EuRBPDB

Description

Ensembl ID: ENSG00000023318 (Gene tree)
Gene ID: 23071
Gene Symbol: ERP44
Alias: KIAA0573|PDIA10|TXNDC4
Full Name: endoplasmic reticulum protein 44
Gene Type: protein_coding
Species: Homo_sapiens
Status: putative
Strand: Minus strand
Length: 119,874 bases
Position: chr9:99,979,179-100,099,052
Accession: 18311
RBP type: non-canonical RBP
Summary: This gene encodes a member of the protein disulfide isomerase (PDI) family of endoplasmic reticulum (ER) proteins. It has an inferred N-terminal signal peptide, a catalytically active thioredoxin (TRX) domain, two TRX-like domains and a C-terminal ER-retention sequence. This protein functions as a pH-regulated chaperone of the secretory pathway and likely plays a role in protein quality control at the endoplasmic reticulum - Golgi interface. [provided by RefSeq, Dec 2016]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & MCF10A	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & U2OS	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000262455	ERP44-201	4854	-	ENSP00000262455	406 (aa)	-	Q9BS26

Gene Model

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000023318	Cholesterol, HDL	7.9320000E-005	-
ENSG00000023318	Pre-Eclampsia	3E-6	23551011

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000023318	rs7028939	9	100046403	?	Preeclampsia	23551011	[1.95-5.15]	3.17	EFO_0000668
ENSG00000023318	rs10988944	9	100011933	?	Adolescent idiopathic scoliosis	30019117			EFO_0005423

Protein-Protein Interaction (PPI)

* RBP PPI network refers to all genes directly bind to RBP

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0003756	protein disulfide isomerase activity	11847130.	IDA	Function
GO:0005515	protein binding	17805346.	IPI	Function
GO:0005576	extracellular region	-	TAS	Component
GO:0005788	endoplasmic reticulum lumen	11847130.	IDA	Component
GO:0005789	endoplasmic reticulum membrane	11847130.	IDA	Component
GO:0005793	endoplasmic reticulum-Golgi intermediate compartment	15308636.	IDA	Component
GO:0006457	protein folding	11847130.	IDA	Process
GO:0006986	response to unfolded protein	11847130.	IDA	Process
GO:0009100	glycoprotein metabolic process	11847130.	IDA	Process
GO:0009986	cell surface	19995400.	IDA	Component
GO:0034976	response to endoplasmic reticulum stress	11847130.	IDA	Process
GO:0035580	specific granule lumen	-	TAS	Component
GO:0043312	neutrophil degranulation	-	TAS	Process
GO:0045454	cell redox homeostasis	11847130.	TAS	Process
GO:0070062	extracellular exosome	19199708.	HDA	Component