EuRBPDB

Basic Information
Cancer Related Information

Description

RBDs

Literatures

Expression

Transcripts

Gene Model

Pathways

GWAS

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000050748 (Gene tree)
Gene ID: 5601
Gene Symbol: MAPK9
Alias: JNK2|p54a|SAPK|PRKM9
Full Name: mitogen-activated protein kinase 9
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Minus strand
Length: 58,957 bases
Position: chr5:180,233,143-180,292,099
Accession: 6886
RBP type: canonical RBP
Summary: The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase targets specific transcription factors, and thus mediates immediate-early gene expression in response to various cell stimuli. It is most closely related to MAPK8, both of which are involved in UV radiation induced apoptosis, thought to be related to the cytochrome c-mediated cell death pathway. This gene and MAPK8 are also known as c-Jun N-terminal kinases. This kinase blocks the ubiquitination of tumor suppressor p53, and thus it increases the stability of p53 in nonstressed cells. Studies of this gene's mouse counterpart suggest a key role in T-cell differentiation. Several alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Sep 2008]

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000443149	RIO1	PF01163.22	0.00088	1	1
ENSP00000397422	RIO1	PF01163.22	0.0012	1	1

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
24740539	Jnk2 deletion disrupts intestinal mucosal homeostasis and maturation by differentially modulating RNA-binding proteins HuR and CUGBP1.	Am J Physiol Cell Physiol	2014 Jun 15	Chung HK	doi: 10.1152/ajpcell.00093.2014
19414512	Life-span extension in mice by preweaning food restriction and by methionine restriction in middle age.	J Gerontol A Biol Sci Med Sci	2009 Jul	Sun L	doi: 10.1093/gerona/glp051

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000523583	MAPK9-211	657	-	ENSP00000430608	103 (aa)	-	E5RJ57
ENST00000393362	MAPK9-204	1344	-	ENSP00000377029	124 (aa)	-	D7R528
ENST00000393360	MAPK9-203	4326	XM_017009641	ENSP00000377028	382 (aa)	XP_016865130	P45984
ENST00000343111	MAPK9-201	4369	-	ENSP00000345524	382 (aa)	-	P45984
ENST00000452135	MAPK9-207	4815	XM_005265940	ENSP00000394560	424 (aa)	XP_005265997	P45984
ENST00000539014	MAPK9-213	1668	XM_017009643	ENSP00000443149	214 (aa)	XP_016865132	D7R525
ENST00000524170	MAPK9-212	538	-	-	- (aa)	-	-
ENST00000347470	MAPK9-202	1509	-	ENSP00000321410	339 (aa)	-	J3KNK1
ENST00000425491	MAPK9-206	2266	-	ENSP00000397422	242 (aa)	-	P45984
ENST00000455781	MAPK9-208	4336	XM_017009638	ENSP00000389338	424 (aa)	XP_016865127	P45984
ENST00000397072	MAPK9-205	1416	-	ENSP00000380262	124 (aa)	-	D7R528
ENST00000523135	MAPK9-210	372	-	-	- (aa)	-	-
ENST00000520212	MAPK9-209	2395	-	-	- (aa)	-	-

Gene Model

Click here to download ENSG00000050748's gene model file

Pathways

Pathway ID	Pathway Name	Source
hsa01522	Endocrine resistance	KEGG
hsa04010	MAPK signaling pathway	KEGG
hsa04012	ErbB signaling pathway	KEGG
hsa04014	Ras signaling pathway	KEGG
hsa04024	cAMP signaling pathway	KEGG
hsa04068	FoxO signaling pathway	KEGG
hsa04071	Sphingolipid signaling pathway	KEGG
hsa04137	Mitophagy - animal	KEGG
hsa04140	Autophagy - animal	KEGG
hsa04141	Protein processing in endoplasmic reticulum	KEGG
hsa04210	Apoptosis	KEGG
hsa04215	Apoptosis - multiple species	KEGG
hsa04217	Necroptosis	KEGG
hsa04310	Wnt signaling pathway	KEGG
hsa04380	Osteoclast differentiation	KEGG
hsa04510	Focal adhesion	KEGG
hsa04530	Tight junction	KEGG
hsa04620	Toll-like receptor signaling pathway	KEGG
hsa04621	NOD-like receptor signaling pathway	KEGG
hsa04622	RIG-I-like receptor signaling pathway	KEGG
hsa04625	C-type lectin receptor signaling pathway	KEGG
hsa04657	IL-17 signaling pathway	KEGG
hsa04658	Th1 and Th2 cell differentiation	KEGG
hsa04659	Th17 cell differentiation	KEGG
hsa04660	T cell receptor signaling pathway	KEGG
hsa04664	Fc epsilon RI signaling pathway	KEGG
hsa04668	TNF signaling pathway	KEGG
hsa04722	Neurotrophin signaling pathway	KEGG
hsa04723	Retrograde endocannabinoid signaling	KEGG
hsa04728	Dopaminergic synapse	KEGG
hsa04750	Inflammatory mediator regulation of TRP channels	KEGG
hsa04910	Insulin signaling pathway	KEGG
hsa04912	GnRH signaling pathway	KEGG
hsa04914	Progesterone-mediated oocyte maturation	KEGG
hsa04917	Prolactin signaling pathway	KEGG
hsa04920	Adipocytokine signaling pathway	KEGG
hsa04926	Relaxin signaling pathway	KEGG
hsa04930	Type II diabetes mellitus	KEGG
hsa04931	Insulin resistance	KEGG
hsa04932	Non-alcoholic fatty liver disease (NAFLD)	KEGG
hsa04933	AGE-RAGE signaling pathway in diabetic complications	KEGG
hsa05120	Epithelial cell signaling in Helicobacter pylori infection	KEGG
hsa05131	Shigellosis	KEGG
hsa05132	Salmonella infection	KEGG
hsa05133	Pertussis	KEGG
hsa05142	Chagas disease (American trypanosomiasis)	KEGG
hsa05145	Toxoplasmosis	KEGG
hsa05152	Tuberculosis	KEGG
hsa05161	Hepatitis B	KEGG
hsa05162	Measles	KEGG
hsa05166	Human T-cell leukemia virus 1 infection	KEGG
hsa05167	Kaposi sarcoma-associated herpesvirus infection	KEGG
hsa05169	Epstein-Barr virus infection	KEGG
hsa05170	Human immunodeficiency virus 1 infection	KEGG
hsa05200	Pathways in cancer	KEGG
hsa05210	Colorectal cancer	KEGG
hsa05212	Pancreatic cancer	KEGG
hsa05231	Choline metabolism in cancer	KEGG
hsa05418	Fluid shear stress and atherosclerosis	KEGG

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000050748	rs13185784	5	180267068	G	TRAIL levels	27989323	[0.049-0.12] SD units decrease	0.0846	EFO_0008300

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000050748's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000050748	MAPK9	100	99.587	ENSANAG00000024448	MAPK9	100	99.587	Aotus_nancymaae
ENSG00000050748	MAPK9	100	99.587	ENSCJAG00000010293	MAPK9	100	99.587	Callithrix_jacchus
ENSG00000050748	MAPK9	100	100.000	ENSTSYG00000012099	MAPK9	92	98.565	Carlito_syrichta
ENSG00000050748	MAPK9	100	99.029	ENSCCAG00000038038	MAPK9	100	98.598	Cebus_capucinus
ENSG00000050748	MAPK9	100	99.587	ENSCATG00000033689	MAPK9	100	99.587	Cercocebus_atys
ENSG00000050748	MAPK9	100	100.000	ENSCANG00000028624	MAPK9	100	100.000	Colobus_angolensis_palliatus
ENSG00000050748	MAPK9	100	100.000	ENSFCAG00000025302	MAPK9	99	98.122	Felis_catus
ENSG00000050748	MAPK9	100	100.000	ENSGGOG00000016519	MAPK9	100	100.000	Gorilla_gorilla
ENSG00000050748	MAPK9	100	99.587	ENSMFAG00000042461	MAPK9	100	99.587	Macaca_fascicularis
ENSG00000050748	MAPK9	100	100.000	ENSMLEG00000027658	MAPK9	100	100.000	Mandrillus_leucophaeus
ENSG00000050748	MAPK9	100	98.131	ENSMICG00000015900	MAPK9	100	98.131	Microcebus_murinus
ENSG00000050748	MAPK9	100	100.000	ENSNLEG00000001965	MAPK9	100	100.000	Nomascus_leucogenys
ENSG00000050748	MAPK9	100	100.000	ENSODEG00000006074	-	99	100.000	Octodon_degus
ENSG00000050748	MAPK9	100	100.000	ENSPPAG00000038007	MAPK9	100	100.000	Pan_paniscus
ENSG00000050748	MAPK9	100	100.000	ENSPPRG00000018998	MAPK9	99	98.122	Panthera_pardus
ENSG00000050748	MAPK9	100	100.000	ENSPTIG00000021236	MAPK9	99	98.122	Panthera_tigris_altaica
ENSG00000050748	MAPK9	100	100.000	ENSPTRG00000017633	MAPK9	100	100.000	Pan_troglodytes
ENSG00000050748	MAPK9	100	99.587	ENSPANG00000013251	MAPK9	100	99.587	Papio_anubis
ENSG00000050748	MAPK9	99	94.211	ENSPCOG00000005660	MAPK9	100	94.211	Propithecus_coquereli
ENSG00000050748	MAPK9	83	99.005	ENSRBIG00000027197	MAPK9	100	100.000	Rhinopithecus_bieti
ENSG00000050748	MAPK9	83	99.005	ENSRROG00000027518	MAPK9	100	100.000	Rhinopithecus_roxellana
ENSG00000050748	MAPK9	100	99.587	ENSSBOG00000019251	MAPK9	100	99.587	Saimiri_boliviensis_boliviensis

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0004705	JUN kinase activity	8654373.	IDA	Function
GO:0004707	MAP kinase activity	21873635.	IBA	Function
GO:0004712	protein serine/threonine/tyrosine kinase activity	-	IEA	Function
GO:0005515	protein binding	10376527.15158451.16189514.16288922.19060904.20871632.21988832.25241761.25416956.28089251.	IPI	Function
GO:0005524	ATP binding	-	IEA	Function
GO:0005634	nucleus	21873635.	IBA	Component
GO:0005654	nucleoplasm	-	TAS	Component
GO:0005737	cytoplasm	21873635.	IBA	Component
GO:0005739	mitochondrion	-	IEA	Component
GO:0005829	cytosol	-	TAS	Component
GO:0006468	protein phosphorylation	22441692.	IMP	Process
GO:0007254	JNK cascade	8654373.	IDA	Process
GO:0007254	JNK cascade	-	TAS	Process
GO:0007258	JUN phosphorylation	-	IEA	Process
GO:0008134	transcription factor binding	10376527.	IDA	Function
GO:0009612	response to mechanical stimulus	21873635.	IBA	Process
GO:0010468	regulation of gene expression	21873635.	IBA	Process
GO:0010628	positive regulation of gene expression	18262097.	IMP	Process
GO:0010744	positive regulation of macrophage derived foam cell differentiation	18262097.	IMP	Process
GO:0018105	peptidyl-serine phosphorylation	21856198.	IDA	Process
GO:0031398	positive regulation of protein ubiquitination	-	IEA	Process
GO:0034614	cellular response to reactive oxygen species	26514923.	IMP	Process
GO:0035556	intracellular signal transduction	21873635.	IBA	Process
GO:0038095	Fc-epsilon receptor signaling pathway	-	TAS	Process
GO:0042752	regulation of circadian rhythm	-	ISS	Process
GO:0043005	neuron projection	21873635.	IBA	Component
GO:0043065	positive regulation of apoptotic process	21873635.	IBA	Process
GO:0048511	rhythmic process	-	IEA	Process
GO:0048666	neuron development	21873635.	IBA	Process
GO:0051090	regulation of DNA-binding transcription factor activity	-	TAS	Process
GO:0061833	protein localization to tricellular tight junction	-	IEA	Process
GO:0071276	cellular response to cadmium ion	26514923.	IMP	Process
GO:0071310	cellular response to organic substance	21873635.	IBA	Process
GO:0071803	positive regulation of podosome assembly	-	IEA	Process
GO:1901485	positive regulation of transcription factor catabolic process	-	IEA	Process
GO:2001235	positive regulation of apoptotic signaling pathway	-	IEA	Process

Cancer associated literatures

PID	Title	Article	Time	Author	Doi
23912840	Specific role of JNK in the maintenance of the tumor-initiating capacity of A549 human non-small cell lung cancer cells.	Oncol Rep	2013 Oct	Okada M	doi: 10.3892/or.2013.2655
24947996	Targeting the K-Ras--JNK axis eliminates cancer stem-like cells and prevents pancreatic tumor formation.	Oncotarget	2014 Jul 15	Okada M	-
19097143	IL-1 beta induces urokinase-plasminogen activator expression and cell migration through PKC alpha, JNK1/2, and NF-kappaB in A549 cells.	J Cell Physiol	2009 Apr	Cheng CY	doi: 10.1002/jcp.21669.
23900581	Modulation of the response of prostate cancer cell lines to cisplatin treatment using small interfering RNA.	Oncol Rep	2013 Oct	Parra E	doi: 10.3892/or.2013.2637
26503828	Phloretin induces apoptosis of non-small cell lung carcinoma A549 cells via JNK1/2 and p38 MAPK pathways.	Oncol Rep	2015 Dec	Min J	-
14724588	Inhibition of JNK reduces G2/M transit independent of p53, leading to endoreduplication, decreased proliferation, and apoptosis in breast cancer cells.	Oncogene	2004 Jan 15	Mingo-Sion AM	-
19806201	Basal cancer cell survival involves JNK2 suppression of a novel JNK1/c-Jun/Bcl-3 apoptotic network.	PLoS One	2009 Oct 6	Ahmed SU	doi: 10.1371/journal.pone.0007305.
25205654	miR200c attenuates P-gp-mediated MDR and metastasis by targeting JNK2/c-Jun signaling pathway in colorectal cancer.	Mol Cancer Ther	2014 Dec	Sui H	doi: 10.1158/1535-7163.MCT-14-0167
15655348	Radiation-stimulated ERK1/2 and JNK1/2 signaling can promote cell cycle progression in human colon cancer cells.	Cell Cycle	2005 Mar	Caron RW	-
22217202	Effect of ulinastatin on growth inhibition, apoptosis of breast carcinoma cells is related to a decrease in signal conduction of JNk-2 and NF-κB.	J Exp Clin Cancer Res	2012 Jan 5	Wang H	doi: 10.1186/1756-9966-31-2.
26235742	JNK is required for maintaining the tumor-initiating cell-like properties of acquired chemoresistant human cancer cells.	Acta Pharmacol Sin	2015 Sep	Liu Y	doi: 10.1038/aps.2015.58

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq	RBD
BLCA	chr5	180249058	Silent	novel	C177C	0.34
BLCA	chr5	180280519	Missense_Mutation	NA	V15L	0.16
BLCA	chr5	180269343	Missense_Mutation	NA	N63K	0.87
BLCA	chr5	180248973	Missense_Mutation	NA	V206I	0.07
BLCA	chr5	180248979	Missense_Mutation	NA	E204K	0.41
BLCA	chr5	180239936	Nonsense_Mutation	NA	E350*	0.26
BRCA	chr5	180280592	5'UTR	novel		0.32
BRCA	chr5	180249088	Silent	NA	I167I	0.2
BRCA	chr5	180236360	3'UTR	novel		0.31
BRCA	chr5	180236311	3'UTR	novel		0.34
BRCA	chr5	180236439	Nonsense_Mutation	NA	S407*	0.38
CESC	chr5	180261761	Missense_Mutation	NA	H125Y	0.28	RIO1
CESC	chr5	180247392	Intron	novel		0.1
CESC	chr5	180247413	Intron	rs200094588		0.29
CESC	chr5	180249112	Silent	NA	V159V	0.53
CESC	chr5	180241150	Missense_Mutation	NA	Q293E	0.44
CESC	chr5	180269336	Missense_Mutation	NA	H66Y	0.48
COAD	chr5	180236325	3'UTR	novel		0.47
COAD	chr5	180241031	Splice_Region	rs560961564	A332A	0.08
COAD	chr5	180238386	Missense_Mutation	NA	V360L	0.3
COAD	chr5	180236361	3'UTR	novel		0.3
COAD	chr5	180242692	Missense_Mutation	novel	K251T	0.17
COAD	chr5	180261689	Missense_Mutation	NA	H149N	0.12	RIO1
COAD	chr5	180242729	Missense_Mutation	novel	E239K	0.07
COAD	chr5	180280542	Missense_Mutation	NA	D7G	0.53
COAD	chr5	180247427	Intron	rs750145718		0.25
COAD	chr5	180280590	5'UTR	novel		0.58
ESCA	chr5	180264803	Frame_Shift_Del	novel	*T97Lfs2**	0.36
ESCA	chr5	180236151	3'UTR	novel		0.13
GBM	chr5	180249007	Silent	rs770875658	P194P	0.34
GBM	chr5	180236422	Missense_Mutation	novel	L413I	0.32
GBM	chr5	180238392	Missense_Mutation	novel	K358Q	0.09
GBM	chr5	180269300	Missense_Mutation	novel	K78E	0.06
GBM	chr5	180236484	Missense_Mutation	NA	S392L	0.08
GBM	chr5	180247340	Intron	novel		0.08
HNSC	chr5	180242687	Missense_Mutation	novel	Q253K	0.09
HNSC	chr5	180261706	Missense_Mutation	NA	H143L	0.24	RIO1
HNSC	chr5	180239940	Silent	novel	A348A	0.38
HNSC	chr5	180269288	Missense_Mutation	novel	H82Y	0.05
HNSC	chr5	180249105	Missense_Mutation	novel	D162H	0.11	RIO1
LAML	chr5	180249015	Missense_Mutation	rs771416686	R192W	0.05
LAML	chr5	180249061	Silent	rs752981113	A176A	0.41
LGG	chr5	180249062	Missense_Mutation	NA	A176V	0.42
LIHC	chr5	180247507	Missense_Mutation	NA	D207A	0.1
LIHC	chr5	180239988	Splice_Site	novel	X333_splice	0.29
LIHC	chr5	180280453	Missense_Mutation	novel	Q37E	0.28
LIHC	chr5	180269379	Frame_Shift_Del	novel	*N51Sfs22**	0.19
LUAD	chr5	180269296	Missense_Mutation	novel	C79F	0.18
LUAD	chr5	180241120	Missense_Mutation	NA	V303L	0.45
LUAD	chr5	180236483	Silent	novel	S392S	0.05
LUAD	chr5	180247482	Missense_Mutation	rs746133033	M215I	0.15
LUAD	chr5	180261755	Nonsense_Mutation	novel	R127*	0.39	RIO1
LUAD	chr5	180264800	Missense_Mutation	NA	L98V	0.32
LUAD	chr5	180239965	Missense_Mutation	NA	A340V	0.28
LUAD	chr5	180247444	Missense_Mutation	rs778148482	T228I	0.13
LUSC	chr5	180280572	5'UTR	novel		0.51
LUSC	chr5	180241078	Missense_Mutation	NA	R317C	0.44
OV	chr5	180242600	Missense_Mutation	novel	S282A	0.12
OV	chr5	180235944	3'UTR	novel		0.81
PAAD	chr5	180239973	Silent	novel	I337I	0.17
PAAD	chr5	180249059	Missense_Mutation	novel	C177Y	0.24
READ	chr5	180236384	Nonstop_Mutation	NA	425Cext1	0.05
READ	chr5	180242588	Nonsense_Mutation	rs373601817	R286*	0.38
READ	chr5	180247426	Intron	rs371829144		0.25
READ	chr5	180247902	Intron	novel		0.23
SARC	chr5	180247413	Intron	rs200094588		0.44
SKCM	chr5	180249046	Missense_Mutation	NA	M181I	0.4
SKCM	chr5	180269318	Missense_Mutation	NA	R72C	0.41
SKCM	chr5	180249071	Missense_Mutation	novel	A173V	0.48
SKCM	chr5	180236431	Missense_Mutation	novel	D410Y	0.31
SKCM	chr5	180242645	Missense_Mutation	NA	P267S	0.25
SKCM	chr5	180261771	Missense_Mutation	NA	M121I	0.09	RIO1
SKCM	chr5	180238329	Splice_Site	novel	X372_splice	0.19
STAD	chr5	180241088	Silent	rs116346965	D313D	0.24
STAD	chr5	180261787	Missense_Mutation	NA	C116Y	0.05	RIO1
STAD	chr5	180241088	Silent	rs116346965	D313D	0.3
STAD	chr5	180236398	Missense_Mutation	novel	E421K	0.29
STAD	chr5	180249123	Missense_Mutation	novel	N156D	0.14	RIO1
STAD	chr5	180236507	Silent	NA	N384N	0.18
STAD	chr5	180249011	Missense_Mutation	NA	A193V	0.1
UCEC	chr5	180236507	Silent	NA	N384N	0.36
UCEC	chr5	180235916	3'UTR	rs36102149		0.38
UCEC	chr5	180280572	5'UTR	novel		0.07
UCEC	chr5	180247310	Intron	novel		0.46
UCEC	chr5	180247426	Intron	rs371829144		0.07
UCEC	chr5	180236448	Missense_Mutation	rs747278411	T404M	0.41
UCEC	chr5	180236297	3'UTR	novel		0.44
UCEC	chr5	180269357	Missense_Mutation	novel	R59C	0.03
UCEC	chr5	180242622	Silent	NA	L274L	0.24
UCEC	chr5	180247310	Intron	novel		0.4
UCEC	chr5	180236336	3'UTR	rs183769334		0.48
UCEC	chr5	180247493	Missense_Mutation	novel	G212C	0.23
UCEC	chr5	180236319	3'UTR	novel		0.37
UCEC	chr5	180236388	Missense_Mutation	rs200458599	R424Q	0.34
UCEC	chr5	180261809	Missense_Mutation	NA	E109K	0.38	RIO1
UCEC	chr5	180238378	Silent	NA	D362D	0.43
UCEC	chr5	180261813	Silent	novel	V107V	0.12
UCEC	chr5	180235812	3'UTR	novel		0.43
UCEC	chr5	180269339	Missense_Mutation	novel	T65P	0.39
UCEC	chr5	180236228	3'UTR	novel		0.37
UCEC	chr5	180236484	Missense_Mutation	NA	S392L	0.4
UCEC	chr5	180235875	3'UTR	novel		0.37
UCEC	chr5	180247202	Intron	rs531440188		0.35
UCEC	chr5	180236120	3'UTR	novel		0.44
UCEC	chr5	180247366	Intron	rs140536742		0.14
UCEC	chr5	180249042	Missense_Mutation	novel	T183A	0.28
UCEC	chr5	180247262	Intron	novel		0.59
UCEC	chr5	180242694	Missense_Mutation	novel	K250N	0.17
UCEC	chr5	180241068	Missense_Mutation	novel	Y320C	0.17
UCEC	chr5	180280556	Silent	rs779045924	S2S	0.37
UCEC	chr5	180239941	Missense_Mutation	NA	A348V	0.16
UCEC	chr5	180264788	Missense_Mutation	novel	Q102K	0.37	RIO1
UCEC	chr5	180269356	Missense_Mutation	novel	R59H	0.34
UCEC	chr5	180241097	Silent	novel	I310I	0.26
UCEC	chr5	180280556	Silent	rs779045924	S2S	0.4
UCEC	chr5	180235919	3'UTR	novel		0.29
UCEC	chr5	180280570	5'UTR	rs780088624		0.23
UCEC	chr5	180247460	Missense_Mutation	NA	V223M	0.34
UCEC	chr5	180236484	Missense_Mutation	NA	S392L	0.05
UCEC	chr5	180247412	Intron	rs752399475		0.14
UCEC	chr5	180235975	3'UTR	novel		0.45
UCEC	chr5	180280578	5'UTR	novel		0.43
UCEC	chr5	180247238	Intron	novel		0.33
UCEC	chr5	180247910	Intron	rs376096901		0.28
UCEC	chr5	180264794	Nonsense_Mutation	novel	E100*	0.11	RIO1
UCEC	chr5	180280461	Missense_Mutation	novel	S34Y	0.27
UCEC	chr5	180242632	Missense_Mutation	novel	F271C	0.39
UCEC	chr5	180247354	Intron	novel		0.12
UCEC	chr5	180261697	Missense_Mutation	novel	G146D	0.48	RIO1
UCEC	chr5	180269356	Missense_Mutation	novel	R59H	0.21
UCEC	chr5	180235916	3'UTR	rs36102149		0.44
UCEC	chr5	180247356	Intron	rs769071234		0.41
UCS	chr5	180249006	Missense_Mutation	novel	E195K	0.08

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
KIRC	AMP	0.589	2.1944e-60
KIRP	AMP	0.1146	0.069756
KIRP	DEL	0.0347	0.11554
LUAD	AMP	0.1802	0.24967
LUSC	DEL	0.5968	0.002071
MESO	DEL	0.1149	0.20184
PRAD	AMP	0.0366	0.16448
SKCM	AMP	0.1253	0.23703
THCA	DEL	0.002	0.23456

Survival Analysis

Cancer	P-value	Q-value
KIRC	0.00019	Kaplan-Meier Survival Analysis
ACC	0.0016	Kaplan-Meier Survival Analysis
UCS	0.022	Kaplan-Meier Survival Analysis
HNSC	0.0027	Kaplan-Meier Survival Analysis
SKCM	0.0027	Kaplan-Meier Survival Analysis
LUSC	0.035	Kaplan-Meier Survival Analysis
ESCA	0.024	Kaplan-Meier Survival Analysis
COAD	0.0015	Kaplan-Meier Survival Analysis
READ	0.0082	Kaplan-Meier Survival Analysis
LIHC	0.02	Kaplan-Meier Survival Analysis
LGG	0.00017	Kaplan-Meier Survival Analysis
THCA	0.04	Kaplan-Meier Survival Analysis

Drugs

EuRBPDB

Description

RBDs

Literatures

Expression

Transcripts

Gene Model

Pathways

GWAS

PPI

Orthologs

Gene Ontology

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Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742