank	novel		0.28
THYM	chr11	65181311	5'Flank	novel		0.08
UCEC	chr11	65206515	Missense_Mutation	NA	A469V	0.13
UCEC	chr11	65210861	Missense_Mutation	novel	D703Y	0.1
UCEC	chr11	65188029	Silent	novel	A306A	0.41
UCEC	chr11	65183187	Missense_Mutation	novel	Q109H	0.36
UCEC	chr11	65206598	Missense_Mutation	novel	V497M	0.2
UCEC	chr11	65206572	Missense_Mutation	rs376981701	R488H	0.21
UCEC	chr11	65180693	5'Flank	novel		0.43
UCEC	chr11	65214026	3'Flank	rs372832352		0.39
UCEC	chr11	65187240	Missense_Mutation	rs192099450	A262D	0.23
UCEC	chr11	65188460	Silent	novel	R326R	0.05
UCEC	chr11	65206515	Missense_Mutation	NA	A469V	0.1
UCEC	chr11	65209907	Missense_Mutation	rs772985471	R618Q	0.41
UCEC	chr11	65182830	Missense_Mutation	novel	E43D	0.09
UCEC	chr11	65185943	Silent	rs17881255	D161D	0.3
UCEC	chr11	65206630	Silent	rs761219620	G507G	0.16
UCEC	chr11	65210418	Silent	NA	F675F	0.05
UCEC	chr11	65213922	3'Flank	rs765489978		0.41
UCEC	chr11	65185976	Silent	rs200819735	D172D	0.18
UCEC	chr11	65210448	Missense_Mutation	novel	M685I	0.16
UCEC	chr11	65214251	3'Flank	novel		0.22
UCEC	chr11	65214183	3'Flank	rs763991765		0.39
UCEC	chr11	65185991	Silent	rs200853785	F177F	0.56
UCEC	chr11	65188710	Missense_Mutation	rs369163523	R377W	0.62
UCEC	chr11	65209365	Missense_Mutation	rs190935218	R591H	0.45
UCEC	chr11	65180865	5'Flank	novel		0.69
UCEC	chr11	65214010	3'Flank	rs781736957		0.33
UCEC	chr11	65208204	Splice_Site	novel	X558_splice	0.28
UCEC	chr11	65180652	5'Flank	novel		0.29
UCEC	chr11	65214169	3'Flank	novel		0.05
UCEC	chr11	65214222	3'Flank	rs567622431		0.34
UCEC	chr11	65206813	Silent	rs771495649	P533P	0.48
UCEC	chr11	65210049	Missense_Mutation	rs770520025	S632L	0.35
UCEC	chr11	65213877	3'Flank	rs543180559		0.31
UCEC	chr11	65188022	Missense_Mutation	rs377052700	T304M	0.15
UCEC	chr11	65210092	Silent	rs756358689	S646S	0.2
UCEC	chr11	65180873	5'Flank	novel		0.46
UCEC	chr11	65214353	3'Flank	novel		0.5
UCEC	chr11	65182824	Missense_Mutation	novel	D41E	0.34
UCEC	chr11	65214015	3'Flank	NA		0.37
UCEC	chr11	65188735	Missense_Mutation	NA	R385Q	0.49
UCEC	chr11	65182907	Missense_Mutation	novel	G69D	0.44
UCEC	chr11	65181252	5'Flank	novel		0.24
UCEC	chr11	65204846	Silent	novel	F443F	0.28
UCEC	chr11	65206520	Missense_Mutation	rs775100954	R471W	0.24
UCEC	chr11	65214056	3'Flank	novel		0.16
UCEC	chr11	65210418	Silent	NA	F675F	0.54
UCEC	chr11	65180882	5'Flank	novel		0.44
UCEC	chr11	65185976	Silent	rs200819735	D172D	0.32
UCEC	chr11	65181238	5'Flank	novel		0.62
UCEC	chr11	65206636	Silent	rs559519689	F509F	0.44
UCEC	chr11	65206515	Missense_Mutation	NA	A469V	0.35
UCEC	chr11	65211351	3'UTR	novel		0.49
UCEC	chr11	65204830	Missense_Mutation	novel	M438T	0.27
UCEC	chr11	65182876	Nonsense_Mutation	novel	E59*	0.16
UCEC	chr11	65185991	Silent	rs200853785	F177F	0.53
UCEC	chr11	65186321	Silent	novel	L248L	0.21
UCEC	chr11	65188669	Missense_Mutation	novel	I363T	0.29
UCEC	chr11	65214010	3'Flank	rs781736957		0.32
UCEC	chr11	65182756	Nonsense_Mutation	novel	Q19*	0.25
UCEC	chr11	65186309	Missense_Mutation	rs759801167	R244W	0.38
UCEC	chr11	65206493	Missense_Mutation	rs758232757	R462C	0.41
UCEC	chr11	65213919	3'Flank	novel		0.48
UCEC	chr11	65214227	3'Flank	rs773357046		0.35
UCEC	chr11	65183538	Silent	novel	V134V	0.37
UCEC	chr11	65210056	Silent	NA	S634S	0.5

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
BRCA	DEL	0.1694	1.2183e-05
ESCA	AMP	0.212	0.018342
TGCT	DEL	0.7	0.21504

Survival Analysis

Cancer	P-value	Q-value
THYM	0.0037	Kaplan-Meier Survival Analysis
KIRC	0.00088	Kaplan-Meier Survival Analysis
STAD	0.012	Kaplan-Meier Survival Analysis
SARC	0.0008	Kaplan-Meier Survival Analysis
ACC	0.026	Kaplan-Meier Survival Analysis
SKCM	0.016	Kaplan-Meier Survival Analysis
KIRP	0.00055	Kaplan-Meier Survival Analysis
PAAD	0.00053	Kaplan-Meier Survival Analysis
LAML	0.00011	Kaplan-Meier Survival Analysis
GBM	0.0056	Kaplan-Meier Survival Analysis
LIHC	0.0055	Kaplan-Meier Survival Analysis
LGG	0.00013	Kaplan-Meier Survival Analysis
OV	0.047	Kaplan-Meier Survival Analysis

Drugs

EuRBPDB

Description

RBPome

Literatures

Expression

Transcripts

Gene Model

Pathways

PPI

Gene Ontology

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742