EuRBPDB

Description

Ensembl ID: ENSG00000025796 (Gene tree)
Gene ID: 11231
Gene Symbol: SEC63
Alias: SEC63L|PRO2507|ERdj2|DNAJC23
Full Name: SEC63 homolog, protein translocation regulator
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Minus strand
Length: 90,523 bases
Position: chr6:107,867,756-107,958,278
Accession: 21082
RBP type: non-canonical RBP
Summary: The Sec61 complex is the central component of the protein translocation apparatus of the endoplasmic reticulum (ER) membrane. The protein encoded by this gene and SEC62 protein are found to be associated with ribosome-free SEC61 complex. It is speculated that Sec61-Sec62-Sec63 may perform post-translational protein translocation into the ER. The Sec61-Sec62-Sec63 complex might also perform the backward transport of ER proteins that are subject to the ubiquitin-proteasome-dependent degradation pathway. The encoded protein is an integral membrane protein located in the rough ER. [provided by RefSeq, Jul 2008]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & HEK293	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
29431736	Capturing the interactome of newly transcribed RNA	RIC & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
22658674	Insights into RNA biology from an atlas of mammalian mRNA-binding proteins	RIC & Hela	2012 May 31	Castello A	DOI: 10.1016/j.cell.2012.04.031
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & Hela	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & MCF10A	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & MCF7	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & U2OS	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
25185157	Phosphorylation of the TATA-binding protein activates the spliced leader silencing pathway in Trypanosoma brucei.	Sci Signal	2014 Sep 2	Hope R	doi: 10.1126/scisignal.2005234.
27454487	Spliceosome SNRNP200 Promotes Viral RNA Sensing and IRF3 Activation of Antiviral Response.	PLoS Pathog	2016 Jul 25	Tremblay N	doi: 10.1371/journal.ppat.1005772

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000484803	SEC63-209	724	-	-	- (aa)	-	-
ENST00000465210	SEC63-206	416	-	-	- (aa)	-	-
ENST00000429168	SEC63-202	647	-	ENSP00000403144	161 (aa)	-	A6PVC9
ENST00000446496	SEC63-203	583	-	ENSP00000410968	80 (aa)	-	F8WB27
ENST00000369002	SEC63-201	6411	XM_017010218	ENSP00000357998	760 (aa)	XP_016865707	Q9UGP8
ENST00000466419	SEC63-207	606	-	-	- (aa)	-	-
ENST00000460009	SEC63-205	482	-	-	- (aa)	-	-
ENST00000473746	SEC63-208	709	-	-	- (aa)	-	-
ENST00000459782	SEC63-204	2025	-	-	- (aa)	-	-
ENST00000489455	SEC63-210	444	-	-	- (aa)	-	-

Gene Model

Pathways

Pathway ID	Pathway Name	Source
hsa03060	Protein export	KEGG
hsa04141	Protein processing in endoplasmic reticulum	KEGG

Protein-Protein Interaction (PPI)

* RBP PPI network refers to all genes directly bind to RBP

Orthologs identified by RBPome

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000025796	SEC63	88	56.643	FBgn0035771	Sec63	96	45.257	Drosophila_melanogaster
ENSG00000025796	SEC63	100	100.000	ENSMUSG00000019802	Sec63	100	96.316	Mus_musculus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0001889	liver development	-	IEA	Process
GO:0003723	RNA binding	22658674.	HDA	Function
GO:0005515	protein binding	21251912.26871637.	IPI	Function
GO:0005783	endoplasmic reticulum	21873635.	IBA	Component
GO:0005783	endoplasmic reticulum	-	IDA	Component
GO:0005789	endoplasmic reticulum membrane	-	TAS	Component
GO:0005829	cytosol	-	TAS	Component
GO:0006612	protein targeting to membrane	10799540.	TAS	Process
GO:0006614	SRP-dependent cotranslational protein targeting to membrane	21873635.	IBA	Process
GO:0006614	SRP-dependent cotranslational protein targeting to membrane	22375059.	IMP	Process
GO:0006620	posttranslational protein targeting to endoplasmic reticulum membrane	21873635.	IBA	Process
GO:0006620	posttranslational protein targeting to endoplasmic reticulum membrane	22375059.	IMP	Process
GO:0006807	nitrogen compound metabolic process	-	IEA	Process
GO:0008565	protein transporter activity	21873635.	IBA	Function
GO:0010259	multicellular organism aging	-	IEA	Process
GO:0016020	membrane	22375059.	IDA	Component
GO:0016021	integral component of membrane	-	IEA	Component
GO:0031204	posttranslational protein targeting to membrane, translocation	29719251.	IMP	Process
GO:0031207	Sec62/Sec63 complex	21873635.	IBA	Component
GO:0038023	signaling receptor activity	10799540.	TAS	Function