EuRBPDB

Description

RBDs

Expression

Transcripts

Gene Model

Pathways

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000046647 (Gene tree)
Gene ID: 54960
Gene Symbol: GEMIN8
Alias: FLJ20514|FAM51A1
Full Name: gem nuclear organelle associated protein 8
Gene Type: protein_coding
Species: Homo_sapiens
Status: putative
Strand: Minus strand
Length: 27,793 bases
Position: chrX:14,002,124-14,029,916
Accession: 26044
RBP type: canonical RBP
Summary: The protein encoded by this gene is part of the SMN complex, which is necessary for spliceosomal snRNP assembly in the cytoplasm and pre-mRNA splicing in the nucleus. The encoded protein binds to both SMN1 and the GEMIN6/GEMIN7 heterodimer, mediating their interaction. This protein is found in nuclear Gemini of Cajal bodies (gems) and in the cytoplasm. Three transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, May 2010]

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000369895	GEMIN8	PF15348.6	5.8e-112	1	1
ENSP00000381398	GEMIN8	PF15348.6	5.8e-112	1	1
ENSP00000369894	GEMIN8	PF15348.6	2.3e-67	1	1

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000460203	GEMIN8-204	839	-	-	- (aa)	-	-
ENST00000380523	GEMIN8-202	1682	-	ENSP00000369895	242 (aa)	-	Q9NWZ8
ENST00000332885	GEMIN8-201	868	-	ENSP00000369894	177 (aa)	-	H7BYE2
ENST00000477386	GEMIN8-205	724	-	-	- (aa)	-	-
ENST00000398355	GEMIN8-203	1119	XM_005274555	ENSP00000381398	242 (aa)	XP_005274612	Q9NWZ8

Gene Model

Click here to download ENSG00000046647's gene model file

Pathways

Pathway ID	Pathway Name	Source
hsa03013	RNA transport	KEGG

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000046647's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000046647	GEMIN8	96	48.069	ENSAPOG00000006835	gemin8	97	48.276	Acanthochromis_polyacanthus
ENSG00000046647	GEMIN8	96	75.107	ENSAMEG00000015945	GEMIN8	98	75.107	Ailuropoda_melanoleuca
ENSG00000046647	GEMIN8	93	50.855	ENSACIG00000006732	gemin8	95	52.423	Amphilophus_citrinellus
ENSG00000046647	GEMIN8	94	48.472	ENSAOCG00000011833	gemin8	89	48.472	Amphiprion_ocellaris
ENSG00000046647	GEMIN8	94	48.472	ENSAPEG00000015680	gemin8	89	48.472	Amphiprion_percula
ENSG00000046647	GEMIN8	94	50.655	ENSATEG00000018220	gemin8	95	52.402	Anabas_testudineus
ENSG00000046647	GEMIN8	97	51.681	ENSACAG00000001988	GEMIN8	99	51.681	Anolis_carolinensis
ENSG00000046647	GEMIN8	100	88.017	ENSANAG00000037448	GEMIN8	100	88.017	Aotus_nancymaae
ENSG00000046647	GEMIN8	99	59.583	ENSBTAG00000010289	GEMIN8	99	59.167	Bos_taurus
ENSG00000046647	GEMIN8	100	88.430	ENSCJAG00000023001	-	100	88.430	Callithrix_jacchus
ENSG00000046647	GEMIN8	100	82.682	ENSCJAG00000004054	-	99	81.683	Callithrix_jacchus
ENSG00000046647	GEMIN8	99	72.917	ENSCAFG00000028737	GEMIN8	99	72.917	Canis_familiaris
ENSG00000046647	GEMIN8	99	72.917	ENSCAFG00020003054	GEMIN8	99	72.917	Canis_lupus_dingo
ENSG00000046647	GEMIN8	99	60.000	ENSCHIG00000009439	GEMIN8	99	60.000	Capra_hircus
ENSG00000046647	GEMIN8	94	82.018	ENSTSYG00000028251	GEMIN8	99	81.250	Carlito_syrichta
ENSG00000046647	GEMIN8	98	71.308	ENSCAPG00000005495	GEMIN8	100	71.308	Cavia_aperea
ENSG00000046647	GEMIN8	99	71.250	ENSCPOG00000005933	GEMIN8	88	71.250	Cavia_porcellus
ENSG00000046647	GEMIN8	100	81.356	ENSCCAG00000029140	-	86	79.752	Cebus_capucinus
ENSG00000046647	GEMIN8	100	95.041	ENSCATG00000042167	GEMIN8	100	95.041	Cercocebus_atys
ENSG00000046647	GEMIN8	99	75.417	ENSCLAG00000001838	GEMIN8	99	75.417	Chinchilla_lanigera
ENSG00000046647	GEMIN8	93	90.854	ENSCSAG00000015017	-	91	93.333	Chlorocebus_sabaeus
ENSG00000046647	GEMIN8	100	94.628	ENSCSAG00000019423	-	100	94.628	Chlorocebus_sabaeus
ENSG00000046647	GEMIN8	94	54.583	ENSCPBG00000015720	GEMIN8	95	54.583	Chrysemys_picta_bellii
ENSG00000046647	GEMIN8	100	69.421	ENSCANG00000033229	-	100	69.421	Colobus_angolensis_palliatus
ENSG00000046647	GEMIN8	100	95.868	ENSCANG00000031301	GEMIN8	100	95.868	Colobus_angolensis_palliatus
ENSG00000046647	GEMIN8	98	70.168	ENSCGRG00001012561	Gemin8	100	69.378	Cricetulus_griseus_chok1gshd
ENSG00000046647	GEMIN8	98	70.168	ENSCGRG00000012265	Gemin8	99	70.168	Cricetulus_griseus_crigri
ENSG00000046647	GEMIN8	97	47.234	ENSCSEG00000005280	gemin8	98	45.106	Cynoglossus_semilaevis
ENSG00000046647	GEMIN8	96	50.215	ENSCVAG00000002926	gemin8	96	50.215	Cyprinodon_variegatus
ENSG00000046647	GEMIN8	98	46.639	ENSDARG00000053496	gemin8	99	46.667	Danio_rerio
ENSG00000046647	GEMIN8	99	73.222	ENSDNOG00000047905	GEMIN8	99	73.222	Dasypus_novemcinctus
ENSG00000046647	GEMIN8	68	62.810	ENSDORG00000013897	-	93	60.526	Dipodomys_ordii
ENSG00000046647	GEMIN8	96	60.086	ENSETEG00000010181	-	70	60.086	Echinops_telfairi
ENSG00000046647	GEMIN8	82	67.808	ENSEASG00005016608	-	54	68.243	Equus_asinus_asinus
ENSG00000046647	GEMIN8	98	76.471	ENSECAG00000010665	GEMIN8	99	76.667	Equus_caballus
ENSG00000046647	GEMIN8	93	53.125	ENSEEUG00000015199	-	65	53.125	Erinaceus_europaeus
ENSG00000046647	GEMIN8	94	49.130	ENSELUG00000021226	gemin8	95	49.130	Esox_lucius
ENSG00000046647	GEMIN8	100	73.554	ENSFCAG00000014428	GEMIN8	100	73.554	Felis_catus
ENSG00000046647	GEMIN8	95	55.230	ENSFALG00000004451	GEMIN8	99	55.230	Ficedula_albicollis
ENSG00000046647	GEMIN8	98	73.529	ENSFDAG00000007127	GEMIN8	100	73.529	Fukomys_damarensis
ENSG00000046647	GEMIN8	96	50.215	ENSFHEG00000018785	gemin8	98	48.069	Fundulus_heteroclitus
ENSG00000046647	GEMIN8	94	46.121	ENSGMOG00000016911	gemin8	100	46.491	Gadus_morhua
ENSG00000046647	GEMIN8	95	51.440	ENSGALG00000016574	GEMIN8	96	54.852	Gallus_gallus
ENSG00000046647	GEMIN8	63	72.414	ENSGAFG00000018921	gemin8	97	50.644	Gambusia_affinis
ENSG00000046647	GEMIN8	63	65.789	ENSGACG00000014592	gemin8	96	47.598	Gasterosteus_aculeatus
ENSG00000046647	GEMIN8	99	53.386	ENSGAGG00000005312	GEMIN8	100	53.386	Gopherus_agassizii
ENSG00000046647	GEMIN8	100	98.347	ENSGGOG00000025262	GEMIN8	100	98.347	Gorilla_gorilla
ENSG00000046647	GEMIN8	94	48.908	ENSHBUG00000012537	gemin8	83	51.092	Haplochromis_burtoni
ENSG00000046647	GEMIN8	88	46.009	ENSHBUG00000012214	GEMIN8	92	48.357	Haplochromis_burtoni
ENSG00000046647	GEMIN8	99	74.477	ENSHGLG00000001816	GEMIN8	99	74.167	Heterocephalus_glaber_female
ENSG00000046647	GEMIN8	99	74.167	ENSHGLG00100019025	GEMIN8	99	74.167	Heterocephalus_glaber_male
ENSG00000046647	GEMIN8	96	50.215	ENSHCOG00000005986	gemin8	97	50.215	Hippocampus_comes
ENSG00000046647	GEMIN8	95	49.153	ENSIPUG00000013983	gemin8	97	53.247	Ictalurus_punctatus
ENSG00000046647	GEMIN8	99	82.500	ENSSTOG00000003330	GEMIN8	99	82.500	Ictidomys_tridecemlineatus
ENSG00000046647	GEMIN8	96	69.658	ENSJJAG00000011347	Gemin8	98	69.658	Jaculus_jaculus
ENSG00000046647	GEMIN8	95	49.569	ENSKMAG00000003680	gemin8	97	50.000	Kryptolebias_marmoratus
ENSG00000046647	GEMIN8	95	54.202	ENSLACG00000011839	GEMIN8	100	52.419	Latimeria_chalumnae
ENSG00000046647	GEMIN8	100	50.612	ENSLOCG00000010057	gemin8	100	50.612	Lepisosteus_oculatus
ENSG00000046647	GEMIN8	98	77.215	ENSLAFG00000001835	GEMIN8	100	77.215	Loxodonta_africana
ENSG00000046647	GEMIN8	100	95.455	ENSMFAG00000000059	GEMIN8	100	95.455	Macaca_fascicularis
ENSG00000046647	GEMIN8	100	69.008	ENSMFAG00000035850	-	100	67.769	Macaca_fascicularis
ENSG00000046647	GEMIN8	100	68.182	ENSMMUG00000045828	-	100	66.942	Macaca_mulatta
ENSG00000046647	GEMIN8	100	95.455	ENSMMUG00000013595	GEMIN8	100	95.455	Macaca_mulatta
ENSG00000046647	GEMIN8	100	95.041	ENSMNEG00000034497	GEMIN8	100	95.041	Macaca_nemestrina
ENSG00000046647	GEMIN8	100	94.628	ENSMLEG00000027629	GEMIN8	100	94.628	Mandrillus_leucophaeus
ENSG00000046647	GEMIN8	100	71.488	ENSMLEG00000036890	-	100	71.488	Mandrillus_leucophaeus
ENSG00000046647	GEMIN8	94	49.345	ENSMAMG00000021990	gemin8	96	49.782	Mastacembelus_armatus
ENSG00000046647	GEMIN8	94	49.345	ENSMZEG00005021141	gemin8	93	51.304	Maylandia_zebra
ENSG00000046647	GEMIN8	97	45.763	ENSMZEG00005021415	-	99	45.763	Maylandia_zebra
ENSG00000046647	GEMIN8	81	60.140	ENSMAUG00000014430	-	89	58.088	Mesocricetus_auratus
ENSG00000046647	GEMIN8	99	83.750	ENSMICG00000015984	GEMIN8	99	83.750	Microcebus_murinus
ENSG00000046647	GEMIN8	98	68.354	ENSMOCG00000008859	Gemin8	99	68.354	Microtus_ochrogaster
ENSG00000046647	GEMIN8	94	48.707	ENSMMOG00000012371	gemin8	96	48.276	Mola_mola
ENSG00000046647	GEMIN8	98	60.593	ENSMODG00000017297	GEMIN8	99	60.593	Monodelphis_domestica
ENSG00000046647	GEMIN8	93	50.222	ENSMALG00000015898	gemin8	87	51.556	Monopterus_albus
ENSG00000046647	GEMIN8	98	66.245	MGP_CAROLIEiJ_G0033569	Gemin8	99	66.245	Mus_caroli
ENSG00000046647	GEMIN8	98	68.354	ENSMUSG00000040621	Gemin8	99	68.354	Mus_musculus
ENSG00000046647	GEMIN8	98	67.932	MGP_PahariEiJ_G0032108	Gemin8	99	67.932	Mus_pahari
ENSG00000046647	GEMIN8	98	68.776	MGP_SPRETEiJ_G0034739	Gemin8	99	68.776	Mus_spretus
ENSG00000046647	GEMIN8	96	72.034	ENSMPUG00000002595	GEMIN8	98	72.881	Mustela_putorius_furo
ENSG00000046647	GEMIN8	100	67.355	ENSMLUG00000029217	-	100	66.942	Myotis_lucifugus
ENSG00000046647	GEMIN8	99	70.417	ENSMLUG00000010141	-	99	70.417	Myotis_lucifugus
ENSG00000046647	GEMIN8	98	70.293	ENSNGAG00000022875	Gemin8	99	70.293	Nannospalax_galili
ENSG00000046647	GEMIN8	94	50.877	ENSNBRG00000024342	gemin8	95	51.965	Neolamprologus_brichardi
ENSG00000046647	GEMIN8	100	95.868	ENSNLEG00000034467	GEMIN8	100	95.868	Nomascus_leucogenys
ENSG00000046647	GEMIN8	100	73.140	ENSNLEG00000030297	-	100	73.140	Nomascus_leucogenys
ENSG00000046647	GEMIN8	98	62.288	ENSMEUG00000014793	GEMIN8	99	62.288	Notamacropus_eugenii
ENSG00000046647	GEMIN8	98	69.620	ENSODEG00000004288	GEMIN8	100	69.620	Octodon_degus
ENSG00000046647	GEMIN8	94	50.000	ENSONIG00000001003	gemin8	95	50.000	Oreochromis_niloticus
ENSG00000046647	GEMIN8	98	58.898	ENSOANG00000002604	GEMIN8	99	58.898	Ornithorhynchus_anatinus
ENSG00000046647	GEMIN8	99	69.583	ENSOCUG00000022328	-	99	69.583	Oryctolagus_cuniculus
ENSG00000046647	GEMIN8	95	40.462	ENSOCUG00000014632	-	98	38.865	Oryctolagus_cuniculus
ENSG00000046647	GEMIN8	94	49.356	ENSORLG00000006606	gemin8	95	50.000	Oryzias_latipes
ENSG00000046647	GEMIN8	100	49.388	ENSORLG00020000188	gemin8	100	50.820	Oryzias_latipes_hni
ENSG00000046647	GEMIN8	94	48.246	ENSOMEG00000009646	gemin8	95	48.246	Oryzias_melastigma
ENSG00000046647	GEMIN8	98	68.487	ENSOGAG00000030851	-	100	68.487	Otolemur_garnettii
ENSG00000046647	GEMIN8	99	74.167	ENSOGAG00000029658	-	99	74.167	Otolemur_garnettii
ENSG00000046647	GEMIN8	99	72.199	ENSOGAG00000002881	-	99	72.199	Otolemur_garnettii
ENSG00000046647	GEMIN8	99	68.333	ENSOGAG00000030890	-	99	68.333	Otolemur_garnettii
ENSG00000046647	GEMIN8	99	60.000	ENSOARG00000011696	GEMIN8	91	60.000	Ovis_aries
ENSG00000046647	GEMIN8	100	99.174	ENSPPAG00000005337	GEMIN8	100	99.174	Pan_paniscus
ENSG00000046647	GEMIN8	100	73.140	ENSPPRG00000007470	GEMIN8	100	73.140	Panthera_pardus
ENSG00000046647	GEMIN8	100	59.677	ENSPTIG00000008428	GEMIN8	100	60.081	Panthera_tigris_altaica
ENSG00000046647	GEMIN8	100	98.354	ENSPTRG00000048272	GEMIN8	100	98.354	Pan_troglodytes
ENSG00000046647	GEMIN8	100	69.421	ENSPANG00000030043	-	100	68.182	Papio_anubis
ENSG00000046647	GEMIN8	100	95.455	ENSPANG00000016642	GEMIN8	100	95.455	Papio_anubis
ENSG00000046647	GEMIN8	94	50.000	ENSPKIG00000020338	GEMIN8	96	50.000	Paramormyrops_kingsleyae
ENSG00000046647	GEMIN8	99	55.372	ENSPSIG00000011906	GEMIN8	100	55.372	Pelodiscus_sinensis
ENSG00000046647	GEMIN8	99	40.647	ENSPMGG00000014057	gemin8	99	41.429	Periophthalmus_magnuspinnatus
ENSG00000046647	GEMIN8	98	61.864	ENSPCIG00000029845	GEMIN8	99	61.864	Phascolarctos_cinereus
ENSG00000046647	GEMIN8	96	50.215	ENSPFOG00000004081	gemin8	97	52.361	Poecilia_formosa
ENSG00000046647	GEMIN8	96	51.931	ENSPLAG00000006720	gemin8	97	51.931	Poecilia_latipinna
ENSG00000046647	GEMIN8	99	49.583	ENSPMEG00000010102	gemin8	94	53.275	Poecilia_mexicana
ENSG00000046647	GEMIN8	94	52.402	ENSPREG00000012475	gemin8	96	53.275	Poecilia_reticulata
ENSG00000046647	GEMIN8	100	96.694	ENSPPYG00000020136	GEMIN8	100	96.694	Pongo_abelii
ENSG00000046647	GEMIN8	99	70.124	ENSPCAG00000013168	-	72	70.124	Procavia_capensis
ENSG00000046647	GEMIN8	99	84.167	ENSPCOG00000015687	GEMIN8	99	84.167	Propithecus_coquereli
ENSG00000046647	GEMIN8	98	68.908	ENSPVAG00000009751	GEMIN8	74	69.456	Pteropus_vampyrus
ENSG00000046647	GEMIN8	94	48.908	ENSPNYG00000015361	gemin8	93	50.218	Pundamilia_nyererei
ENSG00000046647	GEMIN8	94	44.898	ENSPNAG00000017992	gemin8	99	48.684	Pygocentrus_nattereri
ENSG00000046647	GEMIN8	98	66.527	ENSRNOG00000029038	Gemin8	99	69.038	Rattus_norvegicus
ENSG00000046647	GEMIN8	95	96.087	ENSRBIG00000009966	GEMIN8	100	95.868	Rhinopithecus_bieti
ENSG00000046647	GEMIN8	95	96.087	ENSRROG00000039241	GEMIN8	100	95.868	Rhinopithecus_roxellana
ENSG00000046647	GEMIN8	96	85.294	ENSRROG00000031124	-	74	80.165	Rhinopithecus_roxellana
ENSG00000046647	GEMIN8	100	68.595	ENSRROG00000045459	-	100	67.355	Rhinopithecus_roxellana
ENSG00000046647	GEMIN8	100	88.430	ENSSBOG00000018178	-	100	88.430	Saimiri_boliviensis_boliviensis
ENSG00000046647	GEMIN8	100	70.248	ENSSBOG00000021955	-	100	69.008	Saimiri_boliviensis_boliviensis
ENSG00000046647	GEMIN8	99	59.336	ENSSHAG00000001412	GEMIN8	99	59.336	Sarcophilus_harrisii
ENSG00000046647	GEMIN8	94	48.246	ENSSFOG00015023420	gemin8	95	48.246	Scleropages_formosus
ENSG00000046647	GEMIN8	96	48.927	ENSSMAG00000014019	gemin8	99	51.528	Scophthalmus_maximus
ENSG00000046647	GEMIN8	94	51.965	ENSSDUG00000005069	gemin8	84	51.965	Seriola_dumerili
ENSG00000046647	GEMIN8	94	51.965	ENSSLDG00000004417	gemin8	96	51.965	Seriola_lalandi_dorsalis
ENSG00000046647	GEMIN8	99	53.750	ENSSPUG00000003529	GEMIN8	100	54.167	Sphenodon_punctatus
ENSG00000046647	GEMIN8	94	50.655	ENSSPAG00000011260	gemin8	95	50.655	Stegastes_partitus
ENSG00000046647	GEMIN8	99	62.810	ENSSSCG00000012127	GEMIN8	100	64.486	Sus_scrofa
ENSG00000046647	GEMIN8	51	70.968	ENSTGUG00000008162	GEMIN8	100	70.968	Taeniopygia_guttata
ENSG00000046647	GEMIN8	94	48.472	ENSTRUG00000022129	gemin8	95	48.472	Takifugu_rubripes
ENSG00000046647	GEMIN8	94	47.598	ENSTNIG00000001453	gemin8	95	48.035	Tetraodon_nigroviridis
ENSG00000046647	GEMIN8	100	74.793	ENSTBEG00000004921	GEMIN8	71	74.793	Tupaia_belangeri
ENSG00000046647	GEMIN8	98	65.417	ENSTTRG00000009266	-	69	67.500	Tursiops_truncatus
ENSG00000046647	GEMIN8	96	65.106	ENSUAMG00000013267	GEMIN8	99	64.655	Ursus_americanus
ENSG00000046647	GEMIN8	96	68.240	ENSUMAG00000005467	GEMIN8	97	64.681	Ursus_maritimus
ENSG00000046647	GEMIN8	99	72.917	ENSVVUG00000009383	GEMIN8	99	72.500	Vulpes_vulpes
ENSG00000046647	GEMIN8	95	49.587	ENSXETG00000013349	gemin8	97	49.587	Xenopus_tropicalis
ENSG00000046647	GEMIN8	96	49.356	ENSXMAG00000026315	gemin8	97	51.502	Xiphophorus_maculatus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000387	spliceosomal snRNP assembly	16434402.18984161.	IDA	Process
GO:0000387	spliceosomal snRNP assembly	-	TAS	Process
GO:0005515	protein binding	17023415.	IPI	Function
GO:0005634	nucleus	16434402.	IDA	Component
GO:0005654	nucleoplasm	-	TAS	Component
GO:0005737	cytoplasm	17023415.	IDA	Component
GO:0005829	cytosol	18984161.	IDA	Component
GO:0005829	cytosol	-	TAS	Component
GO:0032797	SMN complex	16434402.18984161.	IDA	Component
GO:0034719	SMN-Sm protein complex	18984161.	IDA	Component
GO:0051170	import into nucleus	-	TAS	Process
GO:0097504	Gemini of coiled bodies	-	IEA	Component