EuRBPDB

Description

RBDs

Expression

Transcripts

Gene Model

Pathways

Phenotypes

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000041880 (Gene tree)
Gene ID: 10039
Gene Symbol: PARP3
Alias: ADPRT3|IRT1|hPARP-3|pADPRT-3|ADPRTL3
Full Name: poly(ADP-ribose) polymerase family member 3
Gene Type: protein_coding
Species: Homo_sapiens
Status: putative
Strand: Plus strand
Length: 6,581 bases
Position: chr3:51,942,287-51,948,867
Accession: 273
RBP type: canonical RBP
Summary: The protein encoded by this gene belongs to the PARP family. These enzymes modify nuclear proteins by poly-ADP-ribosylation, which is required for DNA repair, regulation of apoptosis, and maintenance of genomic stability. This gene encodes the poly(ADP-ribosyl)transferase 3, which is preferentially localized to the daughter centriole throughout the cell cycle. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000395951	PARP	PF00644.20	8.2e-53	1	1
ENSP00000401511	PARP	PF00644.20	8.2e-53	1	1
ENSP00000381740	PARP	PF00644.20	8.5e-53	1	1

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000498510	PARP3-209	1040	-	ENSP00000417625	331 (aa)	-	C9J9C7
ENST00000431474	PARP3-203	2360	-	ENSP00000401511	533 (aa)	-	Q9Y6F1
ENST00000417220	PARP3-202	2472	XM_005264779	ENSP00000395951	533 (aa)	XP_005264836	Q9Y6F1
ENST00000486510	PARP3-208	443	-	-	- (aa)	-	-
ENST00000398755	PARP3-201	2336	-	ENSP00000381740	540 (aa)	-	Q9Y6F1
ENST00000470749	PARP3-205	697	-	-	- (aa)	-	-
ENST00000471971	PARP3-206	2070	-	ENSP00000417396	53 (aa)	-	F8WAY7
ENST00000475782	PARP3-207	771	-	-	- (aa)	-	-
ENST00000470601	PARP3-204	940	-	-	- (aa)	-	-

Gene Model

Click here to download ENSG00000041880's gene model file

Pathways

Pathway ID	Pathway Name	Source
hsa03410	Base excision repair	KEGG
hsa04210	Apoptosis	KEGG
hsa04217	Necroptosis	KEGG

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000041880	E-Selectin	3.7883000E-005	19729612

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000041880's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000041880	PARP3	98	57.547	ENSAPOG00000005374	parp3	97	56.792	Acanthochromis_polyacanthus
ENSG00000041880	PARP3	100	79.401	ENSAMEG00000009256	PARP3	100	79.439	Ailuropoda_melanoleuca
ENSG00000041880	PARP3	96	53.696	ENSACIG00000020765	parp3	99	52.222	Amphilophus_citrinellus
ENSG00000041880	PARP3	98	56.981	ENSAOCG00000004597	parp3	97	56.604	Amphiprion_ocellaris
ENSG00000041880	PARP3	95	57.895	ENSAPEG00000016950	parp3	95	57.505	Amphiprion_percula
ENSG00000041880	PARP3	100	54.647	ENSATEG00000005131	parp3	99	54.647	Anabas_testudineus
ENSG00000041880	PARP3	98	61.420	ENSAPLG00000011915	PARP3	93	60.987	Anas_platyrhynchos
ENSG00000041880	PARP3	100	60.440	ENSACAG00000011554	PARP3	100	60.401	Anolis_carolinensis
ENSG00000041880	PARP3	100	87.963	ENSANAG00000038182	PARP3	100	87.963	Aotus_nancymaae
ENSG00000041880	PARP3	96	57.393	ENSACLG00000023617	parp3	99	55.844	Astatotilapia_calliptera
ENSG00000041880	PARP3	100	54.562	ENSAMXG00000015192	parp3	100	54.562	Astyanax_mexicanus
ENSG00000041880	PARP3	99	74.019	ENSBTAG00000000671	PARP3	99	74.019	Bos_taurus
ENSG00000041880	PARP3	100	87.617	ENSCJAG00000005742	PARP3	96	87.013	Callithrix_jacchus
ENSG00000041880	PARP3	100	82.364	ENSCAFG00000010042	PARP3	100	82.552	Canis_familiaris
ENSG00000041880	PARP3	100	82.364	ENSCAFG00020022357	PARP3	100	82.552	Canis_lupus_dingo
ENSG00000041880	PARP3	100	79.737	ENSCHIG00000016033	PARP3	100	79.737	Capra_hircus
ENSG00000041880	PARP3	100	87.453	ENSTSYG00000029098	PARP3	99	87.593	Carlito_syrichta
ENSG00000041880	PARP3	100	73.734	ENSCAPG00000007418	PARP3	100	73.734	Cavia_aperea
ENSG00000041880	PARP3	100	74.632	ENSCPOG00000013871	PARP3	100	74.632	Cavia_porcellus
ENSG00000041880	PARP3	100	87.430	ENSCCAG00000010591	PARP3	100	87.430	Cebus_capucinus
ENSG00000041880	PARP3	100	92.593	ENSCATG00000027356	PARP3	100	92.593	Cercocebus_atys
ENSG00000041880	PARP3	100	81.051	ENSCLAG00000008398	PARP3	100	81.051	Chinchilla_lanigera
ENSG00000041880	PARP3	100	92.308	ENSCSAG00000013930	PARP3	100	92.308	Chlorocebus_sabaeus
ENSG00000041880	PARP3	100	62.222	ENSCPBG00000016574	PARP3	100	62.222	Chrysemys_picta_bellii
ENSG00000041880	PARP3	100	92.120	ENSCANG00000043250	PARP3	100	92.120	Colobus_angolensis_palliatus
ENSG00000041880	PARP3	100	80.675	ENSCGRG00001005456	Parp3	100	80.675	Cricetulus_griseus_chok1gshd
ENSG00000041880	PARP3	100	80.675	ENSCGRG00000009858	Parp3	100	80.675	Cricetulus_griseus_crigri
ENSG00000041880	PARP3	94	55.911	ENSCSEG00000002582	parp3	99	52.230	Cynoglossus_semilaevis
ENSG00000041880	PARP3	100	55.680	ENSCVAG00000001026	parp3	99	55.680	Cyprinodon_variegatus
ENSG00000041880	PARP3	100	54.444	ENSDARG00000003961	parp3	99	54.444	Danio_rerio
ENSG00000041880	PARP3	96	77.882	ENSDNOG00000009183	-	90	81.308	Dasypus_novemcinctus
ENSG00000041880	PARP3	57	82.955	ENSETEG00000002436	-	85	82.955	Echinops_telfairi
ENSG00000041880	PARP3	96	49.068	ENSEBUG00000010916	parp3	94	49.242	Eptatretus_burgeri
ENSG00000041880	PARP3	100	83.490	ENSEASG00005012886	PARP3	100	83.490	Equus_asinus_asinus
ENSG00000041880	PARP3	100	83.490	ENSECAG00000018503	PARP3	100	83.490	Equus_caballus
ENSG00000041880	PARP3	100	74.019	ENSEEUG00000000696	PARP3	99	74.019	Erinaceus_europaeus
ENSG00000041880	PARP3	100	53.717	ENSELUG00000017996	parp3	100	53.717	Esox_lucius
ENSG00000041880	PARP3	100	82.176	ENSFCAG00000009146	PARP3	100	82.176	Felis_catus
ENSG00000041880	PARP3	99	60.335	ENSFALG00000008829	PARP3	99	60.335	Ficedula_albicollis
ENSG00000041880	PARP3	100	82.552	ENSFDAG00000017501	PARP3	100	82.552	Fukomys_damarensis
ENSG00000041880	PARP3	95	56.164	ENSFHEG00000006307	parp3	99	54.833	Fundulus_heteroclitus
ENSG00000041880	PARP3	99	53.211	ENSGMOG00000007866	parp3	100	51.743	Gadus_morhua
ENSG00000041880	PARP3	99	61.677	ENSGALG00000004517	PARP3	100	60.708	Gallus_gallus
ENSG00000041880	PARP3	95	56.164	ENSGAFG00000021665	parp3	99	55.307	Gambusia_affinis
ENSG00000041880	PARP3	95	57.505	ENSGACG00000000906	parp3	94	57.310	Gasterosteus_aculeatus
ENSG00000041880	PARP3	100	62.197	ENSGAGG00000022113	PARP3	100	62.197	Gopherus_agassizii
ENSG00000041880	PARP3	100	96.296	ENSGGOG00000012456	PARP3	100	96.296	Gorilla_gorilla
ENSG00000041880	PARP3	96	57.393	ENSHBUG00000013149	parp3	99	55.844	Haplochromis_burtoni
ENSG00000041880	PARP3	100	80.863	ENSHGLG00000011511	PARP3	100	80.863	Heterocephalus_glaber_female
ENSG00000041880	PARP3	100	80.675	ENSHGLG00100015451	PARP3	100	80.675	Heterocephalus_glaber_male
ENSG00000041880	PARP3	100	57.621	ENSHCOG00000004741	parp3	100	57.621	Hippocampus_comes
ENSG00000041880	PARP3	100	54.275	ENSHCOG00000004731	parp3	100	54.275	Hippocampus_comes
ENSG00000041880	PARP3	100	54.004	ENSIPUG00000018781	parp3	100	54.004	Ictalurus_punctatus
ENSG00000041880	PARP3	100	81.614	ENSSTOG00000002565	PARP3	100	81.614	Ictidomys_tridecemlineatus
ENSG00000041880	PARP3	100	78.839	ENSJJAG00000018752	Parp3	100	78.839	Jaculus_jaculus
ENSG00000041880	PARP3	95	56.751	ENSKMAG00000020655	parp3	99	55.204	Kryptolebias_marmoratus
ENSG00000041880	PARP3	100	57.196	ENSLBEG00000012040	parp3	99	57.196	Labrus_bergylta
ENSG00000041880	PARP3	99	58.912	ENSLACG00000017309	PARP3	99	59.134	Latimeria_chalumnae
ENSG00000041880	PARP3	91	55.918	ENSLOCG00000010661	parp3	98	54.563	Lepisosteus_oculatus
ENSG00000041880	PARP3	99	82.276	ENSLAFG00000005740	PARP3	100	82.276	Loxodonta_africana
ENSG00000041880	PARP3	100	92.683	ENSMFAG00000032908	PARP3	100	92.683	Macaca_fascicularis
ENSG00000041880	PARP3	100	92.495	ENSMMUG00000022203	PARP3	100	92.495	Macaca_mulatta
ENSG00000041880	PARP3	100	92.683	ENSMNEG00000040704	PARP3	100	92.683	Macaca_nemestrina
ENSG00000041880	PARP3	100	92.120	ENSMLEG00000035156	PARP3	100	92.120	Mandrillus_leucophaeus
ENSG00000041880	PARP3	95	58.121	ENSMAMG00000023941	parp3	99	56.320	Mastacembelus_armatus
ENSG00000041880	PARP3	96	57.393	ENSMZEG00005010534	parp3	99	55.844	Maylandia_zebra
ENSG00000041880	PARP3	95	61.448	ENSMGAG00000003932	PARP3	100	60.762	Meleagris_gallopavo
ENSG00000041880	PARP3	100	78.253	ENSMAUG00000010154	Parp3	100	78.253	Mesocricetus_auratus
ENSG00000041880	PARP3	100	84.053	ENSMICG00000017294	PARP3	100	84.053	Microcebus_murinus
ENSG00000041880	PARP3	100	81.238	ENSMOCG00000000186	Parp3	100	81.238	Microtus_ochrogaster
ENSG00000041880	PARP3	95	51.961	ENSMMOG00000021797	parp3	98	51.533	Mola_mola
ENSG00000041880	PARP3	100	66.605	ENSMODG00000011807	PARP3	95	66.481	Monodelphis_domestica
ENSG00000041880	PARP3	100	52.974	ENSMALG00000017172	parp3	99	52.974	Monopterus_albus
ENSG00000041880	PARP3	100	80.337	MGP_CAROLIEiJ_G0032625	Parp3	100	80.337	Mus_caroli
ENSG00000041880	PARP3	100	80.524	ENSMUSG00000023249	Parp3	100	80.524	Mus_musculus
ENSG00000041880	PARP3	100	79.963	MGP_PahariEiJ_G0015493	Parp3	100	79.963	Mus_pahari
ENSG00000041880	PARP3	100	80.712	MGP_SPRETEiJ_G0033770	Parp3	100	80.712	Mus_spretus
ENSG00000041880	PARP3	100	82.176	ENSMPUG00000011779	PARP3	100	82.552	Mustela_putorius_furo
ENSG00000041880	PARP3	72	82.234	ENSMLUG00000007900	PARP3	85	82.234	Myotis_lucifugus
ENSG00000041880	PARP3	100	82.552	ENSNGAG00000020533	Parp3	100	82.552	Nannospalax_galili
ENSG00000041880	PARP3	96	57.198	ENSNBRG00000004669	parp3	99	55.659	Neolamprologus_brichardi
ENSG00000041880	PARP3	96	93.730	ENSNLEG00000007058	PARP3	100	88.889	Nomascus_leucogenys
ENSG00000041880	PARP3	100	63.806	ENSMEUG00000006880	PARP3	100	63.806	Notamacropus_eugenii
ENSG00000041880	PARP3	100	67.228	ENSOPRG00000008739	PARP3	100	67.228	Ochotona_princeps
ENSG00000041880	PARP3	100	77.881	ENSODEG00000018243	PARP3	100	77.881	Octodon_degus
ENSG00000041880	PARP3	96	57.198	ENSONIG00000018986	parp3	99	55.659	Oreochromis_niloticus
ENSG00000041880	PARP3	100	82.552	ENSOCUG00000021270	PARP3	100	82.552	Oryctolagus_cuniculus
ENSG00000041880	PARP3	95	58.904	ENSORLG00000000752	parp3	99	57.435	Oryzias_latipes
ENSG00000041880	PARP3	95	58.317	ENSORLG00020007141	parp3	99	56.877	Oryzias_latipes_hni
ENSG00000041880	PARP3	96	58.333	ENSORLG00015003321	parp3	99	57.063	Oryzias_latipes_hsok
ENSG00000041880	PARP3	95	58.431	ENSOMEG00000013854	parp3	99	56.611	Oryzias_melastigma
ENSG00000041880	PARP3	100	85.130	ENSOGAG00000011207	PARP3	100	85.130	Otolemur_garnettii
ENSG00000041880	PARP3	100	98.148	ENSPPAG00000040859	PARP3	100	98.148	Pan_paniscus
ENSG00000041880	PARP3	100	82.364	ENSPPRG00000006379	PARP3	100	82.364	Panthera_pardus
ENSG00000041880	PARP3	100	82.176	ENSPTIG00000012303	PARP3	100	82.176	Panthera_tigris_altaica
ENSG00000041880	PARP3	100	97.593	ENSPTRG00000014981	PARP3	100	97.593	Pan_troglodytes
ENSG00000041880	PARP3	100	92.120	ENSPANG00000000752	PARP3	100	92.037	Papio_anubis
ENSG00000041880	PARP3	100	54.291	ENSPKIG00000004678	parp3	99	54.291	Paramormyrops_kingsleyae
ENSG00000041880	PARP3	95	57.864	ENSPMGG00000005337	parp3	99	55.210	Periophthalmus_magnuspinnatus
ENSG00000041880	PARP3	100	80.675	ENSPEMG00000000567	Parp3	100	80.675	Peromyscus_maniculatus_bairdii
ENSG00000041880	PARP3	100	65.121	ENSPCIG00000018149	PARP3	100	65.306	Phascolarctos_cinereus
ENSG00000041880	PARP3	95	56.947	ENSPFOG00000002883	parp3	99	55.866	Poecilia_formosa
ENSG00000041880	PARP3	95	57.339	ENSPLAG00000014500	parp3	99	56.052	Poecilia_latipinna
ENSG00000041880	PARP3	95	56.947	ENSPMEG00000002582	parp3	99	55.866	Poecilia_mexicana
ENSG00000041880	PARP3	95	57.339	ENSPREG00000009464	parp3	99	56.157	Poecilia_reticulata
ENSG00000041880	PARP3	100	96.623	ENSPPYG00000013824	PARP3	100	96.623	Pongo_abelii
ENSG00000041880	PARP3	58	70.000	ENSPCAG00000009425	-	100	70.000	Procavia_capensis
ENSG00000041880	PARP3	100	81.269	ENSPCOG00000014233	PARP3	100	80.488	Propithecus_coquereli
ENSG00000041880	PARP3	100	61.423	ENSPVAG00000012472	PARP3	100	61.423	Pteropus_vampyrus
ENSG00000041880	PARP3	96	57.393	ENSPNYG00000006648	parp3	99	55.844	Pundamilia_nyererei
ENSG00000041880	PARP3	92	55.519	ENSPNAG00000015983	parp3	99	54.864	Pygocentrus_nattereri
ENSG00000041880	PARP3	100	80.863	ENSRNOG00000012865	Parp3	100	80.863	Rattus_norvegicus
ENSG00000041880	PARP3	100	91.932	ENSRBIG00000040575	PARP3	100	91.932	Rhinopithecus_bieti
ENSG00000041880	PARP3	100	92.308	ENSRROG00000033856	PARP3	100	92.308	Rhinopithecus_roxellana
ENSG00000041880	PARP3	100	87.430	ENSSBOG00000021070	PARP3	100	87.430	Saimiri_boliviensis_boliviensis
ENSG00000041880	PARP3	100	64.750	ENSSHAG00000007455	PARP3	95	64.695	Sarcophilus_harrisii
ENSG00000041880	PARP3	96	55.706	ENSSFOG00015019314	parp3	99	54.749	Scleropages_formosus
ENSG00000041880	PARP3	95	58.121	ENSSMAG00000000680	parp3	100	56.273	Scophthalmus_maximus
ENSG00000041880	PARP3	95	57.926	ENSSDUG00000012421	parp3	100	56.134	Seriola_dumerili
ENSG00000041880	PARP3	95	57.534	ENSSLDG00000017259	parp3	100	55.762	Seriola_lalandi_dorsalis
ENSG00000041880	PARP3	95	62.622	ENSSPUG00000000291	PARP3	99	61.381	Sphenodon_punctatus
ENSG00000041880	PARP3	97	57.225	ENSSPAG00000007267	parp3	99	56.238	Stegastes_partitus
ENSG00000041880	PARP3	100	82.927	ENSSSCG00000023033	PARP3	100	82.927	Sus_scrofa
ENSG00000041880	PARP3	95	49.614	ENSTGUG00000006405	PARP3	100	49.807	Taeniopygia_guttata
ENSG00000041880	PARP3	100	56.716	ENSTRUG00000002578	parp3	99	56.716	Takifugu_rubripes
ENSG00000041880	PARP3	52	87.395	ENSTBEG00000015722	-	62	86.854	Tupaia_belangeri
ENSG00000041880	PARP3	100	78.799	ENSTTRG00000001441	PARP3	100	78.799	Tursiops_truncatus
ENSG00000041880	PARP3	100	82.552	ENSUAMG00000020872	PARP3	100	82.552	Ursus_americanus
ENSG00000041880	PARP3	100	80.187	ENSUMAG00000021616	PARP3	100	80.187	Ursus_maritimus
ENSG00000041880	PARP3	100	82.176	ENSVVUG00000026860	PARP3	100	82.364	Vulpes_vulpes
ENSG00000041880	PARP3	99	59.813	ENSXETG00000000087	parp3	99	59.813	Xenopus_tropicalis
ENSG00000041880	PARP3	95	56.164	ENSXCOG00000020013	parp3	99	55.307	Xiphophorus_couchianus
ENSG00000041880	PARP3	100	54.851	ENSXMAG00000021153	parp3	97	55.204	Xiphophorus_maculatus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000723	telomere maintenance	21270334.	IMP	Process
GO:0003824	catalytic activity	10338144.	TAS	Function
GO:0003950	NAD+ ADP-ribosyltransferase activity	21873635.	IBA	Function
GO:0003950	NAD+ ADP-ribosyltransferase activity	21211721.21270334.	IDA	Function
GO:0005515	protein binding	20064938.	IPI	Function
GO:0005634	nucleus	21873635.	IBA	Component
GO:0005730	nucleolus	21873635.	IBA	Component
GO:0005814	centriole	-	IEA	Component
GO:0006281	DNA repair	7260241.	TAS	Process
GO:0006302	double-strand break repair	21873635.	IBA	Process
GO:0006302	double-strand break repair	21270334.	IDA	Process
GO:0006302	double-strand break repair	21211721.	IMP	Process
GO:0006471	protein ADP-ribosylation	21270334.24598253.	IDA	Process
GO:0030592	DNA ADP-ribosylation	29361132.	IDA	Process
GO:0035861	site of double-strand break	21873635.	IBA	Component
GO:0035861	site of double-strand break	21270334.	IDA	Component
GO:0045829	negative regulation of isotype switching	-	ISS	Process
GO:0051106	positive regulation of DNA ligation	21211721.	IGI	Process
GO:0060236	regulation of mitotic spindle organization	21270334.	IMP	Process
GO:0070212	protein poly-ADP-ribosylation	21873635.	IBA	Process
GO:0070213	protein auto-ADP-ribosylation	25043379.	IDA	Process
GO:1905662	negative regulation of telomerase RNA reverse transcriptase activity	24528514.	IMP	Process
GO:1990166	protein localization to site of double-strand break	21211721.	IMP	Process
GO:1990404	protein ADP-ribosylase activity	21873635.	IBA	Function
GO:1990404	protein ADP-ribosylase activity	20064938.24598253.25043379.	IDA	Function
GO:2001034	positive regulation of double-strand break repair via nonhomologous end joining	24598253.	IDA	Process