EuRBPDB

Basic Information
Cancer Related Information

Description

RBDs

Expression

Transcripts

Gene Model

Pathways

Phenotypes

GWAS

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000035664 (Gene tree)
Gene ID: 23604
Gene Symbol: DAPK2
Alias: DRP-1|MGC119312
Full Name: death associated protein kinase 2
Gene Type: protein_coding
Species: Homo_sapiens
Status: putative
Strand: Minus strand
Length: 164,998 bases
Position: chr15:63,907,036-64,072,033
Accession: 2675
RBP type: canonical RBP
Summary: This gene encodes a protein that belongs to the serine/threonine protein kinase family. This protein contains a N-terminal protein kinase domain followed by a conserved calmodulin-binding domain with significant similarity to that of death-associated protein kinase 1 (DAPK1), a positive regulator of programmed cell death. Overexpression of this gene was shown to induce cell apoptosis. It uses multiple polyadenylation sites. [provided by RefSeq, Jul 2008]

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000261891	RIO1	PF01163.22	7.2e-05	1	1
ENSP00000408277	RIO1	PF01163.22	7.2e-05	1	1
ENSP00000453235	RIO1	PF01163.22	9.6e-05	1	1
ENSP00000484390	RIO1	PF01163.22	9.6e-05	1	1

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000559007	DAPK2-208	4835	-	ENSP00000453639	91 (aa)	-	H0YMK1
ENST00000261891	DAPK2-201	2603	XM_011521413	ENSP00000261891	370 (aa)	XP_011519715	Q9UIK4
ENST00000457488	DAPK2-202	1741	XM_011521421	ENSP00000408277	370 (aa)	XP_011519723	Q9UIK4
ENST00000561162	DAPK2-212	566	-	ENSP00000453284	88 (aa)	-	H0YLP5
ENST00000559306	DAPK2-209	724	-	ENSP00000452970	80 (aa)	-	H0YKW8
ENST00000557867	DAPK2-203	537	-	-	- (aa)	-	-
ENST00000558069	DAPK2-205	1473	XM_011521416	ENSP00000453235	488 (aa)	XP_011519718	Q9UIK4
ENST00000559897	DAPK2-211	570	-	-	- (aa)	-	-
ENST00000612884	DAPK2-213	8086	XM_011521415	ENSP00000484390	488 (aa)	XP_011519717	Q9UIK4
ENST00000558482	DAPK2-207	909	-	-	- (aa)	-	-
ENST00000559731	DAPK2-210	539	-	-	- (aa)	-	-
ENST00000558076	DAPK2-206	484	-	-	- (aa)	-	-
ENST00000558064	DAPK2-204	584	-	ENSP00000453101	48 (aa)	-	H0YL86

Gene Model

Click here to download ENSG00000035664's gene model file

Pathways

Pathway ID	Pathway Name	Source
hsa04140	Autophagy - animal	KEGG
hsa05200	Pathways in cancer	KEGG
hsa05219	Bladder cancer	KEGG

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000035664	Venous Thromboembolism	3E-6	28203683

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000035664	rs922182	15	63985443	T	Blood protein levels	28240269	[0.29-0.46] unit increase	0.3768	EFO_0008107
ENSG00000035664	rs141207816	15	64057415	A	Platelet distribution width	27863252	[0.17-0.33] unit increase	0.2472325	EFO_0007984
ENSG00000035664	rs332288	15	64017067	T	Venous thromboembolism adjusted for sickle cell variant rs77121243-T	28203683	[1.404-2.284]	1.791	EFO_0004286
ENSG00000035664	rs9806191	15	63945957	?	Cerebrospinal fluid t-tau:AB1-42 ratio	28641921			EFO_0007708
ENSG00000035664	rs12908891	15	63944242	G	Cerebral amyloid deposition (PET imaging)	30361487	[NR] unit increase	0.06	EFO_0007707

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000035664's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000035664	DAPK2	99	78.082	ENSAPOG00000006757	dapk2b	100	78.082	Acanthochromis_polyacanthus
ENSG00000035664	DAPK2	99	75.956	ENSACIG00000002463	dapk2b	100	75.956	Amphilophus_citrinellus
ENSG00000035664	DAPK2	94	81.333	ENSAOCG00000005331	-	100	78.356	Amphiprion_ocellaris
ENSG00000035664	DAPK2	94	81.333	ENSAPEG00000019722	dapk2b	100	78.356	Amphiprion_percula
ENSG00000035664	DAPK2	88	74.286	ENSATEG00000021989	-	99	63.355	Anabas_testudineus
ENSG00000035664	DAPK2	99	74.521	ENSATEG00000007816	dapk2b	100	74.521	Anabas_testudineus
ENSG00000035664	DAPK2	95	69.014	ENSANAG00000032154	DAPK1	92	77.576	Aotus_nancymaae
ENSG00000035664	DAPK2	100	98.649	ENSANAG00000025796	DAPK2	100	98.649	Aotus_nancymaae
ENSG00000035664	DAPK2	88	74.286	ENSACLG00000011302	-	99	63.797	Astatotilapia_calliptera
ENSG00000035664	DAPK2	88	82.857	ENSACLG00000001586	dapk2a	98	84.865	Astatotilapia_calliptera
ENSG00000035664	DAPK2	99	76.738	ENSAMXG00000038379	dapk2b	100	76.738	Astyanax_mexicanus
ENSG00000035664	DAPK2	88	72.857	ENSAMXG00000012193	dapk1	90	75.135	Astyanax_mexicanus
ENSG00000035664	DAPK2	88	77.143	ENSAMXG00000040439	-	98	64.222	Astyanax_mexicanus
ENSG00000035664	DAPK2	88	78.571	ENSAMXG00000010743	dapk2a	99	67.012	Astyanax_mexicanus
ENSG00000035664	DAPK2	100	98.750	ENSCJAG00000004806	DAPK2	100	98.649	Callithrix_jacchus
ENSG00000035664	DAPK2	100	96.486	ENSCAFG00020009392	DAPK2	100	96.486	Canis_lupus_dingo
ENSG00000035664	DAPK2	100	91.250	ENSCHIG00000002285	DAPK2	100	88.800	Capra_hircus
ENSG00000035664	DAPK2	100	97.500	ENSTSYG00000012419	DAPK2	100	95.946	Carlito_syrichta
ENSG00000035664	DAPK2	88	75.714	ENSCAPG00000010131	-	99	82.239	Cavia_aperea
ENSG00000035664	DAPK2	99	91.139	ENSCAPG00000008062	DAPK2	99	87.601	Cavia_aperea
ENSG00000035664	DAPK2	99	94.809	ENSCPOG00000000890	DAPK2	99	94.809	Cavia_porcellus
ENSG00000035664	DAPK2	100	98.750	ENSCCAG00000026794	DAPK2	100	98.649	Cebus_capucinus
ENSG00000035664	DAPK2	100	98.649	ENSCATG00000043801	DAPK2	100	98.649	Cercocebus_atys
ENSG00000035664	DAPK2	99	96.467	ENSCLAG00000013163	DAPK2	99	96.467	Chinchilla_lanigera
ENSG00000035664	DAPK2	100	97.500	ENSCSAG00000012418	DAPK2	94	99.052	Chlorocebus_sabaeus
ENSG00000035664	DAPK2	100	99.189	ENSCANG00000039986	DAPK2	100	99.189	Colobus_angolensis_palliatus
ENSG00000035664	DAPK2	100	97.297	ENSCGRG00001014149	Dapk2	100	97.297	Cricetulus_griseus_chok1gshd
ENSG00000035664	DAPK2	88	74.286	ENSCGRG00000002758	-	92	77.113	Cricetulus_griseus_crigri
ENSG00000035664	DAPK2	100	97.297	ENSCGRG00000013909	Dapk2	100	97.297	Cricetulus_griseus_crigri
ENSG00000035664	DAPK2	100	66.250	ENSCSEG00000014457	-	98	64.459	Cynoglossus_semilaevis
ENSG00000035664	DAPK2	95	78.348	ENSCSEG00000002398	dapk2b	100	77.260	Cynoglossus_semilaevis
ENSG00000035664	DAPK2	99	77.534	ENSCVAG00000021743	dapk2b	100	77.534	Cyprinodon_variegatus
ENSG00000035664	DAPK2	88	82.857	ENSCVAG00000022652	dapk2a	98	69.897	Cyprinodon_variegatus
ENSG00000035664	DAPK2	88	80.000	ENSDARG00000061096	dapk2a	99	67.635	Danio_rerio
ENSG00000035664	DAPK2	99	74.731	ENSDARG00000103666	dapk2b	100	74.731	Danio_rerio
ENSG00000035664	DAPK2	88	75.714	ENSDORG00000012226	-	99	79.636	Dipodomys_ordii
ENSG00000035664	DAPK2	99	94.521	ENSETEG00000001356	DAPK2	99	94.521	Echinops_telfairi
ENSG00000035664	DAPK2	72	62.825	ENSEBUG00000004869	-	68	62.825	Eptatretus_burgeri
ENSG00000035664	DAPK2	88	75.714	ENSELUG00000000497	lsm7	89	63.288	Esox_lucius
ENSG00000035664	DAPK2	97	75.623	ENSELUG00000003738	dapk2b	100	75.623	Esox_lucius
ENSG00000035664	DAPK2	100	97.297	ENSFCAG00000004177	DAPK2	100	97.297	Felis_catus
ENSG00000035664	DAPK2	88	74.286	ENSFDAG00000015227	-	73	79.636	Fukomys_damarensis
ENSG00000035664	DAPK2	99	76.986	ENSFHEG00000001863	dapk2b	100	76.986	Fundulus_heteroclitus
ENSG00000035664	DAPK2	95	65.352	ENSFHEG00000022183	dapk1	95	69.730	Fundulus_heteroclitus
ENSG00000035664	DAPK2	88	75.714	ENSGALG00000037733	-	99	63.319	Gallus_gallus
ENSG00000035664	DAPK2	99	76.712	ENSGAFG00000020656	dapk2b	100	76.712	Gambusia_affinis
ENSG00000035664	DAPK2	95	77.273	ENSGACG00000010201	dapk2b	99	76.022	Gasterosteus_aculeatus
ENSG00000035664	DAPK2	88	84.286	ENSGACG00000017307	dapk2a	99	71.302	Gasterosteus_aculeatus
ENSG00000035664	DAPK2	65	82.917	ENSGAGG00000008137	DAPK2	96	82.917	Gopherus_agassizii
ENSG00000035664	DAPK2	100	99.730	ENSGGOG00000016537	-	100	99.730	Gorilla_gorilla
ENSG00000035664	DAPK2	88	82.857	ENSHBUG00000023341	dapk2a	98	84.865	Haplochromis_burtoni
ENSG00000035664	DAPK2	99	95.924	ENSHGLG00000013578	DAPK2	100	95.890	Heterocephalus_glaber_female
ENSG00000035664	DAPK2	99	95.924	ENSHGLG00100013869	DAPK2	99	95.924	Heterocephalus_glaber_male
ENSG00000035664	DAPK2	88	72.857	ENSHCOG00000000788	-	99	62.806	Hippocampus_comes
ENSG00000035664	DAPK2	99	78.415	ENSHCOG00000013506	dapk2b	100	78.415	Hippocampus_comes
ENSG00000035664	DAPK2	86	66.562	ENSHCOG00000015155	-	85	66.562	Hippocampus_comes
ENSG00000035664	DAPK2	99	78.649	ENSIPUG00000021663	dapk2	100	78.649	Ictalurus_punctatus
ENSG00000035664	DAPK2	88	77.143	ENSIPUG00000014879	DAPK3	99	63.576	Ictalurus_punctatus
ENSG00000035664	DAPK2	100	97.297	ENSSTOG00000016080	DAPK2	100	97.297	Ictidomys_tridecemlineatus
ENSG00000035664	DAPK2	63	82.000	ENSJJAG00000000350	-	99	80.952	Jaculus_jaculus
ENSG00000035664	DAPK2	100	96.250	ENSJJAG00000017017	Dapk2	100	94.595	Jaculus_jaculus
ENSG00000035664	DAPK2	99	76.164	ENSKMAG00000018440	dapk2b	100	76.164	Kryptolebias_marmoratus
ENSG00000035664	DAPK2	94	82.667	ENSLBEG00000017027	dapk2b	100	76.164	Labrus_bergylta
ENSG00000035664	DAPK2	99	80.000	ENSLOCG00000014848	dapk2b	100	80.000	Lepisosteus_oculatus
ENSG00000035664	DAPK2	98	95.580	ENSLAFG00000000338	DAPK2	99	95.580	Loxodonta_africana
ENSG00000035664	DAPK2	100	98.919	ENSMFAG00000028166	DAPK2	100	98.919	Macaca_fascicularis
ENSG00000035664	DAPK2	100	98.919	ENSMMUG00000018177	DAPK2	100	98.919	Macaca_mulatta
ENSG00000035664	DAPK2	100	98.108	ENSMNEG00000037814	DAPK2	100	98.108	Macaca_nemestrina
ENSG00000035664	DAPK2	100	98.649	ENSMLEG00000033599	DAPK2	100	98.649	Mandrillus_leucophaeus
ENSG00000035664	DAPK2	88	74.286	ENSMAMG00000002171	-	99	63.355	Mastacembelus_armatus
ENSG00000035664	DAPK2	99	75.342	ENSMAMG00000007325	dapk2b	100	75.342	Mastacembelus_armatus
ENSG00000035664	DAPK2	88	74.286	ENSMZEG00005024465	-	99	64.018	Maylandia_zebra
ENSG00000035664	DAPK2	69	90.945	ENSMGAG00000003962	DAPK2	100	90.945	Meleagris_gallopavo
ENSG00000035664	DAPK2	100	96.486	ENSMAUG00000018956	Dapk2	100	96.486	Mesocricetus_auratus
ENSG00000035664	DAPK2	88	77.143	ENSMICG00000017284	DAPK1	98	77.297	Microcebus_murinus
ENSG00000035664	DAPK2	100	97.838	ENSMICG00000011065	DAPK2	100	97.838	Microcebus_murinus
ENSG00000035664	DAPK2	100	97.297	ENSMOCG00000014779	Dapk2	100	97.297	Microtus_ochrogaster
ENSG00000035664	DAPK2	99	77.112	ENSMMOG00000003023	dapk2b	90	77.112	Mola_mola
ENSG00000035664	DAPK2	94	89.333	ENSMODG00000010926	DAPK2	99	83.230	Monodelphis_domestica
ENSG00000035664	DAPK2	88	65.714	ENSMALG00000021065	dapk1	89	66.234	Monopterus_albus
ENSG00000035664	DAPK2	99	76.712	ENSMALG00000008825	dapk2b	100	76.712	Monopterus_albus
ENSG00000035664	DAPK2	88	74.286	ENSMALG00000018692	-	99	63.797	Monopterus_albus
ENSG00000035664	DAPK2	100	97.297	MGP_CAROLIEiJ_G0032377	Dapk2	100	97.297	Mus_caroli
ENSG00000035664	DAPK2	100	97.297	ENSMUSG00000032380	Dapk2	100	97.297	Mus_musculus
ENSG00000035664	DAPK2	100	97.297	MGP_PahariEiJ_G0015242	Dapk2	100	97.297	Mus_pahari
ENSG00000035664	DAPK2	100	97.027	MGP_SPRETEiJ_G0033516	Dapk2	100	97.027	Mus_spretus
ENSG00000035664	DAPK2	100	97.500	ENSMPUG00000000608	DAPK2	93	97.027	Mustela_putorius_furo
ENSG00000035664	DAPK2	83	54.545	ENSNBRG00000003426	-	96	66.298	Neolamprologus_brichardi
ENSG00000035664	DAPK2	88	74.286	ENSNBRG00000011614	-	99	64.238	Neolamprologus_brichardi
ENSG00000035664	DAPK2	100	100.000	ENSNLEG00000012381	-	100	100.000	Nomascus_leucogenys
ENSG00000035664	DAPK2	88	74.286	ENSONIG00000018617	-	99	64.018	Oreochromis_niloticus
ENSG00000035664	DAPK2	99	95.902	ENSOCUG00000000435	DAPK2	100	95.902	Oryctolagus_cuniculus
ENSG00000035664	DAPK2	88	75.714	ENSORLG00000017965	-	96	64.062	Oryzias_latipes
ENSG00000035664	DAPK2	99	75.616	ENSORLG00000007399	dapk2b	100	75.616	Oryzias_latipes
ENSG00000035664	DAPK2	99	75.616	ENSORLG00020006496	dapk2b	100	75.616	Oryzias_latipes_hni
ENSG00000035664	DAPK2	88	75.714	ENSORLG00020004064	-	98	62.806	Oryzias_latipes_hni
ENSG00000035664	DAPK2	88	75.714	ENSORLG00015003938	-	96	64.062	Oryzias_latipes_hsok
ENSG00000035664	DAPK2	73	80.074	ENSORLG00015010313	DAPK2	81	79.562	Oryzias_latipes_hsok
ENSG00000035664	DAPK2	99	75.890	ENSORLG00015020580	dapk2b	100	75.890	Oryzias_latipes_hsok
ENSG00000035664	DAPK2	98	92.887	ENSOGAG00000027766	DAPK2	100	92.887	Otolemur_garnettii
ENSG00000035664	DAPK2	100	100.000	ENSPPAG00000036415	DAPK2	100	100.000	Pan_paniscus
ENSG00000035664	DAPK2	100	97.568	ENSPPRG00000007000	DAPK2	100	97.568	Panthera_pardus
ENSG00000035664	DAPK2	100	97.568	ENSPTIG00000020724	DAPK2	100	97.568	Panthera_tigris_altaica
ENSG00000035664	DAPK2	100	100.000	ENSPTRG00000007152	DAPK2	100	100.000	Pan_troglodytes
ENSG00000035664	DAPK2	100	98.919	ENSPANG00000016876	DAPK2	100	98.919	Papio_anubis
ENSG00000035664	DAPK2	88	72.857	ENSPKIG00000005889	-	99	61.454	Paramormyrops_kingsleyae
ENSG00000035664	DAPK2	94	78.797	ENSPKIG00000000674	DAPK2	100	77.260	Paramormyrops_kingsleyae
ENSG00000035664	DAPK2	96	84.416	ENSPSIG00000015800	DAPK2	87	81.593	Pelodiscus_sinensis
ENSG00000035664	DAPK2	99	69.589	ENSPMGG00000004055	dapk2b	100	69.589	Periophthalmus_magnuspinnatus
ENSG00000035664	DAPK2	88	74.286	ENSPEMG00000020977	-	92	73.451	Peromyscus_maniculatus_bairdii
ENSG00000035664	DAPK2	100	97.027	ENSPEMG00000020347	Dapk2	100	97.027	Peromyscus_maniculatus_bairdii
ENSG00000035664	DAPK2	78	69.896	ENSPMAG00000001147	-	100	69.896	Petromyzon_marinus
ENSG00000035664	DAPK2	99	87.123	ENSPCIG00000029457	DAPK2	97	93.805	Phascolarctos_cinereus
ENSG00000035664	DAPK2	99	76.438	ENSPFOG00000005336	dapk2b	100	76.438	Poecilia_formosa
ENSG00000035664	DAPK2	88	74.286	ENSPFOG00000004990	-	99	64.018	Poecilia_formosa
ENSG00000035664	DAPK2	99	76.712	ENSPLAG00000007283	dapk2b	100	76.712	Poecilia_latipinna
ENSG00000035664	DAPK2	88	74.286	ENSPLAG00000015727	-	99	64.018	Poecilia_latipinna
ENSG00000035664	DAPK2	88	74.286	ENSPMEG00000014103	-	99	64.018	Poecilia_mexicana
ENSG00000035664	DAPK2	99	76.022	ENSPMEG00000014459	dapk2b	89	76.022	Poecilia_mexicana
ENSG00000035664	DAPK2	99	76.567	ENSPREG00000009361	dapk2b	94	76.567	Poecilia_reticulata
ENSG00000035664	DAPK2	88	74.286	ENSPREG00000013588	-	99	64.018	Poecilia_reticulata
ENSG00000035664	DAPK2	97	99.444	ENSPPYG00000006543	DAPK2	100	99.444	Pongo_abelii
ENSG00000035664	DAPK2	100	97.568	ENSPCOG00000015063	DAPK2	100	97.568	Propithecus_coquereli
ENSG00000035664	DAPK2	100	97.500	ENSPVAG00000016867	DAPK2	100	93.514	Pteropus_vampyrus
ENSG00000035664	DAPK2	88	74.286	ENSPNYG00000008207	-	90	77.297	Pundamilia_nyererei
ENSG00000035664	DAPK2	88	75.714	ENSPNAG00000010482	-	98	62.670	Pygocentrus_nattereri
ENSG00000035664	DAPK2	94	82.667	ENSPNAG00000013223	dapk2b	100	75.936	Pygocentrus_nattereri
ENSG00000035664	DAPK2	99	96.986	ENSRNOG00000017332	Dapk2	100	96.986	Rattus_norvegicus
ENSG00000035664	DAPK2	100	99.189	ENSRBIG00000029819	DAPK2	100	99.189	Rhinopithecus_bieti
ENSG00000035664	DAPK2	100	99.189	ENSRROG00000029585	DAPK2	100	99.189	Rhinopithecus_roxellana
ENSG00000035664	DAPK2	95	69.014	ENSSBOG00000027113	DAPK1	92	78.443	Saimiri_boliviensis_boliviensis
ENSG00000035664	DAPK2	100	98.750	ENSSBOG00000018728	DAPK2	100	98.378	Saimiri_boliviensis_boliviensis
ENSG00000035664	DAPK2	99	93.973	ENSSHAG00000018240	DAPK2	100	93.973	Sarcophilus_harrisii
ENSG00000035664	DAPK2	99	76.986	ENSSMAG00000015584	dapk2b	100	76.986	Scophthalmus_maximus
ENSG00000035664	DAPK2	99	80.000	ENSSDUG00000008929	dapk2b	99	74.324	Seriola_dumerili
ENSG00000035664	DAPK2	99	77.215	ENSSLDG00000024401	dapk2b	99	70.811	Seriola_lalandi_dorsalis
ENSG00000035664	DAPK2	90	90.090	ENSSPUG00000014936	DAPK2	78	90.090	Sphenodon_punctatus
ENSG00000035664	DAPK2	99	78.630	ENSSPAG00000017851	dapk2b	100	78.630	Stegastes_partitus
ENSG00000035664	DAPK2	97	82.173	ENSTGUG00000003221	DAPK2	99	82.173	Taeniopygia_guttata
ENSG00000035664	DAPK2	99	77.049	ENSTRUG00000012994	dapk2b	99	77.049	Takifugu_rubripes
ENSG00000035664	DAPK2	99	77.384	ENSTNIG00000008407	dapk2b	99	77.384	Tetraodon_nigroviridis
ENSG00000035664	DAPK2	99	95.122	ENSTTRG00000011301	DAPK2	99	95.122	Tursiops_truncatus
ENSG00000035664	DAPK2	100	96.216	ENSUMAG00000012690	DAPK2	96	96.216	Ursus_maritimus
ENSG00000035664	DAPK2	88	74.286	ENSUMAG00000007459	-	82	68.992	Ursus_maritimus
ENSG00000035664	DAPK2	100	96.757	ENSVVUG00000013611	DAPK2	99	96.757	Vulpes_vulpes
ENSG00000035664	DAPK2	97	82.222	ENSXETG00000009747	dapk2	100	82.222	Xenopus_tropicalis
ENSG00000035664	DAPK2	95	75.354	ENSXCOG00000020035	dapk2b	99	75.354	Xiphophorus_couchianus
ENSG00000035664	DAPK2	89	63.908	ENSXCOG00000018726	-	99	63.908	Xiphophorus_couchianus
ENSG00000035664	DAPK2	99	76.712	ENSXMAG00000003350	dapk2b	100	76.712	Xiphophorus_maculatus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0004674	protein serine/threonine kinase activity	21873635.	IBA	Function
GO:0004674	protein serine/threonine kinase activity	16756490.	TAS	Function
GO:0005515	protein binding	25416956.	IPI	Function
GO:0005516	calmodulin binding	10376525.	IDA	Function
GO:0005524	ATP binding	21873635.	IBA	Function
GO:0005524	ATP binding	10376525.	IDA	Function
GO:0005634	nucleus	21873635.	IBA	Component
GO:0005737	cytoplasm	21873635.	IBA	Component
GO:0005737	cytoplasm	10376525.10629061.	IDA	Component
GO:0005794	Golgi apparatus	-	IDA	Component
GO:0006468	protein phosphorylation	10376525.	IDA	Process
GO:0006915	apoptotic process	10629061.	TAS	Process
GO:0010506	regulation of autophagy	16756490.	TAS	Process
GO:0031410	cytoplasmic vesicle	-	IEA	Component
GO:0034423	autophagosome lumen	-	IEA	Component
GO:0035556	intracellular signal transduction	10376525.	IDA	Process
GO:0042802	identical protein binding	10629061.11230133.	IPI	Function
GO:0042981	regulation of apoptotic process	16756490.	TAS	Process
GO:0043231	intracellular membrane-bounded organelle	-	IDA	Component
GO:0043276	anoikis	18957423.	IMP	Process
GO:0046777	protein autophosphorylation	16756490.	TAS	Process
GO:0090023	positive regulation of neutrophil chemotaxis	24163421.	IMP	Process
GO:1990266	neutrophil migration	-	IEA	Process
GO:2000424	positive regulation of eosinophil chemotaxis	24163421.	IMP	Process
GO:2001242	regulation of intrinsic apoptotic signaling pathway	10376525.	IMP	Process

Cancer associated literatures

PID	Title	Article	Time	Author	Doi
27049921	MicroRNA-520g promotes epithelial ovarian cancer progression and chemoresistance via DAPK2 repression.	Oncotarget	2016 May 3	Zhang J	doi: 10.18632/oncotarget.8530.
24038216	The tumor suppressor gene DAPK2 is induced by the myeloid transcription factors PU.1 and C/EBPα during granulocytic differentiation but repressed by PML-RARα in APL.	J Leukoc Biol	2014 Jan	Humbert M	doi: 10.1189/jlb.1112608
12087472	DNA methylation and histone deacetylation associated with silencing DAP kinase gene expression in colorectal and gastric cancers.	Br J Cancer	2002 Jun 5	Satoh A	-
11839665	Hypermethylation of multiple genes in tumor tissues and voided urine in urinary bladder cancer patients.	Clin Cancer Res	2002 Feb	Chan MW	-
25741596	DAPK2 regulates oxidative stress in cancer cells by preserving mitochondrial function.	Cell Death Dis	2015 Mar 5	Schlegel CR	doi: 10.1038/cddis.2015.31.
22160140	Sodium butyrate-induced DAPK-mediated apoptosis in human gastric cancer cells.	Oncol Rep	2012 Apr	Shin H	doi: 10.3892/or.2011.1585

Differential Expression

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq	RBD
BLCA	chr15	63983561	Missense_Mutation	NA	R96S	0.37	RIO1
BLCA	chr15	63983585	Missense_Mutation	novel	T88A	0.28	RIO1
BLCA	chr15	64040248	Nonsense_Mutation	NA	S5*	0.15
BRCA	chr15	64040226	Silent	NA	E12E	0.11
BRCA	chr15	63911813	Intron	novel		0.36
BRCA	chr15	63908575	Missense_Mutation	NA	E353G	0.2
BRCA	chr15	63925946	Missense_Mutation	novel	E269D	0.07
BRCA	chr15	63912157	Missense_Mutation	NA	V300E	0.27
CESC	chr15	63971509	Missense_Mutation	novel	E123K	0.64	RIO1
CESC	chr15	63925981	Missense_Mutation	novel	A258T	0.59
CESC	chr15	63983703	Silent	novel	E48E	0.29
CESC	chr15	63924834	Silent	NA	L280L	0.22
COAD	chr15	63971539	Missense_Mutation	rs553988389	D113N	0.44	RIO1
COAD	chr15	64040208	Missense_Mutation	NA	K18N	0.4
COAD	chr15	63983574	Silent	rs201638173	D91D	0.37
COAD	chr15	63929567	Missense_Mutation	rs140850258	V215I	0.19
COAD	chr15	63926076	Frame_Shift_Del	novel	*P226Lfs17**	0.2
COAD	chr15	63908423	3'UTR	novel		0.27
COAD	chr15	63911792	Intron	novel		0.15
COAD	chr15	63912126	Silent	NA	Y310Y	0.47
COAD	chr15	64040225	Missense_Mutation	NA	P13S	0.32
COAD	chr15	63908661	Intron	novel		0.56
COAD	chr15	63939245	Silent	NA	T190T	0.21
COAD	chr15	63925965	Missense_Mutation	rs749221840	R263Q	0.52
COAD	chr15	64040208	Silent	rs149132625	K18K	0.05
ESCA	chr15	63983556	Silent	rs541062258	T97T	0.11
GBM	chr15	64040189	Missense_Mutation	novel	I25V	0.06
GBM	chr15	63926013	Missense_Mutation	novel	D247G	0.07
HNSC	chr15	63983685	Missense_Mutation	novel	I54M	0.1	RIO1
HNSC	chr15	63911947	Silent	rs201355789	S331S	0.24
HNSC	chr15	63939311	Silent	novel	K168K	0.22
KIRC	chr15	63908599	Missense_Mutation	NA	R345M	0.43
KIRC	chr15	63926011	Nonsense_Mutation	NA	E248*	0.2
KIRP	chr15	63908546	Missense_Mutation	NA	P363S	0.21
KIRP	chr15	63912117	Missense_Mutation	NA	R313S	0.57
LAML	chr15	63929549	Splice_Site	novel	X220_splice	0.18
LGG	chr15	63983612	Missense_Mutation	rs542492420	R79W	0.44	RIO1
LGG	chr15	63911868	Intron	novel		0.33
LIHC	chr15	63912113	Missense_Mutation	novel	W315R	0.32
LIHC	chr15	63983678	Missense_Mutation	rs773075712	R57W	0.16	RIO1
LIHC	chr15	63983665	Missense_Mutation	novel	A61E	0.53	RIO1
LUAD	chr15	63971488	Missense_Mutation	novel	I130V	0.08	RIO1
LUAD	chr15	63911882	Intron	novel		0.24
LUAD	chr15	63971437	Missense_Mutation	NA	H147Y	0.33	RIO1
LUAD	chr15	63912184	Missense_Mutation	NA	Q291L	0.25
LUAD	chr15	64040170	Missense_Mutation	novel	S31I	0.12
LUSC	chr15	64040219	Nonsense_Mutation	novel	K15*	0.5
LUSC	chr15	64040220	Missense_Mutation	novel	F14L	0.34
LUSC	chr15	64040245	Missense_Mutation	novel	M6T	0.23
OV	chr15	63971467	Missense_Mutation	novel	V137M	0.07	RIO1
OV	chr15	63911778	Intron	novel		1
OV	chr15	63911948	Missense_Mutation	rs200773863	S331L	0.33
READ	chr15	63911808	Intron	novel		0.23
SARC	chr15	63912134	Missense_Mutation	novel	K308E	0.41
SARC	chr15	63911757	Intron	novel		0.47
SKCM	chr15	63930425	Missense_Mutation	novel	G205D	0.3
SKCM	chr15	63983682	Silent	rs763131157	K55K	0.3
SKCM	chr15	63912147	Silent	novel	L303L	0.26
SKCM	chr15	63983640	Silent	NA	E69E	0.33
SKCM	chr15	63908536	Missense_Mutation	rs765741864	R366K	0.56
SKCM	chr15	63971540	Silent	rs144523094	F112F	0.54
SKCM	chr15	63926071	Silent	NA	L228L	0.63
SKCM	chr15	63930435	Missense_Mutation	rs774205620	E202K	0.58
SKCM	chr15	63983576	Missense_Mutation	NA	D91N	0.65	RIO1
SKCM	chr15	63983682	Silent	rs763131157	K55K	0.15
SKCM	chr15	63971468	Silent	rs751829648	G136G	0.34
SKCM	chr15	63908536	Missense_Mutation	rs765741864	R366K	0.17
SKCM	chr15	63983643	Silent	rs765120420	R68R	0.28
SKCM	chr15	64040202	Silent	NA	E20E	0.32
SKCM	chr15	63911872	Intron	novel		0.38
SKCM	chr15	63983571	Silent	novel	V92V	0.5
SKCM	chr15	63983721	Silent	novel	E42E	0.27
STAD	chr15	64040187	Silent	rs377251760	I25I	0.5
STAD	chr15	63983745	Missense_Mutation	novel	F34L	0.23
STAD	chr15	63908568	Silent	NA	I355I	0.43
STAD	chr15	63983702	Missense_Mutation	novel	Y49H	0.32	RIO1
STAD	chr15	63930443	Missense_Mutation	novel	V199A	0.18
STAD	chr15	63911954	Missense_Mutation	novel	T329S	0.23
UCEC	chr15	63983560	Missense_Mutation	rs201432861	R96H	0.24	RIO1
UCEC	chr15	63908504	3'UTR	novel		0.26
UCEC	chr15	63911900	Splice_Region	novel		0.35
UCEC	chr15	63924841	Missense_Mutation	novel	E278V	0.25
UCEC	chr15	63983553	Silent	rs62639967	D98D	0.3
UCEC	chr15	63908539	Missense_Mutation	novel	R365K	0.48
UCEC	chr15	63971430	Missense_Mutation	novel	D149G	0.44	RIO1
UCEC	chr15	63929552	Missense_Mutation	NA	L220I	0.08
UCEC	chr15	63911938	Silent	novel	K334K	0.28
UCEC	chr15	63911845	Intron	novel		0.19
UCEC	chr15	63912169	Missense_Mutation	rs766325954	R296H	0.27
UCEC	chr15	63930430	Silent	novel	P203P	0.47
UCEC	chr15	63929698	Intron	rs751468060		0.44
UCEC	chr15	64040177	Silent	novel	L29L	0.49
UCEC	chr15	63983610	Silent	novel	R79R	0.34
UCEC	chr15	63926027	Silent	NA	V242V	0.46
UCEC	chr15	63939286	Missense_Mutation	rs777665315	E177K	0.44
UCEC	chr15	63924817	Missense_Mutation	rs775505588	T286M	0.21
UCEC	chr15	63926009	Missense_Mutation	novel	E248D	0.38
UCEC	chr15	63983571	Silent	novel	V92V	0.4
UCEC	chr15	63912174	Missense_Mutation	novel	M294I	0.41
UCEC	chr15	63925984	Silent	novel	L257L	0.21
UCEC	chr15	63926051	Silent	NA	E234E	0.36
UCEC	chr15	63925942	Missense_Mutation	rs34270163	R271W	0.17
UCEC	chr15	63929700	Intron	rs564463666		0.46
UCEC	chr15	63939284	Missense_Mutation	novel	E177D	0.37
UCEC	chr15	63983708	Missense_Mutation	novel	L47F	0.34	RIO1

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
KICH	AMP	0.2879	0.21756
KIRP	DEL	0.0972	0.2062
LGG	AMP	0.0156	0.19963
PAAD	AMP	0.0598	0.20695
PAAD	DEL	0.1087	0.13216

Survival Analysis

Cancer	P-value	Q-value
KIRC	0.00012	Kaplan-Meier Survival Analysis
ACC	0.018	Kaplan-Meier Survival Analysis
HNSC	0.013	Kaplan-Meier Survival Analysis
SKCM	0.0001	Kaplan-Meier Survival Analysis
KIRP	0.00096	Kaplan-Meier Survival Analysis
PCPG	0.038	Kaplan-Meier Survival Analysis
CESC	0.023	Kaplan-Meier Survival Analysis
LAML	0.0081	Kaplan-Meier Survival Analysis
DLBC	0.022	Kaplan-Meier Survival Analysis
LGG	0.013	Kaplan-Meier Survival Analysis
THCA	0.0059	Kaplan-Meier Survival Analysis
LUAD	0.00012	Kaplan-Meier Survival Analysis
UVM	0.0063	Kaplan-Meier Survival Analysis

Drugs

EuRBPDB

Description

RBDs

Expression

Transcripts

Gene Model

Pathways

Phenotypes

GWAS

PPI

Orthologs

Gene Ontology

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742