EuRBPDB

Description

Ensembl ID: ENSG00000038358 (Gene tree)
Gene ID: 23644
Gene Symbol: EDC4
Alias: RCD-8|Ge-1|HEDLS
Full Name: enhancer of mRNA decapping 4
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Plus strand
Length: 11,492 bases
Position: chr16:67,873,023-67,884,514
Accession: 17157
RBP type: non-canonical RBP
Summary: (Enhancer Of MRNA Decapping 4) is a Protein Coding gene. Diseases associated with EDC4 include Focal Hand Dystonia. Among its related pathways are Deadenylation-dependent mRNA decay and Gene Expression.

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & HEK293	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & MCF10A	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & U2OS	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
24755989	LMKB/MARF1 localizes to mRNA processing bodies, interacts with Ge-1, and regulates IFI44L gene expression.	PLoS One	2014 Apr 22	Bloch DB	doi: 10.1371/journal.pone.0094784
20543818	The C-terminal alpha-alpha superhelix of Pat is required for mRNA decapping in metazoa.	EMBO J	2010 Jul 21	Braun JE	doi: 10.1038/emboj.2010.124

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000573985	EDC4-206	482	-	ENSP00000458357	154 (aa)	-	I3L0V0
ENST00000572031	EDC4-203	584	-	-	- (aa)	-	-
ENST00000575514	EDC4-211	1016	-	-	- (aa)	-	-
ENST00000536072	EDC4-202	2375	-	-	- (aa)	-	-
ENST00000572221	EDC4-204	5267	-	-	- (aa)	-	-
ENST00000574770	EDC4-208	1425	-	-	- (aa)	-	-
ENST00000573992	EDC4-207	3934	-	-	- (aa)	-	-
ENST00000577028	EDC4-213	747	-	-	- (aa)	-	-
ENST00000575507	EDC4-210	570	-	-	- (aa)	-	-
ENST00000572724	EDC4-205	516	-	-	- (aa)	-	-
ENST00000577105	EDC4-214	580	-	ENSP00000459624	135 (aa)	-	I3L2F4
ENST00000576972	EDC4-212	747	-	-	- (aa)	-	-
ENST00000358933	EDC4-201	4800	-	ENSP00000351811	1401 (aa)	-	Q6P2E9
ENST00000575033	EDC4-209	530	-	ENSP00000460563	176 (aa)	-	I3L3M2

Gene Model

Pathways

Pathway ID	Pathway Name	Source
hsa03018	RNA degradation	KEGG

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000038358	Cholesterol, HDL	8E-6	21347282
ENSG00000038358	Metabolic Syndrome X	2E-10	22399527

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000038358	rs8060686	16	67877614	T	HDL cholesterol	21347282	[0.04-0.103] unit decrease	0.0715	EFO_0004612
ENSG00000038358	rs8060686	16	67877614	T	Metabolic syndrome	22399527	[NR] mmol/l decrease	0.11	EFO_0000195
ENSG00000038358	rs56374641	16	67874810	T	HDL cholesterol x physical activity interaction (2df test)	30670697			EFO_0007805\|EFO_0003940

Protein-Protein Interaction (PPI)

* RBP PPI network refers to all genes directly bind to RBP

Orthologs identified by RBPome

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000038358	EDC4	99	98.148	ENSMUSG00000036270	Edc4	100	94.950	Mus_musculus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000932	P-body	21873635.	IBA	Component
GO:0000932	P-body	20826699.	IDA	Component
GO:0005515	protein binding	15231747.16364915.19966221.20543818.20584987.21903422.22982864.23064648.25036637.26496610.27918561.	IPI	Function
GO:0005634	nucleus	7520377.	IDA	Component
GO:0005654	nucleoplasm	-	IDA	Component
GO:0005737	cytoplasm	9067524.	TAS	Component
GO:0005829	cytosol	-	TAS	Component
GO:0008150	biological_process	-	ND	Process
GO:0016020	membrane	19946888.	HDA	Component
GO:0031087	deadenylation-independent decapping of nuclear-transcribed mRNA	21873635.	IBA	Process
GO:0036464	cytoplasmic ribonucleoprotein granule	-	IDA	Component
GO:0043928	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	-	TAS	Process