EuRBPDB

Description

RBPome

PRI

Literatures

Expression

Transcripts

Gene Model

Phenotypes

GWAS

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000048828 (Gene tree)
Gene ID: 23196
Gene Symbol: FAM120A
Alias: KIAA0183|OSSA|C9orf10
Full Name: family with sequence similarity 120A
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Plus strand
Length: 114,420 bases
Position: chr9:93,451,696-93,566,115
Accession: 13247
RBP type: non-canonical RBP
Summary: (Family With Sequence Similarity 120A) is a Protein Coding gene. Diseases associated with FAM120A include Myiasis and Retinitis Pigmentosa 59. An important paralog of this gene is FAM120C.

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
22681889	The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts	4SURIC & HEK293	2012 May	Baltz AG	DOI: 10.1016/j.molcel.2012.05.021
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & HEK293	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
29431736	Capturing the interactome of newly transcribed RNA	PolyT-RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
29431736	Capturing the interactome of newly transcribed RNA	RIC & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
29431736	Capturing the interactome of newly transcribed RNA	RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
22658674	Insights into RNA biology from an atlas of mammalian mRNA-binding proteins	RIC & Hela	2012 May 31	Castello A	DOI: 10.1016/j.cell.2012.04.031
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & Hela	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & MCF10A	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & MCF7	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & U2OS	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
27453046	Comprehensive Identification of RNA-Binding Domains in Human Cells	RIC & Hela	2016 Aug 18	Castello A	DOI: 10.1016/j.molcel.2016.06.029
30352994	Discovery of RNA-binding proteins and characterization of their dynamic responses by enhanced RNA interactome capture	RIC & Jurkat	2018 Oct 23	Perez-Perri JI	DOI:10.1038/s41467-018-06557-8

Protein-RNA interaction（RNA-Binding Site）

Click here to download all RNA binding sites

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
31289130	Sequestration of microRNA-mediated target repression by the Ago2-associated RNA binding protein FAM120A.	RNA	2019 Jul 9	Kelly TJ	doi: 10.1261/rna.071621.119
19015244	A novel RNA-binding protein, Ossa/C9orf10, regulates activity of Src kinases to protect cells from oxidative stress-induced apoptosis.	Mol Cell Biol	2009 Jan	Tanaka M	doi: 10.1128/MCB.01035-08

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000427765	FAM120A-203	1710	-	ENSP00000412440	494 (aa)	-	A0A0C4DG79
ENST00000475933	FAM120A-205	562	-	-	- (aa)	-	-
ENST00000446420	FAM120A-204	1701	XM_011518416	ENSP00000396534	495 (aa)	XP_011516718	A0A0C4DH52
ENST00000375389	FAM120A-202	3585	-	ENSP00000364538	628 (aa)	-	Q9NZB2
ENST00000277165	FAM120A-201	5118	XM_005251842	ENSP00000277165	1118 (aa)	XP_005251899	Q9NZB2

Gene Model

Click here to download ENSG00000048828's gene model file

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000048828	Insulin-Like Growth Factor I	2.0270000E-006	27329260
ENSG00000048828	Insulin-Like Growth Factor I	8.5860000E-007	27329260
ENSG00000048828	Insulin-Like Growth Factor I	6.3360000E-007	27329260
ENSG00000048828	Schizophrenia	6E-6	26198764
ENSG00000048828	Body Mass Index	2E-6	26604143
ENSG00000048828	Education	4E-8	27225129

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000048828	rs10821136	9	93476449	T	Educational attainment (years of education)	27225129	NR unit increase	0.012968686	EFO_0004784
ENSG00000048828	rs7869969	9	93455165	G	Childhood body mass index	26604143	[0.02-0.052] unit increase	0.036	EFO_0004340
ENSG00000048828	rs12554020	9	93507955	C	Schizophrenia	26198764	[NR]	1.07	EFO_0000692
ENSG00000048828	rs10992756	9	93491157	T	Intelligence (MTAG)	29326435	[0.014-0.026] unit decrease	0.019726846	EFO_0004337
ENSG00000048828	rs10821147	9	93509085	A	Upper eyelid morphology	29921221	[NR] unit increase	0.01	EFO_0007858
ENSG00000048828	rs4744250	9	93509470	A	Cognitive performance	30038396	[0.012-0.024] unit increase	0.0183	EFO_0008354
ENSG00000048828	rs10512225	9	93464818	A	Highest math class taken (MTAG)	30038396	[0.0075-0.0141] unit decrease	0.0108	EFO_0004875
ENSG00000048828	rs17532098	9	93500443	T	Feeling hurt	29500382	z score increase	5.57	EFO_0009599
ENSG00000048828	rs4744250	9	93509470	A	Cognitive performance (MTAG)	30038396	[0.015-0.024] unit increase	0.0196	EFO_0008354
ENSG00000048828	rs12376738	9	93539518	T	Depression	29942085	z score increase	5.651	EFO_0003761
ENSG00000048828	rs11975	9	93565409	A	Neurociticism	29500382	z score decrease	6.6	EFO_0007660
ENSG00000048828	rs78046549	9	93506196	T	Neuroticism	29942085	z score increase	6.631	EFO_0007660
ENSG00000048828	rs10821129	9	93460335	A	Neuroticism	29942085	z score decrease	6.123	EFO_0007660
ENSG00000048828	rs17532098	9	93500443	T	Worry	29942085	[0.016-0.031] unit increase	0.02318	EFO_0005230
ENSG00000048828	rs7023933	9	93463196	T	Worry	29942085	[0.012-0.025] unit increase	0.01848	EFO_0005230
ENSG00000048828	rs7869969	9	93455165	?	Neuroticism	30595370			EFO_0007660

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000048828's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs identified by RBPome

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000048828	FAM120A	96	52.686	ENSDARG00000019205	fam120c	84	65.306	Danio_rerio
ENSG00000048828	FAM120A	100	59.681	ENSG00000184083	FAM120C	90	54.686	Homo_sapiens
ENSG00000048828	FAM120A	100	96.422	ENSMUSG00000038014	Fam120a	100	96.422	Mus_musculus
ENSG00000048828	FAM120A	100	58.648	ENSMUSG00000025262	Fam120c	91	53.543	Mus_musculus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0003723	RNA binding	22658674.22681889.	HDA	Function
GO:0005634	nucleus	21873635.	IBA	Component
GO:0005829	cytosol	-	IDA	Component
GO:0005886	plasma membrane	-	IEA	Component
GO:0016020	membrane	19946888.	HDA	Component