EuRBPDB

Description

RBPome

Literatures

Expression

Transcripts

Gene Model

Pathways

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000047410 (Gene tree)
Gene ID: 7175
Gene Symbol: TPR
Alias: N
Full Name: translocated promoter region, nuclear basket protein
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Minus strand
Length: 64,197 bases
Position: chr1:186,311,652-186,375,848
Accession: 12017
RBP type: non-canonical RBP
Summary: This gene encodes a large coiled-coil protein that forms intranuclear filaments attached to the inner surface of nuclear pore complexes (NPCs). The protein directly interacts with several components of the NPC. It is required for the nuclear export of mRNAs and some proteins. Oncogenic fusions of the 5' end of this gene with several different kinase genes occur in some neoplasias. [provided by RefSeq, Jul 2008]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & HEK293	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
29431736	Capturing the interactome of newly transcribed RNA	PolyT-RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
22658674	Insights into RNA biology from an atlas of mammalian mRNA-binding proteins	RIC & Hela	2012 May 31	Castello A	DOI: 10.1016/j.cell.2012.04.031
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & Hela	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & MCF10A	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & U2OS	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
27805000	Regulation of RNA-binding proteins affinity to export receptors enables the nuclear basket proteins to distinguish and retain aberrant mRNAs.	Sci Rep	2016 Nov 2	Soheilypour M	doi: 10.1038/srep35380.

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000367478	TPR-201	9708	-	ENSP00000356448	2363 (aa)	-	P12270
ENST00000474852	TPR-205	2757	-	-	- (aa)	-	-
ENST00000491783	TPR-207	882	-	-	- (aa)	-	-
ENST00000481347	TPR-206	2727	-	-	- (aa)	-	-
ENST00000467810	TPR-203	581	-	-	- (aa)	-	-
ENST00000451586	TPR-202	515	-	ENSP00000408103	150 (aa)	-	Q5SWX9
ENST00000469463	TPR-204	420	-	-	- (aa)	-	-
ENST00000613151	TPR-209	2478	-	ENSP00000483425	726 (aa)	-	P12270
ENST00000492973	TPR-208	453	-	-	- (aa)	-	-

Gene Model

Click here to download ENSG00000047410's gene model file

Pathways

Pathway ID	Pathway Name	Source
hsa03013	RNA transport	KEGG
hsa05200	Pathways in cancer	KEGG
hsa05216	Thyroid cancer	KEGG

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000047410's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs identified by RBPome

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000047410	TPR	99	93.620	ENSMUSG00000006005	Tpr	99	93.492	Mus_musculus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000122	negative regulation of transcription by RNA polymerase II	21613532.	IMP	Process
GO:0000776	kinetochore	20133940.	IDA	Component
GO:0000776	kinetochore	19273613.	IDA	Component
GO:0003682	chromatin binding	17897941.	IDA	Function
GO:0003723	RNA binding	22658674.	HDA	Function
GO:0003729	mRNA binding	17897941.	IDA	Function
GO:0005215	transporter activity	11952838.	IMP	Function
GO:0005515	protein binding	12802065.15654337.17897941.18794356.18981471.19273613.20133940.22253824.24581499.24970816.	IPI	Function
GO:0005634	nucleus	15654337.	IDA	Component
GO:0005635	nuclear envelope	17098863.24970816.	IDA	Component
GO:0005643	nuclear pore	21873635.	IBA	Component
GO:0005643	nuclear pore	9828100.9864356.11514627.12802065.	IDA	Component
GO:0005654	nucleoplasm	-	TAS	Component
GO:0005737	cytoplasm	11952838.12802065.	IDA	Component
GO:0005868	cytoplasmic dynein complex	20133940.	IDA	Component
GO:0006110	regulation of glycolytic process	-	TAS	Process
GO:0006404	RNA import into nucleus	9864356.	IDA	Process
GO:0006405	RNA export from nucleus	11952838.	IMP	Process
GO:0006406	mRNA export from nucleus	-	TAS	Process
GO:0006409	tRNA export from nucleus	-	TAS	Process
GO:0006606	protein import into nucleus	9864356.	IDA	Process
GO:0006606	protein import into nucleus	18794356.	IMP	Process
GO:0006606	protein import into nucleus	11952838.	IMP	Process
GO:0006611	protein export from nucleus	11952838.	IMP	Process
GO:0006999	nuclear pore organization	15229283.	IMP	Process
GO:0006999	nuclear pore organization	11952838.	IMP	Process
GO:0007094	mitotic spindle assembly checkpoint	21873635.	IBA	Process
GO:0007094	mitotic spindle assembly checkpoint	20133940.	IMP	Process
GO:0010793	regulation of mRNA export from nucleus	22253824.	IMP	Process
GO:0010965	regulation of mitotic sister chromatid separation	20133940.	IMP	Process
GO:0015631	tubulin binding	20133940.	IDA	Function
GO:0016032	viral process	-	TAS	Process
GO:0016925	protein sumoylation	-	TAS	Process
GO:0017056	structural constituent of nuclear pore	21873635.	IBA	Function
GO:0017056	structural constituent of nuclear pore	22253824.	IDA	Function
GO:0019083	viral transcription	-	TAS	Process
GO:0019898	extrinsic component of membrane	12802065.	IDA	Component
GO:0031072	heat shock protein binding	17897941.	IDA	Function
GO:0031453	positive regulation of heterochromatin assembly	20407419.	IMP	Process
GO:0031647	regulation of protein stability	21613532.	IMP	Process
GO:0031965	nuclear membrane	9024684.9828100.9864356.11514627.11839768.11952838.12802065.15229283.18794356.20407419.22253824.	IDA	Component
GO:0031990	mRNA export from nucleus in response to heat stress	17897941.	IDA	Process
GO:0032880	regulation of protein localization	18981471.	IMP	Process
GO:0034399	nuclear periphery	9024684.11514627.11839768.11952838.15229283.22401879.	IDA	Component
GO:0034605	cellular response to heat	17897941.	IDA	Process
GO:0035457	cellular response to interferon-alpha	-	ISS	Process
GO:0042306	regulation of protein import into nucleus	22253824.	IMP	Process
GO:0042307	positive regulation of protein import into nucleus	18794356.	IMP	Process
GO:0042405	nuclear inclusion body	11514627.11839768.	IDA	Component
GO:0042803	protein homodimerization activity	11514627.12802065.	IDA	Function
GO:0043495	protein membrane anchor	12802065.	IMP	Function
GO:0043578	nuclear matrix organization	11952838.	IMP	Process
GO:0043657	host cell	-	IEA	Component
GO:0044615	nuclear pore nuclear basket	9024684.11839768.15229283.18981471.	IDA	Component
GO:0045947	negative regulation of translational initiation	21613532.	IMP	Process
GO:0046825	regulation of protein export from nucleus	22253824.	IMP	Process
GO:0046827	positive regulation of protein export from nucleus	-	ISS	Process
GO:0046832	negative regulation of RNA export from nucleus	22253824.	IDA	Process
GO:0046832	negative regulation of RNA export from nucleus	21613532.	IMP	Process
GO:0051019	mitogen-activated protein kinase binding	18794356.	IDA	Function
GO:0051292	nuclear pore complex assembly	12802065.	IMP	Process
GO:0051301	cell division	-	IEA	Process
GO:0060964	regulation of gene silencing by miRNA	-	TAS	Process
GO:0070840	dynein complex binding	20133940.	IDA	Function
GO:0070849	response to epidermal growth factor	18794356.	IDA	Process
GO:0072686	mitotic spindle	20133940.	IDA	Component
GO:0075733	intracellular transport of virus	-	TAS	Process
GO:0090267	positive regulation of mitotic cell cycle spindle assembly checkpoint	18981471.19273613.	IMP	Process
GO:0090316	positive regulation of intracellular protein transport	19273613.	IMP	Process
GO:1900034	regulation of cellular response to heat	-	TAS	Process
GO:1901673	regulation of mitotic spindle assembly	19273613.	IMP	Process