EuRBPDB

Description

RBDs

Literatures

Expression

Transcripts

Gene Model

GWAS

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000032219 (Gene tree)
Gene ID: 5926
Gene Symbol: ARID4A
Alias: RBP1|RBP-1|RBBP1
Full Name: AT-rich interaction domain 4A
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Plus strand
Length: 75,611 bases
Position: chr14:58,298,385-58,373,995
Accession: 9885
RBP type: canonical RBP
Summary: The protein encoded by this gene is a ubiquitously expressed nuclear protein. It binds directly, with several other proteins, to retinoblastoma protein (pRB) which regulates cell proliferation. pRB represses transcription by recruiting the encoded protein. This protein, in turn, serves as a bridging molecule to recruit HDACs and, in addition, provides a second HDAC-independent repression function. The encoded protein possesses transcriptional repression activity. Multiple alternatively spliced transcripts have been observed for this gene, although not all transcript variants have been fully described. [provided by RefSeq, Jul 2008]

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000344556	Tudor-knot	PF11717.8	9.5e-13	1	1
ENSP00000397368	Tudor-knot	PF11717.8	9.5e-13	1	1
ENSP00000378597	Tudor-knot	PF11717.8	9.9e-13	1	1
ENSP00000416053	Tudor-knot	PF11717.8	1e-12	1	1
ENSP00000347602	Tudor-knot	PF11717.8	1.1e-12	1	1

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
24928548	Gene expression analysis in MCF-7 breast cancer cells treated with recombinant bromelain.	Appl Biochem Biotechnol	2014 Aug	Fouz N	doi: 10.1007/s12010-014-0947-6
27449001	The 5' untranslated region of the rbp1 mRNA is required for translation of its mRNA under low temperatures in the cyanobacterium Synechococcus elongatus.	Arch Microbiol	2017 Jan	Hayashi R	doi: 10.1007/s00203-016-1270-0

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000417477	ARID4A-204	2537	XM_017021565	ENSP00000416053	748 (aa)	XP_016877054	H7C485
ENST00000395168	ARID4A-203	4051	-	ENSP00000378597	1203 (aa)	-	P29374
ENST00000355431	ARID4A-202	5891	XM_005267964	ENSP00000347602	1257 (aa)	XP_005268021	P29374
ENST00000466065	ARID4A-209	370	-	-	- (aa)	-	-
ENST00000431612	ARID4A-207	697	-	ENSP00000410417	40 (aa)	-	F8WAR5
ENST00000469635	ARID4A-210	578	-	-	- (aa)	-	-
ENST00000348476	ARID4A-201	5562	XM_005267965	ENSP00000344556	1188 (aa)	XP_005268022	P29374
ENST00000431317	ARID4A-206	5783	-	ENSP00000397368	1188 (aa)	-	P29374
ENST00000424658	ARID4A-205	582	-	ENSP00000415872	54 (aa)	-	C9JIF4
ENST00000445108	ARID4A-208	965	-	ENSP00000392567	265 (aa)	-	C9J1W3
ENST00000553355	ARID4A-211	619	-	-	- (aa)	-	-

Gene Model

Click here to download ENSG00000032219's gene model file

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000032219	rs8012947	14	58317737	A	Alcohol consumption in current drinkers	28937693	[0.011-0.023] unit increase	0.017	EFO_0007878
ENSG00000032219	rs2145598	14	58327283	A	Coronary artery disease	29212778	[0.018-0.038] unit decrease	0.0283	EFO_0000378
ENSG00000032219	rs1051860	14	58371950	A	Educational attainment (MTAG)	30038396	[0.0059-0.0109] unit decrease	0.0084	EFO_0004784
ENSG00000032219	rs1051860	14	58371950	A	Highest math class taken (MTAG)	30038396	[0.0075-0.0141] unit decrease	0.0108	EFO_0004875
ENSG00000032219	rs1051860	14	58371950	A	Educational attainment (years of education)	30038396	[0.0052-0.0106] unit decrease	0.0079	EFO_0004784
ENSG00000032219	rs10137475	14	58331235	A	Educational attainment (years of education)	30038396	[0.0053-0.0107] unit increase	0.008	EFO_0004784
ENSG00000032219	rs1190982	14	58349121	?	Waist-hip ratio	30595370			EFO_0004343
ENSG00000032219	rs1951202	14	58312699	?	Red blood cell count	30595370			EFO_0004305
ENSG00000032219	rs2180870	14	58316061	C	Alcohol consumption (drinks per week)	30643251	[0.008-0.0164] unit decrease	0.012177537	EFO_0007878
ENSG00000032219	rs1051860	14	58371950	A	Waist-to-hip ratio adjusted for BMI (additive genetic model)	30778226	[0.0068-0.0154] unit increase	0.0111	EFO_0007788
ENSG00000032219	rs1051860	14	58371950	A	Waist-to-hip ratio adjusted for BMI (additive genetic model)	30778226	[0.0087-0.0181] unit increase	0.0134	EFO_0007788
ENSG00000032219	rs1051860	14	58371950	A	Waist-to-hip ratio adjusted for BMI (additive genetic model)	30778226	[0.01-0.023] unit increase	0.0168	EFO_0007788
ENSG00000032219	rs1051860	14	58371950	A	Waist-to-hip ratio adjusted for BMI (additive genetic model)	30778226	[0.0083-0.0205] unit increase	0.0144	EFO_0007788

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000032219's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000032219	ARID4A	98	97.436	ENSAPOG00000018856	arid4a	70	65.432	Acanthochromis_polyacanthus
ENSG00000032219	ARID4A	98	98.113	ENSAMEG00000002532	ARID4A	99	93.187	Ailuropoda_melanoleuca
ENSG00000032219	ARID4A	95	94.737	ENSACIG00000021943	-	92	56.224	Amphilophus_citrinellus
ENSG00000032219	ARID4A	98	97.436	ENSATEG00000014386	arid4a	77	57.517	Anabas_testudineus
ENSG00000032219	ARID4A	99	95.181	ENSAPLG00000006185	ARID4A	94	95.181	Anas_platyrhynchos
ENSG00000032219	ARID4A	98	97.436	ENSACAG00000014637	ARID4A	99	70.161	Anolis_carolinensis
ENSG00000032219	ARID4A	100	100.000	ENSANAG00000037559	ARID4A	100	97.375	Aotus_nancymaae
ENSG00000032219	ARID4A	95	92.105	ENSACLG00000005837	arid4a	87	53.882	Astatotilapia_calliptera
ENSG00000032219	ARID4A	100	83.333	ENSAMXG00000000379	arid4a	90	70.600	Astyanax_mexicanus
ENSG00000032219	ARID4A	100	100.000	ENSBTAG00000018898	ARID4A	100	93.265	Bos_taurus
ENSG00000032219	ARID4A	100	100.000	ENSCJAG00000018764	ARID4A	100	97.454	Callithrix_jacchus
ENSG00000032219	ARID4A	100	100.000	ENSCAFG00000023936	ARID4A	100	94.277	Canis_familiaris
ENSG00000032219	ARID4A	100	96.296	ENSCAFG00020008690	ARID4A	99	94.118	Canis_lupus_dingo
ENSG00000032219	ARID4A	95	97.368	ENSCHIG00000021589	ARID4A	100	91.838	Capra_hircus
ENSG00000032219	ARID4A	96	100.000	ENSTSYG00000013397	ARID4A	99	94.590	Carlito_syrichta
ENSG00000032219	ARID4A	56	86.842	ENSCAPG00000008719	-	100	86.842	Cavia_aperea
ENSG00000032219	ARID4A	65	79.184	ENSCPOG00000032725	-	97	79.184	Cavia_porcellus
ENSG00000032219	ARID4A	100	97.358	ENSCCAG00000019639	ARID4A	99	95.024	Cebus_capucinus
ENSG00000032219	ARID4A	100	100.000	ENSCATG00000041635	ARID4A	100	98.886	Cercocebus_atys
ENSG00000032219	ARID4A	70	81.594	ENSCLAG00000003914	-	99	81.594	Chinchilla_lanigera
ENSG00000032219	ARID4A	100	100.000	ENSCSAG00000014425	ARID4A	98	98.577	Chlorocebus_sabaeus
ENSG00000032219	ARID4A	100	90.909	ENSCHOG00000003408	ARID4A	94	86.517	Choloepus_hoffmanni
ENSG00000032219	ARID4A	100	98.795	ENSCPBG00000024815	ARID4A	96	98.795	Chrysemys_picta_bellii
ENSG00000032219	ARID4A	100	98.807	ENSCANG00000034778	ARID4A	100	98.807	Colobus_angolensis_palliatus
ENSG00000032219	ARID4A	100	100.000	ENSCGRG00001018168	Arid4a	100	88.016	Cricetulus_griseus_chok1gshd
ENSG00000032219	ARID4A	98	98.113	ENSCGRG00000005293	Arid4a	96	87.459	Cricetulus_griseus_crigri
ENSG00000032219	ARID4A	98	97.436	ENSCSEG00000011930	arid4a	56	66.598	Cynoglossus_semilaevis
ENSG00000032219	ARID4A	100	87.037	ENSDARG00000043873	arid4a	98	62.027	Danio_rerio
ENSG00000032219	ARID4A	100	100.000	ENSDNOG00000004090	ARID4A	100	91.581	Dasypus_novemcinctus
ENSG00000032219	ARID4A	100	100.000	ENSDORG00000002170	Arid4a	100	85.726	Dipodomys_ordii
ENSG00000032219	ARID4A	96	94.231	ENSETEG00000014494	ARID4A	92	85.445	Echinops_telfairi
ENSG00000032219	ARID4A	100	100.000	ENSEASG00005016222	ARID4A	99	93.805	Equus_asinus_asinus
ENSG00000032219	ARID4A	100	100.000	ENSECAG00000019256	ARID4A	100	93.805	Equus_caballus
ENSG00000032219	ARID4A	100	100.000	ENSEEUG00000001510	ARID4A	100	82.063	Erinaceus_europaeus
ENSG00000032219	ARID4A	98	97.436	ENSELUG00000003087	arid4a	92	68.565	Esox_lucius
ENSG00000032219	ARID4A	100	100.000	ENSFCAG00000019223	ARID4A	100	94.118	Felis_catus
ENSG00000032219	ARID4A	98	100.000	ENSFALG00000003561	ARID4A	94	96.386	Ficedula_albicollis
ENSG00000032219	ARID4A	100	100.000	ENSFDAG00000005958	-	100	91.979	Fukomys_damarensis
ENSG00000032219	ARID4A	98	94.872	ENSFHEG00000004741	arid4a	69	64.815	Fundulus_heteroclitus
ENSG00000032219	ARID4A	100	83.333	ENSGMOG00000017334	-	61	65.319	Gadus_morhua
ENSG00000032219	ARID4A	98	100.000	ENSGALG00000012037	ARID4A	100	78.288	Gallus_gallus
ENSG00000032219	ARID4A	95	92.105	ENSGACG00000004018	arid4a	100	46.997	Gasterosteus_aculeatus
ENSG00000032219	ARID4A	98	100.000	ENSGAGG00000012085	ARID4A	96	97.590	Gopherus_agassizii
ENSG00000032219	ARID4A	100	100.000	ENSGGOG00000027092	ARID4A	100	99.682	Gorilla_gorilla
ENSG00000032219	ARID4A	70	87.500	ENSHGLG00000001903	-	99	87.500	Heterocephalus_glaber_female
ENSG00000032219	ARID4A	70	86.553	ENSHGLG00100005885	-	99	86.553	Heterocephalus_glaber_male
ENSG00000032219	ARID4A	100	85.185	ENSIPUG00000001971	arid4a	95	61.408	Ictalurus_punctatus
ENSG00000032219	ARID4A	100	100.000	ENSSTOG00000019680	ARID4A	100	94.281	Ictidomys_tridecemlineatus
ENSG00000032219	ARID4A	89	100.000	ENSJJAG00000016742	Arid4a	100	93.583	Jaculus_jaculus
ENSG00000032219	ARID4A	98	94.872	ENSKMAG00000018271	arid4a	71	57.143	Kryptolebias_marmoratus
ENSG00000032219	ARID4A	98	97.436	ENSLBEG00000018330	arid4a	52	84.483	Labrus_bergylta
ENSG00000032219	ARID4A	98	97.436	ENSLACG00000018876	ARID4A	100	64.125	Latimeria_chalumnae
ENSG00000032219	ARID4A	100	100.000	ENSLAFG00000008653	ARID4A	99	93.566	Loxodonta_africana
ENSG00000032219	ARID4A	100	100.000	ENSMFAG00000037044	ARID4A	100	98.886	Macaca_fascicularis
ENSG00000032219	ARID4A	100	100.000	ENSMMUG00000003514	ARID4A	100	98.966	Macaca_mulatta
ENSG00000032219	ARID4A	100	100.000	ENSMNEG00000037476	ARID4A	100	98.966	Macaca_nemestrina
ENSG00000032219	ARID4A	100	100.000	ENSMLEG00000043095	ARID4A	100	98.886	Mandrillus_leucophaeus
ENSG00000032219	ARID4A	95	94.737	ENSMAMG00000006769	arid4a	62	56.461	Mastacembelus_armatus
ENSG00000032219	ARID4A	95	92.105	ENSMZEG00005017186	arid4a	87	53.882	Maylandia_zebra
ENSG00000032219	ARID4A	98	100.000	ENSMGAG00000013615	ARID4A	100	78.176	Meleagris_gallopavo
ENSG00000032219	ARID4A	98	98.113	ENSMAUG00000016160	Arid4a	96	81.892	Mesocricetus_auratus
ENSG00000032219	ARID4A	100	100.000	ENSMICG00000011761	ARID4A	100	95.393	Microcebus_murinus
ENSG00000032219	ARID4A	100	100.000	ENSMOCG00000010098	Arid4a	100	86.270	Microtus_ochrogaster
ENSG00000032219	ARID4A	98	94.872	ENSMMOG00000020283	arid4a	78	71.190	Mola_mola
ENSG00000032219	ARID4A	98	100.000	ENSMODG00000007881	ARID4A	95	98.795	Monodelphis_domestica
ENSG00000032219	ARID4A	98	92.308	ENSMALG00000019138	arid4a	100	45.195	Monopterus_albus
ENSG00000032219	ARID4A	100	100.000	MGP_CAROLIEiJ_G0017824	Arid4a	100	85.420	Mus_caroli
ENSG00000032219	ARID4A	100	100.000	ENSMUSG00000048118	Arid4a	100	85.432	Mus_musculus
ENSG00000032219	ARID4A	100	100.000	MGP_PahariEiJ_G0029580	Arid4a	100	85.079	Mus_pahari
ENSG00000032219	ARID4A	100	100.000	MGP_SPRETEiJ_G0018669	Arid4a	100	85.194	Mus_spretus
ENSG00000032219	ARID4A	100	100.000	ENSMPUG00000006137	ARID4A	100	94.515	Mustela_putorius_furo
ENSG00000032219	ARID4A	98	98.113	ENSMLUG00000012354	ARID4A	99	92.801	Myotis_lucifugus
ENSG00000032219	ARID4A	100	96.296	ENSNGAG00000015701	Arid4a	98	89.162	Nannospalax_galili
ENSG00000032219	ARID4A	100	100.000	ENSNLEG00000013149	ARID4A	100	99.125	Nomascus_leucogenys
ENSG00000032219	ARID4A	92	95.492	ENSOPRG00000002859	ARID4A	71	89.290	Ochotona_princeps
ENSG00000032219	ARID4A	67	82.200	ENSODEG00000014309	-	99	80.076	Octodon_degus
ENSG00000032219	ARID4A	98	97.436	ENSONIG00000011016	arid4a	54	39.429	Oreochromis_niloticus
ENSG00000032219	ARID4A	95	97.368	ENSOANG00000011836	ARID4A	99	73.320	Ornithorhynchus_anatinus
ENSG00000032219	ARID4A	100	100.000	ENSOCUG00000001052	ARID4A	100	89.515	Oryctolagus_cuniculus
ENSG00000032219	ARID4A	95	94.737	ENSORLG00020001443	arid4a	71	84.483	Oryzias_latipes_hni
ENSG00000032219	ARID4A	100	98.148	ENSOGAG00000000385	ARID4A	100	91.759	Otolemur_garnettii
ENSG00000032219	ARID4A	100	100.000	ENSOARG00000021110	ARID4A	100	92.953	Ovis_aries
ENSG00000032219	ARID4A	100	100.000	ENSPPAG00000042713	ARID4A	100	99.841	Pan_paniscus
ENSG00000032219	ARID4A	100	100.000	ENSPPRG00000009142	ARID4A	100	94.122	Panthera_pardus
ENSG00000032219	ARID4A	100	100.000	ENSPTIG00000007597	ARID4A	100	94.202	Panthera_tigris_altaica
ENSG00000032219	ARID4A	100	100.000	ENSPTRG00000006393	ARID4A	100	99.841	Pan_troglodytes
ENSG00000032219	ARID4A	100	100.000	ENSPANG00000022390	ARID4A	100	98.966	Papio_anubis
ENSG00000032219	ARID4A	95	71.315	ENSPKIG00000015415	arid4a	82	75.654	Paramormyrops_kingsleyae
ENSG00000032219	ARID4A	99	97.590	ENSPSIG00000014845	ARID4A	94	97.590	Pelodiscus_sinensis
ENSG00000032219	ARID4A	100	100.000	ENSPEMG00000008231	Arid4a	100	86.429	Peromyscus_maniculatus_bairdii
ENSG00000032219	ARID4A	100	83.333	ENSPMAG00000005967	arid4a	92	57.347	Petromyzon_marinus
ENSG00000032219	ARID4A	98	100.000	ENSPCIG00000017482	ARID4A	93	97.222	Phascolarctos_cinereus
ENSG00000032219	ARID4A	98	97.436	ENSPFOG00000018637	arid4a	70	65.000	Poecilia_formosa
ENSG00000032219	ARID4A	98	97.436	ENSPLAG00000003432	arid4a	70	65.000	Poecilia_latipinna
ENSG00000032219	ARID4A	98	97.436	ENSPMEG00000010607	arid4a	70	65.208	Poecilia_mexicana
ENSG00000032219	ARID4A	100	100.000	ENSPPYG00000005857	ARID4A	100	99.523	Pongo_abelii
ENSG00000032219	ARID4A	100	100.000	ENSPCAG00000002099	ARID4A	89	97.326	Procavia_capensis
ENSG00000032219	ARID4A	100	100.000	ENSPCOG00000013924	ARID4A	100	95.631	Propithecus_coquereli
ENSG00000032219	ARID4A	100	93.407	ENSPVAG00000003866	ARID4A	100	93.407	Pteropus_vampyrus
ENSG00000032219	ARID4A	95	92.105	ENSPNYG00000009221	arid4a	86	54.277	Pundamilia_nyererei
ENSG00000032219	ARID4A	100	85.185	ENSPNAG00000000710	arid4a	52	83.133	Pygocentrus_nattereri
ENSG00000032219	ARID4A	100	100.000	ENSRNOG00000026239	Arid4a	100	84.365	Rattus_norvegicus
ENSG00000032219	ARID4A	100	100.000	ENSRBIG00000032944	ARID4A	99	98.013	Rhinopithecus_bieti
ENSG00000032219	ARID4A	100	100.000	ENSRROG00000034002	ARID4A	100	98.807	Rhinopithecus_roxellana
ENSG00000032219	ARID4A	100	100.000	ENSSBOG00000027453	ARID4A	100	96.977	Saimiri_boliviensis_boliviensis
ENSG00000032219	ARID4A	95	97.368	ENSSHAG00000018032	ARID4A	99	82.157	Sarcophilus_harrisii
ENSG00000032219	ARID4A	98	97.436	ENSSFOG00015019230	arid4a	100	54.212	Scleropages_formosus
ENSG00000032219	ARID4A	98	87.179	ENSSMAG00000012268	arid4a	92	45.308	Scophthalmus_maximus
ENSG00000032219	ARID4A	95	94.737	ENSSDUG00000000343	arid4a	92	55.031	Seriola_dumerili
ENSG00000032219	ARID4A	56	53.367	ENSSLDG00000022684	arid4a	50	79.545	Seriola_lalandi_dorsalis
ENSG00000032219	ARID4A	96	100.000	ENSSARG00000006966	ARID4A	100	91.415	Sorex_araneus
ENSG00000032219	ARID4A	93	87.045	ENSSPUG00000018360	ARID4A	100	74.744	Sphenodon_punctatus
ENSG00000032219	ARID4A	95	94.737	ENSSPAG00000004467	arid4a	94	51.687	Stegastes_partitus
ENSG00000032219	ARID4A	100	98.148	ENSSSCG00000005073	ARID4A	100	92.188	Sus_scrofa
ENSG00000032219	ARID4A	100	90.741	ENSTGUG00000013032	-	100	79.474	Taeniopygia_guttata
ENSG00000032219	ARID4A	98	94.872	ENSTRUG00000008557	arid4a	53	34.018	Takifugu_rubripes
ENSG00000032219	ARID4A	98	94.872	ENSTNIG00000002593	arid4a	59	70.743	Tetraodon_nigroviridis
ENSG00000032219	ARID4A	99	96.958	ENSTBEG00000017302	ARID4A	82	89.222	Tupaia_belangeri
ENSG00000032219	ARID4A	100	96.296	ENSUAMG00000007706	ARID4A	99	92.931	Ursus_americanus
ENSG00000032219	ARID4A	100	100.000	ENSUMAG00000016791	ARID4A	99	93.584	Ursus_maritimus
ENSG00000032219	ARID4A	98	100.000	ENSVPAG00000003645	ARID4A	93	92.352	Vicugna_pacos
ENSG00000032219	ARID4A	100	100.000	ENSVVUG00000029542	ARID4A	100	94.118	Vulpes_vulpes
ENSG00000032219	ARID4A	98	100.000	ENSXETG00000011968	arid4a	96	81.928	Xenopus_tropicalis
ENSG00000032219	ARID4A	98	97.436	ENSXMAG00000004904	arid4a	70	63.918	Xiphophorus_maculatus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	-	ISA	Function
GO:0003677	DNA binding	15640446.	IDA	Function
GO:0005634	nucleus	21873635.	IBA	Component
GO:0005654	nucleoplasm	-	IDA	Component
GO:0005654	nucleoplasm	-	TAS	Component
GO:0005829	cytosol	-	IDA	Component
GO:0005886	plasma membrane	-	IDA	Component
GO:0006349	regulation of gene expression by genetic imprinting	-	IEA	Process
GO:0006357	regulation of transcription by RNA polymerase II	21873635.	IBA	Process
GO:0007283	spermatogenesis	-	IEA	Process
GO:0017053	transcriptional repressor complex	11283269.	IDA	Component
GO:0034773	histone H4-K20 trimethylation	-	IEA	Process
GO:0036124	histone H3-K9 trimethylation	-	IEA	Process
GO:0044212	transcription regulatory region DNA binding	21873635.	IBA	Function
GO:0045892	negative regulation of transcription, DNA-templated	12724404.	IDA	Process
GO:0045944	positive regulation of transcription by RNA polymerase II	-	IEA	Process
GO:0048821	erythrocyte development	-	IEA	Process
GO:0080182	histone H3-K4 trimethylation	-	IEA	Process
GO:0097368	establishment of Sertoli cell barrier	-	IEA	Process