EuRBPDB

Basic Information
Cancer Related Information

Description

RBDs

Expression

Transcripts

Gene Model

Pathways

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000018869 (Gene tree)
Gene ID: 147948
Gene Symbol: ZNF582
Alias: FLJ30927
Full Name: zinc finger protein 582
Gene Type: protein_coding
Species: Homo_sapiens
Status: putative
Strand: Minus strand
Length: 18,754 bases
Position: chr19:56,374,832-56,393,585
Accession: 26421
RBP type: canonical RBP
Summary: The protein encoded by this gene is a zing finger protein and putative transcription factor that is highly methylated in cervical cancers. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2016]

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000301310	zf-C2H2	PF00096.26	3.1e-54	1	9
ENSP00000301310	zf-C2H2	PF00096.26	3.1e-54	2	9
ENSP00000301310	zf-C2H2	PF00096.26	3.1e-54	3	9
ENSP00000301310	zf-C2H2	PF00096.26	3.1e-54	4	9
ENSP00000301310	zf-C2H2	PF00096.26	3.1e-54	5	9
ENSP00000301310	zf-C2H2	PF00096.26	3.1e-54	6	9
ENSP00000301310	zf-C2H2	PF00096.26	3.1e-54	7	9
ENSP00000301310	zf-C2H2	PF00096.26	3.1e-54	8	9
ENSP00000301310	zf-C2H2	PF00096.26	3.1e-54	9	9
ENSP00000465619	zf-C2H2	PF00096.26	3.1e-54	1	9
ENSP00000465619	zf-C2H2	PF00096.26	3.1e-54	2	9
ENSP00000465619	zf-C2H2	PF00096.26	3.1e-54	3	9
ENSP00000465619	zf-C2H2	PF00096.26	3.1e-54	4	9
ENSP00000465619	zf-C2H2	PF00096.26	3.1e-54	5	9
ENSP00000465619	zf-C2H2	PF00096.26	3.1e-54	6	9
ENSP00000465619	zf-C2H2	PF00096.26	3.1e-54	7	9
ENSP00000465619	zf-C2H2	PF00096.26	3.1e-54	8	9
ENSP00000465619	zf-C2H2	PF00096.26	3.1e-54	9	9
ENSP00000483414	zf-C2H2	PF00096.26	3.1e-54	1	9
ENSP00000483414	zf-C2H2	PF00096.26	3.1e-54	2	9
ENSP00000483414	zf-C2H2	PF00096.26	3.1e-54	3	9
ENSP00000483414	zf-C2H2	PF00096.26	3.1e-54	4	9
ENSP00000483414	zf-C2H2	PF00096.26	3.1e-54	5	9
ENSP00000483414	zf-C2H2	PF00096.26	3.1e-54	6	9
ENSP00000483414	zf-C2H2	PF00096.26	3.1e-54	7	9
ENSP00000483414	zf-C2H2	PF00096.26	3.1e-54	8	9
ENSP00000483414	zf-C2H2	PF00096.26	3.1e-54	9	9
ENSP00000301310	zf-met	PF12874.7	7.4e-08	1	1
ENSP00000465619	zf-met	PF12874.7	7.4e-08	1	1
ENSP00000483414	zf-met	PF12874.7	7.4e-08	1	1

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000301310	ZNF582-201	2824	-	ENSP00000301310	517 (aa)	-	Q96NG8
ENST00000589895	ZNF582-205	509	-	ENSP00000465639	78 (aa)	-	K7EKI7
ENST00000593145	ZNF582-206	712	-	ENSP00000466452	178 (aa)	-	A0A075B771
ENST00000619584	ZNF582-207	2297	-	ENSP00000483414	517 (aa)	-	Q96NG8
ENST00000589143	ZNF582-204	625	-	ENSP00000468679	103 (aa)	-	K7ESE7
ENST00000586929	ZNF582-202	2053	-	ENSP00000465619	517 (aa)	-	Q96NG8
ENST00000587778	ZNF582-203	733	-	ENSP00000466875	181 (aa)	-	A0A075B772

Gene Model

Click here to download ENSG00000018869's gene model file

Pathways

Pathway ID	Pathway Name	Source
hsa05168	Herpes simplex virus 1 infection	KEGG

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000018869's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000018869	ZNF582	99	86.940	ENSAMEG00000009560	ZNF582	100	86.940	Ailuropoda_melanoleuca
ENSG00000018869	ZNF582	99	96.104	ENSANAG00000026033	ZNF582	94	94.971	Aotus_nancymaae
ENSG00000018869	ZNF582	100	87.621	ENSBTAG00000030348	ZNF582	100	87.621	Bos_taurus
ENSG00000018869	ZNF582	99	96.104	ENSCJAG00000020283	ZNF582	100	93.037	Callithrix_jacchus
ENSG00000018869	ZNF582	100	86.731	ENSCHIG00000016463	-	100	86.796	Capra_hircus
ENSG00000018869	ZNF582	100	90.716	ENSTSYG00000029281	ZNF582	100	90.716	Carlito_syrichta
ENSG00000018869	ZNF582	99	84.416	ENSCPOG00000032242	-	100	80.695	Cavia_porcellus
ENSG00000018869	ZNF582	99	96.104	ENSCCAG00000025711	ZNF582	100	94.971	Cebus_capucinus
ENSG00000018869	ZNF582	100	96.325	ENSCATG00000036892	ZNF582	94	96.325	Cercocebus_atys
ENSG00000018869	ZNF582	92	81.303	ENSCLAG00000000758	-	88	81.303	Chinchilla_lanigera
ENSG00000018869	ZNF582	100	96.712	ENSCSAG00000001670	ZNF582	94	96.712	Chlorocebus_sabaeus
ENSG00000018869	ZNF582	92	85.645	ENSCHOG00000012411	ZNF582	89	85.645	Choloepus_hoffmanni
ENSG00000018869	ZNF582	99	97.403	ENSCANG00000037320	ZNF582	100	96.132	Colobus_angolensis_palliatus
ENSG00000018869	ZNF582	90	74.286	ENSCGRG00001020646	Gm3854	96	68.776	Cricetulus_griseus_chok1gshd
ENSG00000018869	ZNF582	90	74.286	ENSCGRG00000008411	Gm3854	96	68.776	Cricetulus_griseus_crigri
ENSG00000018869	ZNF582	100	89.942	ENSEASG00005020473	ZNF582	100	89.942	Equus_asinus_asinus
ENSG00000018869	ZNF582	91	89.407	ENSECAG00000011892	ZNF582	95	89.407	Equus_caballus
ENSG00000018869	ZNF582	100	100.000	ENSGGOG00000003541	ZNF582	100	99.226	Gorilla_gorilla
ENSG00000018869	ZNF582	98	85.743	ENSHGLG00000009291	-	99	85.743	Heterocephalus_glaber_female
ENSG00000018869	ZNF582	98	85.743	ENSHGLG00100007619	ZNF582	99	85.743	Heterocephalus_glaber_male
ENSG00000018869	ZNF582	100	96.518	ENSMFAG00000002728	ZNF582	100	96.518	Macaca_fascicularis
ENSG00000018869	ZNF582	100	96.518	ENSMMUG00000000362	ZNF582	100	96.518	Macaca_mulatta
ENSG00000018869	ZNF582	100	96.132	ENSMNEG00000028263	ZNF582	99	96.195	Macaca_nemestrina
ENSG00000018869	ZNF582	100	96.132	ENSMLEG00000030585	ZNF582	100	96.132	Mandrillus_leucophaeus
ENSG00000018869	ZNF582	99	92.208	ENSMICG00000012915	ZNF582	100	91.103	Microcebus_murinus
ENSG00000018869	ZNF582	94	82.322	ENSMPUG00000006660	ZNF582	99	82.322	Mustela_putorius_furo
ENSG00000018869	ZNF582	94	79.630	ENSNGAG00000000088	Gm3854	99	79.630	Nannospalax_galili
ENSG00000018869	ZNF582	100	97.790	ENSNLEG00000010794	ZNF582	100	97.679	Nomascus_leucogenys
ENSG00000018869	ZNF582	94	75.103	ENSODEG00000009980	ZNF582	98	75.103	Octodon_degus
ENSG00000018869	ZNF582	99	85.380	ENSOCUG00000029075	ZNF582	100	85.380	Oryctolagus_cuniculus
ENSG00000018869	ZNF582	100	99.613	ENSPPAG00000029277	ZNF582	100	99.613	Pan_paniscus
ENSG00000018869	ZNF582	100	99.613	ENSPTRG00000011539	ZNF582	100	99.613	Pan_troglodytes
ENSG00000018869	ZNF582	100	96.518	ENSPANG00000000398	ZNF582	100	96.518	Papio_anubis
ENSG00000018869	ZNF582	99	100.000	ENSPPYG00000010446	ZNF582	91	97.679	Pongo_abelii
ENSG00000018869	ZNF582	92	78.947	ENSPCAG00000000878	ZNF582	90	78.947	Procavia_capensis
ENSG00000018869	ZNF582	99	94.805	ENSPCOG00000014863	ZNF582	100	93.230	Propithecus_coquereli
ENSG00000018869	ZNF582	100	96.325	ENSRBIG00000042067	ZNF582	94	96.325	Rhinopithecus_bieti
ENSG00000018869	ZNF582	100	96.132	ENSRROG00000036529	ZNF582	100	96.132	Rhinopithecus_roxellana
ENSG00000018869	ZNF582	99	96.104	ENSSBOG00000024080	ZNF582	94	94.391	Saimiri_boliviensis_boliviensis
ENSG00000018869	ZNF582	100	87.814	ENSSSCG00000003322	-	100	87.814	Sus_scrofa
ENSG00000018869	ZNF582	100	89.362	ENSTTRG00000011290	ZNF582	91	89.362	Tursiops_truncatus
ENSG00000018869	ZNF582	88	86.374	ENSUAMG00000010469	ZNF582	99	86.374	Ursus_americanus
ENSG00000018869	ZNF582	88	86.593	ENSUMAG00000024767	-	99	86.593	Ursus_maritimus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	-	ISA	Function
GO:0003677	DNA binding	-	IEA	Function
GO:0005634	nucleus	21873635.	IBA	Component
GO:0006357	regulation of transcription by RNA polymerase II	-	IEA	Process
GO:0046872	metal ion binding	-	IEA	Function

Cancer associated literatures

PID	Title	Article	Time	Author	Doi
27865370	Hypermethylated ZNF582 and PAX1 are effective biomarkers for detection of oral dysplasia and oral cancer.	Oral Oncol	2016 Nov	Cheng SJ	doi: 10.1016/j.oraloncology.2016.09.007
29224816	Hypermethylated ZNF582 and PAX1 genes in oral scrapings collected from cancer-adjacent normal oral mucosal sites are associated with aggressive progression and poor prognosis of oral cancer.	Oral Oncol	2017 Dec	Cheng SJ	doi: 10.1016/j.oraloncology.2017.11.013
30732145	ZNF582 methylation as a potential biomarker to predict cervical intraepithelial neoplasia type III/worse: A meta-analysis of related studies in Chinese population.	Medicine (Baltimore)	2019 Feb	Li N	doi: 10.1097/MD.0000000000014297.

Differential Expression

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq	RBD
ACC	chr19	56390061	Silent	novel	L58L	0.44
BLCA	chr19	56384752	Missense_Mutation	novel	S222F	0.4
BLCA	chr19	56385016	Missense_Mutation	novel	N134S	0.21
BLCA	chr19	56384726	Frame_Shift_Ins	novel	*E231Ffs50**	0.14
BLCA	chr19	56384132	Missense_Mutation	NA	G429R	0.08
BLCA	chr19	56384931	Missense_Mutation	novel	Q162H	0.13
BLCA	chr19	56384825	Missense_Mutation	novel	P198S	0.06
BLCA	chr19	56384831	Missense_Mutation	novel	E196Q	0.38
BLCA	chr19	56384026	Nonsense_Mutation	NA	S464*	0.19
BLCA	chr19	56384341	Missense_Mutation	NA	R359K	0.11
BLCA	chr19	56383814	3'UTR	novel		0.23
BRCA	chr19	56384011	Missense_Mutation	novel	P469L	0.09
BRCA	chr19	56393454	5'UTR	novel		0.33
BRCA	chr19	56385179	Missense_Mutation	novel	E80K	0.13
BRCA	chr19	56385077	Missense_Mutation	NA	E114Q	0.12
BRCA	chr19	56384902	Missense_Mutation	rs201702956	G172A	0.16
BRCA	chr19	56384902	Missense_Mutation	NA	G172E	0.19
BRCA	chr19	56384722	Missense_Mutation	NA	C232Y	0.18
BRCA	chr19	56390426	Missense_Mutation	novel	D29N	0.04
BRCA	chr19	56391822	5'UTR	rs779648469		0.27
BRCA	chr19	56391825	5'UTR	rs748896347		0.15
CESC	chr19	56390496	Silent	novel	S5S	0.14
CESC	chr19	56393267	Intron	novel		0.33
CESC	chr19	56384040	Silent	novel	T459T	0.26
CESC	chr19	56384607	Missense_Mutation	NA	L270F	0.23
CESC	chr19	56390050	Silent	NA	G61G	0.34
CESC	chr19	56385179	Missense_Mutation	NA	E80Q	0.79
COAD	chr19	56384181	Silent	novel	V412V	0.1
COAD	chr19	56384035	Missense_Mutation	novel	S461I	0.27
COAD	chr19	56384621	Nonsense_Mutation	rs374319071	R266*	0.28
COAD	chr19	56390094	Missense_Mutation	NA	L47I	0.28
COAD	chr19	56384542	Missense_Mutation	NA	F292C	0.11
COAD	chr19	56390372	Splice_Region	novel		0.32
ESCA	chr19	56393269	Intron	novel		0.37
ESCA	chr19	56393360	Intron	novel		0.08
ESCA	chr19	56384289	Missense_Mutation	novel	F376L	0.46
ESCA	chr19	56385037	Missense_Mutation	novel	Q127R	0.09
ESCA	chr19	56384298	Silent	novel	G373G	0.3
ESCA	chr19	56377770	3'Flank	rs547205680		0.52
ESCA	chr19	56384441	Missense_Mutation	novel	L326V	0.09	zf-C2H2
GBM	chr19	56384507	Missense_Mutation	novel	I304L	0.1
GBM	chr19	56384410	Missense_Mutation	novel	R336M	0.07
GBM	chr19	56383964	Missense_Mutation	novel	E485K	0.04
GBM	chr19	56384502	Missense_Mutation	novel	H305Q	0.05
GBM	chr19	56384855	Frame_Shift_Ins	novel	*N188Qfs8**	0.11
GBM	chr19	56391778	5'UTR	novel		0.3
GBM	chr19	56383986	Silent	novel	T477T	0.04
GBM	chr19	56384994	Missense_Mutation	novel	Q141H	0.19
GBM	chr19	56384814	Missense_Mutation	novel	C201W	0.06
HNSC	chr19	56384112	Nonsense_Mutation	novel	C435*	0.33
HNSC	chr19	56384887	Missense_Mutation	NA	R177T	0.36
HNSC	chr19	56384959	Missense_Mutation	novel	D153G	0.28
HNSC	chr19	56384960	Missense_Mutation	novel	D153N	0.36
HNSC	chr19	56391825	5'UTR	rs748896347		0.1
HNSC	chr19	56383891	Missense_Mutation	novel	G509E	0.33
HNSC	chr19	56390379	Silent	novel	S44S	0.32
HNSC	chr19	56384663	Missense_Mutation	novel	E252K	0.2
HNSC	chr19	56384356	Missense_Mutation	novel	L354P	0.44
HNSC	chr19	56390395	Missense_Mutation	novel	Y39C	0.39
HNSC	chr19	56385158	Missense_Mutation	novel	E87K	0.22
HNSC	chr19	56385159	Silent	novel	K86K	0.22
KIRP	chr19	56384274	Frame_Shift_Del	novel	*Q381Hfs58**	0.51
KIRP	chr19	56384975	Missense_Mutation	novel	E148Q	0.44
LIHC	chr19	56384551	Missense_Mutation	novel	G289V	0.34
LIHC	chr19	56383863	Silent	novel	*518*	0.45
LIHC	chr19	56384980	Missense_Mutation	novel	H146L	0.4
LIHC	chr19	56384802	Silent	NA	G205G	0.22
LIHC	chr19	56383833	3'UTR	novel		0.27
LUAD	chr19	56383945	Missense_Mutation	rs571710209	S491N	0.16
LUAD	chr19	56384078	Missense_Mutation	novel	E447Q	0.1
LUAD	chr19	56384555	Missense_Mutation	NA	C288S	0.5
LUAD	chr19	56384161	Missense_Mutation	novel	G419V	0.6
LUAD	chr19	56383923	Missense_Mutation	NA	R498S	0.12
LUAD	chr19	56393484	5'UTR	novel		0.57
LUAD	chr19	56384173	Missense_Mutation	NA	R415T	0.08
LUAD	chr19	56393479	5'UTR	novel		0.82
LUAD	chr19	56384777	Missense_Mutation	NA	L214I	0.56
LUAD	chr19	56384638	Missense_Mutation	novel	C260S	0.36
LUAD	chr19	56390022	Missense_Mutation	NA	V71L	0.09
LUSC	chr19	56383941	Silent	NA	Y492Y	0.29
LUSC	chr19	56385039	Silent	rs763639138	N126N	0.32
LUSC	chr19	56384018	Missense_Mutation	rs141898302	V467I	0.31
LUSC	chr19	56384088	Silent	novel	V443V	0.25
LUSC	chr19	56390089	Frame_Shift_Del	novel	*V49Ffs6**	0.17
LUSC	chr19	56391808	5'UTR	novel		0.18
LUSC	chr19	56384675	Missense_Mutation	NA	V248L	0.2
LUSC	chr19	56384409	Missense_Mutation	novel	R336S	0.49
LUSC	chr19	56383999	Missense_Mutation	rs774405206	H473R	0.48
LUSC	chr19	56383980	Silent	NA	V479V	0.22
MESO	chr19	56384998	Missense_Mutation	novel	H140L	0.25
OV	chr19	56383796	3'UTR	novel		0.1
OV	chr19	56390468	Missense_Mutation	novel	F15V	0.23
OV	chr19	56384257	Missense_Mutation	NA	R387I	0.14
OV	chr19	56383698	3'UTR	novel		0.1
PAAD	chr19	56390431	Missense_Mutation	novel	Q27P	0.16
PAAD	chr19	56383851	3'UTR	novel		0.09
PAAD	chr19	56383742	3'UTR	novel		0.26
PRAD	chr19	56384870	In_Frame_Ins	novel	Q182_K183insALLHTVN	0.05
READ	chr19	56384976	Missense_Mutation	novel	E147D	0.25
READ	chr19	56384693	Missense_Mutation	novel	F242V	0.08
READ	chr19	56377825	3'Flank	novel		0.16
READ	chr19	56383798	3'UTR	novel		0.38
READ	chr19	56384472	Silent	novel	E315E	0.47
READ	chr19	56390009	Missense_Mutation	novel	L75Q	0.41
READ	chr19	56384133	Nonsense_Mutation	NA	C428*	0.17
READ	chr19	56384341	Missense_Mutation	rs777829187	R359I	0.44
READ	chr19	56390093	Missense_Mutation	novel	L47R	0.3
SARC	chr19	56393268	Intron	novel		0.36
SKCM	chr19	56384378	Missense_Mutation	novel	A347T	0.43
SKCM	chr19	56384379	Silent	novel	K346K	0.42
SKCM	chr19	56390032	Silent	novel	V67V	0.16
SKCM	chr19	56384674	Missense_Mutation	NA	V248A	0.16
SKCM	chr19	56383773	3'UTR	novel		0.8
SKCM	chr19	56384299	Missense_Mutation	rs757297944	G373E	0.77
SKCM	chr19	56384572	Missense_Mutation	NA	P282L	0.24
SKCM	chr19	56390464	Missense_Mutation	NA	S16F	0.43
SKCM	chr19	56384593	Missense_Mutation	rs759782368	R275Q	0.19
SKCM	chr19	56384019	Silent	rs185773528	T466T	0.36
SKCM	chr19	56384909	Missense_Mutation	rs753825380	P170S	0.29
SKCM	chr19	56384235	Silent	NA	P394P	0.31
SKCM	chr19	56384672	Missense_Mutation	NA	H249Y	0.59
SKCM	chr19	56384868	Silent	NA	K183K	0.44
SKCM	chr19	56390065	Silent	rs147410977	S56S	0.37
SKCM	chr19	56385066	Missense_Mutation	NA	S117R	0.41
SKCM	chr19	56384999	Missense_Mutation	rs532568887	H140Y	0.32
SKCM	chr19	56384657	Missense_Mutation	NA	P254S	0.14
SKCM	chr19	56383910	Missense_Mutation	NA	A503P	0.41
SKCM	chr19	56384713	Missense_Mutation	NA	A235V	0.26
SKCM	chr19	56391793	5'UTR	NA		0.07
SKCM	chr19	56384967	Silent	NA	P150P	0.32
SKCM	chr19	56383991	Missense_Mutation	NA	E476K	0.65
SKCM	chr19	56383822	3'UTR	novel		0.23
STAD	chr19	56390476	Missense_Mutation	novel	A12V	0.4
STAD	chr19	56384345	Nonsense_Mutation	NA	Q358*	0.22
STAD	chr19	56393471	5'UTR	NA		0.15
STAD	chr19	56383736	3'UTR	novel		0.2
STAD	chr19	56384539	Missense_Mutation	rs368835838	N293S	0.27
STAD	chr19	56390064	In_Frame_Del	rs759853852	S56del	0.34
STAD	chr19	56384650	Missense_Mutation	NA	E256A	0.41
STAD	chr19	56384775	Silent	novel	L214L	0.34
STAD	chr19	56384238	Silent	rs139795329	K393K	0.24
STAD	chr19	56390457	Missense_Mutation	NA	E18D	0.06
STAD	chr19	56383789	3'UTR	novel		0.26
STAD	chr19	56393516	5'UTR	novel		0.17
STAD	chr19	56385116	Missense_Mutation	NA	Q101K	0.21
STAD	chr19	56384956	Missense_Mutation	novel	Q154R	0.38
UCEC	chr19	56384900	Missense_Mutation	novel	Y173H	0.32
UCEC	chr19	56383854	3'UTR	novel		0.27
UCEC	chr19	56384241	Missense_Mutation	NA	E392D	0.34
UCEC	chr19	56383875	Silent	NA	S514S	0.29
UCEC	chr19	56384756	Missense_Mutation	NA	H221N	0.28
UCEC	chr19	56383976	Missense_Mutation	NA	I481V	0.37
UCEC	chr19	56377936	3'Flank	novel		0.37
UCEC	chr19	56384351	Nonsense_Mutation	rs771021591	R356*	0.34
UCEC	chr19	56384495	Missense_Mutation	novel	E308K	0.46
UCEC	chr19	56393315	Intron	novel		0.31
UCEC	chr19	56384621	Nonsense_Mutation	rs374319071	R266*	0.2
UCEC	chr19	56384723	Missense_Mutation	novel	C232R	0.06
UCEC	chr19	56384446	Missense_Mutation	novel	S324F	0.08	zf-C2H2
UCEC	chr19	56377860	3'Flank	NA		0.26
UCEC	chr19	56377968	3'Flank	novel		0.47
UCEC	chr19	56384487	Silent	NA	P310P	0.41
UCEC	chr19	56393799	5'Flank	novel		0.41
UCEC	chr19	56377860	3'Flank	NA		0.41
UCEC	chr19	56384399	Nonsense_Mutation	novel	E340*	0.34
UCEC	chr19	56384621	Nonsense_Mutation	rs374319071	R266*	0.41
UCEC	chr19	56384305	Missense_Mutation	novel	V371A	0.47
UCEC	chr19	56384769	Silent	novel	Q216Q	0.55
UCEC	chr19	56384937	Missense_Mutation	novel	F160L	0.09
UCEC	chr19	56390031	Missense_Mutation	novel	E68K	0.46
UCEC	chr19	56384099	Missense_Mutation	novel	H440N	0.46
UCEC	chr19	56377860	3'Flank	NA		0.54
UCEC	chr19	56384580	Silent	rs772863769	G279G	0.31
UCEC	chr19	56384253	Silent	NA	I388I	0.27
UCEC	chr19	56377935	3'Flank	novel		0.3
UCEC	chr19	56384356	Missense_Mutation	novel	L354R	0.37
UCEC	chr19	56384826	Silent	novel	K197K	0.13
UCEC	chr19	56384201	Missense_Mutation	rs374309437	R406W	0.37
UCEC	chr19	56391774	5'UTR	novel		0.29
UCEC	chr19	56384861	Missense_Mutation	novel	L186I	0.37
UCEC	chr19	56385095	Missense_Mutation	rs367953813	L108I	0.41
UCEC	chr19	56384363	Missense_Mutation	novel	S352P	0.45
UCEC	chr19	56384371	Missense_Mutation	NA	N349S	0.46
UCEC	chr19	56377860	3'Flank	NA		0.56
UCEC	chr19	56390041	Silent	novel	P64P	0.08
UCEC	chr19	56384386	Missense_Mutation	novel	C344Y	0.08
UCEC	chr19	56383707	3'UTR	novel		0.27
UCEC	chr19	56383708	3'UTR	novel		0.27
UCEC	chr19	56384779	Missense_Mutation	NA	R213Q	0.36
UCEC	chr19	56384019	Silent	rs185773528	T466T	0.44
UCEC	chr19	56384310	Nonsense_Mutation	NA	C369*	0.44
UCEC	chr19	56384593	Missense_Mutation	rs759782368	R275Q	0.4
UCEC	chr19	56384257	Missense_Mutation	NA	R387I	0.26
UCEC	chr19	56384580	Silent	rs772863769	G279G	0.2
UCEC	chr19	56393306	Intron	novel		0.1
UCEC	chr19	56377935	3'Flank	novel		0.35
UCEC	chr19	56383884	Silent	rs181687862	N511N	0.31
UCEC	chr19	56393447	5'UTR	novel		0.16

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
BLCA	AMP	0.3039	0.013691
BRCA	AMP	0.1843	0.0014488
CESC	DEL	0.0746	0.027508
DLBC	AMP	0.1875	0.017368
KIRP	DEL	0.0486	0.054726
LGG	DEL	0.4971	1.4433e-28
PAAD	DEL	0.0652	0.035089
PRAD	AMP	0.0264	0.17703
READ	DEL	0.103	0.23023
TGCT	DEL	0.2867	0.0046229
UCS	DEL	0.1607	0.12448

Survival Analysis

Cancer	P-value	Q-value
KIRC	0.00011	Kaplan-Meier Survival Analysis
STAD	0.025	Kaplan-Meier Survival Analysis
SARC	0.009	Kaplan-Meier Survival Analysis
MESO	0.026	Kaplan-Meier Survival Analysis
HNSC	0.04	Kaplan-Meier Survival Analysis
LUSC	0.011	Kaplan-Meier Survival Analysis
BRCA	0.0037	Kaplan-Meier Survival Analysis
KIRP	0.013	Kaplan-Meier Survival Analysis
PAAD	0.0014	Kaplan-Meier Survival Analysis
BLCA	0.021	Kaplan-Meier Survival Analysis
CESC	0.0016	Kaplan-Meier Survival Analysis
UCEC	0.035	Kaplan-Meier Survival Analysis
GBM	0.02	Kaplan-Meier Survival Analysis
LIHC	0.019	Kaplan-Meier Survival Analysis
LGG	0.00016	Kaplan-Meier Survival Analysis
LUAD	0.012	Kaplan-Meier Survival Analysis