EuRBPDB

Description

Ensembl ID: ENSG00000025800 (Gene tree)
Gene ID: 23633
Gene Symbol: KPNA6
Alias: IPOA7|KPNA7|MGC17918|FLJ11249
Full Name: karyopherin subunit alpha 6
Gene Type: protein_coding
Species: Homo_sapiens
Status: putative
Strand: Plus strand
Length: 68,531 bases
Position: chr1:32,108,038-32,176,568
Accession: 6399
RBP type: non-canonical RBP
Summary: Nucleocytoplasmic transport, a signal- and energy-dependent process, takes place through nuclear pore complexes embedded in the nuclear envelope. The import of proteins containing a nuclear localization signal (NLS) requires the NLS import receptor, a heterodimer of importin alpha and beta subunits also known as karyopherins. Importin alpha binds the NLS-containing cargo in the cytoplasm and importin beta docks the complex at the cytoplasmic side of the nuclear pore complex. In the presence of nucleoside triphosphates and the small GTP binding protein Ran, the complex moves into the nuclear pore complex and the importin subunits dissociate. Importin alpha enters the nucleoplasm with its passenger protein and importin beta remains at the pore. The protein encoded by this gene is a member of the importin alpha family. [provided by RefSeq, Jul 2008]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
29431736	Capturing the interactome of newly transcribed RNA	RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000471599	KPNA6-204	3941	-	ENSP00000474234	186 (aa)	-	S4R3E5
ENST00000373625	KPNA6-201	7378	XM_005270711	ENSP00000362728	536 (aa)	XP_005270768	O60684
ENST00000446515	KPNA6-202	965	-	ENSP00000415677	321 (aa)	-	Q5TFJ7
ENST00000469790	KPNA6-203	879	-	-	- (aa)	-	-

Gene Model

Protein-Protein Interaction (PPI)

* RBP PPI network refers to all genes directly bind to RBP

Orthologs identified by RBPome

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000025800	KPNA6	98	43.833	WBGene00002074	ima-3	99	43.833	Caenorhabditis_elegans
ENSG00000025800	KPNA6	98	45.265	FBgn0027338	Kap-alpha3	99	45.265	Drosophila_melanogaster
ENSG00000025800	KPNA6	99	47.850	FBgn0267727	Pen	99	47.850	Drosophila_melanogaster
ENSG00000025800	KPNA6	99	81.041	ENSG00000114030	KPNA1	100	81.227	Homo_sapiens
ENSG00000025800	KPNA6	95	48.337	ENSG00000102753	KPNA3	95	48.337	Homo_sapiens
ENSG00000025800	KPNA6	94	53.620	YNL189W	SRP1	94	53.620	Saccharomyces_cerevisiae

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0005515	protein binding	10523667.16713569.20064372.22810585.25158218.25416956.25599645.25910212.26420826.26496610.28169297.	IPI	Function
GO:0005643	nuclear pore	21873635.	IBA	Component
GO:0005654	nucleoplasm	21873635.	IBA	Component
GO:0005829	cytosol	21873635.	IBA	Component
GO:0006607	NLS-bearing protein import into nucleus	21873635.	IBA	Process
GO:0008139	nuclear localization sequence binding	21873635.	IBA	Function
GO:0008565	protein transporter activity	21873635.	IBA	Function
GO:0016020	membrane	19946888.	HDA	Component
GO:0030683	evasion or tolerance by virus of host immune response	-	IEA	Process
GO:0043657	host cell	-	IEA	Component
GO:0045944	positive regulation of transcription by RNA polymerase II	-	IEA	Process
GO:0060135	maternal process involved in female pregnancy	-	IEA	Process
GO:0061608	nuclear import signal receptor activity	-	IEA	Function
GO:0075506	entry of viral genome into host nucleus through nuclear pore complex via importin	28189564.	IMP	Process
GO:1900017	positive regulation of cytokine production involved in inflammatory response	-	IEA	Process
GO:1903902	positive regulation of viral life cycle	28189564.	IMP	Process