EuRBPDB

Description

RBDs

RBPome

Literatures

Expression

Transcripts

Gene Model

Phenotypes

GWAS

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000033030 (Gene tree)
Gene ID: 55596
Gene Symbol: ZCCHC8
Alias: DKFZp434E2220
Full Name: zinc finger CCHC-type containing 8
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Minus strand
Length: 29,475 bases
Position: chr12:122,471,599-122,501,073
Accession: 25265
RBP type: canonical RBP
Summary: This gene encodes a scaffold protein which serves as an assessory factor to the nuclear RNA exosome complex. The encoded protein forms a trimeric human nuclear exosome targeting (NEXT) complex, together with hMTR4 and the RNA-binding factor RBM7 which promotes the exosomal degradation of non-coding promoter-upstream transcripts, enhancer RNAs and 3'-extended products of histone- and small nuclear RNA transcription. This complex is also thought to recruit the exosome to degrade intronic RNAs via its interaction with both the exosome and the spliceosome. It contains both an N-terminal zinc-knuckle domain and a C-terminal proline-rich domain. [provided by RefSeq, Apr 2017]

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000488055	zf-CCHC	PF00098.23	0.00016	1	1

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & HEK293	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
29431736	Capturing the interactome of newly transcribed RNA	PolyT-RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
22658674	Insights into RNA biology from an atlas of mammalian mRNA-binding proteins	RIC & Hela	2012 May 31	Castello A	DOI: 10.1016/j.cell.2012.04.031
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & Hela	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & MCF10A	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & MCF7	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & U2OS	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
16263084	Zcchc8 is a glycogen synthase kinase-3 substrate that interacts with RNA-binding proteins.	Biochem Biophys Res Commun	2005 Dec 23	Gustafson MP	-
21855801	Interaction profiling identifies the human nuclear exosome targeting complex.	Mol Cell	2011 Aug 19	Lubas M	doi: 10.1016/j.molcel.2011.06.028.
27871484	Identification of a Nuclear Exosome Decay Pathway for Processed Transcripts.	Mol Cell	2016 Nov 3	Meola N	doi: 10.1016/j.molcel.2016.09.025
29844170	Structural basis for MTR4-ZCCHC8 interactions that stimulate the MTR4 helicase in the nuclear exosome-targeting complex.	Proc Natl Acad Sci U S A	2018 Jun 12	Puno MR	doi: 10.1073/pnas.1803530115

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000536306	ZCCHC8-201	2904	XM_024449044	ENSP00000441423	469 (aa)	XP_024304812	Q6NZY4
ENST00000633063	ZCCHC8-210	2955	XM_017019606	ENSP00000488055	707 (aa)	XP_016875095	Q6NZY4
ENST00000538493	ZCCHC8-204	1142	-	-	- (aa)	-	-
ENST00000538116	ZCCHC8-203	1829	-	-	- (aa)	-	-
ENST00000540586	ZCCHC8-205	1250	-	ENSP00000440234	38 (aa)	-	F5GYI9
ENST00000546149	ZCCHC8-209	657	-	-	- (aa)	-	-
ENST00000544054	ZCCHC8-208	1561	-	ENSP00000441112	211 (aa)	-	F5GX80
ENST00000536663	ZCCHC8-202	1252	-	ENSP00000437578	185 (aa)	-	F5H6J5
ENST00000542892	ZCCHC8-206	1774	-	-	- (aa)	-	-
ENST00000543897	ZCCHC8-207	5663	-	ENSP00000438993	469 (aa)	-	Q6NZY4

Gene Model

Click here to download ENSG00000033030's gene model file

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000033030	Atrial Fibrillation	8E-7	27790247
ENSG00000033030	Blood Pressure	8E-7	27790247
ENSG00000033030	Cholesterol	8E-7	27790247
ENSG00000033030	Coronary Disease	8E-7	27790247
ENSG00000033030	Diabetes Mellitus	8E-7	27790247
ENSG00000033030	Electrocardiography	8E-7	27790247
ENSG00000033030	Glucose	8E-7	27790247
ENSG00000033030	Heart Failure	8E-7	27790247
ENSG00000033030	Hematocrit	8E-7	27790247
ENSG00000033030	Cholesterol, HDL	8E-7	27790247
ENSG00000033030	Mortality	8E-7	27790247
ENSG00000033030	Neoplasms	8E-7	27790247
ENSG00000033030	Triglycerides	8E-7	27790247
ENSG00000033030	Body Mass Index	8E-7	27790247
ENSG00000033030	Stroke	8E-7	27790247
ENSG00000033030	Blood Pressure	4E-6	27790247
ENSG00000033030	Cholesterol	4E-6	27790247
ENSG00000033030	Electrocardiography	4E-6	27790247
ENSG00000033030	Glucose	4E-6	27790247
ENSG00000033030	Hematocrit	4E-6	27790247
ENSG00000033030	Cholesterol, HDL	4E-6	27790247
ENSG00000033030	Triglycerides	4E-6	27790247
ENSG00000033030	Body Mass Index	4E-6	27790247

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000033030	rs12369179	12	122479003	?	Age-related disease endophenotypes	27790247			EFO_0004574\|EFO_0006336\|EFO_0004530\|EFO_0006335\|EFO_0004348\|EFO_0007928\|EFO_0004468\|EFO_0004340\|EFO_0004612
ENSG00000033030	rs10773208	12	122485609	T	Educational attainment (years of education)	30038396	[0.0079-0.0141] unit decrease	0.011	EFO_0004784
ENSG00000033030	rs77786029	12	122496512	?	Red cell distribution width	30595370			EFO_0005192

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000033030's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000033030	ZCCHC8	100	97.368	ENSAMEG00000014731	ZCCHC8	100	83.989	Ailuropoda_melanoleuca
ENSG00000033030	ZCCHC8	96	50.244	ENSACIG00000002185	zcchc8	79	60.417	Amphilophus_citrinellus
ENSG00000033030	ZCCHC8	100	92.105	ENSAPLG00000007582	ZCCHC8	92	66.168	Anas_platyrhynchos
ENSG00000033030	ZCCHC8	100	100.000	ENSANAG00000035627	ZCCHC8	100	94.915	Aotus_nancymaae
ENSG00000033030	ZCCHC8	100	97.368	ENSBTAG00000006114	ZCCHC8	100	85.896	Bos_taurus
ENSG00000033030	ZCCHC8	100	97.838	ENSCJAG00000020409	ZCCHC8	100	93.099	Callithrix_jacchus
ENSG00000033030	ZCCHC8	100	92.105	ENSCAFG00000007859	ZCCHC8	100	86.639	Canis_familiaris
ENSG00000033030	ZCCHC8	100	92.105	ENSCAFG00020016406	ZCCHC8	99	85.785	Canis_lupus_dingo
ENSG00000033030	ZCCHC8	100	97.368	ENSCHIG00000000649	ZCCHC8	100	86.096	Capra_hircus
ENSG00000033030	ZCCHC8	100	100.000	ENSTSYG00000011362	ZCCHC8	100	86.723	Carlito_syrichta
ENSG00000033030	ZCCHC8	100	97.368	ENSCAPG00000017455	ZCCHC8	99	80.155	Cavia_aperea
ENSG00000033030	ZCCHC8	100	97.368	ENSCPOG00000014385	ZCCHC8	99	79.805	Cavia_porcellus
ENSG00000033030	ZCCHC8	100	100.000	ENSCCAG00000028625	ZCCHC8	100	93.803	Cebus_capucinus
ENSG00000033030	ZCCHC8	100	97.368	ENSCATG00000041134	ZCCHC8	100	96.747	Cercocebus_atys
ENSG00000033030	ZCCHC8	100	100.000	ENSCSAG00000002121	ZCCHC8	100	91.268	Chlorocebus_sabaeus
ENSG00000033030	ZCCHC8	100	84.211	ENSCPBG00000002676	ZCCHC8	100	65.170	Chrysemys_picta_bellii
ENSG00000033030	ZCCHC8	54	41.905	ENSCSAVG00000011682	-	91	35.548	Ciona_savignyi
ENSG00000033030	ZCCHC8	100	92.105	ENSCGRG00001023706	Zcchc8	100	82.113	Cricetulus_griseus_chok1gshd
ENSG00000033030	ZCCHC8	100	92.105	ENSCGRG00000015199	Zcchc8	100	82.113	Cricetulus_griseus_crigri
ENSG00000033030	ZCCHC8	100	100.000	ENSDNOG00000046140	-	100	86.230	Dasypus_novemcinctus
ENSG00000033030	ZCCHC8	100	97.368	ENSDORG00000008756	Zcchc8	100	83.192	Dipodomys_ordii
ENSG00000033030	ZCCHC8	99	78.571	ENSETEG00000004735	ZCCHC8	91	76.471	Echinops_telfairi
ENSG00000033030	ZCCHC8	100	97.368	ENSEASG00005012441	ZCCHC8	97	87.102	Equus_asinus_asinus
ENSG00000033030	ZCCHC8	100	97.368	ENSECAG00000006984	ZCCHC8	100	87.853	Equus_caballus
ENSG00000033030	ZCCHC8	99	90.476	ENSFCAG00000027671	ZCCHC8	100	88.999	Felis_catus
ENSG00000033030	ZCCHC8	100	76.316	ENSFALG00000009102	ZCCHC8	99	62.857	Ficedula_albicollis
ENSG00000033030	ZCCHC8	100	94.737	ENSFDAG00000010964	ZCCHC8	87	90.244	Fukomys_damarensis
ENSG00000033030	ZCCHC8	100	84.211	ENSGALG00000004486	ZCCHC8	99	63.885	Gallus_gallus
ENSG00000033030	ZCCHC8	97	53.297	ENSGACG00000008163	zcchc8	99	43.169	Gasterosteus_aculeatus
ENSG00000033030	ZCCHC8	100	81.579	ENSGAGG00000007842	ZCCHC8	100	65.306	Gopherus_agassizii
ENSG00000033030	ZCCHC8	100	92.105	ENSSTOG00000001683	ZCCHC8	100	87.006	Ictidomys_tridecemlineatus
ENSG00000033030	ZCCHC8	99	89.100	ENSJJAG00000011650	Zcchc8	100	82.405	Jaculus_jaculus
ENSG00000033030	ZCCHC8	100	89.474	ENSLAFG00000016477	ZCCHC8	100	83.053	Loxodonta_africana
ENSG00000033030	ZCCHC8	100	100.000	ENSMFAG00000045203	ZCCHC8	100	96.888	Macaca_fascicularis
ENSG00000033030	ZCCHC8	100	100.000	ENSMMUG00000013643	ZCCHC8	100	96.605	Macaca_mulatta
ENSG00000033030	ZCCHC8	100	100.000	ENSMLEG00000031615	ZCCHC8	100	93.777	Mandrillus_leucophaeus
ENSG00000033030	ZCCHC8	100	84.211	ENSMGAG00000004799	ZCCHC8	99	64.565	Meleagris_gallopavo
ENSG00000033030	ZCCHC8	100	89.474	ENSMAUG00000018909	Zcchc8	100	82.278	Mesocricetus_auratus
ENSG00000033030	ZCCHC8	100	97.368	ENSMICG00000013486	ZCCHC8	100	88.434	Microcebus_murinus
ENSG00000033030	ZCCHC8	97	52.717	ENSMMOG00000017082	zcchc8	99	38.492	Mola_mola
ENSG00000033030	ZCCHC8	100	92.105	ENSMODG00000012264	ZCCHC8	100	71.774	Monodelphis_domestica
ENSG00000033030	ZCCHC8	100	89.474	MGP_CAROLIEiJ_G0027732	Zcchc8	100	77.388	Mus_caroli
ENSG00000033030	ZCCHC8	100	89.474	ENSMUSG00000029427	Zcchc8	100	79.747	Mus_musculus
ENSG00000033030	ZCCHC8	100	92.105	MGP_PahariEiJ_G0024312	Zcchc8	100	80.450	Mus_pahari
ENSG00000033030	ZCCHC8	100	89.474	MGP_SPRETEiJ_G0028730	Zcchc8	100	79.747	Mus_spretus
ENSG00000033030	ZCCHC8	100	94.737	ENSMPUG00000001986	ZCCHC8	100	87.429	Mustela_putorius_furo
ENSG00000033030	ZCCHC8	100	94.737	ENSMLUG00000005334	ZCCHC8	100	83.731	Myotis_lucifugus
ENSG00000033030	ZCCHC8	100	94.737	ENSNGAG00000015385	Zcchc8	100	82.682	Nannospalax_galili
ENSG00000033030	ZCCHC8	100	100.000	ENSNLEG00000001723	ZCCHC8	100	99.010	Nomascus_leucogenys
ENSG00000033030	ZCCHC8	100	86.842	ENSMEUG00000003497	ZCCHC8	100	75.659	Notamacropus_eugenii
ENSG00000033030	ZCCHC8	100	89.474	ENSOPRG00000013758	ZCCHC8	100	74.298	Ochotona_princeps
ENSG00000033030	ZCCHC8	100	86.842	ENSOANG00000006199	ZCCHC8	100	68.328	Ornithorhynchus_anatinus
ENSG00000033030	ZCCHC8	100	100.000	ENSOCUG00000013759	ZCCHC8	100	85.373	Oryctolagus_cuniculus
ENSG00000033030	ZCCHC8	100	97.368	ENSOGAG00000015900	ZCCHC8	100	87.728	Otolemur_garnettii
ENSG00000033030	ZCCHC8	100	97.368	ENSOARG00000010728	ZCCHC8	100	85.035	Ovis_aries
ENSG00000033030	ZCCHC8	100	100.000	ENSPPAG00000044102	ZCCHC8	100	99.717	Pan_paniscus
ENSG00000033030	ZCCHC8	99	90.476	ENSPPRG00000023848	ZCCHC8	100	88.293	Panthera_pardus
ENSG00000033030	ZCCHC8	99	90.476	ENSPTIG00000017015	ZCCHC8	100	88.717	Panthera_tigris_altaica
ENSG00000033030	ZCCHC8	100	100.000	ENSPTRG00000005579	ZCCHC8	100	99.717	Pan_troglodytes
ENSG00000033030	ZCCHC8	100	80.645	ENSPSIG00000011004	ZCCHC8	94	63.776	Pelodiscus_sinensis
ENSG00000033030	ZCCHC8	100	45.794	ENSPMGG00000000988	zcchc8	96	41.121	Periophthalmus_magnuspinnatus
ENSG00000033030	ZCCHC8	100	92.105	ENSPEMG00000007962	Zcchc8	100	81.793	Peromyscus_maniculatus_bairdii
ENSG00000033030	ZCCHC8	100	85.405	ENSPCIG00000028643	ZCCHC8	99	70.219	Phascolarctos_cinereus
ENSG00000033030	ZCCHC8	100	100.000	ENSPPYG00000005068	ZCCHC8	100	91.748	Pongo_abelii
ENSG00000033030	ZCCHC8	100	92.105	ENSPCAG00000016551	ZCCHC8	100	76.305	Procavia_capensis
ENSG00000033030	ZCCHC8	100	97.368	ENSPCOG00000014512	ZCCHC8	100	84.485	Propithecus_coquereli
ENSG00000033030	ZCCHC8	100	92.105	ENSPVAG00000001276	ZCCHC8	100	84.605	Pteropus_vampyrus
ENSG00000033030	ZCCHC8	100	92.105	ENSRNOG00000001243	Zcchc8	100	80.141	Rattus_norvegicus
ENSG00000033030	ZCCHC8	100	77.465	ENSRBIG00000044855	ZCCHC8	100	77.465	Rhinopithecus_bieti
ENSG00000033030	ZCCHC8	100	100.000	ENSRROG00000030441	ZCCHC8	100	97.313	Rhinopithecus_roxellana
ENSG00000033030	ZCCHC8	100	100.000	ENSSBOG00000032964	ZCCHC8	100	93.785	Saimiri_boliviensis_boliviensis
ENSG00000033030	ZCCHC8	100	89.474	ENSSHAG00000010725	ZCCHC8	99	67.538	Sarcophilus_harrisii
ENSG00000033030	ZCCHC8	97	58.659	ENSSFOG00015018295	zcchc8	99	49.866	Scleropages_formosus
ENSG00000033030	ZCCHC8	99	70.000	ENSSARG00000003982	ZCCHC8	100	69.108	Sorex_araneus
ENSG00000033030	ZCCHC8	100	89.474	ENSSPUG00000011326	ZCCHC8	95	63.682	Sphenodon_punctatus
ENSG00000033030	ZCCHC8	100	97.368	ENSSSCG00000009792	ZCCHC8	89	86.319	Sus_scrofa
ENSG00000033030	ZCCHC8	100	78.947	ENSTGUG00000006286	ZCCHC8	100	63.020	Taeniopygia_guttata
ENSG00000033030	ZCCHC8	91	53.216	ENSTRUG00000008040	zcchc8	93	45.542	Takifugu_rubripes
ENSG00000033030	ZCCHC8	97	52.198	ENSTNIG00000015824	zcchc8	99	42.916	Tetraodon_nigroviridis
ENSG00000033030	ZCCHC8	100	92.105	ENSTTRG00000015809	ZCCHC8	100	83.898	Tursiops_truncatus
ENSG00000033030	ZCCHC8	100	97.368	ENSUAMG00000013723	ZCCHC8	97	88.217	Ursus_americanus
ENSG00000033030	ZCCHC8	100	97.368	ENSUMAG00000005282	ZCCHC8	100	88.045	Ursus_maritimus
ENSG00000033030	ZCCHC8	100	92.105	ENSVVUG00000017779	ZCCHC8	99	85.382	Vulpes_vulpes
ENSG00000033030	ZCCHC8	100	73.684	ENSXETG00000007797	zcchc8	99	54.913	Xenopus_tropicalis

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000398	mRNA splicing, via spliceosome	11991638.	IC	Process
GO:0003723	RNA binding	22658674.	HDA	Function
GO:0005515	protein binding	16263084.17525332.27871484.27905398.	IPI	Function
GO:0005634	nucleus	21855801.	IDA	Component
GO:0005654	nucleoplasm	16263084.	IDA	Component
GO:0005730	nucleolus	21855801.	IDA	Component
GO:0008270	zinc ion binding	-	IEA	Function
GO:0016604	nuclear body	-	IDA	Component
GO:0031499	TRAMP complex	21855801.	IDA	Component
GO:0071013	catalytic step 2 spliceosome	11991638.	IDA	Component