EuRBPDB

Basic Information
Cancer Related Information

Description

RBPome

Expression

Transcripts

Gene Model

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000042493 (Gene tree)
Gene ID: 822
Gene Symbol: CAPG
Alias: MCP|AFCP
Full Name: capping actin protein, gelsolin like
Gene Type: protein_coding
Species: Homo_sapiens
Status: putative
Strand: Minus strand
Length: 23,720 bases
Position: chr2:85,394,748-85,418,467
Accession: 1474
RBP type: non-canonical RBP
Summary: This gene encodes a member of the gelsolin/villin family of actin-regulatory proteins. The encoded protein reversibly blocks the barbed ends of F-actin filaments in a Ca2+ and phosphoinositide-regulated manner, but does not sever preformed actin filaments. By capping the barbed ends of actin filaments, the encoded protein contributes to the control of actin-based motility in non-muscle cells. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Jan 2012]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
29431736	Capturing the interactome of newly transcribed RNA	PolyT-RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & MCF10A	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000409921	CAPG-205	1195	-	ENSP00000387063	333 (aa)	-	P40121
ENST00000479651	CAPG-213	265	-	-	- (aa)	-	-
ENST00000491267	CAPG-215	549	-	-	- (aa)	-	-
ENST00000471064	CAPG-212	486	-	-	- (aa)	-	-
ENST00000447219	CAPG-208	930	-	ENSP00000398232	253 (aa)	-	E7ENU9
ENST00000409670	CAPG-203	1183	-	ENSP00000386315	348 (aa)	-	P40121
ENST00000263867	CAPG-201	1442	XM_011533122	ENSP00000263867	348 (aa)	XP_011531424	P40121
ENST00000449030	CAPG-209	839	-	ENSP00000403330	253 (aa)	-	E7ENU9
ENST00000483659	CAPG-214	767	-	-	- (aa)	-	-
ENST00000439385	CAPG-207	865	-	ENSP00000391923	253 (aa)	-	E7ENU9
ENST00000415012	CAPG-206	531	-	-	- (aa)	-	-
ENST00000409724	CAPG-204	1151	-	ENSP00000386965	348 (aa)	-	P40121
ENST00000409275	CAPG-202	835	-	ENSP00000386596	218 (aa)	-	B8ZZL6
ENST00000453973	CAPG-210	452	-	ENSP00000397381	103 (aa)	-	H7C0X8
ENST00000459793	CAPG-211	943	-	-	- (aa)	-	-

Gene Model

Click here to download ENSG00000042493's gene model file

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000042493's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs identified by RBPome

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000042493	CAPG	100	92.694	ENSMUSG00000056737	Capg	100	92.550	Mus_musculus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0001726	ruffle	-	IEA	Component
GO:0005515	protein binding	18266911.25416956.	IPI	Function
GO:0005634	nucleus	18266911.	IDA	Component
GO:0005654	nucleoplasm	18938132.	IDA	Component
GO:0005730	nucleolus	18938132.	IDA	Component
GO:0005737	cytoplasm	18266911.18938132.19166812.24236012.25468996.	IDA	Component
GO:0005814	centriole	19166812.	IDA	Component
GO:0008290	F-actin capping protein complex	1322908.	TAS	Component
GO:0019904	protein domain specific binding	18266911.	IPI	Function
GO:0022617	extracellular matrix disassembly	24236012.	IMP	Process
GO:0030027	lamellipodium	-	IEA	Component
GO:0042470	melanosome	-	IEA	Component
GO:0044877	protein-containing complex binding	18266911.	IDA	Function
GO:0045296	cadherin binding	25468996.	HDA	Function
GO:0051015	actin filament binding	-	IEA	Function
GO:0051016	barbed-end actin filament capping	-	IEA	Process
GO:0065003	protein-containing complex assembly	1322908.	NAS	Process
GO:0070062	extracellular exosome	19056867.20458337.23533145.	HDA	Component
GO:0071803	positive regulation of podosome assembly	24236012.	IMP	Process
GO:0072686	mitotic spindle	19166812.	IDA	Component
GO:0090543	Flemming body	19166812.	IDA	Component

Cancer associated literatures

PID	Title	Article	Time	Author	Doi
23782053	Laser microdissection and two-dimensional difference gel electrophoresis reveal the role of a novel macrophage-capping protein in lymph node metastasis in gastric cancer.	J Proteome Res	2013 Aug 2	Ichikawa H	doi: 10.1021/pr400439m
16767159	Suppression of tumorigenicity, but not anchorage independence, of human cancer cells by new candidate tumor suppressor gene CapG.	Oncogene	2006 Nov 30	Watari A	-
23085225	Proteomic identification of the macrophage-capping protein as a protein contributing to the malignant features of hepatocellular carcinoma.	J Proteomics	2013 Jan 14	Kimura K	doi: 10.1016/j.jprot.2012.10.004
30155403	Capping Actin Protein Overexpression in Human Colorectal Carcinoma and Its Contributed Tumor Migration.	Anal Cell Pathol (Amst)	2018 Aug 1	Tsai TJ	doi: 10.1155/2018/8623937
18059028	Invasive breast cancer cells exhibit increased mobility of the actin-binding protein CapG.	Int J Cancer	2008 Apr 1	Renz M	-
22190510	Prognostic evaluation of CapG, gelsolin, P-gp, GSTP1, and Topo-II proteins in non-small cell lung cancer.	Anat Rec (Hoboken)	2012 Feb	Zhu WY	doi: 10.1002/ar.21523
18461482	Dynamics of the CapG actin-binding protein in the cell nucleus studied by FRAP and FCS.	Chromosome Res	2008	Renz M	doi: 10.1007/s10577-008-1234-6.
28790116	Targeted Proteomics Identifies Proteomic Signatures in Liquid Biopsies of the Endometrium to Diagnose Endometrial Cancer and Assist in the Prediction of the Optimal Surgical Treatment.	Clin Cancer Res	2017 Nov 1	Martinez-Garcia E	doi: 10.1158/1078-0432.CCR-17-0474

Differential Expression

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq
ACC	chr2	85401228	Silent	rs769755908	T151T	0.89
ACC	chr2	85401646	Silent	rs774052021	A78A	0.88
BLCA	chr2	85394920	Silent	novel	F340F	0.08
BLCA	chr2	85402145	Translation_Start_Site	NA	M1?	0.6
BLCA	chr2	85398743	Nonsense_Mutation	novel	E236*	0.21
BLCA	chr2	85399274	Silent	novel	A176A	0.56
BRCA	chr2	85401923	Missense_Mutation	NA	G20S	0.11
BRCA	chr2	85401800	Missense_Mutation	NA	L61V	0.29
CESC	chr2	85395552	Missense_Mutation	rs566538644	A323T	0.5
CESC	chr2	85401541	Silent	novel	G113G	0.24
COAD	chr2	85401809	Missense_Mutation	novel	V58F	0.15
COAD	chr2	85395552	Missense_Mutation	rs566538644	A323T	0.16
COAD	chr2	85395617	Missense_Mutation	novel	A301V	0.35
COAD	chr2	85395616	Silent	novel	A301A	0.11
COAD	chr2	85401622	Silent	rs2229669	T86T	0.11
COAD	chr2	85398702	Silent	novel	A249A	0.17
GBM	chr2	85401316	Missense_Mutation	novel	E122G	0.16
GBM	chr2	85401870	Missense_Mutation	novel	E37D	0.27
KIRC	chr2	85401782	Splice_Region	novel		0.27
LGG	chr2	85401815	Nonsense_Mutation	novel	E56*	0.43
LGG	chr2	85394932	Missense_Mutation	novel	E336D	0.27
LIHC	chr2	85395607	In_Frame_Del	novel	K304del	0.21
LUAD	chr2	85401251	Missense_Mutation	NA	G144R	0.27
LUAD	chr2	85401546	Missense_Mutation	rs749388241	R112W	0.15
LUAD	chr2	85401283	Frame_Shift_Del	novel	*P133Qfs10**	0.08
LUAD	chr2	85401546	Missense_Mutation	rs749388241	R112W	0.17
LUAD	chr2	85399141	Frame_Shift_Del	novel	*I221Sfs10**	0.07
LUAD	chr2	85401848	Missense_Mutation	NA	G45W	0.15
LUSC	chr2	85401264	Silent	NA	L139L	0.28
LUSC	chr2	85394897	Missense_Mutation	novel	K348R	0.35
LUSC	chr2	85399247	Frame_Shift_Del	novel	*I184Rfs16**	0.44
LUSC	chr2	85394865	3'UTR	novel		0.37
LUSC	chr2	85401594	Missense_Mutation	rs750346858	R96C	0.31
OV	chr2	85401912	Frame_Shift_Ins	NA	*W24Vfs50**	0.56
READ	chr2	85394853	3'UTR	novel		0.22
READ	chr2	85402127	Frame_Shift_Del	novel	*Q7Rfs23**	0.06
SARC	chr2	85399233	Missense_Mutation	rs774144382	A190V	0.79
SKCM	chr2	85394864	3'UTR	novel		0.29
SKCM	chr2	85399234	Missense_Mutation	novel	A190T	0.27
SKCM	chr2	85401845	Missense_Mutation	NA	D46Y	0.15
SKCM	chr2	85401793	Missense_Mutation	NA	L63R	0.35
SKCM	chr2	85401582	Missense_Mutation	rs775328091	G100S	0.62
STAD	chr2	85395623	Missense_Mutation	rs761175093	R299Q	0.14
STAD	chr2	85401224	Missense_Mutation	rs185763147	R153W	0.18
STAD	chr2	85401287	Missense_Mutation	NA	A132T	0.26
STAD	chr2	85401923	Missense_Mutation	NA	G20S	0.28
STAD	chr2	85394885	3'UTR	rs370042827		0.26
STAD	chr2	85401318	Silent	NA	V121V	0.18
UCEC	chr2	85398750	Silent	novel	G233G	0.44
UCEC	chr2	85401878	Missense_Mutation	novel	A35T	0.16
UCEC	chr2	85395586	Silent	novel	Q311Q	0.37
UCEC	chr2	85394858	3'UTR	rs368776211		0.61
UCEC	chr2	85399245	Missense_Mutation	NA	E186G	0.09
UCEC	chr2	85401790	Nonsense_Mutation	novel	W64*	0.54
UCEC	chr2	85398070	Missense_Mutation	novel	D281G	0.42
UCEC	chr2	85401579	Missense_Mutation	novel	N101D	0.23
UCEC	chr2	85395564	Missense_Mutation	rs768616851	R319C	0.39
UCEC	chr2	85401876	Silent	rs756599713	A35A	0.33
UCEC	chr2	85395564	Missense_Mutation	rs768616851	R319C	0.3
UCEC	chr2	85398779	Missense_Mutation	novel	L224M	0.34
UCEC	chr2	85401783	Splice_Site	novel	X66_splice	0.34
UCEC	chr2	85398779	Missense_Mutation	novel	L224M	0.33
UCEC	chr2	85394909	Frame_Shift_Del	novel	*F344Sfs41**	0.38
UCEC	chr2	85399241	Silent	rs766537492	R187R	0.51
UCEC	chr2	85401221	Missense_Mutation	novel	A154S	0.2
UCEC	chr2	85401870	Missense_Mutation	novel	E37D	0.34
UCEC	chr2	85399277	Silent	rs148517446	F175F	0.33
UCEC	chr2	85401187	Missense_Mutation	NA	C165F	0.41
UCEC	chr2	85398148	Missense_Mutation	novel	S255F	0.42
UCEC	chr2	85395547	Silent	rs374063250	P324P	0.22

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
KIRP	DEL	0.0278	0.08832
PAAD	DEL	0.0489	0.2014
READ	DEL	0.0727	0.19022
SARC	AMP	0.1984	0.15096

Survival Analysis

Cancer	P-value	Q-value
SARC	0.033	Kaplan-Meier Survival Analysis
KIRP	0.014	Kaplan-Meier Survival Analysis
PAAD	0.018	Kaplan-Meier Survival Analysis
BLCA	0.007	Kaplan-Meier Survival Analysis
READ	0.035	Kaplan-Meier Survival Analysis
KICH	0.0073	Kaplan-Meier Survival Analysis
UCEC	0.011	Kaplan-Meier Survival Analysis
GBM	0.013	Kaplan-Meier Survival Analysis
LIHC	0.00011	Kaplan-Meier Survival Analysis
DLBC	0.021	Kaplan-Meier Survival Analysis
THCA	0.011	Kaplan-Meier Survival Analysis
UVM	0.023	Kaplan-Meier Survival Analysis

Drugs

EuRBPDB

Description

RBPome

Expression

Transcripts

Gene Model

PPI

Orthologs

Gene Ontology

Select Dataset :

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Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742