EuRBPDB

Description

RBDs

RBPome

PRI

Literatures

Expression

Transcripts

Gene Model

Pathways

Phenotypes

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000021776 (Gene tree)
Gene ID: 9716
Gene Symbol: AQR
Alias: KIAA0560|fSAP164|IBP160
Full Name: aquarius intron-binding spliceosomal factor
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Minus strand
Length: 118,058 bases
Position: chr15:34,851,782-34,969,839
Accession: 29513
RBP type: canonical RBP
Summary: (Aquarius Intron-Binding Spliceosomal Factor) is a Protein Coding gene. Among its related pathways are mRNA Splicing - Major Pathway and Transcription-Coupled Nucleotide Excision Repair (TC-NER). An important paralog of this gene is ZNFX1.

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000156471	ResIII	PF04851.15	6.3e-05	1	1

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
22681889	The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts	4SURIC & HEK293	2012 May	Baltz AG	DOI: 10.1016/j.molcel.2012.05.021
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & HEK293	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
29431736	Capturing the interactome of newly transcribed RNA	PolyT-RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
29431736	Capturing the interactome of newly transcribed RNA	RIC & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
29431736	Capturing the interactome of newly transcribed RNA	RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
22658674	Insights into RNA biology from an atlas of mammalian mRNA-binding proteins	RIC & Hela	2012 May 31	Castello A	DOI: 10.1016/j.cell.2012.04.031
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & Hela	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & MCF7	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & U2OS	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
27453046	Comprehensive Identification of RNA-Binding Domains in Human Cells	RIC & Hela	2016 Aug 18	Castello A	DOI: 10.1016/j.molcel.2016.06.029
30352994	Discovery of RNA-binding proteins and characterization of their dynamic responses by enhanced RNA interactome capture	RIC & Jurkat	2018 Oct 23	Perez-Perri JI	DOI:10.1038/s41467-018-06557-8

Protein-RNA interaction（RNA-Binding Site）

Click here to download all RNA binding sites

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
28787592	The Conserved Intron Binding Protein EMB-4 Plays Differential Roles in Germline Small RNA Pathways of C.elegans.	Dev Cell	2017 Aug 7	Tyc KM	doi: 10.1016/j.devcel.2017.07.003.

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000558202	AQR-203	497	-	-	- (aa)	-	-
ENST00000156471	AQR-201	9694	-	ENSP00000156471	1485 (aa)	-	O60306
ENST00000559090	AQR-204	3637	-	-	- (aa)	-	-
ENST00000559767	AQR-205	752	-	-	- (aa)	-	-
ENST00000560117	AQR-206	543	-	ENSP00000453278	180 (aa)	-	H0YLN9
ENST00000543879	AQR-202	5722	-	ENSP00000445700	646 (aa)	-	H0YH15

Gene Model

Click here to download ENSG00000021776's gene model file

Pathways

Pathway ID	Pathway Name	Source
hsa03040	Spliceosome	KEGG

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000021776	Child Development Disorders, Pervasive	4.9331000E-005	-
ENSG00000021776	Child Development Disorders, Pervasive	4.9331000E-005	-

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000021776's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000021776	AQR	95	80.697	ENSAPOG00000011277	aqr	97	82.720	Acanthochromis_polyacanthus
ENSG00000021776	AQR	100	96.187	ENSAMEG00000005194	AQR	100	96.187	Ailuropoda_melanoleuca
ENSG00000021776	AQR	89	80.949	ENSACIG00000015226	aqr	98	80.949	Amphilophus_citrinellus
ENSG00000021776	AQR	95	80.488	ENSAOCG00000018671	aqr	97	82.086	Amphiprion_ocellaris
ENSG00000021776	AQR	95	80.418	ENSAPEG00000015999	aqr	94	82.014	Amphiprion_percula
ENSG00000021776	AQR	96	79.639	ENSATEG00000010820	aqr	94	81.655	Anabas_testudineus
ENSG00000021776	AQR	91	89.949	ENSAPLG00000008144	AQR	100	90.369	Anas_platyrhynchos
ENSG00000021776	AQR	95	88.293	ENSACAG00000000687	AQR	96	87.535	Anolis_carolinensis
ENSG00000021776	AQR	100	97.453	ENSANAG00000035427	AQR	100	97.453	Aotus_nancymaae
ENSG00000021776	AQR	97	78.715	ENSACLG00000012554	aqr	93	81.151	Astatotilapia_calliptera
ENSG00000021776	AQR	97	79.614	ENSAMXG00000014751	aqr	100	82.549	Astyanax_mexicanus
ENSG00000021776	AQR	100	96.299	ENSBTAG00000012712	AQR	100	96.299	Bos_taurus
ENSG00000021776	AQR	100	98.056	ENSCJAG00000021021	AQR	100	98.056	Callithrix_jacchus
ENSG00000021776	AQR	100	95.556	ENSCAFG00020006355	AQR	98	97.692	Canis_lupus_dingo
ENSG00000021776	AQR	100	95.357	ENSCHIG00000025362	AQR	100	95.357	Capra_hircus
ENSG00000021776	AQR	100	96.850	ENSTSYG00000004244	AQR	100	96.850	Carlito_syrichta
ENSG00000021776	AQR	68	94.569	ENSCAPG00000016131	AQR	99	94.569	Cavia_aperea
ENSG00000021776	AQR	100	94.882	ENSCCAG00000018954	AQR	99	97.847	Cebus_capucinus
ENSG00000021776	AQR	100	97.441	ENSCATG00000040332	AQR	100	97.441	Cercocebus_atys
ENSG00000021776	AQR	95	98.200	ENSCLAG00000007219	AQR	100	97.030	Chinchilla_lanigera
ENSG00000021776	AQR	100	98.861	ENSCSAG00000007154	AQR	100	98.861	Chlorocebus_sabaeus
ENSG00000021776	AQR	95	90.035	ENSCPBG00000023856	AQR	97	90.614	Chrysemys_picta_bellii
ENSG00000021776	AQR	92	61.849	ENSCING00000003235	-	99	61.849	Ciona_intestinalis
ENSG00000021776	AQR	92	60.103	ENSCSAVG00000009111	-	99	60.103	Ciona_savignyi
ENSG00000021776	AQR	100	97.374	ENSCANG00000042952	AQR	100	97.374	Colobus_angolensis_palliatus
ENSG00000021776	AQR	100	94.882	ENSCGRG00001020556	Aqr	100	95.084	Cricetulus_griseus_chok1gshd
ENSG00000021776	AQR	100	94.882	ENSCGRG00000007912	Aqr	100	95.084	Cricetulus_griseus_crigri
ENSG00000021776	AQR	88	80.579	ENSCSEG00000004847	aqr	95	80.898	Cynoglossus_semilaevis
ENSG00000021776	AQR	95	80.919	ENSCVAG00000003393	aqr	96	82.042	Cyprinodon_variegatus
ENSG00000021776	AQR	99	76.116	ENSDARG00000016775	aqr	96	75.981	Danio_rerio
ENSG00000021776	AQR	95	98.200	ENSDNOG00000013414	AQR	99	97.773	Dasypus_novemcinctus
ENSG00000021776	AQR	99	91.599	ENSDORG00000015152	Aqr	99	91.599	Dipodomys_ordii
ENSG00000021776	AQR	99	62.088	FBgn0051368	CG31368	92	65.404	Drosophila_melanogaster
ENSG00000021776	AQR	78	87.805	ENSEBUG00000015201	aqr	88	77.020	Eptatretus_burgeri
ENSG00000021776	AQR	100	96.113	ENSEASG00005016758	AQR	100	96.113	Equus_asinus_asinus
ENSG00000021776	AQR	100	96.381	ENSECAG00000016399	AQR	100	98.438	Equus_caballus
ENSG00000021776	AQR	96	88.630	ENSEEUG00000003975	AQR	94	88.630	Erinaceus_europaeus
ENSG00000021776	AQR	98	78.082	ENSELUG00000001544	aqr	98	78.760	Esox_lucius
ENSG00000021776	AQR	100	96.431	ENSFCAG00000014069	AQR	100	96.431	Felis_catus
ENSG00000021776	AQR	91	89.384	ENSFALG00000005683	AQR	95	89.805	Ficedula_albicollis
ENSG00000021776	AQR	100	95.895	ENSFDAG00000000252	AQR	100	95.895	Fukomys_damarensis
ENSG00000021776	AQR	97	78.962	ENSFHEG00000020202	aqr	96	80.984	Fundulus_heteroclitus
ENSG00000021776	AQR	95	79.902	ENSGMOG00000009823	aqr	97	77.139	Gadus_morhua
ENSG00000021776	AQR	94	90.071	ENSGALG00000009838	AQR	96	87.637	Gallus_gallus
ENSG00000021776	AQR	98	78.532	ENSGAFG00000019657	aqr	97	78.532	Gambusia_affinis
ENSG00000021776	AQR	95	79.272	ENSGACG00000010437	aqr	100	80.868	Gasterosteus_aculeatus
ENSG00000021776	AQR	95	90.142	ENSGAGG00000019581	AQR	97	89.965	Gopherus_agassizii
ENSG00000021776	AQR	100	98.384	ENSGGOG00000014073	AQR	100	99.488	Gorilla_gorilla
ENSG00000021776	AQR	97	78.700	ENSHBUG00000017573	aqr	97	78.747	Haplochromis_burtoni
ENSG00000021776	AQR	100	95.357	ENSHGLG00000013912	AQR	100	95.357	Heterocephalus_glaber_female
ENSG00000021776	AQR	99	94.936	ENSHGLG00100005299	AQR	98	97.103	Heterocephalus_glaber_male
ENSG00000021776	AQR	93	79.344	ENSHCOG00000001340	aqr	96	82.723	Hippocampus_comes
ENSG00000021776	AQR	95	80.851	ENSIPUG00000006431	aqr	94	81.172	Ictalurus_punctatus
ENSG00000021776	AQR	99	95.909	ENSSTOG00000024444	AQR	98	97.993	Ictidomys_tridecemlineatus
ENSG00000021776	AQR	99	94.587	ENSJJAG00000018777	Aqr	100	94.486	Jaculus_jaculus
ENSG00000021776	AQR	97	78.681	ENSKMAG00000011179	aqr	98	78.069	Kryptolebias_marmoratus
ENSG00000021776	AQR	92	81.560	ENSLBEG00000028346	aqr	97	83.071	Labrus_bergylta
ENSG00000021776	AQR	94	85.827	ENSLACG00000012039	AQR	99	82.912	Latimeria_chalumnae
ENSG00000021776	AQR	92	84.895	ENSLOCG00000012184	aqr	96	84.346	Lepisosteus_oculatus
ENSG00000021776	AQR	100	95.839	ENSLAFG00000017667	AQR	100	95.839	Loxodonta_africana
ENSG00000021776	AQR	100	98.190	ENSMFAG00000030453	AQR	100	98.190	Macaca_fascicularis
ENSG00000021776	AQR	100	98.861	ENSMMUG00000002337	AQR	100	98.861	Macaca_mulatta
ENSG00000021776	AQR	97	98.960	ENSMNEG00000031809	AQR	100	98.810	Macaca_nemestrina
ENSG00000021776	AQR	100	98.190	ENSMLEG00000043611	AQR	100	98.190	Mandrillus_leucophaeus
ENSG00000021776	AQR	96	79.861	ENSMAMG00000005722	aqr	96	82.514	Mastacembelus_armatus
ENSG00000021776	AQR	97	78.631	ENSMZEG00005002419	aqr	97	78.631	Maylandia_zebra
ENSG00000021776	AQR	95	89.303	ENSMGAG00000012303	AQR	99	87.624	Meleagris_gallopavo
ENSG00000021776	AQR	91	95.016	ENSMAUG00000021062	Aqr	100	95.016	Mesocricetus_auratus
ENSG00000021776	AQR	100	96.653	ENSMICG00000016979	AQR	100	96.653	Microcebus_murinus
ENSG00000021776	AQR	98	94.997	ENSMOCG00000001431	Aqr	98	97.026	Microtus_ochrogaster
ENSG00000021776	AQR	95	76.648	ENSMMOG00000009958	aqr	97	76.430	Mola_mola
ENSG00000021776	AQR	95	92.308	ENSMODG00000001369	AQR	98	89.658	Monodelphis_domestica
ENSG00000021776	AQR	91	77.513	ENSMALG00000016665	aqr	96	78.691	Monopterus_albus
ENSG00000021776	AQR	100	94.949	MGP_CAROLIEiJ_G0024103	Aqr	100	94.949	Mus_caroli
ENSG00000021776	AQR	100	94.627	ENSMUSG00000040383	Aqr	100	94.627	Mus_musculus
ENSG00000021776	AQR	100	94.882	MGP_PahariEiJ_G0025546	Aqr	100	94.882	Mus_pahari
ENSG00000021776	AQR	100	94.882	MGP_SPRETEiJ_G0025019	Aqr	100	94.882	Mus_spretus
ENSG00000021776	AQR	100	95.710	ENSMPUG00000008166	AQR	100	95.710	Mustela_putorius_furo
ENSG00000021776	AQR	99	95.702	ENSMLUG00000006223	AQR	99	95.702	Myotis_lucifugus
ENSG00000021776	AQR	100	94.751	ENSNGAG00000017515	Aqr	100	94.751	Nannospalax_galili
ENSG00000021776	AQR	89	81.825	ENSNBRG00000023535	aqr	97	81.825	Neolamprologus_brichardi
ENSG00000021776	AQR	100	99.327	ENSNLEG00000011180	AQR	100	99.327	Nomascus_leucogenys
ENSG00000021776	AQR	85	95.484	ENSMEUG00000011715	AQR	80	95.484	Notamacropus_eugenii
ENSG00000021776	AQR	83	99.227	ENSOPRG00000016495	AQR	83	99.227	Ochotona_princeps
ENSG00000021776	AQR	97	78.660	ENSONIG00000001395	aqr	97	78.660	Oreochromis_niloticus
ENSG00000021776	AQR	100	96.046	ENSOCUG00000003488	AQR	100	96.046	Oryctolagus_cuniculus
ENSG00000021776	AQR	92	81.150	ENSORLG00000013184	aqr	99	81.459	Oryzias_latipes
ENSG00000021776	AQR	96	78.691	ENSORLG00020017700	aqr	98	79.004	Oryzias_latipes_hni
ENSG00000021776	AQR	97	78.030	ENSORLG00015000439	aqr	99	79.436	Oryzias_latipes_hsok
ENSG00000021776	AQR	97	78.444	ENSOMEG00000014207	aqr	99	80.552	Oryzias_melastigma
ENSG00000021776	AQR	100	92.933	ENSOGAG00000016007	AQR	100	92.933	Otolemur_garnettii
ENSG00000021776	AQR	100	96.097	ENSOARG00000020005	AQR	100	96.097	Ovis_aries
ENSG00000021776	AQR	100	99.731	ENSPPAG00000030601	AQR	100	99.731	Pan_paniscus
ENSG00000021776	AQR	100	96.364	ENSPPRG00000008641	AQR	100	96.364	Panthera_pardus
ENSG00000021776	AQR	100	96.431	ENSPTIG00000018387	AQR	100	96.431	Panthera_tigris_altaica
ENSG00000021776	AQR	100	99.865	ENSPTRG00000006891	AQR	100	99.865	Pan_troglodytes
ENSG00000021776	AQR	100	98.861	ENSPANG00000019671	AQR	100	98.861	Papio_anubis
ENSG00000021776	AQR	91	76.109	ENSPKIG00000003825	aqr	99	79.072	Paramormyrops_kingsleyae
ENSG00000021776	AQR	95	89.660	ENSPSIG00000007656	AQR	95	90.136	Pelodiscus_sinensis
ENSG00000021776	AQR	89	81.124	ENSPMGG00000000136	aqr	93	81.124	Periophthalmus_magnuspinnatus
ENSG00000021776	AQR	100	90.101	ENSPEMG00000016395	Aqr	100	90.101	Peromyscus_maniculatus_bairdii
ENSG00000021776	AQR	95	92.144	ENSPCIG00000021761	AQR	94	88.363	Phascolarctos_cinereus
ENSG00000021776	AQR	97	79.473	ENSPFOG00000015147	aqr	97	79.265	Poecilia_formosa
ENSG00000021776	AQR	97	79.542	ENSPLAG00000021235	aqr	97	83.270	Poecilia_latipinna
ENSG00000021776	AQR	97	79.542	ENSPMEG00000004188	aqr	97	82.506	Poecilia_mexicana
ENSG00000021776	AQR	85	83.215	ENSPREG00000007197	aqr	96	83.215	Poecilia_reticulata
ENSG00000021776	AQR	99	98.518	ENSPPYG00000006319	AQR	100	98.518	Pongo_abelii
ENSG00000021776	AQR	100	83.885	ENSPCOG00000021390	AQR	100	83.885	Propithecus_coquereli
ENSG00000021776	AQR	97	78.769	ENSPNYG00000016598	aqr	98	82.038	Pundamilia_nyererei
ENSG00000021776	AQR	87	82.271	ENSPNAG00000001173	aqr	97	82.271	Pygocentrus_nattereri
ENSG00000021776	AQR	100	95.354	ENSRNOG00000008912	Aqr	100	95.354	Rattus_norvegicus
ENSG00000021776	AQR	100	96.703	ENSRBIG00000038017	AQR	100	96.703	Rhinopithecus_bieti
ENSG00000021776	AQR	100	98.861	ENSRROG00000044173	AQR	100	98.861	Rhinopithecus_roxellana
ENSG00000021776	AQR	100	98.324	ENSSBOG00000000986	AQR	100	98.324	Saimiri_boliviensis_boliviensis
ENSG00000021776	AQR	96	91.024	ENSSHAG00000016987	AQR	99	88.769	Sarcophilus_harrisii
ENSG00000021776	AQR	95	81.748	ENSSFOG00015010484	aqr	98	83.206	Scleropages_formosus
ENSG00000021776	AQR	96	79.457	ENSSMAG00000018736	aqr	99	77.424	Scophthalmus_maximus
ENSG00000021776	AQR	93	81.788	ENSSDUG00000015005	aqr	96	83.866	Seriola_dumerili
ENSG00000021776	AQR	91	81.772	ENSSLDG00000021156	aqr	97	83.790	Seriola_lalandi_dorsalis
ENSG00000021776	AQR	96	79.764	ENSSPAG00000015693	aqr	95	83.257	Stegastes_partitus
ENSG00000021776	AQR	100	96.247	ENSSSCG00000004802	AQR	100	96.381	Sus_scrofa
ENSG00000021776	AQR	94	89.024	ENSTGUG00000011770	AQR	99	89.151	Taeniopygia_guttata
ENSG00000021776	AQR	98	77.694	ENSTRUG00000014255	aqr	94	80.808	Takifugu_rubripes
ENSG00000021776	AQR	93	80.736	ENSTNIG00000017238	aqr	94	80.736	Tetraodon_nigroviridis
ENSG00000021776	AQR	100	95.623	ENSTTRG00000014800	AQR	100	95.623	Tursiops_truncatus
ENSG00000021776	AQR	100	95.509	ENSUAMG00000015052	AQR	100	95.509	Ursus_americanus
ENSG00000021776	AQR	100	96.314	ENSUMAG00000015725	AQR	100	96.314	Ursus_maritimus
ENSG00000021776	AQR	100	96.364	ENSVPAG00000010622	AQR	100	96.364	Vicugna_pacos
ENSG00000021776	AQR	100	96.431	ENSVVUG00000026312	AQR	100	96.431	Vulpes_vulpes
ENSG00000021776	AQR	97	80.483	ENSXETG00000012901	aqr	90	85.437	Xenopus_tropicalis
ENSG00000021776	AQR	96	79.373	ENSXMAG00000009596	aqr	96	79.373	Xiphophorus_maculatus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000398	mRNA splicing, via spliceosome	11991638.	IC	Process
GO:0000398	mRNA splicing, via spliceosome	28076346.	IDA	Process
GO:0000398	mRNA splicing, via spliceosome	-	TAS	Process
GO:0003723	RNA binding	22658674.22681889.	HDA	Function
GO:0003723	RNA binding	21873635.	IBA	Function
GO:0003729	mRNA binding	21873635.	IBA	Function
GO:0004386	helicase activity	-	IEA	Function
GO:0005515	protein binding	22365833.25599396.	IPI	Function
GO:0005524	ATP binding	-	IEA	Function
GO:0005634	nucleus	21873635.	IBA	Component
GO:0005634	nucleus	28076346.	IDA	Component
GO:0005654	nucleoplasm	-	IDA	Component
GO:0005654	nucleoplasm	-	TAS	Component
GO:0005681	spliceosomal complex	21873635.	IBA	Component
GO:0006283	transcription-coupled nucleotide-excision repair	-	TAS	Process
GO:0016020	membrane	19946888.	HDA	Component
GO:0071007	U2-type catalytic step 2 spliceosome	28076346.	IDA	Component
GO:0071013	catalytic step 2 spliceosome	21873635.	IBA	Component
GO:0071013	catalytic step 2 spliceosome	11991638.	IDA	Component