EuRBPDB

Description

Ensembl ID: ENSG00000014641 (Gene tree)
Gene ID: 4190
Gene Symbol: MDH1
Alias: N
Full Name: malate dehydrogenase 1
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Plus strand
Length: 18,589 bases
Position: chr2:63,588,609-63,607,197
Accession: 6970
RBP type: non-canonical RBP
Summary: This gene encodes an enzyme that catalyzes the NAD/NADH-dependent, reversible oxidation of malate to oxaloacetate in many metabolic pathways, including the citric acid cycle. Two main isozymes are known to exist in eukaryotic cells: one is found in the mitochondrial matrix and the other in the cytoplasm. This gene encodes the cytosolic isozyme, which plays a key role in the malate-aspartate shuttle that allows malate to pass through the mitochondrial membrane to be transformed into oxaloacetate for further cellular processes. Alternatively spliced transcript variants have been found for this gene. A recent study showed that a C-terminally extended isoform is produced by use of an alternative in-frame translation termination codon via a stop codon readthrough mechanism, and that this isoform is localized in the peroxisomes. Pseudogenes have been identified on chromosomes X and 6. [provided by RefSeq, Feb 2016]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
29431736	Capturing the interactome of newly transcribed RNA	PolyT-RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & MCF10A	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
27453046	Comprehensive Identification of RNA-Binding Domains in Human Cells	RIC & Hela	2016 Aug 18	Castello A	DOI: 10.1016/j.molcel.2016.06.029

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
26767003	Identification of mutant genes with high-frequency, high-risk, and high-expression in lung adenocarcinoma.	Thorac Cancer	2014 May	Li G	doi: 10.1111/1759-7714.12080
2295630	Regulatory regions of the mitochondrial and cytosolic isoenzyme genes participating in the malate-aspartate shuttle.	J Biol Chem	1990 Jan 25	Setoyama C	-

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000432309	MDH1-205	844	-	ENSP00000410073	222 (aa)	-	C9JF79
ENST00000462944	MDH1-209	634	-	-	- (aa)	-	-
ENST00000436321	MDH1-206	680	-	ENSP00000394504	119 (aa)	-	C9JRL4
ENST00000421012	MDH1-204	573	-	ENSP00000400937	87 (aa)	-	F8WFC2
ENST00000484538	MDH1-211	910	-	-	- (aa)	-	-
ENST00000539945	MDH1-215	1443	-	ENSP00000438144	352 (aa)	-	P40925
ENST00000233114	MDH1-201	1650	-	ENSP00000233114	334 (aa)	-	P40925
ENST00000495083	MDH1-214	552	-	-	- (aa)	-	-
ENST00000485155	MDH1-212	571	-	-	- (aa)	-	-
ENST00000544381	MDH1-216	1346	-	ENSP00000446395	245 (aa)	-	P40925
ENST00000442225	MDH1-207	785	-	ENSP00000399004	67 (aa)	-	C9IZI0
ENST00000409908	MDH1-203	700	-	ENSP00000386743	169 (aa)	-	B8ZZ51
ENST00000485781	MDH1-213	893	-	-	- (aa)	-	-
ENST00000409476	MDH1-202	808	-	ENSP00000386719	210 (aa)	-	B9A041
ENST00000454035	MDH1-208	575	-	ENSP00000409027	114 (aa)	-	C9JLV6
ENST00000472098	MDH1-210	936	-	-	- (aa)	-	-

Gene Model

Pathways

Pathway ID	Pathway Name	Source
hsa00020	Citrate cycle (TCA cycle)	KEGG
hsa00270	Cysteine and methionine metabolism	KEGG
hsa00620	Pyruvate metabolism	KEGG
hsa00630	Glyoxylate and dicarboxylate metabolism	KEGG
hsa01100	Metabolic pathways	KEGG
hsa01200	Carbon metabolism	KEGG
hsa04964	Proximal tubule bicarbonate reclamation	KEGG

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000014641	Blood Pressure	3.4586055E-009	-

Protein-Protein Interaction (PPI)

* RBP PPI network refers to all genes directly bind to RBP

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0004470	malic enzyme activity	8786100.	TAS	Function
GO:0005515	protein binding	21044950.	IPI	Function
GO:0005615	extracellular space	22664934.	HDA	Component
GO:0005829	cytosol	21873635.	IBA	Component
GO:0005829	cytosol	-	TAS	Component
GO:0006094	gluconeogenesis	-	TAS	Process
GO:0006099	tricarboxylic acid cycle	21873635.	IBA	Process
GO:0006107	oxaloacetate metabolic process	21873635.	IBA	Process
GO:0006108	malate metabolic process	21873635.	IBA	Process
GO:0006734	NADH metabolic process	21873635.	IBA	Process
GO:0030060	L-malate dehydrogenase activity	21873635.	IBA	Function
GO:0047860	diiodophenylpyruvate reductase activity	-	IEA	Function
GO:0051287	NAD binding	-	IEA	Function
GO:0070062	extracellular exosome	19056867.23533145.	HDA	Component