EuRBPDB

Description

RBDs

Expression

Transcripts

Gene Model

Pathways

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000037757 (Gene tree)
Gene ID: 84245
Gene Symbol: MRI1
Alias: MGC3207|Ypr118w|mtnA|MRDI
Full Name: methylthioribose-1-phosphate isomerase 1
Gene Type: protein_coding
Species: Homo_sapiens
Status: putative
Strand: Plus strand
Length: 9,791 bases
Position: chr19:13,764,492-13,774,282
Accession: 28469
RBP type: canonical RBP
Summary: This enzyme functions in the methionine salvage pathway by catalyzing the interconversion of methylthioribose-1-phosphate and methythioribulose-1-phosphate. Elevated expression of the encoded protein is associated with metastatic melanoma and this protein promotes melanoma cell invasion independent of its enzymatic activity. Mutations in this gene may be associated with vanishing white matter disease (VMWD). [provided by RefSeq, Jul 2016]

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000040663	IF-2B	PF01008.17	3.9e-77	1	1
ENSP00000314871	IF-2B	PF01008.17	4.4e-63	1	2
ENSP00000314871	IF-2B	PF01008.17	4.4e-63	2	2

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000319545	MRI1-202	3027	-	ENSP00000314871	322 (aa)	-	Q9BV20
ENST00000589290	MRI1-204	602	-	-	- (aa)	-	-
ENST00000593245	MRI1-206	786	-	-	- (aa)	-	-
ENST00000588526	MRI1-203	862	-	-	- (aa)	-	-
ENST00000040663	MRI1-201	1735	XM_011528356	ENSP00000040663	369 (aa)	XP_011526658	Q9BV20
ENST00000591688	MRI1-205	897	-	-	- (aa)	-	-

Gene Model

Click here to download ENSG00000037757's gene model file

Pathways

Pathway ID	Pathway Name	Source
hsa00270	Cysteine and methionine metabolism	KEGG
hsa01100	Metabolic pathways	KEGG

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000037757's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000037757	MRI1	96	69.492	ENSAPOG00000009673	mri1	98	69.492	Acanthochromis_polyacanthus
ENSG00000037757	MRI1	97	88.089	ENSAMEG00000012918	MRI1	100	88.643	Ailuropoda_melanoleuca
ENSG00000037757	MRI1	96	69.492	ENSACIG00000009199	mri1	98	69.492	Amphilophus_citrinellus
ENSG00000037757	MRI1	96	69.492	ENSAOCG00000009931	mri1	98	69.492	Amphiprion_ocellaris
ENSG00000037757	MRI1	96	69.492	ENSAPEG00000013553	mri1	98	69.492	Amphiprion_percula
ENSG00000037757	MRI1	96	68.927	ENSATEG00000019410	mri1	98	68.927	Anabas_testudineus
ENSG00000037757	MRI1	96	74.648	ENSACAG00000003475	MRI1	98	74.366	Anolis_carolinensis
ENSG00000037757	MRI1	98	86.777	ENSANAG00000035382	-	100	86.777	Aotus_nancymaae
ENSG00000037757	MRI1	100	95.393	ENSANAG00000020896	-	100	95.393	Aotus_nancymaae
ENSG00000037757	MRI1	96	69.492	ENSACLG00000020412	mri1	98	69.492	Astatotilapia_calliptera
ENSG00000037757	MRI1	96	68.451	ENSAMXG00000011982	mri1	98	68.451	Astyanax_mexicanus
ENSG00000037757	MRI1	97	93.017	ENSBTAG00000002524	MRI1	91	93.017	Bos_taurus
ENSG00000037757	MRI1	95	43.875	WBGene00007236	C01G10.9	93	43.875	Caenorhabditis_elegans
ENSG00000037757	MRI1	99	91.781	ENSCJAG00000044187	MRI1	97	91.781	Callithrix_jacchus
ENSG00000037757	MRI1	99	91.576	ENSCAFG00000016615	MRI1	100	92.179	Canis_familiaris
ENSG00000037757	MRI1	97	92.179	ENSCAFG00020006659	MRI1	100	92.179	Canis_lupus_dingo
ENSG00000037757	MRI1	99	92.120	ENSCHIG00000019343	MRI1	99	92.120	Capra_hircus
ENSG00000037757	MRI1	66	81.224	ENSTSYG00000034486	MRI1	100	81.224	Carlito_syrichta
ENSG00000037757	MRI1	63	90.948	ENSCAPG00000015487	MRI1	97	90.948	Cavia_aperea
ENSG00000037757	MRI1	96	87.921	ENSCPOG00000013191	MRI1	98	87.921	Cavia_porcellus
ENSG00000037757	MRI1	99	94.293	ENSCCAG00000014292	-	98	94.293	Cebus_capucinus
ENSG00000037757	MRI1	98	85.950	ENSCCAG00000035484	-	100	85.950	Cebus_capucinus
ENSG00000037757	MRI1	100	80.161	ENSCATG00000029747	MRI1	100	80.161	Cercocebus_atys
ENSG00000037757	MRI1	98	86.981	ENSCLAG00000013025	MRI1	99	86.981	Chinchilla_lanigera
ENSG00000037757	MRI1	100	95.733	ENSCSAG00000006463	MRI1	100	95.733	Chlorocebus_sabaeus
ENSG00000037757	MRI1	54	53.769	ENSCING00000000162	-	99	53.266	Ciona_intestinalis
ENSG00000037757	MRI1	95	57.429	ENSCSAVG00000003107	-	99	56.857	Ciona_savignyi
ENSG00000037757	MRI1	88	96.933	ENSCANG00000043216	MRI1	100	96.403	Colobus_angolensis_palliatus
ENSG00000037757	MRI1	100	86.450	ENSCGRG00001015655	MRI1	100	86.450	Cricetulus_griseus_chok1gshd
ENSG00000037757	MRI1	100	86.450	ENSCGRG00000005697	MRI1	100	86.450	Cricetulus_griseus_crigri
ENSG00000037757	MRI1	96	68.927	ENSCSEG00000011410	mri1	98	68.927	Cynoglossus_semilaevis
ENSG00000037757	MRI1	96	69.492	ENSCVAG00000023215	mri1	98	69.492	Cyprinodon_variegatus
ENSG00000037757	MRI1	96	68.362	ENSDARG00000075754	mri1	96	77.778	Danio_rerio
ENSG00000037757	MRI1	97	86.872	ENSDNOG00000047045	MRI1	99	86.872	Dasypus_novemcinctus
ENSG00000037757	MRI1	98	87.293	ENSDORG00000010875	Mri1	99	87.293	Dipodomys_ordii
ENSG00000037757	MRI1	97	59.290	FBgn0039849	CG11334	100	59.016	Drosophila_melanogaster
ENSG00000037757	MRI1	86	90.190	ENSETEG00000017174	MRI1	100	90.190	Echinops_telfairi
ENSG00000037757	MRI1	97	59.777	ENSEBUG00000014184	mri1	100	59.777	Eptatretus_burgeri
ENSG00000037757	MRI1	97	89.106	ENSEASG00005000151	MRI1	100	89.106	Equus_asinus_asinus
ENSG00000037757	MRI1	97	89.106	ENSECAG00000010706	MRI1	100	89.106	Equus_caballus
ENSG00000037757	MRI1	96	62.147	ENSELUG00000016174	mri1	99	62.117	Esox_lucius
ENSG00000037757	MRI1	93	84.393	ENSFCAG00000011508	MRI1	97	86.127	Felis_catus
ENSG00000037757	MRI1	64	88.511	ENSFDAG00000017424	MRI1	91	88.511	Fukomys_damarensis
ENSG00000037757	MRI1	96	70.056	ENSFHEG00000009358	MRI1	98	70.056	Fundulus_heteroclitus
ENSG00000037757	MRI1	81	77.922	ENSGMOG00000002273	mri1	97	62.315	Gadus_morhua
ENSG00000037757	MRI1	91	58.631	ENSGALG00000034575	MRI1	97	58.333	Gallus_gallus
ENSG00000037757	MRI1	96	69.209	ENSGAFG00000010575	mri1	98	69.209	Gambusia_affinis
ENSG00000037757	MRI1	91	68.843	ENSGACG00000018995	mri1	99	68.843	Gasterosteus_aculeatus
ENSG00000037757	MRI1	97	75.766	ENSGAGG00000010411	MRI1	99	74.930	Gopherus_agassizii
ENSG00000037757	MRI1	100	99.187	ENSGGOG00000006628	MRI1	100	99.187	Gorilla_gorilla
ENSG00000037757	MRI1	96	69.492	ENSHBUG00000018620	mri1	98	69.492	Haplochromis_burtoni
ENSG00000037757	MRI1	97	87.151	ENSHGLG00000010969	MRI1	99	87.151	Heterocephalus_glaber_female
ENSG00000037757	MRI1	97	81.337	ENSHGLG00100007151	MRI1	99	81.337	Heterocephalus_glaber_male
ENSG00000037757	MRI1	96	68.644	ENSHCOG00000014695	mri1	98	68.644	Hippocampus_comes
ENSG00000037757	MRI1	96	69.209	ENSIPUG00000008756	mri1	98	69.209	Ictalurus_punctatus
ENSG00000037757	MRI1	96	91.808	ENSSTOG00000020750	MRI1	98	91.808	Ictidomys_tridecemlineatus
ENSG00000037757	MRI1	99	87.978	ENSJJAG00000018104	Mri1	99	87.978	Jaculus_jaculus
ENSG00000037757	MRI1	96	69.774	ENSKMAG00000018700	mri1	98	69.774	Kryptolebias_marmoratus
ENSG00000037757	MRI1	96	68.927	ENSLBEG00000004998	mri1	98	68.927	Labrus_bergylta
ENSG00000037757	MRI1	96	70.056	ENSLACG00000006845	MRI1	99	70.056	Latimeria_chalumnae
ENSG00000037757	MRI1	97	79.832	ENSLAFG00000012910	MRI1	100	79.832	Loxodonta_africana
ENSG00000037757	MRI1	86	97.468	ENSMFAG00000044250	MRI1	100	97.468	Macaca_fascicularis
ENSG00000037757	MRI1	100	97.290	ENSMMUG00000018068	MRI1	100	97.290	Macaca_mulatta
ENSG00000037757	MRI1	100	97.290	ENSMNEG00000002628	MRI1	100	96.894	Macaca_nemestrina
ENSG00000037757	MRI1	100	97.290	ENSMLEG00000035138	MRI1	100	97.290	Mandrillus_leucophaeus
ENSG00000037757	MRI1	96	68.644	ENSMAMG00000011686	mri1	98	68.644	Mastacembelus_armatus
ENSG00000037757	MRI1	96	69.492	ENSMZEG00005007657	mri1	98	69.492	Maylandia_zebra
ENSG00000037757	MRI1	72	87.097	ENSMAUG00000003451	Mri1	100	87.097	Mesocricetus_auratus
ENSG00000037757	MRI1	100	91.870	ENSMICG00000031875	MRI1	100	91.870	Microcebus_murinus
ENSG00000037757	MRI1	100	85.366	ENSMOCG00000009591	Mri1	100	85.366	Microtus_ochrogaster
ENSG00000037757	MRI1	96	69.492	ENSMMOG00000021373	mri1	68	69.492	Mola_mola
ENSG00000037757	MRI1	96	81.127	ENSMODG00000011870	MRI1	100	81.127	Monodelphis_domestica
ENSG00000037757	MRI1	96	67.797	ENSMALG00000006021	mri1	98	67.797	Monopterus_albus
ENSG00000037757	MRI1	99	86.104	MGP_CAROLIEiJ_G0031299	Mri1	99	86.104	Mus_caroli
ENSG00000037757	MRI1	99	86.376	ENSMUSG00000004996	Mri1	99	86.376	Mus_musculus
ENSG00000037757	MRI1	100	85.366	MGP_PahariEiJ_G0022905	Mri1	100	85.366	Mus_pahari
ENSG00000037757	MRI1	99	86.376	MGP_SPRETEiJ_G0032417	Mri1	99	86.376	Mus_spretus
ENSG00000037757	MRI1	97	91.341	ENSMPUG00000003316	MRI1	100	91.341	Mustela_putorius_furo
ENSG00000037757	MRI1	96	91.292	ENSMLUG00000004766	MRI1	99	91.292	Myotis_lucifugus
ENSG00000037757	MRI1	97	88.268	ENSNGAG00000022102	Mri1	99	88.268	Nannospalax_galili
ENSG00000037757	MRI1	96	61.345	ENSNBRG00000023766	mri1	98	61.345	Neolamprologus_brichardi
ENSG00000037757	MRI1	100	97.205	ENSNLEG00000013138	MRI1	100	97.205	Nomascus_leucogenys
ENSG00000037757	MRI1	83	82.353	ENSMEUG00000013717	MRI1	99	67.036	Notamacropus_eugenii
ENSG00000037757	MRI1	58	90.233	ENSOPRG00000015475	-	100	90.233	Ochotona_princeps
ENSG00000037757	MRI1	50	90.811	ENSOPRG00000008859	-	100	90.811	Ochotona_princeps
ENSG00000037757	MRI1	94	86.994	ENSODEG00000010083	-	94	86.994	Octodon_degus
ENSG00000037757	MRI1	99	83.836	ENSODEG00000019755	-	99	83.836	Octodon_degus
ENSG00000037757	MRI1	96	69.492	ENSONIG00000017732	mri1	98	69.492	Oreochromis_niloticus
ENSG00000037757	MRI1	86	80.442	ENSOANG00000012399	MRI1	98	80.442	Ornithorhynchus_anatinus
ENSG00000037757	MRI1	96	87.640	ENSOCUG00000024840	MRI1	98	87.640	Oryctolagus_cuniculus
ENSG00000037757	MRI1	96	68.927	ENSORLG00000011911	mri1	98	68.927	Oryzias_latipes
ENSG00000037757	MRI1	96	68.927	ENSORLG00020005135	MRI1	98	68.927	Oryzias_latipes_hni
ENSG00000037757	MRI1	96	68.927	ENSORLG00015003701	MRI1	98	68.927	Oryzias_latipes_hsok
ENSG00000037757	MRI1	91	65.179	ENSOMEG00000013120	mri1	99	65.179	Oryzias_melastigma
ENSG00000037757	MRI1	100	89.218	ENSOGAG00000007183	MRI1	100	89.218	Otolemur_garnettii
ENSG00000037757	MRI1	99	76.011	ENSOARG00000008222	MRI1	99	76.011	Ovis_aries
ENSG00000037757	MRI1	100	86.992	ENSPPAG00000033346	MRI1	91	97.059	Pan_paniscus
ENSG00000037757	MRI1	99	90.217	ENSPPRG00000006539	MRI1	99	90.217	Panthera_pardus
ENSG00000037757	MRI1	97	91.061	ENSPTIG00000005216	MRI1	100	91.061	Panthera_tigris_altaica
ENSG00000037757	MRI1	100	98.916	ENSPTRG00000010563	MRI1	100	98.916	Pan_troglodytes
ENSG00000037757	MRI1	100	97.561	ENSPANG00000010977	MRI1	100	97.561	Papio_anubis
ENSG00000037757	MRI1	96	61.017	ENSPKIG00000003387	mri1	99	60.909	Paramormyrops_kingsleyae
ENSG00000037757	MRI1	96	68.079	ENSPMGG00000016429	mri1	98	68.079	Periophthalmus_magnuspinnatus
ENSG00000037757	MRI1	100	86.450	ENSPEMG00000006105	Mri1	100	86.450	Peromyscus_maniculatus_bairdii
ENSG00000037757	MRI1	96	64.023	ENSPMAG00000006128	mri1	99	64.023	Petromyzon_marinus
ENSG00000037757	MRI1	97	81.844	ENSPCIG00000019032	MRI1	100	81.844	Phascolarctos_cinereus
ENSG00000037757	MRI1	96	69.774	ENSPFOG00000004311	mri1	98	69.774	Poecilia_formosa
ENSG00000037757	MRI1	96	69.492	ENSPLAG00000010852	mri1	98	69.492	Poecilia_latipinna
ENSG00000037757	MRI1	96	69.774	ENSPMEG00000014113	mri1	98	69.774	Poecilia_mexicana
ENSG00000037757	MRI1	77	64.912	ENSPREG00000000422	mri1	81	64.912	Poecilia_reticulata
ENSG00000037757	MRI1	100	92.973	ENSPPYG00000010570	MRI1	100	92.973	Pongo_abelii
ENSG00000037757	MRI1	99	89.344	ENSPCAG00000014275	MRI1	99	89.344	Procavia_capensis
ENSG00000037757	MRI1	88	93.538	ENSPCOG00000021500	MRI1	100	93.538	Propithecus_coquereli
ENSG00000037757	MRI1	98	90.634	ENSPVAG00000006322	MRI1	99	90.634	Pteropus_vampyrus
ENSG00000037757	MRI1	96	69.492	ENSPNYG00000001542	mri1	98	69.492	Pundamilia_nyererei
ENSG00000037757	MRI1	96	67.606	ENSPNAG00000012506	mri1	98	67.606	Pygocentrus_nattereri
ENSG00000037757	MRI1	100	86.450	ENSRNOG00000026211	Mri1	100	86.450	Rattus_norvegicus
ENSG00000037757	MRI1	100	97.561	ENSRBIG00000028556	MRI1	100	96.584	Rhinopithecus_bieti
ENSG00000037757	MRI1	100	97.019	ENSRROG00000031188	MRI1	100	97.019	Rhinopithecus_roxellana
ENSG00000037757	MRI1	93	41.935	YPR118W	-	97	41.191	Saccharomyces_cerevisiae
ENSG00000037757	MRI1	88	94.154	ENSSBOG00000034840	-	100	94.154	Saimiri_boliviensis_boliviensis
ENSG00000037757	MRI1	98	80.165	ENSSBOG00000029825	-	100	80.165	Saimiri_boliviensis_boliviensis
ENSG00000037757	MRI1	97	80.726	ENSSHAG00000011531	MRI1	100	80.726	Sarcophilus_harrisii
ENSG00000037757	MRI1	84	69.453	ENSSFOG00015018651	mri1	95	69.453	Scleropages_formosus
ENSG00000037757	MRI1	96	68.927	ENSSMAG00000004636	mri1	98	68.927	Scophthalmus_maximus
ENSG00000037757	MRI1	96	69.492	ENSSDUG00000002275	mri1	98	69.492	Seriola_dumerili
ENSG00000037757	MRI1	96	69.492	ENSSLDG00000012900	mri1	98	69.492	Seriola_lalandi_dorsalis
ENSG00000037757	MRI1	99	86.141	ENSSARG00000007904	MRI1	99	86.141	Sorex_araneus
ENSG00000037757	MRI1	96	56.863	ENSSPUG00000002937	MRI1	97	56.583	Sphenodon_punctatus
ENSG00000037757	MRI1	96	69.492	ENSSPAG00000008235	mri1	98	69.492	Stegastes_partitus
ENSG00000037757	MRI1	97	92.997	ENSSSCG00000013756	MRI1	90	92.997	Sus_scrofa
ENSG00000037757	MRI1	96	69.209	ENSTRUG00000010929	mri1	98	69.209	Takifugu_rubripes
ENSG00000037757	MRI1	96	67.514	ENSTNIG00000014065	mri1	99	67.514	Tetraodon_nigroviridis
ENSG00000037757	MRI1	70	93.103	ENSTBEG00000008620	MRI1	100	67.722	Tupaia_belangeri
ENSG00000037757	MRI1	99	91.848	ENSTTRG00000010347	MRI1	99	91.848	Tursiops_truncatus
ENSG00000037757	MRI1	97	92.458	ENSUAMG00000015405	MRI1	100	92.458	Ursus_americanus
ENSG00000037757	MRI1	97	90.223	ENSUMAG00000004743	MRI1	100	90.223	Ursus_maritimus
ENSG00000037757	MRI1	63	91.758	ENSVPAG00000011144	-	63	91.758	Vicugna_pacos
ENSG00000037757	MRI1	97	92.179	ENSVVUG00000026734	MRI1	91	92.179	Vulpes_vulpes
ENSG00000037757	MRI1	96	67.688	ENSXETG00000021867	mri1	99	67.688	Xenopus_tropicalis
ENSG00000037757	MRI1	84	70.323	ENSXCOG00000014431	mri1	91	70.323	Xiphophorus_couchianus
ENSG00000037757	MRI1	96	70.056	ENSXMAG00000027505	MRI1	98	70.056	Xiphophorus_maculatus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0001650	fibrillar center	-	IDA	Component
GO:0005654	nucleoplasm	-	IDA	Component
GO:0005829	cytosol	-	IDA	Component
GO:0005829	cytosol	-	TAS	Component
GO:0019284	L-methionine salvage from S-adenosylmethionine	-	IEA	Process
GO:0019509	L-methionine salvage from methylthioadenosine	21873635.	IBA	Process
GO:0019509	L-methionine salvage from methylthioadenosine	-	IEA	Process
GO:0019509	L-methionine salvage from methylthioadenosine	-	TAS	Process
GO:0042802	identical protein binding	16189514.19447967.25416956.	IPI	Function
GO:0042995	cell projection	-	IEA	Component
GO:0046523	S-methyl-5-thioribose-1-phosphate isomerase activity	21873635.	IBA	Function
GO:0046523	S-methyl-5-thioribose-1-phosphate isomerase activity	-	TAS	Function