EuRBPDB

Basic Information
Cancer Related Information

Description

RBDs

RBPome

PRI

Literatures

Expression

Transcripts

Gene Model

Phenotypes

GWAS

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000037474 (Gene tree)
Gene ID: 54888
Gene Symbol: NSUN2
Alias: FLJ20303|TRM4|Misu|MRT5
Full Name: NOP2/Sun RNA methyltransferase 2
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Minus strand
Length: 34,122 bases
Position: chr5:6,599,239-6,633,360
Accession: 25994
RBP type: canonical RBP
Summary: This gene encodes a methyltransferase that catalyzes the methylation of cytosine to 5-methylcytosine (m5C) at position 34 of intron-containing tRNA(Leu)(CAA) precursors. This modification is necessary to stabilize the anticodon-codon pairing and correctly translate the mRNA. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene.[provided by RefSeq, Mar 2011]

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000420957	Methyltr_RsmB-F	PF01189.17	6e-38	1	1
ENSP00000264670	Methyltr_RsmB-F	PF01189.17	6.8e-38	1	1

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
22681889	The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts	4SURIC & HEK293	2012 May	Baltz AG	DOI: 10.1016/j.molcel.2012.05.021
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & HEK293	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
29431736	Capturing the interactome of newly transcribed RNA	NascentRICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
29431736	Capturing the interactome of newly transcribed RNA	PolyT-RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
29431736	Capturing the interactome of newly transcribed RNA	RIC & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
29431736	Capturing the interactome of newly transcribed RNA	RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
22658674	Insights into RNA biology from an atlas of mammalian mRNA-binding proteins	RIC & Hela	2012 May 31	Castello A	DOI: 10.1016/j.cell.2012.04.031
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & Hela	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & MCF10A	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & MCF7	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & U2OS	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
27453046	Comprehensive Identification of RNA-Binding Domains in Human Cells	RIC & Hela	2016 Aug 18	Castello A	DOI: 10.1016/j.molcel.2016.06.029
30352994	Discovery of RNA-binding proteins and characterization of their dynamic responses by enhanced RNA interactome capture	RIC & Jurkat	2018 Oct 23	Perez-Perri JI	DOI:10.1038/s41467-018-06557-8

Protein-RNA interaction（RNA-Binding Site）

Click here to download all RNA binding sites

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
28341602	Cytosolic YB-1 and NSUN2 are the only proteins recognizing specific motifs present in mRNAs enriched in exosomes.	Biochim Biophys Acta Proteins Proteom	2017 Jun	Kossinova OA	doi: 10.1016/j.bbapap.2017.03.010
28418038	5-methylcytosine promotes mRNA export - NSUN2 as the methyltransferase and ALYREF as an m5C reader.	Cell Res	2017 May	Yang X	doi: 10.1038/cr.2017.55

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000513888	NSUN2-208	1290	-	-	- (aa)	-	-
ENST00000506139	NSUN2-206	2619	-	ENSP00000420957	732 (aa)	-	Q08J23
ENST00000505264	NSUN2-204	472	-	-	- (aa)	-	-
ENST00000502932	NSUN2-202	512	-	-	- (aa)	-	-
ENST00000507888	NSUN2-207	715	-	-	- (aa)	-	-
ENST00000514127	NSUN2-209	614	-	ENSP00000426459	102 (aa)	-	A0A140T9Z1
ENST00000264670	NSUN2-201	3303	-	ENSP00000264670	767 (aa)	-	Q08J23
ENST00000504374	NSUN2-203	3217	-	ENSP00000421783	202 (aa)	-	A0A140T9Y7
ENST00000505892	NSUN2-205	3558	-	-	- (aa)	-	-

Gene Model

Click here to download ENSG00000037474's gene model file

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000037474	Body Fat Distribution	4.5060000E-005	-
ENSG00000037474	Platelet Function Tests	2.7579556E-006	-
ENSG00000037474	Dextroamphetamine	9.0344000E-006	-
ENSG00000037474	Dextroamphetamine	2.8045000E-006	-
ENSG00000037474	Dextroamphetamine	2.8373000E-006	-
ENSG00000037474	Dextroamphetamine	6.0481000E-005	-
ENSG00000037474	Adipose Tissue	3E-6	22589738

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000037474	rs7717596	5	6610278	?	Heel bone mineral density	30595370			EFO_0009270

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000037474's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000037474	NSUN2	93	72.690	ENSAPOG00000000894	nsun2	87	73.625	Acanthochromis_polyacanthus
ENSG00000037474	NSUN2	99	85.752	ENSAMEG00000002744	NSUN2	97	87.248	Ailuropoda_melanoleuca
ENSG00000037474	NSUN2	93	68.776	ENSACIG00000013142	nsun2	91	69.986	Amphilophus_citrinellus
ENSG00000037474	NSUN2	99	66.332	ENSAOCG00000019227	nsun2	94	71.781	Amphiprion_ocellaris
ENSG00000037474	NSUN2	93	72.093	ENSAPEG00000002772	nsun2	94	71.781	Amphiprion_percula
ENSG00000037474	NSUN2	99	66.332	ENSATEG00000006961	nsun2	94	71.231	Anabas_testudineus
ENSG00000037474	NSUN2	81	79.695	ENSAPLG00000011518	NSUN2	88	78.730	Anas_platyrhynchos
ENSG00000037474	NSUN2	92	78.094	ENSACAG00000000677	NSUN2	85	78.094	Anolis_carolinensis
ENSG00000037474	NSUN2	100	95.828	ENSANAG00000034451	NSUN2	100	96.006	Aotus_nancymaae
ENSG00000037474	NSUN2	99	66.332	ENSACLG00000014258	nsun2	95	70.999	Astatotilapia_calliptera
ENSG00000037474	NSUN2	95	71.526	ENSAMXG00000017682	nsun2	99	71.633	Astyanax_mexicanus
ENSG00000037474	NSUN2	97	82.632	ENSBTAG00000015466	NSUN2	97	83.091	Bos_taurus
ENSG00000037474	NSUN2	89	36.298	WBGene00021686	Y48G8AL.5	97	33.094	Caenorhabditis_elegans
ENSG00000037474	NSUN2	98	93.947	ENSCJAG00000008689	NSUN2	72	93.935	Callithrix_jacchus
ENSG00000037474	NSUN2	93	89.650	ENSCAFG00000010334	NSUN2	94	87.449	Canis_familiaris
ENSG00000037474	NSUN2	87	89.655	ENSCAFG00020022862	NSUN2	96	87.536	Canis_lupus_dingo
ENSG00000037474	NSUN2	97	82.763	ENSCHIG00000019385	NSUN2	97	84.311	Capra_hircus
ENSG00000037474	NSUN2	98	90.212	ENSTSYG00000005709	NSUN2	98	90.212	Carlito_syrichta
ENSG00000037474	NSUN2	88	84.365	ENSCAPG00000013519	NSUN2	99	84.720	Cavia_aperea
ENSG00000037474	NSUN2	98	85.733	ENSCPOG00000008196	NSUN2	98	85.733	Cavia_porcellus
ENSG00000037474	NSUN2	75	90.132	ENSCCAG00000034245	-	92	90.525	Cebus_capucinus
ENSG00000037474	NSUN2	96	96.351	ENSCCAG00000025648	-	100	96.219	Cebus_capucinus
ENSG00000037474	NSUN2	100	93.351	ENSCATG00000042165	-	100	93.351	Cercocebus_atys
ENSG00000037474	NSUN2	100	97.914	ENSCATG00000045020	-	100	97.914	Cercocebus_atys
ENSG00000037474	NSUN2	94	86.087	ENSCLAG00000003188	NSUN2	99	86.087	Chinchilla_lanigera
ENSG00000037474	NSUN2	100	97.914	ENSCSAG00000017339	NSUN2	100	97.914	Chlorocebus_sabaeus
ENSG00000037474	NSUN2	66	91.525	ENSCHOG00000003644	NSUN2	87	91.525	Choloepus_hoffmanni
ENSG00000037474	NSUN2	89	82.362	ENSCPBG00000006615	NSUN2	89	81.762	Chrysemys_picta_bellii
ENSG00000037474	NSUN2	88	48.824	ENSCING00000009504	-	100	48.824	Ciona_intestinalis
ENSG00000037474	NSUN2	87	46.588	ENSCSAVG00000001710	-	98	46.559	Ciona_savignyi
ENSG00000037474	NSUN2	97	97.039	ENSCANG00000029527	NSUN2	99	97.039	Colobus_angolensis_palliatus
ENSG00000037474	NSUN2	100	86.962	ENSCGRG00001003947	Nsun2	98	87.234	Cricetulus_griseus_chok1gshd
ENSG00000037474	NSUN2	96	87.602	ENSCGRG00000005703	Nsun2	99	87.602	Cricetulus_griseus_crigri
ENSG00000037474	NSUN2	84	69.512	ENSCVAG00000021836	nsun2	94	69.512	Cyprinodon_variegatus
ENSG00000037474	NSUN2	99	69.500	ENSDARG00000056665	nsun2	99	70.580	Danio_rerio
ENSG00000037474	NSUN2	89	85.169	ENSDNOG00000013848	NSUN2	99	84.985	Dasypus_novemcinctus
ENSG00000037474	NSUN2	96	88.163	ENSDORG00000010247	Nsun2	100	88.302	Dipodomys_ordii
ENSG00000037474	NSUN2	92	43.689	FBgn0026079	Nsun2	95	42.781	Drosophila_melanogaster
ENSG00000037474	NSUN2	81	90.184	ENSETEG00000000983	NSUN2	98	68.633	Echinops_telfairi
ENSG00000037474	NSUN2	92	48.204	ENSEBUG00000006751	nsun2	83	50.075	Eptatretus_burgeri
ENSG00000037474	NSUN2	100	88.266	ENSEASG00005018580	NSUN2	100	88.266	Equus_asinus_asinus
ENSG00000037474	NSUN2	100	88.136	ENSECAG00000016357	NSUN2	100	88.136	Equus_caballus
ENSG00000037474	NSUN2	66	79.917	ENSEEUG00000001691	NSUN2	98	79.917	Erinaceus_europaeus
ENSG00000037474	NSUN2	99	66.332	ENSELUG00000024082	nsun2	89	72.886	Esox_lucius
ENSG00000037474	NSUN2	99	87.516	ENSFCAG00000015602	NSUN2	98	87.668	Felis_catus
ENSG00000037474	NSUN2	89	79.559	ENSFALG00000007188	NSUN2	88	79.046	Ficedula_albicollis
ENSG00000037474	NSUN2	95	84.247	ENSFDAG00000003589	NSUN2	100	84.247	Fukomys_damarensis
ENSG00000037474	NSUN2	93	71.745	ENSFHEG00000017930	nsun2	94	71.311	Fundulus_heteroclitus
ENSG00000037474	NSUN2	58	80.263	ENSGMOG00000008921	nsun2	99	62.302	Gadus_morhua
ENSG00000037474	NSUN2	89	79.738	ENSGALG00000013064	NSUN2	87	79.053	Gallus_gallus
ENSG00000037474	NSUN2	93	71.727	ENSGAFG00000018743	nsun2	96	70.919	Gambusia_affinis
ENSG00000037474	NSUN2	84	71.646	ENSGACG00000008974	nsun2	99	72.239	Gasterosteus_aculeatus
ENSG00000037474	NSUN2	89	81.818	ENSGAGG00000015773	NSUN2	97	79.412	Gopherus_agassizii
ENSG00000037474	NSUN2	100	99.609	ENSGGOG00000016583	NSUN2	100	99.609	Gorilla_gorilla
ENSG00000037474	NSUN2	99	65.829	ENSHBUG00000022199	nsun2	95	70.451	Haplochromis_burtoni
ENSG00000037474	NSUN2	94	86.981	ENSHGLG00000013825	NSUN2	100	85.919	Heterocephalus_glaber_female
ENSG00000037474	NSUN2	88	88.253	ENSHGLG00100013746	NSUN2	100	88.253	Heterocephalus_glaber_male
ENSG00000037474	NSUN2	93	71.170	ENSHCOG00000020484	nsun2	92	72.222	Hippocampus_comes
ENSG00000037474	NSUN2	98	68.814	ENSIPUG00000014849	nsun2	98	70.385	Ictalurus_punctatus
ENSG00000037474	NSUN2	100	89.309	ENSSTOG00000004090	NSUN2	100	89.309	Ictidomys_tridecemlineatus
ENSG00000037474	NSUN2	100	87.176	ENSJJAG00000013996	Nsun2	98	87.649	Jaculus_jaculus
ENSG00000037474	NSUN2	99	65.829	ENSKMAG00000000810	nsun2	93	71.610	Kryptolebias_marmoratus
ENSG00000037474	NSUN2	93	70.816	ENSLBEG00000025697	nsun2	95	69.607	Labrus_bergylta
ENSG00000037474	NSUN2	98	73.333	ENSLOCG00000008755	nsun2	93	74.521	Lepisosteus_oculatus
ENSG00000037474	NSUN2	94	87.101	ENSLAFG00000009411	NSUN2	98	87.110	Loxodonta_africana
ENSG00000037474	NSUN2	100	97.784	ENSMFAG00000045240	NSUN2	100	97.784	Macaca_fascicularis
ENSG00000037474	NSUN2	100	97.784	ENSMMUG00000002561	NSUN2	100	97.784	Macaca_mulatta
ENSG00000037474	NSUN2	100	97.784	ENSMNEG00000033485	NSUN2	100	97.784	Macaca_nemestrina
ENSG00000037474	NSUN2	96	97.023	ENSMLEG00000017173	NSUN2	99	97.023	Mandrillus_leucophaeus
ENSG00000037474	NSUN2	93	71.099	ENSMAMG00000004850	nsun2	91	72.472	Mastacembelus_armatus
ENSG00000037474	NSUN2	99	66.332	ENSMZEG00005000101	nsun2	95	70.862	Maylandia_zebra
ENSG00000037474	NSUN2	89	80.059	ENSMGAG00000006349	NSUN2	89	80.059	Meleagris_gallopavo
ENSG00000037474	NSUN2	100	86.310	ENSMAUG00000014207	Nsun2	98	86.702	Mesocricetus_auratus
ENSG00000037474	NSUN2	95	90.872	ENSMICG00000016549	NSUN2	94	90.933	Microcebus_murinus
ENSG00000037474	NSUN2	100	86.050	ENSMOCG00000009613	Nsun2	98	86.551	Microtus_ochrogaster
ENSG00000037474	NSUN2	93	71.133	ENSMMOG00000021188	nsun2	98	68.933	Mola_mola
ENSG00000037474	NSUN2	93	82.231	ENSMODG00000002039	NSUN2	91	82.231	Monodelphis_domestica
ENSG00000037474	NSUN2	96	69.485	ENSMALG00000002740	nsun2	94	71.623	Monopterus_albus
ENSG00000037474	NSUN2	100	87.223	MGP_CAROLIEiJ_G0018690	Nsun2	98	87.633	Mus_caroli
ENSG00000037474	NSUN2	100	87.223	ENSMUSG00000021595	Nsun2	100	87.874	Mus_musculus
ENSG00000037474	NSUN2	100	87.223	MGP_PahariEiJ_G0015771	Nsun2	100	87.732	Mus_pahari
ENSG00000037474	NSUN2	100	87.093	MGP_SPRETEiJ_G0019574	Nsun2	100	87.732	Mus_spretus
ENSG00000037474	NSUN2	90	87.228	ENSMPUG00000007561	NSUN2	96	87.228	Mustela_putorius_furo
ENSG00000037474	NSUN2	97	87.802	ENSMLUG00000009609	NSUN2	98	87.802	Myotis_lucifugus
ENSG00000037474	NSUN2	100	85.267	ENSNGAG00000007424	Nsun2	100	84.973	Nannospalax_galili
ENSG00000037474	NSUN2	100	98.957	ENSNLEG00000011344	NSUN2	100	98.957	Nomascus_leucogenys
ENSG00000037474	NSUN2	98	65.657	ENSMEUG00000007117	-	57	85.526	Notamacropus_eugenii
ENSG00000037474	NSUN2	88	84.424	ENSOPRG00000011324	NSUN2	99	84.424	Ochotona_princeps
ENSG00000037474	NSUN2	99	84.079	ENSODEG00000018305	NSUN2	100	89.740	Octodon_degus
ENSG00000037474	NSUN2	99	69.301	ENSONIG00000007761	nsun2	98	70.455	Oreochromis_niloticus
ENSG00000037474	NSUN2	90	79.887	ENSOANG00000009243	NSUN2	96	79.887	Ornithorhynchus_anatinus
ENSG00000037474	NSUN2	88	86.449	ENSOCUG00000007918	NSUN2	99	85.863	Oryctolagus_cuniculus
ENSG00000037474	NSUN2	99	66.834	ENSORLG00000014332	nsun2	91	71.671	Oryzias_latipes
ENSG00000037474	NSUN2	99	67.397	ENSORLG00020019799	nsun2	97	68.800	Oryzias_latipes_hni
ENSG00000037474	NSUN2	99	66.332	ENSORLG00015007992	nsun2	93	71.749	Oryzias_latipes_hsok
ENSG00000037474	NSUN2	89	72.006	ENSOMEG00000013504	nsun2	97	68.980	Oryzias_melastigma
ENSG00000037474	NSUN2	100	88.575	ENSOGAG00000015015	NSUN2	98	88.787	Otolemur_garnettii
ENSG00000037474	NSUN2	96	82.580	ENSOARG00000015042	NSUN2	96	82.580	Ovis_aries
ENSG00000037474	NSUN2	100	99.348	ENSPPAG00000036124	NSUN2	100	99.348	Pan_paniscus
ENSG00000037474	NSUN2	100	86.962	ENSPPRG00000001946	NSUN2	98	87.101	Panthera_pardus
ENSG00000037474	NSUN2	93	82.591	ENSPTIG00000013257	NSUN2	100	83.639	Panthera_tigris_altaica
ENSG00000037474	NSUN2	100	99.348	ENSPTRG00000016715	NSUN2	100	99.348	Pan_troglodytes
ENSG00000037474	NSUN2	100	97.784	ENSPANG00000004215	NSUN2	100	97.784	Papio_anubis
ENSG00000037474	NSUN2	98	71.825	ENSPKIG00000024200	nsun2	93	71.644	Paramormyrops_kingsleyae
ENSG00000037474	NSUN2	83	81.162	ENSPSIG00000015282	NSUN2	88	81.162	Pelodiscus_sinensis
ENSG00000037474	NSUN2	93	67.036	ENSPMGG00000004138	nsun2	93	68.195	Periophthalmus_magnuspinnatus
ENSG00000037474	NSUN2	97	86.425	ENSPEMG00000021790	Nsun2	97	86.425	Peromyscus_maniculatus_bairdii
ENSG00000037474	NSUN2	74	72.483	ENSPMAG00000002838	NSUN2	100	67.730	Petromyzon_marinus
ENSG00000037474	NSUN2	95	82.186	ENSPCIG00000011853	NSUN2	93	82.186	Phascolarctos_cinereus
ENSG00000037474	NSUN2	93	72.061	ENSPFOG00000004139	nsun2	97	70.732	Poecilia_formosa
ENSG00000037474	NSUN2	93	72.337	ENSPLAG00000007091	nsun2	99	71.571	Poecilia_latipinna
ENSG00000037474	NSUN2	93	72.199	ENSPMEG00000000122	nsun2	97	70.867	Poecilia_mexicana
ENSG00000037474	NSUN2	93	71.250	ENSPREG00000017479	nsun2	96	70.315	Poecilia_reticulata
ENSG00000037474	NSUN2	100	99.218	ENSPPYG00000015332	NSUN2	100	99.218	Pongo_abelii
ENSG00000037474	NSUN2	82	89.928	ENSPCAG00000010931	NSUN2	83	89.928	Procavia_capensis
ENSG00000037474	NSUN2	89	96.648	ENSPCOG00000012979	NSUN2	100	89.570	Propithecus_coquereli
ENSG00000037474	NSUN2	96	86.957	ENSPVAG00000010643	NSUN2	98	86.765	Pteropus_vampyrus
ENSG00000037474	NSUN2	99	66.332	ENSPNYG00000010677	nsun2	95	70.862	Pundamilia_nyererei
ENSG00000037474	NSUN2	99	62.958	ENSPNAG00000006827	nsun2	99	64.770	Pygocentrus_nattereri
ENSG00000037474	NSUN2	99	85.884	ENSRNOG00000017254	Nsun2	95	86.303	Rattus_norvegicus
ENSG00000037474	NSUN2	100	98.175	ENSRBIG00000035794	NSUN2	100	98.175	Rhinopithecus_bieti
ENSG00000037474	NSUN2	100	98.175	ENSRROG00000035277	NSUN2	100	98.175	Rhinopithecus_roxellana
ENSG00000037474	NSUN2	89	35.994	YBL024W	NCL1	96	35.425	Saccharomyces_cerevisiae
ENSG00000037474	NSUN2	100	95.437	ENSSBOG00000035262	NSUN2	100	95.437	Saimiri_boliviensis_boliviensis
ENSG00000037474	NSUN2	91	84.300	ENSSHAG00000011056	NSUN2	98	84.322	Sarcophilus_harrisii
ENSG00000037474	NSUN2	99	68.408	ENSSFOG00015001631	nsun2	95	69.542	Scleropages_formosus
ENSG00000037474	NSUN2	93	71.093	ENSSMAG00000020669	nsun2	98	68.428	Scophthalmus_maximus
ENSG00000037474	NSUN2	93	71.527	ENSSDUG00000002080	nsun2	91	72.638	Seriola_dumerili
ENSG00000037474	NSUN2	93	72.028	ENSSLDG00000004496	nsun2	90	73.525	Seriola_lalandi_dorsalis
ENSG00000037474	NSUN2	93	75.664	ENSSPUG00000008865	NSUN2	89	75.664	Sphenodon_punctatus
ENSG00000037474	NSUN2	93	71.175	ENSSPAG00000003665	nsun2	92	73.202	Stegastes_partitus
ENSG00000037474	NSUN2	99	85.084	ENSSSCG00000017104	NSUN2	95	85.411	Sus_scrofa
ENSG00000037474	NSUN2	88	80.593	ENSTGUG00000007789	NSUN2	100	80.444	Taeniopygia_guttata
ENSG00000037474	NSUN2	94	70.082	ENSTRUG00000011788	nsun2	98	69.128	Takifugu_rubripes
ENSG00000037474	NSUN2	93	71.170	ENSTNIG00000009258	nsun2	94	72.926	Tetraodon_nigroviridis
ENSG00000037474	NSUN2	96	81.436	ENSTBEG00000014695	NSUN2	99	81.436	Tupaia_belangeri
ENSG00000037474	NSUN2	98	82.533	ENSTTRG00000012662	NSUN2	98	82.533	Tursiops_truncatus
ENSG00000037474	NSUN2	99	83.442	ENSUAMG00000024741	NSUN2	91	97.159	Ursus_americanus
ENSG00000037474	NSUN2	91	86.838	ENSUMAG00000021149	NSUN2	99	86.838	Ursus_maritimus
ENSG00000037474	NSUN2	89	93.855	ENSVPAG00000005110	-	85	94.521	Vicugna_pacos
ENSG00000037474	NSUN2	87	89.955	ENSVVUG00000017691	NSUN2	94	89.955	Vulpes_vulpes
ENSG00000037474	NSUN2	89	76.901	ENSXETG00000001732	nsun2	85	76.901	Xenopus_tropicalis
ENSG00000037474	NSUN2	93	71.289	ENSXCOG00000002584	nsun2	95	70.596	Xiphophorus_couchianus
ENSG00000037474	NSUN2	93	71.967	ENSXMAG00000013597	nsun2	95	71.271	Xiphophorus_maculatus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000049	tRNA binding	21873635.	IBA	Function
GO:0003723	RNA binding	22658674.22681889.	HDA	Function
GO:0005634	nucleus	21873635.	IBA	Component
GO:0005654	nucleoplasm	-	TAS	Component
GO:0005730	nucleolus	17071714.	IDA	Component
GO:0005737	cytoplasm	21873635.	IBA	Component
GO:0005737	cytoplasm	17071714.	IDA	Component
GO:0005819	spindle	-	IEA	Component
GO:0006400	tRNA modification	-	TAS	Process
GO:0007286	spermatid development	-	IEA	Process
GO:0008168	methyltransferase activity	21873635.	IBA	Function
GO:0016428	tRNA (cytosine-5-)-methyltransferase activity	17071714.	EXP	Function
GO:0016428	tRNA (cytosine-5-)-methyltransferase activity	21873635.	IBA	Function
GO:0016428	tRNA (cytosine-5-)-methyltransferase activity	17071714.	IDA	Function
GO:0030488	tRNA methylation	21873635.	IBA	Process
GO:0030488	tRNA methylation	17071714.	IDA	Process
GO:0033313	meiotic cell cycle checkpoint	-	IEA	Process
GO:0033391	chromatoid body	-	IEA	Component
GO:0048820	hair follicle maturation	-	IEA	Process
GO:0051301	cell division	-	IEA	Process

Cancer associated literatures

PID	Title	Article	Time	Author	Doi
19740597	Genomic gain of 5p15 leads to over-expression of Misu (NSUN2) in breast cancer.	Cancer Lett	2010 Mar 1	Frye M	doi: 10.1016/j.canlet.2009.08.004
27447970	Overexpression of NSUN2 by DNA hypomethylation is associated with metastatic progression in human breast cancer.	Oncotarget	2017 Mar 28	Yi J	doi: 10.18632/oncotarget.10612.
28829218	Association of tRNA methyltransferase NSUN2/IGF-II molecular signature with ovarian cancer survival.	Future Oncol	2017 Sep	Yang JC	doi: 10.2217/fon-2017-0084

Differential Expression

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq	RBD
BLCA	chr5	6625670	Splice_Site	novel	X120_splice	0.53
BLCA	chr5	6620161	Missense_Mutation	novel	D254Y	0.09	Methyltr_RsmB-F
BLCA	chr5	6620242	Missense_Mutation	NA	Q227E	0.23	Methyltr_RsmB-F
BLCA	chr5	6623227	Missense_Mutation	rs778979236	R175Q	0.47	Methyltr_RsmB-F
BLCA	chr5	6632616	Missense_Mutation	novel	R79S	0.43
BLCA	chr5	6611737	Missense_Mutation	rs375801396	I361M	0.2
BLCA	chr5	6605357	Silent	NA	R551R	0.08
BLCA	chr5	6607234	Missense_Mutation	novel	E492Q	0.03
BLCA	chr5	6604219	Missense_Mutation	NA	D626N	0.33
BLCA	chr5	6604637	Nonsense_Mutation	novel	E596*	0.35
BLCA	chr5	6600126	Missense_Mutation	novel	M702L	0.33
BRCA	chr5	6600034	Silent	NA	V732V	0.27
BRCA	chr5	6600222	Missense_Mutation	rs759251595	A670S	0.67
BRCA	chr5	6620263	Missense_Mutation	rs745927756	R220C	0.16	Methyltr_RsmB-F
BRCA	chr5	6604219	Missense_Mutation	NA	D626N	0.08
CESC	chr5	6606901	Missense_Mutation	novel	S507L	0.09
CESC	chr5	6599497	3'UTR	novel		0.33
CESC	chr5	6600229	Missense_Mutation	novel	N667K	0.24
CESC	chr5	6600063	Missense_Mutation	rs746142475	A723T	0.3
CESC	chr5	6631973	Missense_Mutation	novel	A87T	0.39
CESC	chr5	6632709	Silent	NA	F48F	0.49
CESC	chr5	6599450	3'UTR	novel		0.09
COAD	chr5	6609880	Frame_Shift_Del	NA	*F423Lfs6**	0.21
COAD	chr5	6620130	Missense_Mutation	rs200539341	R264Q	0.08	Methyltr_RsmB-F
COAD	chr5	6609855	Missense_Mutation	novel	S432P	0.05
COAD	chr5	6616733	Frame_Shift_Del	NA	*S339Vfs17**	0.16	Methyltr_RsmB-F
COAD	chr5	6600188	Missense_Mutation	novel	R681Q	0.22
COAD	chr5	6632753	Missense_Mutation	novel	W34R	0.16
COAD	chr5	6620283	Missense_Mutation	NA	A213V	0.31	Methyltr_RsmB-F
COAD	chr5	6625664	Missense_Mutation	novel	P122H	0.07
COAD	chr5	6604694	Intron	novel		0.21
COAD	chr5	6604838	Intron	novel		0.25
COAD	chr5	6610973	Missense_Mutation	NA	A403V	0.16
COAD	chr5	6605401	Frame_Shift_Del	novel	*Y537Mfs10**	0.1
COAD	chr5	6620440	Intron	novel		0.17
COAD	chr5	6625668	Missense_Mutation	NA	Y121H	0.3
COAD	chr5	6625612	Silent	rs201206063	S139S	0.31
COAD	chr5	6611077	Silent	NA	T368T	0.06
GBM	chr5	6605358	Missense_Mutation	rs773400155	R551Q	0.17
GBM	chr5	6625612	Silent	rs201206063	S139S	0.16
GBM	chr5	6632617	Missense_Mutation	novel	R79I	0.44
GBM	chr5	6620138	Silent	novel	F261F	0.13
GBM	chr5	6604644	Silent	rs146819725	S593S	0.48
GBM	chr5	6622024	Missense_Mutation	rs767166292	P205L	0.41	Methyltr_RsmB-F
GBM	chr5	6604177	Nonsense_Mutation	novel	K640*	0.15
HNSC	chr5	6599919	3'UTR	rs372577186		0.21
HNSC	chr5	6611073	Missense_Mutation	novel	D370N	0.22
HNSC	chr5	6605350	Missense_Mutation	novel	E554K	0.12
HNSC	chr5	6606865	Missense_Mutation	novel	P519L	0.4
HNSC	chr5	6625632	Silent	novel	R133R	0.67
HNSC	chr5	6620262	Missense_Mutation	novel	R220L	0.26	Methyltr_RsmB-F
HNSC	chr5	6620114	Silent	novel	V269V	0.21
HNSC	chr5	6632675	Missense_Mutation	NA	E60K	0.07
HNSC	chr5	6609874	Silent	novel	A425A	0.51
HNSC	chr5	6631965	Missense_Mutation	novel	E89D	0.18
KIRC	chr5	6620209	Frame_Shift_Del	novel	*V238Wfs14**	0.3	Methyltr_RsmB-F
KIRC	chr5	6611077	Silent	NA	T368T	0.05
KIRC	chr5	6600147	Missense_Mutation	NA	R695G	0.12
KIRP	chr5	6620223	Missense_Mutation	NA	S233N	0.06	Methyltr_RsmB-F
KIRP	chr5	6620167	Missense_Mutation	NA	D252N	0.34	Methyltr_RsmB-F
KIRP	chr5	6600055	Silent	NA	T725T	0.45
KIRP	chr5	6616789	Missense_Mutation	novel	T320K	0.48	Methyltr_RsmB-F
LAML	chr5	6606827	Missense_Mutation	novel	P532A	0.23
LGG	chr5	6620103	Splice_Region	novel		0.25
LGG	chr5	6620380	Intron	novel		0.35
LGG	chr5	6632602	Missense_Mutation	novel	K84R	0.12
LIHC	chr5	6602466	Silent	NA	D664D	0.35
LIHC	chr5	6604776	Intron	novel		0.23
LUAD	chr5	6625641	Missense_Mutation	NA	N130D	0.45
LUAD	chr5	6600222	Missense_Mutation	rs759251595	A670S	0.24
LUAD	chr5	6599929	Silent	NA	R767R	0.16
LUAD	chr5	6605389	Missense_Mutation	NA	P541S	0.1
LUAD	chr5	6625568	Frame_Shift_Del	novel	*E154Ifs5**	0.06
LUAD	chr5	6607346	Frame_Shift_Del	novel	*Q454Pfs16**	0.23
LUAD	chr5	6609827	Missense_Mutation	novel	K441M	0.12
LUAD	chr5	6600176	Missense_Mutation	novel	S685C	0.27
LUAD	chr5	6616769	Missense_Mutation	novel	E327K	0.67	Methyltr_RsmB-F
LUAD	chr5	6599973	Missense_Mutation	NA	D753H	0.05
LUAD	chr5	6625662	Missense_Mutation	NA	E123K	0.26
LUAD	chr5	6617965	Missense_Mutation	NA	S292I	0.1	Methyltr_RsmB-F
LUAD	chr5	6620190	Missense_Mutation	NA	S244F	0.1	Methyltr_RsmB-F
LUAD	chr5	6610955	Missense_Mutation	novel	C409Y	0.08
LUAD	chr5	6620157	Missense_Mutation	rs375926964	G255V	0.11	Methyltr_RsmB-F
LUAD	chr5	6620158	Missense_Mutation	novel	G255C	0.11	Methyltr_RsmB-F
LUSC	chr5	6611084	Missense_Mutation	NA	V366E	0.37
LUSC	chr5	6616757	Missense_Mutation	NA	V331L	0.28	Methyltr_RsmB-F
LUSC	chr5	6616799	Missense_Mutation	novel	V317L	0.11	Methyltr_RsmB-F
LUSC	chr5	6602487	Silent	rs200618355	I657I	0.31
LUSC	chr5	6620204	Silent	NA	V239V	0.1
LUSC	chr5	6632664	Missense_Mutation	novel	W63C	0.22
LUSC	chr5	6620254	Silent	rs757734986	L223L	0.56
LUSC	chr5	6605307	Missense_Mutation	novel	R568P	0.09
LUSC	chr5	6607197	Splice_Region	novel		0.24
LUSC	chr5	6620199	Missense_Mutation	NA	H241R	0.14	Methyltr_RsmB-F
LUSC	chr5	6620177	Frame_Shift_Del	novel	*R248Sfs4**	0.28	Methyltr_RsmB-F
LUSC	chr5	6600013	Silent	NA	G739G	0.55
MESO	chr5	6604685	Frame_Shift_Del	novel	*V580Lfs52**	0.31
OV	chr5	6605383	Missense_Mutation	novel	F543V	0.12
OV	chr5	6620150	Missense_Mutation	novel	K257N	0.06	Methyltr_RsmB-F
OV	chr5	6600135	Missense_Mutation	rs190753127	L699F	0.63
OV	chr5	6605316	Frame_Shift_Del	novel	*K565Gfs9**	0.04
OV	chr5	6600180	Frame_Shift_Ins	novel	*A684Rfs11**	0.06
OV	chr5	6611047	Missense_Mutation	novel	D378E	0.31
PAAD	chr5	6604218	Missense_Mutation	novel	D626A	0.18
PAAD	chr5	6620406	Intron	novel		0.13
PCPG	chr5	6600159	Missense_Mutation	novel	P691T	0.06
PRAD	chr5	6605282	Silent	novel	E576E	0.36
READ	chr5	6620262	Missense_Mutation	rs146332265	R220H	0.22	Methyltr_RsmB-F
READ	chr5	6625569	Missense_Mutation	novel	E154K	0.33
READ	chr5	6607308	Missense_Mutation	novel	D467A	0.06
SKCM	chr5	6599788	3'UTR	novel		0.33
SKCM	chr5	6620113	Missense_Mutation	NA	P270S	0.09	Methyltr_RsmB-F
SKCM	chr5	6620114	Silent	novel	V269V	0.09
SKCM	chr5	6611002	Silent	NA	F393F	0.34
SKCM	chr5	6604159	Missense_Mutation	novel	Y646H	0.1
SKCM	chr5	6604673	Missense_Mutation	NA	G584R	0.34
SKCM	chr5	6611002	Silent	NA	F393F	0.32
SKCM	chr5	6616775	Missense_Mutation	NA	P325S	0.55	Methyltr_RsmB-F
SKCM	chr5	6620112	Missense_Mutation	NA	P270L	0.41	Methyltr_RsmB-F
SKCM	chr5	6617990	Missense_Mutation	NA	W284G	0.09	Methyltr_RsmB-F
SKCM	chr5	6600133	Silent	rs1057838	L699L	0.45
SKCM	chr5	6600230	Missense_Mutation	novel	N667S	0.52
SKCM	chr5	6609849	Missense_Mutation	novel	P434S	0.39
SKCM	chr5	6625632	Missense_Mutation	NA	R133G	0.58
SKCM	chr5	6622025	Missense_Mutation	novel	P205T	0.4	Methyltr_RsmB-F
SKCM	chr5	6632625	Silent	NA	A76A	0.6
SKCM	chr5	6599929	Silent	NA	R767R	0.33
STAD	chr5	6616795	Missense_Mutation	NA	Y318C	0.08	Methyltr_RsmB-F
STAD	chr5	6602486	Missense_Mutation	rs770178867	V658M	0.26
STAD	chr5	6599889	3'UTR	rs201896744		0.29
STAD	chr5	6604619	Missense_Mutation	rs371887249	R602W	0.33
STAD	chr5	6623228	Missense_Mutation	rs200377019	R175W	0.34	Methyltr_RsmB-F
STAD	chr5	6605289	Missense_Mutation	novel	N574S	0.35
STAD	chr5	6620263	Missense_Mutation	rs745927756	R220C	0.13	Methyltr_RsmB-F
STAD	chr5	6607197	Splice_Region	novel		0.23
STAD	chr5	6620244	Missense_Mutation	NA	H226R	0.23	Methyltr_RsmB-F
STAD	chr5	6610996	Silent	rs536258085	P395P	0.08
STAD	chr5	6620122	Frame_Shift_Del	novel	C267*	0.38	Methyltr_RsmB-F
STAD	chr5	6631870	Splice_Region	novel		0.41
STAD	chr5	6604649	Missense_Mutation	NA	N592D	0.1
STAD	chr5	6599942	Missense_Mutation	NA	V763A	0.13
STAD	chr5	6604187	Silent	NA	P636P	0.18
STAD	chr5	6599932	Silent	rs763226756	P766P	0.37
STAD	chr5	6620364	Intron	novel		0.25
THYM	chr5	6620141	Silent	novel	L260L	0.09
UCEC	chr5	6599957	Missense_Mutation	rs747294033	C758Y	0.46
UCEC	chr5	6620130	Missense_Mutation	rs200539341	R264Q	0.22	Methyltr_RsmB-F
UCEC	chr5	6625632	Nonsense_Mutation	NA	R133*	0.25
UCEC	chr5	6632733	Missense_Mutation	novel	E40D	0.27
UCEC	chr5	6631959	Silent	novel	L91L	0.36
UCEC	chr5	6625648	Nonsense_Mutation	NA	W127*	0.13
UCEC	chr5	6607208	Silent	rs370596266	G500G	0.38
UCEC	chr5	6604644	Silent	rs146819725	S593S	0.47
UCEC	chr5	6622037	Missense_Mutation	rs746566794	D201N	0.31	Methyltr_RsmB-F
UCEC	chr5	6599519	3'UTR	novel		0.4
UCEC	chr5	6625632	Nonsense_Mutation	NA	R133*	0.42
UCEC	chr5	6599881	3'UTR	novel		0.35
UCEC	chr5	6605336	Silent	novel	R558R	0.38
UCEC	chr5	6625613	Missense_Mutation	rs750141088	S139L	0.21
UCEC	chr5	6618002	Missense_Mutation	novel	N280H	0.17	Methyltr_RsmB-F
UCEC	chr5	6609849	Missense_Mutation	novel	P434S	0.05
UCEC	chr5	6620104	Splice_Site	NA	X272_splice	0.16
UCEC	chr5	6600100	Silent	novel	K710K	0.21
UCEC	chr5	6607310	Silent	novel	T466T	0.17
UCEC	chr5	6620149	Nonsense_Mutation	novel	E258*	0.15	Methyltr_RsmB-F
UCEC	chr5	6599755	3'UTR	novel		0.32
UCEC	chr5	6605308	Missense_Mutation	novel	R568W	0.05
UCEC	chr5	6604694	Intron	novel		0.38
UCEC	chr5	6599600	3'UTR	novel		0.38
UCEC	chr5	6611769	Nonsense_Mutation	novel	E351*	0.38
UCEC	chr5	6605337	Missense_Mutation	novel	R558M	0.32
UCEC	chr5	6599519	3'UTR	novel		0.29
UCEC	chr5	6599998	Silent	novel	P744P	0.37
UCEC	chr5	6600164	Missense_Mutation	novel	F689C	0.18
UCEC	chr5	6600100	Missense_Mutation	rs765960947	K710N	0.39
UCEC	chr5	6600146	Missense_Mutation	rs761905973	R695Q	0.39
UCEC	chr5	6604761	Intron	novel		0.48
UCEC	chr5	6620234	Missense_Mutation	novel	K229N	0.14	Methyltr_RsmB-F
UCEC	chr5	6620452	Intron	novel		0.33
UCEC	chr5	6623272	Missense_Mutation	rs752681389	R160H	0.34
UCEC	chr5	6625587	Missense_Mutation	novel	F148L	0.22
UCEC	chr5	6600223	Silent	rs778129357	D669D	0.08
UCEC	chr5	6605402	Missense_Mutation	novel	F536L	0.17
UCEC	chr5	6620130	Missense_Mutation	rs200539341	R264Q	0.14	Methyltr_RsmB-F
UCEC	chr5	6599724	3'UTR	novel		0.38
UCEC	chr5	6600196	Silent	rs770100002	C678C	0.46
UCEC	chr5	6599480	3'UTR	novel		0.2
UCEC	chr5	6623227	Missense_Mutation	rs778979236	R175Q	0.34	Methyltr_RsmB-F
UCEC	chr5	6611000	Missense_Mutation	novel	P394H	0.33
UCEC	chr5	6604721	Intron	novel		0.21
UCEC	chr5	6602487	Silent	rs200618355	I657I	0.47
UCEC	chr5	6620278	Missense_Mutation	NA	D215N	0.17	Methyltr_RsmB-F
UCEC	chr5	6625631	Missense_Mutation	NA	R133Q	0.2
UCEC	chr5	6599519	3'UTR	novel		0.25
UCEC	chr5	6607227	Missense_Mutation	novel	N494S	0.12
UCEC	chr5	6604860	Intron	novel		0.5
UCEC	chr5	6611072	Missense_Mutation	novel	D370G	0.13
UCEC	chr5	6623227	Missense_Mutation	rs778979236	R175Q	0.1	Methyltr_RsmB-F
UCEC	chr5	6604619	Missense_Mutation	rs371887249	R602W	0.41
UCEC	chr5	6611000	Missense_Mutation	novel	P394H	0.32
UCEC	chr5	6622027	Missense_Mutation	rs762223733	V204A	0.48	Methyltr_RsmB-F
UCEC	chr5	6600170	Missense_Mutation	rs756450204	R687Q	0.22
UCEC	chr5	6620134	Missense_Mutation	rs761937596	D263Y	0.29	Methyltr_RsmB-F
UCEC	chr5	6600196	Silent	rs770100002	C678C	0.82
UCEC	chr5	6607268	Silent	NA	G480G	0.32
UCEC	chr5	6616846	Missense_Mutation	rs144569332	R301Q	0.31	Methyltr_RsmB-F
UCEC	chr5	6599593	3'UTR	novel		0.64
UCEC	chr5	6600204	Missense_Mutation	rs773052587	V676I	0.36
UCEC	chr5	6604618	Missense_Mutation	rs759577308	R602Q	0.45
UCS	chr5	6607230	Missense_Mutation	novel	N493T	0.35

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
KIRP	DEL	0.0208	0.09673
LGG	DEL	0.0721	0.0003285
SKCM	DEL	0.1526	0.011094
TGCT	DEL	0.58	0.098913
THCA	DEL	0.004	0.23456

Survival Analysis

Cancer	P-value	Q-value
KIRC	0.0022	Kaplan-Meier Survival Analysis
HNSC	0.042	Kaplan-Meier Survival Analysis
KIRP	0.0033	Kaplan-Meier Survival Analysis
BLCA	0.048	Kaplan-Meier Survival Analysis
LAML	0.015	Kaplan-Meier Survival Analysis
KICH	0.033	Kaplan-Meier Survival Analysis
UCEC	0.0014	Kaplan-Meier Survival Analysis
LIHC	0.0097	Kaplan-Meier Survival Analysis
LGG	0.0063	Kaplan-Meier Survival Analysis
UVM	0.017	Kaplan-Meier Survival Analysis