EuRBPDB

Description

RBPome

Expression

Transcripts

Gene Model

Pathways

Phenotypes

GWAS

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000035928 (Gene tree)
Gene ID: 5981
Gene Symbol: RFC1
Alias: A1|PO-GA|RFC140|MHCBFB
Full Name: replication factor C subunit 1
Gene Type: protein_coding
Species: Homo_sapiens
Status: putative
Strand: Minus strand
Length: 78,933 bases
Position: chr4:39,287,449-39,366,381
Accession: 9969
RBP type: non-canonical RBP
Summary: This gene encodes the large subunit of replication factor C, a five subunit DNA polymerase accessory protein, which is a DNA-dependent ATPase required for eukaryotic DNA replication and repair. The large subunit acts as an activator of DNA polymerases, binds to the 3' end of primers, and promotes coordinated synthesis of both strands. It may also have a role in telomere stability. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq, Mar 2011]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & HEK293	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
29431736	Capturing the interactome of newly transcribed RNA	PolyT-RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
29431736	Capturing the interactome of newly transcribed RNA	RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & Hela	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000512726	RFC1-214	752	-	-	- (aa)	-	-
ENST00000509084	RFC1-211	483	-	-	- (aa)	-	-
ENST00000639695	RFC1-217	867	-	ENSP00000491208	289 (aa)	-	A0A1W2PP02
ENST00000505077	RFC1-210	566	-	-	- (aa)	-	-
ENST00000418436	RFC1-203	1255	-	-	- (aa)	-	-
ENST00000502991	RFC1-205	567	-	-	- (aa)	-	-
ENST00000503784	RFC1-206	504	-	ENSP00000422740	132 (aa)	-	D6RAD2
ENST00000349703	RFC1-201	4859	XM_017008528	ENSP00000261424	1147 (aa)	-	P35251
ENST00000512881	RFC1-215	537	-	-	- (aa)	-	-
ENST00000504554	RFC1-207	561	-	ENSP00000422129	187 (aa)	-	H0Y8U4
ENST00000512275	RFC1-213	841	-	ENSP00000422475	130 (aa)	-	E0CX09
ENST00000514572	RFC1-216	584	-	ENSP00000424713	101 (aa)	-	H0Y9P8
ENST00000504849	RFC1-208	873	-	-	- (aa)	-	-
ENST00000510783	RFC1-212	723	-	-	- (aa)	-	-
ENST00000502706	RFC1-204	690	-	-	- (aa)	-	-
ENST00000504974	RFC1-209	495	-	-	- (aa)	-	-
ENST00000381897	RFC1-202	4886	XM_011513730	ENSP00000371321	1148 (aa)	XP_011512033	P35251

Gene Model

Click here to download ENSG00000035928's gene model file

Pathways

Pathway ID	Pathway Name	Source
hsa03030	DNA replication	KEGG
hsa03420	Nucleotide excision repair	KEGG
hsa03430	Mismatch repair	KEGG

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000035928	Body Weights and Measures	1.44978996857227E-7	17903300
ENSG00000035928	Body Weights and Measures	6.13264584392605E-8	17903300
ENSG00000035928	Interleukin-6	2.58046033519532E-7	17903293
ENSG00000035928	Echocardiography	1.256040363962E-5	17903301
ENSG00000035928	Platelet Function Tests	4.2200000E-006	-

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000035928	rs78773383	4	39364100	G	Mean corpuscular hemoglobin	27863252	[0.018-0.032] unit increase	0.02522975	EFO_0004527
ENSG00000035928	rs78773383	4	39364100	G	Mean corpuscular volume	27863252	[0.019-0.033] unit increase	0.02597567	EFO_0004526
ENSG00000035928	rs6835111	4	39359449	?	Mean corpuscular volume	29403010	[0.025-0.042] unit decrease novel	0.03388	EFO_0004526
ENSG00000035928	rs6835111	4	39359449	?	Mean corpuscular hemoglobin	29403010	[0.022-0.039] unit decrease novel	0.03048	EFO_0004527
ENSG00000035928	rs6844176	4	39364970	?	Mean corpuscular hemoglobin	30595370			EFO_0004527

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000035928's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs identified by RBPome

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000035928	RFC1	94	56.667	FBgn0004913	Gnf1	79	46.231	Drosophila_melanogaster

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000122	negative regulation of transcription by RNA polymerase II	-	IEA	Process
GO:0003677	DNA binding	21873635.	IBA	Function
GO:0003689	DNA clamp loader activity	-	IEA	Function
GO:0003690	double-stranded DNA binding	-	IEA	Function
GO:0005515	protein binding	9488738.15655353.16438930.	IPI	Function
GO:0005524	ATP binding	-	IEA	Function
GO:0005634	nucleus	21873635.	IBA	Component
GO:0005634	nucleus	-	IDA	Component
GO:0005654	nucleoplasm	-	IDA	Component
GO:0005654	nucleoplasm	-	TAS	Component
GO:0005663	DNA replication factor C complex	9488738.	IDA	Component
GO:0005730	nucleolus	-	IEA	Component
GO:0005737	cytoplasm	-	IEA	Component
GO:0006261	DNA-dependent DNA replication	8248204.	TAS	Process
GO:0006283	transcription-coupled nucleotide-excision repair	-	TAS	Process
GO:0006296	nucleotide-excision repair, DNA incision, 5'-to lesion	-	TAS	Process
GO:0006297	nucleotide-excision repair, DNA gap filling	-	TAS	Process
GO:0007004	telomere maintenance via telomerase	8954124.	TAS	Process
GO:0008047	enzyme activator activity	8954124.	TAS	Function
GO:0019904	protein domain specific binding	-	IEA	Function
GO:0019985	translesion synthesis	-	TAS	Process
GO:0031391	Elg1 RFC-like complex	23277426.	IDA	Component
GO:0032201	telomere maintenance via semi-conservative replication	-	TAS	Process
GO:0033683	nucleotide-excision repair, DNA incision	-	TAS	Process
GO:0042276	error-prone translesion synthesis	-	TAS	Process
GO:0042769	DNA damage response, detection of DNA damage	-	TAS	Process
GO:0043085	positive regulation of catalytic activity	-	IEA	Process
GO:0043565	sequence-specific DNA binding	-	IEA	Function
GO:0045893	positive regulation of transcription, DNA-templated	-	IEA	Process
GO:0061860	DNA clamp unloader activity	23277426.	IMP	Function
GO:0070062	extracellular exosome	19056867.	HDA	Component
GO:0070987	error-free translesion synthesis	-	TAS	Process
GO:0090618	DNA clamp unloading	23277426.	IMP	Process