EuRBPDB

Description

Ensembl ID: ENSG00000035687 (Gene tree)
Gene ID: 159
Gene Symbol: ADSS
Alias: N
Full Name: adenylosuccinate synthase
Gene Type: protein_coding
Species: Homo_sapiens
Status: putative
Strand: Minus strand
Length: 43,643 bases
Position: chr1:244,408,492-244,452,134
Accession: 292
RBP type: non-canonical RBP
Summary: This gene encodes the enzyme adenylosuccinate synthetase which catalyzes the first committed step in the conversion of inosine monophosphate to adenosine monophosphate. A pseudogene of this gene is found on chromosome 17.[provided by RefSeq, Nov 2010]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & MCF10A	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000462358	ADSS-202	932	-	-	- (aa)	-	-
ENST00000366535	ADSS-201	2780	XM_011544108	ENSP00000355493	456 (aa)	XP_011542410	P30520
ENST00000468215	ADSS-203	807	-	-	- (aa)	-	-

Gene Model

Pathways

Pathway ID	Pathway Name	Source
hsa00230	Purine metabolism	KEGG
hsa00250	Alanine, aspartate and glutamate metabolism	KEGG
hsa01100	Metabolic pathways	KEGG

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000035687	Stroke	1.6065703E-004	-
ENSG00000035687	Stroke	6.4727866E-004	-
ENSG00000035687	Stroke	2.8417984E-004	-
ENSG00000035687	Vitamin A	4.6840000E-005	-
ENSG00000035687	Vitamin A	4.6850000E-005	-
ENSG00000035687	Vitamin A	3.3790000E-005	-
ENSG00000035687	Alzheimer Disease	5E-6	25188341
ENSG00000035687	Dementia	5E-6	25188341
ENSG00000035687	Insulin-Like Growth Factor Binding Proteins	4E-6	23251661

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000035687	rs3102460	1	244413415	G	Obesity-related traits	23251661	[NR] ng/mL increase	0.03	EFO_0005118
ENSG00000035687	rs3003214	1	244441734	A	Dementia and core Alzheimer's disease neuropathologic changes	25188341	[0.21-0.53] unit increase	0.37	HP_0000726\|EFO_0006801
ENSG00000035687	rs7521072	1	244429978	?	Age at menopause	30595370			EFO_0004704

Protein-Protein Interaction (PPI)

* RBP PPI network refers to all genes directly bind to RBP

Orthologs identified by RBPome

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000035687	ADSS	95	62.529	FBgn0027493	AdSS	96	62.529	Drosophila_melanogaster
ENSG00000035687	ADSS	93	56.845	YNL220W	ADE12	99	56.845	Saccharomyces_cerevisiae

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000287	magnesium ion binding	-	IEA	Function
GO:0002376	immune system process	15786719.	NAS	Process
GO:0004019	adenylosuccinate synthase activity	21873635.	IBA	Function
GO:0004019	adenylosuccinate synthase activity	2004783.	IDA	Function
GO:0004019	adenylosuccinate synthase activity	1592113.	NAS	Function
GO:0005515	protein binding	23455924.	IPI	Function
GO:0005525	GTP binding	1592113.15786719.	NAS	Function
GO:0005737	cytoplasm	21873635.	IBA	Component
GO:0005829	cytosol	-	IDA	Component
GO:0005829	cytosol	-	TAS	Component
GO:0005886	plasma membrane	-	IDA	Component
GO:0006167	AMP biosynthetic process	2004783.	IDA	Process
GO:0006167	AMP biosynthetic process	1592113.15786719.	NAS	Process
GO:0006531	aspartate metabolic process	-	IEA	Process
GO:0009168	purine ribonucleoside monophosphate biosynthetic process	-	TAS	Process
GO:0014074	response to purine-containing compound	-	IEA	Process
GO:0042301	phosphate ion binding	1592113.15786719.	NAS	Function
GO:0044208	'de novo' AMP biosynthetic process	21873635.	IBA	Process
GO:0044208	'de novo' AMP biosynthetic process	-	IEA	Process
GO:0046040	IMP metabolic process	21873635.	IBA	Process
GO:0060359	response to ammonium ion	-	IEA	Process
GO:0070062	extracellular exosome	23533145.	HDA	Component
GO:0071257	cellular response to electrical stimulus	-	IEA	Process