EuRBPDB

Description

RBPome

Literatures

Expression

Transcripts

Gene Model

Phenotypes

GWAS

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000047849 (Gene tree)
Gene ID: 4134
Gene Symbol: MAP4
Alias: N
Full Name: microtubule associated protein 4
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Minus strand
Length: 238,590 bases
Position: chr3:47,850,690-48,089,279
Accession: 6862
RBP type: non-canonical RBP
Summary: The protein encoded by this gene is a major non-neuronal microtubule-associated protein. This protein contains a domain similar to the microtubule-binding domains of neuronal microtubule-associated protein (MAP2) and microtubule-associated protein tau (MAPT/TAU). This protein promotes microtubule assembly, and has been shown to counteract destabilization of interphase microtubule catastrophe promotion. Cyclin B was found to interact with this protein, which targets cell division cycle 2 (CDC2) kinase to microtubules. The phosphorylation of this protein affects microtubule properties and cell cycle progression. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2008]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
22681889	The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts	4SURIC & HEK293	2012 May	Baltz AG	DOI: 10.1016/j.molcel.2012.05.021
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & HEK293	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
29431736	Capturing the interactome of newly transcribed RNA	PolyT-RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
29431736	Capturing the interactome of newly transcribed RNA	RIC & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
29431736	Capturing the interactome of newly transcribed RNA	RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
22658674	Insights into RNA biology from an atlas of mammalian mRNA-binding proteins	RIC & Hela	2012 May 31	Castello A	DOI: 10.1016/j.cell.2012.04.031
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & Hela	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & MCF10A	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & MCF7	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & U2OS	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
27453046	Comprehensive Identification of RNA-Binding Domains in Human Cells	RIC & Hela	2016 Aug 18	Castello A	DOI: 10.1016/j.molcel.2016.06.029
30352994	Discovery of RNA-binding proteins and characterization of their dynamic responses by enhanced RNA interactome capture	RIC & Jurkat	2018 Oct 23	Perez-Perri JI	DOI:10.1038/s41467-018-06557-8

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
30234379	Identify Cross Talk Between Circadian Rhythm and Coronary Heart Disease by Multiple Correlation Analysis.	J Comput Biol	2018 Dec	Yan X	doi: 10.1089/cmb.2017.0254

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000468075	MAP4-212	487	-	ENSP00000487698	76 (aa)	-	A0A0J9YVV8
ENST00000360240	MAP4-202	5142	XM_017006402	ENSP00000353375	1152 (aa)	XP_016861891	P27816
ENST00000434267	MAP4-209	2772	-	ENSP00000402767	99 (aa)	-	P27816
ENST00000477765	MAP4-213	284	-	-	- (aa)	-	-
ENST00000395734	MAP4-204	5590	-	ENSP00000379083	1135 (aa)	-	P27816
ENST00000482752	MAP4-214	386	-	-	- (aa)	-	-
ENST00000426837	MAP4-207	8920	XM_011533703	ENSP00000407602	2297 (aa)	XP_011532005	E7EVA0
ENST00000633710	MAP4-216	570	-	ENSP00000487797	140 (aa)	-	A0A0J9YW37
ENST00000383736	MAP4-203	2282	-	ENSP00000373242	760 (aa)	-	B5MEG9
ENST00000423088	MAP4-206	899	-	ENSP00000415689	283 (aa)	-	H7C456
ENST00000497735	MAP4-215	2156	-	-	- (aa)	-	-
ENST00000420772	MAP4-205	3478	-	ENSP00000409731	828 (aa)	-	F8W9U4
ENST00000429422	MAP4-208	3724	-	ENSP00000416743	493 (aa)	-	H7C4C5
ENST00000335271	MAP4-201	1564	-	ENSP00000334770	463 (aa)	-	H0Y2V1
ENST00000462206	MAP4-211	572	-	-	- (aa)	-	-
ENST00000439356	MAP4-210	2743	-	ENSP00000397414	99 (aa)	-	P27816

Gene Model

Click here to download ENSG00000047849's gene model file

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000047849	Alcoholism	7.45338e-005	22978509
ENSG00000047849	Alcoholism	7.39231e-005	22978509
ENSG00000047849	Arterial Pressure	3E-8	21909110
ENSG00000047849	Education	8E-9	27225129

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000047849	rs319690	3	47885994	C	Diastolic blood pressure	28739976	[0.14-0.33] unit decrease	0.233	EFO_0006336
ENSG00000047849	rs319690	3	47885994	C	Systolic blood pressure	28739976	[0.22-0.52] unit decrease	0.368	EFO_0006335
ENSG00000047849	rs7429990	3	47860313	A	Educational attainment (years of education)	27225129	NR unit decrease	0.014693202	EFO_0004784
ENSG00000047849	rs1060407	3	47916547	T	Mean arterial pressure	27618448	[0.15-0.35] unit decrease	0.25045192	EFO_0006340
ENSG00000047849	rs62260764	3	47949010	C	Educational attainment (MTAG)	30038396	[0.011-0.017] unit decrease	0.0141	EFO_0004784
ENSG00000047849	rs62260764	3	47949010	G	Highest math class taken	30038396	[0.015-0.025] unit increase	0.0203	EFO_0004875
ENSG00000047849	rs62260764	3	47949010	C	Self-reported math ability (MTAG)	30038396	[0.0096-0.0178] unit decrease	0.0137	EFO_0004875
ENSG00000047849	rs62260764	3	47949010	C	Highest math class taken (MTAG)	30038396	[0.014-0.022] unit decrease	0.0178	EFO_0004875
ENSG00000047849	rs75485436	3	47893519	G	Macrophage inflammatory protein 1b levels	27989323	[0.29-0.4] SD units decrease	0.3426	EFO_0008219
ENSG00000047849	rs199779881	3	48026776	TTC	Macrophage inflammatory protein 1b levels	27989323	[0.3-0.42] SD units decrease	0.3626	EFO_0008219
ENSG00000047849	rs112427907	3	47953780	G	Stem cell growth factor beta levels	27989323	[0.11-0.26] SD units decrease	0.1836	EFO_0008292
ENSG00000047849	rs319690	3	47885994	T	Blood pressure	21909110	[0.20-0.40] mmHg increase	0.297	EFO_0006340
ENSG00000047849	rs62260764	3	47949010	C	Cognitive performance (MTAG)	30038396	[0.0097-0.0199] unit decrease	0.0148	EFO_0008354
ENSG00000047849	rs34170328	3	47979792	?	General cognitive ability	29844566	z-score increase	4.613	EFO_0004337
ENSG00000047849	rs62260764	3	47949010	C	Educational attainment (years of education)	30038396	[0.01-0.016] unit decrease	0.0132	EFO_0004784
ENSG00000047849	rs35979968	3	48050845	T	Systolic blood pressure	30578418	[0.25-0.41] mmHg decrease	0.3319	EFO_0006335
ENSG00000047849	rs319690	3	47885994	T	Diastolic blood pressure	27841878	unit increase	0.208	EFO_0006336
ENSG00000047849	rs319690	3	47885994	T	Systolic blood pressure	27841878	unit increase	0.291	EFO_0006335
ENSG00000047849	rs145407011	3	48024338	T	Breast cancer	29059683	[0.059-0.137] unit decrease	0.0978	EFO_0000305

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000047849's network

Orthologs identified by RBPome

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000047849	MAP4	97	79.730	ENSMUSG00000032479	Map4	99	92.174	Mus_musculus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000226	microtubule cytoskeleton organization	21873635.	IBA	Process
GO:0000226	microtubule cytoskeleton organization	-	ISS	Process
GO:0003723	RNA binding	22658674.22681889.	HDA	Function
GO:0005198	structural molecule activity	1905296.	TAS	Function
GO:0005515	protein binding	17474147.	IPI	Function
GO:0005829	cytosol	-	IDA	Component
GO:0005874	microtubule	-	IEA	Component
GO:0005875	microtubule associated complex	1905296.	TAS	Component
GO:0005886	plasma membrane	-	IDA	Component
GO:0005930	axoneme	23572511.	IDA	Component
GO:0007052	mitotic spindle organization	21822276.	IMP	Process
GO:0008017	microtubule binding	21873635.	IBA	Function
GO:0015630	microtubule cytoskeleton	-	IDA	Component
GO:0030424	axon	-	ISS	Component
GO:0031175	neuron projection development	21873635.	IBA	Process
GO:0043005	neuron projection	21873635.	IBA	Component
GO:0051012	microtubule sliding	21822276.	IMP	Process
GO:0051294	establishment of spindle orientation	21822276.	IGI	Process
GO:0051294	establishment of spindle orientation	21822276.	IMP	Process
GO:0051301	cell division	21822276.	IMP	Process
GO:0072686	mitotic spindle	21822276.	IDA	Component
GO:1902856	negative regulation of non-motile cilium assembly	23572511.	IMP	Process