EuRBPDB

Basic Information
Cancer Related Information

Description

RBPome

Expression

Transcripts

Gene Model

Pathways

Phenotypes

GWAS

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000018510 (Gene tree)
Gene ID: 8540
Gene Symbol: AGPS
Alias: ADHAPS|ADAS|ALDHPSY|ADPS|ADAP-S
Full Name: alkylglycerone phosphate synthase
Gene Type: protein_coding
Species: Homo_sapiens
Status: putative
Strand: Plus strand
Length: 166,656 bases
Position: chr2:177,392,644-177,559,299
Accession: 327
RBP type: non-canonical RBP
Summary: This gene is a member of the FAD-binding oxidoreductase/transferase type 4 family. It encodes a protein that catalyzes the second step of ether lipid biosynthesis in which acyl-dihydroxyacetonephosphate (DHAP) is converted to alkyl-DHAP by the addition of a long chain alcohol and the removal of a long-chain acid anion. The protein is localized to the inner aspect of the peroxisomal membrane and requires FAD as a cofactor. Mutations in this gene have been associated with rhizomelic chondrodysplasia punctata, type 3 and Zellweger syndrome. [provided by RefSeq, Jul 2008]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & U2OS	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000460342	AGPS-203	576	-	-	- (aa)	-	-
ENST00000637633	AGPS-204	2143	-	ENSP00000490844	543 (aa)	-	A0A1B0GWA2
ENST00000409888	AGPS-202	815	-	ENSP00000386688	189 (aa)	-	B8ZZ81
ENST00000642466	AGPS-205	2273	-	ENSP00000494433	560 (aa)	-	A0A2R8YEL0
ENST00000264167	AGPS-201	7764	XM_011512041	ENSP00000264167	658 (aa)	XP_011510343	O00116

Gene Model

Click here to download ENSG00000018510's gene model file

Pathways

Pathway ID	Pathway Name	Source
hsa00565	Ether lipid metabolism	KEGG
hsa01100	Metabolic pathways	KEGG
hsa04146	Peroxisome	KEGG

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000018510	Insulin	5.94238606994105E-8	17903298
ENSG00000018510	Echocardiography	1.20879885520644E-5	17903301
ENSG00000018510	Platelet Function Tests	1.8342300E-005	-

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000018510	rs1348850	2	177553847	A	Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL)	28090653	[1.02-1.46]	1.22	EFO_0004735\|EFO_0007965\|EFO_0000220

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000018510's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs identified by RBPome

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000018510	AGPS	98	54.426	WBGene00000081	ads-1	96	53.927	Caenorhabditis_elegans

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0005515	protein binding	25416956.	IPI	Function
GO:0005730	nucleolus	-	IDA	Component
GO:0005739	mitochondrion	20833797.	HDA	Component
GO:0005777	peroxisome	9553082.10415121.	IDA	Component
GO:0005778	peroxisomal membrane	21525035.	HDA	Component
GO:0005782	peroxisomal matrix	-	TAS	Component
GO:0005829	cytosol	-	TAS	Component
GO:0006625	protein targeting to peroxisome	-	TAS	Process
GO:0008609	alkylglycerone-phosphate synthase activity	9553082.10415121.	IDA	Function
GO:0008610	lipid biosynthetic process	9553082.	IDA	Process
GO:0008611	ether lipid biosynthetic process	-	IEA	Process
GO:0008611	ether lipid biosynthetic process	-	ISS	Process
GO:0008611	ether lipid biosynthetic process	-	TAS	Process
GO:0016020	membrane	19946888.	HDA	Component
GO:0016491	oxidoreductase activity	-	IEA	Function
GO:0055114	oxidation-reduction process	-	IEA	Process
GO:0071949	FAD binding	-	ISS	Function

Cancer associated literatures

PID	Title	Article	Time	Author	Doi
25542233	The effect of benzyl isothiocyanate and its computer-aided design derivants targeting alkylglycerone phosphate synthase on the inhibition of human glioma U87MG cell line.	Tumour Biol	2015 May	Zhu Y	doi: 10.1007/s13277-014-2986-6
24815474	Alkylglyceronephosphate synthase (AGPS) alters lipid signaling pathways and supports chemotherapy resistance of glioma and hepatic carcinoma cell lines.	Asian Pac J Cancer Prev	2014	Zhu Y	-
23980144	Ether lipid generating enzyme AGPS alters the balance of structural and signaling lipids to fuel cancer pathogenicity.	Proc Natl Acad Sci U S A	2013 Sep 10	Benjamin DI	doi: 10.1073/pnas.1310894110

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq
ACC	chr2	177420352	Missense_Mutation	novel	G115V	0.39
BLCA	chr2	177499639	Nonsense_Mutation	novel	Q462*	0.23
BLCA	chr2	177482096	Missense_Mutation	NA	I381M	0.16
BLCA	chr2	177434354	Silent	novel	P126P	0.43
BLCA	chr2	177513883	Nonsense_Mutation	novel	Q558*	0.8
BLCA	chr2	177538113	Missense_Mutation	NA	S632C	0.28
BLCA	chr2	177497747	Silent	NA	K448K	0.67
BLCA	chr2	177538275	3'UTR	novel		0.39
BLCA	chr2	177436843	Missense_Mutation	novel	S174L	0.06
BRCA	chr2	177538227	3'UTR	rs780791158		0.51
BRCA	chr2	177538407	3'UTR	novel		0.3
BRCA	chr2	177437020	Missense_Mutation	NA	M201I	0.09
BRCA	chr2	177393004	Missense_Mutation	novel	T72M	0.24
BRCA	chr2	177436782	Missense_Mutation	NA	D154N	0.18
BRCA	chr2	177538412	3'UTR	novel		0.23
CESC	chr2	177461985	Missense_Mutation	novel	M321I	0.46
CESC	chr2	177538214	3'UTR	novel		0.26
CESC	chr2	177440964	Splice_Site	novel	X213_splice	0.36
CESC	chr2	177436881	Missense_Mutation	NA	H187Y	0.23
CESC	chr2	177497697	Missense_Mutation	NA	L432V	0.29
CESC	chr2	177505564	Missense_Mutation	novel	A512T	0.5
CHOL	chr2	177538206	3'UTR	novel		0.63
COAD	chr2	177462012	Missense_Mutation	NA	E330D	0.39
COAD	chr2	177445603	Missense_Mutation	novel	T283S	0.09
COAD	chr2	177497719	Frame_Shift_Del	novel	*F440Lfs8**	0.24
COAD	chr2	177434378	Silent	NA	N134N	0.39
COAD	chr2	177538214	3'UTR	novel		0.44
COAD	chr2	177538214	3'UTR	novel		0.4
COAD	chr2	177538077	Missense_Mutation	NA	G620D	0.13
COAD	chr2	177538227	3'UTR	novel		0.19
COAD	chr2	177538227	3'UTR	rs780791158		0.47
COAD	chr2	177436867	Missense_Mutation	NA	R182Q	0.06
COAD	chr2	177462006	Silent	novel	N328N	0.07
ESCA	chr2	177461971	Missense_Mutation	rs375775258	R317C	0.15
ESCA	chr2	177440997	Missense_Mutation	novel	L224V	0.29
ESCA	chr2	177434388	Missense_Mutation	novel	V138L	0.11
ESCA	chr2	177468503	Missense_Mutation	novel	H362Y	0.37
GBM	chr2	177436843	Nonsense_Mutation	NA	S174*	0.4
HNSC	chr2	177437028	Missense_Mutation	NA	R204L	0.31
HNSC	chr2	177461896	Frame_Shift_Del	novel	*E293Kfs18**	0.47
HNSC	chr2	177523766	Missense_Mutation	novel	I606V	0.23
HNSC	chr2	177420292	Missense_Mutation	novel	G95V	0.25
HNSC	chr2	177436855	Missense_Mutation	novel	E178A	0.07
KIRC	chr2	177461938	Missense_Mutation	NA	E306Q	0.35
KIRC	chr2	177521344	Nonsense_Mutation	novel	*L592Nfs3**	0.05
KIRP	chr2	177437028	Missense_Mutation	NA	R204L	0.04
KIRP	chr2	177436770	Missense_Mutation	NA	L150V	0.06
KIRP	chr2	177393019	Missense_Mutation	NA	A77V	0.58
LGG	chr2	177461950	Missense_Mutation	novel	V310I	0.15
LGG	chr2	177521312	Missense_Mutation	NA	F581V	0.34
LIHC	chr2	177505564	Missense_Mutation	novel	A512T	0.36
LIHC	chr2	177392795	Silent	novel	A2A	0.44
LIHC	chr2	177392770	5'UTR	novel		0.16
LUAD	chr2	177513823	Missense_Mutation	NA	V538L	0.24
LUAD	chr2	177441034	Missense_Mutation	novel	G236V	0.15
LUAD	chr2	177392794	Missense_Mutation	novel	A2E	0.6
LUAD	chr2	177445594	Missense_Mutation	NA	A280S	0.11
LUAD	chr2	177461973	Silent	rs146526791	R317R	0.07
LUAD	chr2	177497766	Splice_Site	novel	X454_splice	0.33
LUAD	chr2	177513906	Splice_Region	novel	C565C	0.27
LUAD	chr2	177538093	Silent	NA	Q625Q	0.07
LUAD	chr2	177437053	Splice_Region	novel	P212P	0.29
LUSC	chr2	177521365	Frame_Shift_Del	novel	*E599Gfs4**	0.09
LUSC	chr2	177538244	3'UTR	novel		0.38
LUSC	chr2	177505517	Missense_Mutation	novel	A496G	0.09
LUSC	chr2	177505526	Missense_Mutation	novel	D499G	0.48
LUSC	chr2	177482119	Missense_Mutation	NA	K389T	0.09
LUSC	chr2	177538144	Silent	novel	V642V	0.16
LUSC	chr2	177442473	Missense_Mutation	novel	D259V	0.28
LUSC	chr2	177538246	3'UTR	novel		0.26
LUSC	chr2	177420351	Frame_Shift_Del	novel	*R117Gfs22**	0.1
LUSC	chr2	177523782	Missense_Mutation	novel	G611V	0.13
MESO	chr2	177434381	Silent	novel	T135T	0.24
OV	chr2	177538227	3'UTR	rs780791158		0.47
OV	chr2	177437027	Silent	NA	R204R	0.12
PRAD	chr2	177538099	Silent	novel	L627L	0.21
PRAD	chr2	177521308	Silent	novel	F579F	0.29
PRAD	chr2	177493158	Missense_Mutation	rs144444120	P415L	0.38
READ	chr2	177499709	Frame_Shift_Ins	novel		0.06
READ	chr2	177493186	Silent	novel	K424K	0.52
READ	chr2	177437028	Missense_Mutation	NA	R204Q	0.43
SKCM	chr2	177508004	Missense_Mutation	NA	S527F	0.21
SKCM	chr2	177499632	Silent	novel	D459D	0.32
SKCM	chr2	177499675	Missense_Mutation	novel	R474C	0.35
SKCM	chr2	177436991	Missense_Mutation	novel	H192Y	0.16
SKCM	chr2	177461978	Missense_Mutation	NA	S319L	0.16
SKCM	chr2	177434404	Missense_Mutation	NA	K143T	0.65
SKCM	chr2	177482062	Missense_Mutation	NA	T370I	0.23
SKCM	chr2	177508021	Missense_Mutation	novel	P533S	0.23
SKCM	chr2	177521268	Splice_Site	NA	X566_splice	0.16
SKCM	chr2	177521269	Splice_Region	novel	R566R	0.16
STAD	chr2	177499685	Missense_Mutation	NA	V477A	0.29
STAD	chr2	177441015	Missense_Mutation	NA	L230I	0.15
STAD	chr2	177538214	3'UTR	novel		0.24
STAD	chr2	177538227	3'UTR	rs780791158		0.54
STAD	chr2	177538214	3'UTR	novel		0.14
STAD	chr2	177497719	Frame_Shift_Del	novel	*F440Lfs8**	0.16
STAD	chr2	177521335	Silent	rs772375722	I588I	0.06
STAD	chr2	177434362	Missense_Mutation	novel	K129T	0.34
STAD	chr2	177538227	3'UTR	novel		0.26
STAD	chr2	177523807	Splice_Site	novel	X619_splice	0.34
STAD	chr2	177521351	Missense_Mutation	rs764836897	V594I	0.16
STAD	chr2	177521284	Silent	rs773126499	Y571Y	0.51
THCA	chr2	177420358	Nonsense_Mutation	novel	*Y118Kfs4**	0.09
THYM	chr2	177497722	Missense_Mutation	novel	F440S	0.06
UCEC	chr2	177538420	3'UTR	novel		0.8
UCEC	chr2	177538319	3'UTR	novel		0.38
UCEC	chr2	177482079	Nonsense_Mutation	NA	E376*	0.31
UCEC	chr2	177445550	Missense_Mutation	NA	R265Q	0.35
UCEC	chr2	177538166	Missense_Mutation	NA	N650D	0.29
UCEC	chr2	177482082	Missense_Mutation	novel	A377T	0.45
UCEC	chr2	177538198	3'UTR	rs762195351		0.52
UCEC	chr2	177434327	Splice_Region	novel	R117R	0.31
UCEC	chr2	177436773	Missense_Mutation	novel	N151H	0.48
UCEC	chr2	177538198	3'UTR	rs762195351		0.36
UCEC	chr2	177499721	Missense_Mutation	novel	A489V	0.43
UCEC	chr2	177420359	Splice_Site	novel	X117_splice	0.09
UCEC	chr2	177538304	3'UTR	novel		0.38
UCEC	chr2	177392962	Missense_Mutation	novel	C58Y	0.4
UCEC	chr2	177521350	Silent	rs753841033	T593T	0.58
UCEC	chr2	177445550	Missense_Mutation	NA	R265Q	0.48
UCEC	chr2	177497744	Frame_Shift_Del	novel	*K449Sfs15**	0.32
UCEC	chr2	177523752	Missense_Mutation	novel	A601D	0.41
UCEC	chr2	177437028	Missense_Mutation	NA	R204Q	0.35
UCEC	chr2	177442486	Missense_Mutation	novel	M263I	0.38
UCEC	chr2	177437020	Missense_Mutation	NA	M201I	0.44
UCEC	chr2	177482064	Missense_Mutation	novel	L371I	0.4
UCEC	chr2	177461893	Missense_Mutation	novel	L291F	0.41
UCEC	chr2	177497750	Missense_Mutation	novel	K449N	0.14
UCEC	chr2	177493200	Splice_Site	novel	X429_splice	0.27
UCEC	chr2	177499690	Nonsense_Mutation	novel	Q479*	0.33
UCEC	chr2	177497748	Missense_Mutation	novel	K449E	0.35
UCEC	chr2	177499675	Missense_Mutation	novel	R474C	0.53
UCEC	chr2	177523748	Missense_Mutation	novel	A600T	0.35
UCEC	chr2	177436830	Missense_Mutation	novel	E170K	0.19
UCEC	chr2	177505574	Missense_Mutation	novel	R515Q	0.09
UCEC	chr2	177513829	Missense_Mutation	NA	L540I	0.44
UCEC	chr2	177436769	Silent	NA	S149S	0.25
UCEC	chr2	177521284	Silent	rs773126499	Y571Y	0.06
UCEC	chr2	177523769	Frame_Shift_Ins	NA	*A608Cfs2**	0.43
UCEC	chr2	177499727	Missense_Mutation	NA	F491C	0.15
UCEC	chr2	177445545	Splice_Site	NA	X264_splice	0.33
UCEC	chr2	177437027	Nonsense_Mutation	novel	R204*	0.39
UCEC	chr2	177513847	Nonsense_Mutation	novel	E546*	0.43
UCEC	chr2	177538289	3'UTR	novel		0.28
UCEC	chr2	177445550	Missense_Mutation	NA	R265Q	0.42
UCEC	chr2	177538247	3'UTR	novel		0.5
UCEC	chr2	177523805	Missense_Mutation	novel	V619L	0.38

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
CESC	AMP	0.1186	0.012962
PAAD	AMP	0.0598	0.1091
PAAD	DEL	0.0326	0.2014

Survival Analysis

Cancer	P-value	Q-value
THYM	0.017	Kaplan-Meier Survival Analysis
KIRC	0.0001	Kaplan-Meier Survival Analysis
MESO	0.0002	Kaplan-Meier Survival Analysis
ACC	0.00011	Kaplan-Meier Survival Analysis
UCS	0.032	Kaplan-Meier Survival Analysis
HNSC	0.011	Kaplan-Meier Survival Analysis
SKCM	0.016	Kaplan-Meier Survival Analysis
COAD	0.0062	Kaplan-Meier Survival Analysis
PAAD	0.00097	Kaplan-Meier Survival Analysis
CESC	0.0069	Kaplan-Meier Survival Analysis
READ	0.033	Kaplan-Meier Survival Analysis
LIHC	0.00017	Kaplan-Meier Survival Analysis
THCA	0.014	Kaplan-Meier Survival Analysis
LUAD	0.0001	Kaplan-Meier Survival Analysis

Drugs

EuRBPDB

Description

RBPome

Expression

Transcripts

Gene Model

Pathways

Phenotypes

GWAS

PPI

Orthologs

Gene Ontology

Select Dataset :

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Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742